STRUCTURAL ANALYSIS OF 14-3-3 PHOSPHOPEPTIDE COMPLEXES IDENTIFIES A DUAL ROLE FOR THE NUCLEAR EXPORT SIGNAL OF 14-3-3 IN LIGAND BINDING

20250201 20180803 20180425 20250201 IID90034 Middle T antigen Murine polyomavirus (strain BG) 421 P0DOJ7 P03076 Q76TX4 Q76W01 Q89765 Plays a role in transformation by modulating the activities of cellular proteins involved in control of cell proliferation and by acting as a functional homolog of an activated tyrosine kinase-associated growth-factor receptor. Recruits upon association with host Ppp2/PP2A the Src tyrosine kinase components Src, Yes and Fyn, thereby activating their kinase activity. Activation of Shc1, Pclg1 and p85 mediate signal transduction pathways leading to cell cycle progression and cell division. MT plays also a role in regulation of early and late gene expression and in viral DNA replication. 0 0 Phosphotyrosine; by host 250 250 Phosphoserine; by host 257 257 Phosphotyrosine; by host 315 315 Phosphotyrosine; by host 322 322 Middle T antigen MDRVLSRADKERLLELLKLPRQLWGDFGRMQQAYKQQSLLLHPDKGGSHALMQELNSLWGTFKTEVYNLRMNLGGTGFQVRRLHADGWNLSTKDTFGDRYYQRFCRMPLTCLVNVKYSSCSCILCLLRKQHRELKDKCDARCLVLGECFCLECYMQWFGTPTRDVLNLYADFIASMPIDWLDLDVHSVYNPKRRSEELRRAATVHYTMTTGHSAMEASTSQGNGMISSESGTPATSRRLRLPSLLSNPTYSVMRSHSYPPTRVLQQIHPHILLEEDEILVLLSPMTAYPRTPPELLYPESDQDQLEPLEEEEEEYMPMEDLYLDILPEEQVPQLIPPPIIPRAGLSPWEGLILRDLQRAHFDPILDASQRMRATHRAALRAHSMQRHLRRLGRTLLLVTFLAALLGICLMLFILIKRSRHF 1 1fu5B 312 326 order 2 2 1qjbQ 254 259 order 1 3 1qjbS 254 259 order 1 1 1qjb X-RAY 6.2 10488331 K.RITTINGER,J.BUDMAN,J.XU,S.VOLINIA,L.C.CANTLEY,S.J.SMERDON,S.J.GAMBLIN,M.B.YAFFE STRUCTURAL ANALYSIS OF 14-3-3 PHOSPHOPEPTIDE COMPLEXES IDENTIFIES A DUAL ROLE FOR THE NUCLEAR EXPORT SIGNAL OF 14-3-3 IN LIGAND BINDING 1999 MOL.CELL 4 153 x-ray 1qjb Q 254 259 83 0 x-ray 1qjb S 254 259 83 0 1 1qjb 6172 Hetero tetramer 1qjbS P0DOJ7 IID90034 1qjbQ P0DOJ7 IID90034 1qjbB P63104 IID00061 1qjbA P63104 IID00061 1qjbB-1qjbA 1qjbQ-1qjbA 1qjbS-1qjbB 2 1fu5 NMR 11123912 T.WEBER,B.SCHAFFHAUSEN,Y.LIU,U.L.GUNTHER NMR STRUCTURE OF THE N-SH2 OF THE P85 SUBUNIT OF PHOSPHOINOSITIDE 3-KINASE COMPLEXED TO A DOUBLY PHOSPHORYLATED PEPTIDE REVEALS A SECOND PHOSPHOTYROSINE BINDING SITE. 2000 BIOCHEMISTRY 39 15860 nmr 1fu5 B 312 326 86 0 1 1fu5 5005 Hetero dimer 1fu5B P0DOJ7 IID90034 1fu5A Q63787 IID50255 1fu5B-1fu5A 1-78,84-212,246-284,317-374,393-415 79-83,213-245,285-316,375-392,416-421 79-83,224-241,285-288,301-309,316-316,375-392,416-421 10-23,236-246,271-282,302-323,326-341,386-405