A MOTIF IN THE VERTEBRATE TELOMERASE N-TERMINAL LINKER OF TERT CONTRIBUTES TO RNA BINDING AND TELOMERASE ACTIVITY AND PROCESSIVITY.

20210801 20180803 20170315 20210801 IID50329 Telomerase reverse transcriptase Telomerase catalytic subunit Takifugu rubripes 1074 Q4KTA7 Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. TFLY; involved in RNA binding 300 305 0 0 tert TERT_TAKRU MSITDLSPTLGILRSLYPHVQVLVDFADDIVFREGHKATLIEESDTSHFKSFVRGIFVCFHKELQQVPSCNQICTLPELLAFVLNSVKRKRKRNVLAHGYNFQSLAQEERDADQFKLQGDVTQSAAYVHGSDLWRKVSMRLGTDITRYLFESCSVFVAVPPSCLFQVCGIPIYDCFSLATASLGFSLQSRGCRERCLGVNSMKRRAFNVKRYLRKRKTETDQKDEARVCSGKRRRVMEEDKVSCETMQDGESGKTTLVQKQPGSKKRSEMEATLLPLEGGPSWRSGTFPPLPPSQSFMRTLGFLYGGRGMRSFLLNRKKKTAEGFRKIQGRDLIRIVFFEGVLYLNGLERKPKKLPRRFFNMVPLFSQLLRQHRRCPYSRLLQKTCPLVGIKDAGQAELSSFLPQHCGSHRVYLFVRECLLAVIPQELWGSEHNRLLYFARVRFFLRSGKFERLSVAELMWKIKVNNCDWLKISKTGRVPPSELSYRTQILGQFLAWLLDGFVVGLVRACFYATESMGQKNAIRFYRQEVWAKLQDLAFRSHISKGQMVELTPDQVAALPKSTIISRLRFIPKTDGMRPITRVIGADAKTRLYQSHVRDLLDMLRACVCSTPSLLGSTVWGMTDIHKVLSSIAPAQKEKPQPLYFVKMDVSGAYESLPHNKLIEVINQVLTPVLNEVFTIRRFAKIWADSHEGLKKAFIRQADFLEANMGSINMKQFLTSLQKKGKLHHSVLVEQIFSSDLEGKDALQFFTQILKGSVIQFGKKTYRQCQGVPQGSAVSSVLCCLCYGHMENVLFKDIINKKSCLMRLVDDFLLITPNLHDAQTFLKILLAGVPQYGLVVNPQKVVVNFEDYGSTDSCPGLRVLPLRCLFPWCGLLLDTHTLDIYKDYSSYADLSLRYSLTLGSCHSAGHQMKRKLMGILRLKCHALFLDLKTNSLEAIYKNIYKLLLLHALRFHVCAQSLPFGQSVAKNPAYFLLMIWDMVEYTNYLIRLSNNGLISGSTSQTGSVQYEAVELLFCLSFLLVLSKHRRLYKDLLLHLHKRKRRLEQCLGDLRLARVRQAANPRNPLDFLAIKT 1 4lmoA 294 544 order 1 2 4lmoB 294 544 order 1 3 4lmoC 294 544 order 1 4 4lmoD 294 544 order 1 1 4lmo X-RAY 291K 7 24055314 M.HARKISHEIMER,M.MASON,E.SHUVAEVA,E.SKORDALAKES A MOTIF IN THE VERTEBRATE TELOMERASE N-TERMINAL LINKER OF TERT CONTRIBUTES TO RNA BINDING AND TELOMERASE ACTIVITY AND PROCESSIVITY. 2013 STRUCTURE 21 1870 x-ray 4lmo A 294 544 100 0 x-ray 4lmo B 294 544 100 0 x-ray 4lmo C 294 544 100 0 x-ray 4lmo D 294 544 100 0 1 4lmo_4 573 Monomer monomer 4lmoD Q4KTA7 IID50329 2 4lmo_3 573 Monomer monomer 4lmoC Q4KTA7 IID50329 3 4lmo_2 573 Monomer monomer 4lmoB Q4KTA7 IID50329 4 4lmo_1 573 Monomer monomer 4lmoA Q4KTA7 IID50329 4-103,113-175,298-298,304-304,309-392,397-705,712-851,860-902,907-994,1006-1074 1-3,104-112,176-297,299-303,305-308,393-396,706-711,852-859,903-906,995-1005 4-178,311-318,323-338,357-393,399-901,911-1047,1053-1074 1-3,179-310,319-322,339-356,394-398,902-910,1048-1052 197-229,235-310,319-322,339-356,394-398,902-910,1048-1052 1014-1045