20250201 20180803 20180328 20250201 IID50376 cAMP-dependent protein kinase inhibitor alpha cAMP-dependent protein kinase inhibitor, muscle/brain isoform Rattus norvegicus 76 P63249 P27776 Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains. 0 0 N-acetylthreonine 2 2 Pkia cAMP-dependent protein kinase in MTDVETTYADFIASGRTGRRNAIHDILVSSASGNSNELALKLAGLDINKTEGEDDGQRSSTEQSGEAQGEAAKSES 1 1q8uB 6 25 order 2 3 1q62I 6 25 order 3 5 1l3rI 6 25 order 1 7 1svhB 6 24 order 5 9 1svhB 25 25 disorder 5 11 1ydtI 6 25 order 4 13 1ydsI 6 25 order 6 1 1l3r X-RAY 277K 8 11896404 MADHUSUDAN,P.AKAMINE,N.H.XUONG,S.S.TAYLOR CRYSTAL STRUCTURE OF A TRANSITION STATE MIMIC OF THE CATALYTIC SUBUNIT OF CAMP-DEPENDENT PROTEIN KINASE. 2002 NAT.STRUCT.BIOL. 9 273 x-ray 1l3r I 6 25 90 0 1 1l3r_1 3353 Hetero dimer 1l3rE P05132 IID50138 1l3rI P63249 IID50376 1l3rE-1l3rI 2 1q8u X-RAY 278K 6.4 14656443 C.BREITENLECHNER,M.GASSEL,H.HIDAKA,V.KINZEL,R.HUBER,R.A.ENGH,D.BOSSEMEYER PROTEIN KINASE A IN COMPLEX WITH RHO-KINASE INHIBITORS Y-27632, FASUDIL, AND H-1152P: STRUCTURAL BASIS OF SELECTIVITY. 2003 STRUCTURE 11 1595 x-ray 1q8u B 6 25 100 0 1 1q8u_1 648 Hetero dimer 1q8uA P00517 IID50134 1q8uB P63249 IID50376 1q8uB-1q8uA 3 1q62 X-RAY 277.15K 6.5 12798691 M.GASSEL,C.B.BREITENLECHNER,P.RUEGER,U.JUCKNISCHKE,T.SCHNEIDER,R.HUBER,D.BOSSEMEYER,R.A.ENGH MUTANTS OF PROTEIN KINASE A THAT MIMIC THE ATP-BINDING SITE OF PROTEIN KINASE B (AKT) 2003 J.MOL.BIOL. 329 1021 x-ray 1q62 I 6 25 100 0 1 1q62_1 648 Hetero dimer 1q62A P00517 IID50134 1q62I P63249 IID50376 1q62I-1q62A 4 1ydt X-RAY 6.5 8824261 R.A.ENGH,A.GIROD,V.KINZEL,R.HUBER,D.BOSSEMEYER CRYSTAL STRUCTURES OF CATALYTIC SUBUNIT OF CAMP-DEPENDENT PROTEIN KINASE IN COMPLEX WITH ISOQUINOLINESULFONYL PROTEIN KINASE INHIBITORS H7, H8, AND H89. STRUCTURAL IMPLICATIONS FOR SELECTIVITY. 1996 J.BIOL.CHEM. 271 26157 x-ray 1ydt I 6 25 100 0 1 1ydt_1 648 Hetero dimer 1ydtE P00517 IID50134 1ydtI P63249 IID50376 1ydtI-1ydtE 5 1svh X-RAY 278K 6.4 14998327 C.B.BREITENLECHNER,T.WEGGE,L.BERILLON,K.GRAUL,K.MARZENELL,W.G.FRIEBE,U.THOMAS,R.SCHUMACHER,R.HUBER,R.A.ENGH,B.MASJOST STRUCTURE-BASED OPTIMIZATION OF NOVEL AZEPANE DERIVATIVES AS PKB INHIBITORS 2004 J.MED.CHEM. 47 1375 x-ray 1svh B 6 25 100 1 25 25 1 1svh_1 648 Hetero dimer 1svhA P00517 IID50134 1svhB P63249 IID50376 1svhB-1svhA 6 1yds X-RAY 6.5 8824261 R.A.ENGH,A.GIROD,V.KINZEL,R.HUBER,D.BOSSEMEYER CRYSTAL STRUCTURES OF CATALYTIC SUBUNIT OF CAMP-DEPENDENT PROTEIN KINASE IN COMPLEX WITH ISOQUINOLINESULFONYL PROTEIN KINASE INHIBITORS H7, H8, AND H89. STRUCTURAL IMPLICATIONS FOR SELECTIVITY. 1996 J.BIOL.CHEM. 271 26157 x-ray 1yds I 6 25 100 0 1 1yds_1 648 Hetero dimer 1ydsE P00517 IID50134 1ydsI P63249 IID50376 1ydsI-1ydsE ProS 1 possible 1,3,5,7,11,13 6 25 Same region of the rabbit ortholog (P61926, 97.4 0dentity) is disordered in the free state. 2-13,35-51 1-1,14-34,52-76 10-14,23-28 1-9,15-22,29-76 4-9,15-22,35-50