THE STRUCTURE OF HLA-B8 COMPLEXED TO AN IMMUNODOMINANT VIRAL DETERMINANT: PEPTIDE-INDUCED CONFORMATIONAL CHANGES AND A MODE OF MHC CLASS I DIMERIZATION.

20210801 20180803 20180425 20210801 IID90029 Epstein-Barr nuclear antigen 3 Epstein-Barr nuclear antigen 3A Epstein-Barr virus (strain B95-8) 944 P12977 P03202 Q66540 Q69021 Q8AZJ8 Plays an essential role for activation and immortalization of human B-cells. Represses transcription of viral promoters TP1 and Cp through interaction with host RBPJ, and inhibits EBNA2-mediated activation of these promoters. Since Cp is the promoter for all EBNA mRNAs, EBNA3A probably contributes to a negative autoregulatory control loop. 0 0 0 0 MDKDRPGPPALDDNMEEEVPSTSVVQEQVSAGDWENVLIELSDSSSEKEAEDAHLEPAQKGTKRKRVDHDAGGSAPARPMLPPQPDLPGREAILRRFPLDLRTLLQAIGAAATRIDTRAIDQFFGSQISNTEMYIMYAMAIRQAIRDRRRNPASRRDQAKWRLQTLAAGWPMGYQAYSSWMYSYTDHQTTPTFVHLQATLGCTGGRRCHVTFSAGTFKLPRCTPGDRQWLYVQSSVGNIVQSCNPRYSIFFDYMAIHRSLTKIWEEVLTPDQRVSFMEFLGFLQRTDLSYIKSFVSDALGTTSIQTPWIDDNPSTETAQAWNAGFLRGRAYGIDLLRTEGEHVEGATGETREESEDTESDGDDEDLPCIVSRGGPKVKRPPIFIRRLHRLLLMRAGKRTEQGKEVLEKARGSTYGTPRPPVPKPRPEVPQSDETATSHGSAQVPEPPTIHLAAQGMAYPLHEQHGMAPCPVAQAPPTPLPPVSPGDQLPGVFSDGRVACAPVPAPAGPIVRPWEPSLTQAAGQAFAPVRPQHMPVEPVPVPTVALERPVYPKPVRPAPPKIAMQGPGETSGIRRARERWRPAPWTPNPPRSPSQMSVRDRLARLRAEAQVKQASVEVQPPQLTQVSPQQPMEGPLVPEQQMFPGAPFSQVADVVRAPGVPAMQPQYFDLPLIQPISQGAPVAPLRASMGPVPPVPATQPQYFDIPLTEPINQGASAAHFLPQQPMEGPLVPEQWMFPGAALSQSVRPGVAQSQYFDLPLTQPINHGAPAAHFLHQPPMEGPWVPEQWMFQGAPPSQGTDVVQHQLDALGYTLHGLNHPGVPVSPAVNQYHLSQAAFGLPIDEDESGEGSDTSEPCEALDLSIHGRPCPQAPEWPVQEEGGQDATEVLDLSIHGRPRPRTPEWPVQGEGGQNVTGPETRRVVVSAVVHMCQDDEFPDLQDPPDEA 1 1xr8C 406 414 order 2 2 1m05E 325 333 order 1 3 1m05F 325 333 order 1 1 1m05 X-RAY 12391232 L.KJER-NIELSEN,C.S.CLEMENTS,A.G.BROOKS,A.W.PURCELL,M.R.FONTES,J.MCCLUSKEY,J.ROSSJOHN THE STRUCTURE OF HLA-B8 COMPLEXED TO AN IMMUNODOMINANT VIRAL DETERMINANT: PEPTIDE-INDUCED CONFORMATIONAL CHANGES AND A MODE OF MHC CLASS I DIMERIZATION. 2003 J.IMMUNOL. 169 5153 x-ray 1m05 E 325 333 88 0 x-ray 1m05 F 325 333 88 0 1 1m05_1 1342 Hetero trimer 1m05E P12977 IID90029 1m05B P61769 1m05A P30460 1m05E-1m05A 1m05B-1m05A 2 1m05_2 1342 Hetero trimer 1m05F P12977 IID90029 1m05D P61769 1m05C P30460 1m05D-1m05C 2 1xr8 X-RAY 277K 6.5 17057332 G.RODER,T.BLICHER,S.JUSTESEN,B.JOHANNESEN,O.KRISTENSEN,J.KASTRUP,S.BUUS,M.GAJHEDE CRYSTAL STRUCTURES OF TWO PEPTIDE-HLA-B*1501 COMPLEXES; STRUCTURAL CHARACTERIZATION OF THE HLA-B62 SUPERTYPE 2006 ACTA CRYSTALLOGR.,SECT.D 62 1300 x-ray 1xr8 C 406 414 100 0 1 1xr8_1 3346 Hetero trimer 1xr8C P12977 IID90029 1xr8B P61769 1xr8A P30464 1xr8C-1xr8A 1xr8B-1xr8A 1-88,131-186,332-944 89-130,187-331 3021 PF05009 139->386 6.6e-127 Epstein-Barr virus nuclear antigen 3 (EBNA-3) hmm pfm 7938 PF05009 139->386 2e-92 Epstein-Barr virus nuclear antigen 3 (EBNA-3) rps pfm