20210801 20180803 20171220 20210801 IID50335 Dual specificity protein phosphatase 6 Mitogen-activated protein kinase phosphatase 3 Rattus norvegicus 381 Q64346 Inactivates MAP kinases. Has a specificity for the ERK family (PubMed:8626780). Implicated in muscle and neuronal differentiation (PubMed:8631996). Plays an important role in alleviating chronic postoperative pain. Necessary for the normal dephosphorylation of the long-lasting phosphorylated forms of spinal MAPK1/3 and MAP kinase p38 induced by peripheral surgery, which drives the resolution of acute postoperative allodynia (By similarity). Also important for dephosphorylation of MAPK1/3 in local wound tissue, which further contributes to resolution of acute pain (By similarity). 0 0 0 0 Dusp6 DUS6_RAT MIDTLRPVPFASEMAISKTVAWLNEQLELGNEQLLLMDCRPQELYESSHIESAINVAIPGIMLRRLQKGNLPVRALFTRCEDRDRFTRRCGTDTVVLYDENSSDWNENTGGESVLGLLLKKLKDEGCRAFYLEGGFSKFQAEFALHCETNLDGSCSSSSPPLPVLGLGGLRISSDSSSDIESDLDRDPNSATDSDGSPLSNSQPSFPVEILPFLYLGCAKDSTNLDVLEEFGIKYILNVTPNLPNLFENAGEFKYKQIPISDHWSQNLSQFFPEAISFIDEARGKNCGVLVHCLAGISRSVTVTVAYLMQKLNLSMNDAYDIVKMKKSNISPNFNFMGQLLDFERTLGLSSPCDNRVPAQQLYFTAPSNQNVYQVDSLQST 1 2fysC 60 63 disorder 1 2 2fysC 64 74 order 1 3 2fysC 75 76 disorder 1 4 2fysD 60 63 disorder 1 5 2fysD 64 74 order 1 6 2fysD 75 76 disorder 1 1 2fys X-RAY 294K 6.5). 16567630 S.LIU,J.P.SUN,B.ZHOU,Z.Y.ZHANG 2006 PROC.NATL.ACAD.SCI.USA 103 5326 x-ray 2fys C 60 76 100 2 60 63 75 76 x-ray 2fys D 60 76 100 2 60 63 75 76 1 2fys_1 1126 Hetero dimer 2fysD Q64346 IID50335 2fysB P63086 IID50321 2fysD-2fysB 2 2fys_2 1126 Hetero dimer 2fysC Q64346 IID50335 2fysA P63086 IID50321 2fysC-2fysA 16-57,74-74,89-89,92-102,113-149,206-349 1-15,58-73,75-88,90-91,103-112,150-205,350-381 1-152,202-352 153-201,353-381 197-201,353-381 23-36,115-123,151-187