20210801 20180803 20180425 20210801 IID90028 Ankyrin repeat domain-containing protein A238L p28 African swine fever virus 239 O36972 Inhibits activation of the NF-kappa-B transcription factor by preventing binding of NF-kappa-B subunits RELA and NFKB3 to DNA. Inhibits also the activity of the calcium/calmodulin-regulated phosphatase calcineurin. 0 0 0 0 MDTIGLFSVEAEHLFVEWVKKCIKKGDLTLFETLFNADPWIVNRCNKNKITVFMLICIYGRLDFLRFLFKQESYPGEIVNHYRRDKDGNSAWHYLAEKNNHLLLEEVLDYFGKNGIRVCFPNFNGVTPIMKAAMRGRTLSVLSLLKYGANPNRKDYLKGFTTWDWAVFTGHADLVKTLNKGYQKPLFMHFPLYKLDVFHRRFKKKPKIIITGCEDNVYEKLPEQNSNFLCVKKLNKYGK 1 4f0zC 200 204 disorder 1 2 4f0zC 205 234 order 1 3 4f0zC 235 239 disorder 1 1 4f0z X-RAY 295K 23468591 S.GRIGORIU,R.BOND,P.COSSIO,J.A.CHEN,N.LY,G.HUMMER,R.PAGE,M.S.CYERT,W.PETI THE MOLECULAR MECHANISM OF SUBSTRATE ENGAGEMENT AND IMMUNOSUPPRESSANT INHIBITION OF CALCINEURIN. 2013 PLOS BIOL. 11 1492 x-ray 4f0z C 200 239 100 2 200 204 235 239 1 4f0z_1 2094 Hetero trimer 4f0zA Q08209 IID00069 4f0zB P63098 IID00060 4f0zC O36972 IID90028 4f0zB-4f0zC 4f0zA-4f0zB 4f0zA-4f0zC 42-180 1-41,181-239 3020 PF00023 124->155 4.1e-07 Ankyrin repeat hmm pfm 5291 1s70B_ 22->178 1.5e-25 hmm scp 7937 PF13637 125->178 1e-04 Ankyrin repeats (many copies) rps pfm 10119 4cj9A 42->178 6e-15 rps scp