20250201 20180803 20171122 20250201 IID50397 cAMP-dependent protein kinase inhibitor alpha Sus scrofa 76 Q71U53 Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains. 0 0 N-acetylthreonine 2 2 PKIA cAMP-dependent protein kinase in MTDVETTYADFIASGRTGRRNAIHDILVSSASGNSNELALKLAGLDINKTEGEEDAQRSSTEQSGEAQGEAAKSES 1 1q61I 6 25 order 1 2 2f7xI 6 25 order 2 3 1q24I 6 25 order 3 1 1q61 X-RAY 277.15K 6.4 12798691 M.GASSEL,C.B.BREITENLECHNER,P.RUEGER,U.JUCKNISCHKE,T.SCHNEIDER,R.HUBER,D.BOSSEMEYER,R.A.ENGH MUTANTS OF PROTEIN KINASE A THAT MIMIC THE ATP-BINDING SITE OF PROTEIN KINASE B (AKT) 2003 J.MOL.BIOL. 329 1021 x-ray 1q61 I 6 25 100 0 1 1q61_1 1050 Hetero dimer 1q61A P00517 IID50134 1q61I Q71U53 IID50397 1q61I-1q61A 2 2f7x X-RAY 277K 16403626 Q.LI,T.LI,G.D.ZHU,J.GONG,A.CLAIBONE,C.DALTON,Y.LUO,E.F.JOHNSON,Y.SHI,X.LIU,V.KLINGHOFER,J.L.BAUCH,K.C.MARSH,J.J.BOUSKA,S.ARRIES,R.DE JONG,T.OLTERSDORF,V.S.STOLL,C.G.JAKOB,S.H.ROSENBERG,V.L.GIRANDA DISCOVERY OF TRANS-3,4'-BISPYRIDINYLETHYLENES AS POTENT AND NOVEL INHIBITORS OF PROTEIN KINASE B (PKB/AKT) FOR THE TREATMENT OF CANCER: SYNTHESIS AND BIOLOGICAL EVALUATION. 2006 BIOORG.MED.CHEM.LETT. 16 1679 x-ray 2f7x I 6 25 100 0 1 2f7x_1 1050 Hetero dimer 2f7xE P00517 IID50134 2f7xI Q71U53 IID50397 2f7xI-2f7xE 3 1q24 X-RAY 277.16K 6.4 12798691 M.GASSEL,C.B.BREITENLECHNER,P.RUEGER,U.JUCKNISCHKE,T.SCHNEIDER,R.HUBER,D.BOSSEMEYER,R.A.ENGH MUTANTS OF PROTEIN KINASE A THAT MIMIC THE ATP-BINDING SITE OF PROTEIN KINASE B (AKT) 2003 J.MOL.BIOL. 329 1021 x-ray 1q24 I 6 25 100 0 1 1q24_1 1050 Hetero dimer 1q24A P00517 IID50134 1q24I Q71U53 IID50397 1q24I-1q24A ProS 1 possible 1,2,3 6 25 Same region of the rabbit ortholog (P61926, 100 0dentity) is disordered in the free state. 2-13,35-51 1-1,14-34,52-76 10-19,24-28 1-9,20-23,29-76 5-9,20-23,35-50