PSEUDO-MEROHEDRAL TWINNING AND NONCRYSTALLOGRAPHIC SYMMETRY IN ORTHORHOMBIC CRYSTALS OF SIVMAC239 NEF CORE DOMAIN BOUND TO DIFFERENT-LENGTH TCRZETA FRAGMENTS.

20210801 20180803 20171122 20210801 IID90022 Protein Nef 3'ORF Negative factor Simian immunodeficiency virus (isolate 1A11) 263 P31818 Interferes with TCR signaling from the cell membrane. Interacts with CD247/TCRZ (TCR zeta chain) and exert potent down-regulation of cell surface TCR/CD3 complexes. 0 0 0 0 MGGTISMRRSRSTGDLRQRLLRARGETYERLLGEVEDGSSQSLGELDKGLSSLSCEGQKYNQEQYMNTPWRNPAEEREKLAYRKQNMDDIDEEDDDLVGDTVRPKVPLRTMSYKLAIDMSHFIKEKGGLEGIYYSARRHRILDIYLEKEEGIIPDWQDYTSGPGIRYPKTFGWLWKLVPVNVSDEAQEDEEHYLMHPAQTSQWDDPWGEVPAWKFDPTLAYTYEAYVRYPEEFGSKSGLSEEEVRRRLTARGLLNMADKKETR 1 3ik5A 95 99 disorder 1 2 3ik5A 100 180 order 1 3 3ik5A 181 196 disorder 1 4 3ik5A 197 234 order 1 5 3ik5A 235 235 disorder 1 6 3ik5C 95 99 disorder 1 7 3ik5C 100 181 order 1 8 3ik5C 182 199 disorder 1 9 3ik5C 200 234 order 1 10 3ik5C 235 235 disorder 1 1 3ik5 X-RAY 277K 7.5 20124696 W.M.KIM,A.B.SIGALOV,L.J.STERN PSEUDO-MEROHEDRAL TWINNING AND NONCRYSTALLOGRAPHIC SYMMETRY IN ORTHORHOMBIC CRYSTALS OF SIVMAC239 NEF CORE DOMAIN BOUND TO DIFFERENT-LENGTH TCRZETA FRAGMENTS. 2010 ACTA CRYSTALLOGR.,SECT.D 66 163 x-ray 3ik5 A 95 235 97 3 95 99 181 196 235 235 x-ray 3ik5 C 95 235 97 3 95 99 182 199 235 235 1 3ik5 3663 Hetero tetramer 3ik5D P20963 IID00544 3ik5B P20963 IID00544 3ik5C P31818 IID90022 3ik5A P31818 IID90022 3ik5D-3ik5C 3ik5B-3ik5A 3ik5C-3ik5A 6-83,101-234 1-5,84-100,235-263 3014 PF00469 2->234 1.6e-100 Negative factor, (F-Protein) or Nef hmm pfm 5284 1efnB_ 103->233 3.1e-63 hmm scp 7931 PF00469 2->231 8e-72 Negative factor, (F-Protein) or Nef rps pfm 10112 3reaA 90->231 9e-48 rps scp