20210801 20180803 20180228 20210801 IID90016 Middle T antigen Murine polyomavirus (strain A2) 421 P03077 Plays a role in transformation by modulating the activities of cellular proteins involved in control of cell proliferation and by acting as a functional homolog of an activated tyrosine kinase-associated growth-factor receptor. Recruits upon association with host Ppp2/PP2A the Src tyrosine kinase components Src, Yes and Fyn, thereby activating their kinase activity. Activation of Shc1, Pclg1 and p85 mediate signal transduction pathways leading to cell cycle progression and cell division. MT plays also a role in regulation of early and late gene expression and in viral DNA replication. 0 0 Phosphotyrosine; by host 250 250 Phosphoserine; by host 257 257 Phosphotyrosine; by host 315 315 Phosphotyrosine; by host 322 322 MDRVLSRADKERLLELLKLPRQLWGDFGRMQQAYKQQSLLLHPDKGGSHALMQELNSLWGTFKTEVYNLRMNLGGTGFQVRRLHADGWNLSTKDTFGDRYYQRFCRMPLTCLVNVKYSSCSCILCLLRKQHRELKDKCDARCLVLGECFCLECYMQWFGTPTRDVLNLYADFIASMPIDWLDLDVHSVYNPKRRSEELRRAATVHYTMTTGHSAMEASTSQGNGMISSESGTPATSRRLRLPSLLSNPTYSVMRSHSYPPTRVLQQIHPHILLEEDEILVLLSPMTAYPRTPPELLYPESDQDQLEPLEEEEEEYMPMEDLYLDILPGEQVPQLIPPPIIPRAGLSPWEGLILRDLQRAHFDPILDASQRMRATHRAALRAHSMQRHLRRLGRTLLLVTFLAALLGICLMLFILIKRSRHF 1 1yguC 248 251 order 1 2 1yguD 248 251 order 1 1 1ygu X-RAY 293K 5 15684325 H.J.NAM,F.POY,H.SAITO,C.A.FREDERICK 2005 J.EXP.MED. 201 441 x-ray 1ygu C 248 251 75 0 x-ray 1ygu D 248 251 75 0 1 1ygu_1 1656 Hetero dimer 1yguA P08575 IID00537 1yguC P03077 IID90016 1yguA-1yguC 2 1ygu_2 1656 Hetero dimer 1yguB P08575 IID00537 1yguD P03077 IID90016 1yguD-1yguB 1-181,393-415 182-250,288-333,370-392,416-421 251-287,334-369 3009 PF02380 92->183 3.2e-35 T-antigen specific domain hmm pfm 5278 2pkgC1 100->178 1.4e-25 hmm scp 5279 1fafA_ 1->76 1.4e-19 hmm scp 7925 PF02380 93->183 3e-28 T-antigen specific domain rps pfm 10105 1fafA 1->79 7e-22 rps scp 10106 2pkgC1 102->178 1e-22 rps scp