20210801 20180803 20180228 20210801 IID90023 Protein Nef 3'ORF Negative factor Human immunodeficiency virus type 1 group M subtype B 206 Q70627 Extracellular Nef protein targets CD4(+) T-lymphocytes for apoptosis by interacting with CXCR4 surface receptors. PxxP; stabilizes the interaction of NEF/MHC-I with host AP1M1; necessary for MHC-I internalization 72 75 Dileucine internalization motif; necessary for CD4 internalization 164 165 Diacidic; necessary for CD4 internalization 174 175 Phosphoserine; by host 6 6 MGGKWSKSSVIGWPTVRERMRRAEPAADGVGAASQDLEKHGAITSSNTAATNADCAWLEAQEEEEVGFPVTPQVPLRPMTYKAAVDLSHFLKEKGGLEGLIHSQRRQDILDLWIYHTQGYFPDWQNYTPGPGIRYPLTFGWCYKLVPVEPEKLEEANKGENTSLLHPVSLHGMDDPEREVLEWRFDSRLAFHHVARELHPEYFKNC 2 2nefA 56 158 order 1 4 2nefA 56 70 high_rmsd 1 5 2nefA 189 190 high_rmsd 1 5 2nefA 174 205 order 1 1 2nef NMR 9194185 S.GRZESIEK,A.BAX,J.S.HU,J.KAUFMAN,I.PALMER,S.J.STAHL,N.TJANDRA,P.T.WINGFIELD 1997 PROTEIN SCI. 6 1248 nmr 2nef A 56 205 99 0 1 2nef_1 2778 Monomer monomer 2nefA Q70627 IID90023 2-204 1-1,205-206 3015 PF00469 2->205 1.4e-97 Negative factor, (F-Protein) or Nef hmm pfm 5285 2nefA_ 56->206 3.3e-75 hmm scp 7932 PF00469 2->201 3e-84 Negative factor, (F-Protein) or Nef rps pfm 10113 3reaA 52->201 2e-64 rps scp