20210801 20180803 20171025 20210801 IID90006 Tegument protein VP16 Alpha trans-inducing protein Alpha-TIF ICP25 Vmw65 Human herpesvirus 1 (strain F) 490 P04486 Transcriptional activator of immediate-early (IE) gene products (alpha genes). Acts as a key activator of lytic infection by initiating the lytic program through the assembly of the transcriptional regulatory VP16-induced complex composed of VP16 and two cellular factors, HCFC1 and POU2F 1. VP16-induced complex represents a regulatory switch: when it is on, it promotes IE-gene expression and thus lytic infection, and when it is off, it limits IE-gene transcription favoring latent infection (By similarity). May play a role in the aggregation of tegument proteins around nucleocapsids during virus morphogenesis. Phosphoserine 18 18 Phosphoserine 353 353 Phosphoserine 411 411 Phosphoserine 452 452 UL48 VP16_HHV1F MDLLVDELFADMDADGASPPPPRPAGGPKNTPAAPPLYATGRLSQAQLMPSPPMPVPPAALFNRLLDDLGFSAGPALCTMLDTWNEDLFSALPTNADLYRECKFLSTLPSDVVEWGDAYVPERAQIDIRAHGDVAFPTLPATRDGLGLYYEALSRFFHAELRAREESYRTVLANFCSALYRYLRASVRQLHRQAHMRGRDRDLGEMLRATIADRYYRETARLARVLFLHLYLFLTREILWAAYAEQMMRPDLFDCLCCDLESWRQLAGLFQPFMFVNGALTVRGVPIEARRLRELNHIREHLNLPLVRSAATEEPGAPLTTPPTLHGNQARASGYFMVLIRAKLDSYSSFTTSPSEAVMREHAYSRARTKNNYGSTIEGLLDLPDDDAPEEAGLAAPRLSFLPAGHTRRLSTAPPTDVSLGDELHLDGEDVAMAHADALDDFDLDMLGDGDSPGPGFTPHDSAPYGALDMADFEFEQMFTDALGIDEYGG 1 2k2uB 456 490 order 1 2 412 490 disorder 2 1 2k2u NMR 18630911 C.LANGLOIS,C.MAS,P.DI LELLO,L.M.JENKINS,P.LEGAULT,J.G.OMICHINSKI 2008 J.AM.CHEM.SOC. 130 10596 nmr 2k2u B 456 490 100 0 1 2k2u 3710 Hetero dimer 2k2uB P04486 IID90006 2k2uA P32776 IID50021 2k2uB-2k2uA 2 none NMR 1314658 O'Hare P, Williams G. 1992 Biochemistry 31 4150 ProS 1 verified 1 456 490 2 412 490 This region is the carboxyl subdomain of the VP16 TAD. It interactes with different partners. 46-351,372-373,395-403 1-45,352-371,374-394,404-490 39-49,58-194,199-312,320-353,395-406,414-430,436-490 1-38,195-198,354-394 1-15,24-38,195-198,354-394 14-28,49-58,378-393,432-451