20250201 IID50350 Tumor protein 63 Transformation-related protein 63 Tumor protein p73-like Mus musculus 680 O88898 O88897 O88899 O89097 Q8C826 Q9QWY9 Q9QWZ0 Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. Involved in Notch signaling by probably inducing JAG1 and JAG2. Activates transcription of the p21 promoter (By similarity). Activates RIPK4 transcription. Plays a role in the regulation of epithelial morphogenesis. The ratio of DeltaN-type and TA*-type isoforms may govern the maintenance of epithelial stem cell compartments and regulate the initiation of epithelial stratification from the undifferentiated embryonal ectoderm. Required for limb formation from the apical ectodermal ridge. 0 0 0 0 Tp63 Tumor protein 63 MNFETSRCATLQYCPDPYIQRFIETPAHFSWKESYYRSAMSQSTQTSEFLSPEVFQHIWDFLEQPICSVQPIELNFVDEPSENGATNKIEISMDCIRMQDSDLSDPMWPQYTNLGLLNSMDQQIQNGSSSTSPYNTDHAQNSVTAPSPYAQPSSTFDALSPSPAIPSNTDYPGPHSFDVSFQQSSTAKSATWTYSTELKKLYCQIAKTCPIQIKVMTPPPQGAVIRAMPVYKKAEHVTEVVKRCPNHELSREFNEGQIAPPSHLIRVEGNSHAQYVEDPITGRQSVLVPYEPPQVGTEFTTVLYNFMCNSSCVGGMNRRPILIIVTLETRDGQVLGRRCFEARICACPGRDRKADEDSIRKQQVSDSAKNGDGTKRPFRQNTHGIQMTSIKKRRSPDDELLYLPVRGRETYEMLLKIKESLELMQYLPQHTIETYRQQQQQQHQHLLQKQTSMQSQSSYGNSSPPLNKMNSMNKLPSVSQLINPQQRNALTPTTMPEGMGANIPMMGTHMPMAGDMNGLSPTQALPPPLSMPSTSHCTPPPPYPTDCSIVSFLARLGCSSCLDYFTTQGLTTIYQIEHYSMDDLASLKIPEQFRHAIWKGILDHRQLHDFSSPPHLLRTPSGASTVSVGSSETRGERVIDAVRFTLRQTISFPPRDEWNDFNFDMDSRRNKQQRIKEEGE 1 5n2oA 545 609 order 1 2 5n2oA 545 545 high_rmsd 1 1 5n2o NMR 29339502 C.RUSSO,C.OSTERBURG,A.SIRICO,D.ANTONINI,R.AMBROSIO,J.M.WURZ,J.RINNENTHAL,M.FERNIANI,S.KEHRLOESSER,B.SCHAFER,P.GUNTERT,S.SINHA,V.DOTSCH,C.MISSERO 2018 PROC. NATL. ACAD. SCI. 115 E906 nmr 5n2o A 545 609 98 0 1 5n2o_1 3595 Monomer monomer 5n2oA O88898 IID50350 163-255,257-363,399-446,546-606,646-651 1-162,256-256,364-398,447-545,607-645,652-680 7-26,54-59,161-355,397-430,543-608,635-671 1-6,27-53,60-160,356-396,431-542,609-634,672-680 1-6,27-37,47-53,60-78,87-112,119-137,143-147,356-359,431-437,445-449,458-461,470-475,512-520,672-680 437-450,452-463