20210801 20180803 20180328 20210801 IID90036 Tyrosine-protein kinase-interacting protein Saimiriine herpesvirus 2 (strain 488) 256 P22575 Q778B4 Plays a critical role in virus induced T-cell transformation. Binds to T-cell-specific tyrosine kinase LCK SH2 and SH3 domains, thereby activating its kinase activity. Once phosphorylated by host LCK, forms a complex with at least STAT 1 and 3, resulting on the phosphorylation of STAT3 and presumably STAT1, and their migration into the nucleus to induce transcription of target genes. Stimulates host ILF3/NF-AT-90 activity. Association with host NXF1/TAP transduces the signal up-regulating surface expression of adhesion molecules as well as activating NF-kappa-B activity. Acts synergistically with StpC to stimulate NF-kappa-B activity and interleukin-2 gene expression. Activation of NF-kappa-B protects lymphocytes from apoptosis, thereby facilitating viral induced cell transformation. May cause down-regulation of host LCK and cell apoptosis when stably overexpressed ex vivo. Interaction with WDR48 induce degradation of T-cell receptor in a lysosome-dependent fashion, when both proteins are overexpressed. The biological effect of this interaction remains controversial since no T-cell receptor degradation is observed in infected cells. 0 0 Phosphotyrosine; by host LCK 114 114 Phosphotyrosine; by host 127 127 MANEGEEIELTEFPETEKERKDEEKLSSCSEETTNTSSSSGSDHVPVPIEVNVIIQNSSRTEDELQNSKEIELTGFQGKLSSCSEETTAPSSSYSSKQASVFIEENGDNETSTYRPQNVLTNLNSLYTTFEDARAQGKGMVRHKSEDLQSFLEKYPPDFRKPKRDLSATWDPGMPTPPLPPRPANLGERQASTVRLHVKESNCKQPRERKANERNIVKDLKRLENKINVIICLVVVILAVLLLVTVLSILHIGMKS 1 1wa7B 170 191 order 1 2 1wa7B 170 173 high_rmsd 1 3 1wa7B 190 191 high_rmsd 1 1 1wa7 NMR 11955060 K.SCHWEIMER,S.HOFFMANN,F.BAUER,U.FRIEDRICH,C.KARDINAL,S.M.FELLER,B.BIESINGER,H.STICHT 2002 BIOCHEMISTRY 41 5120 nmr 1wa7 B 170 191 100 0 1 1wa7 3950 Hetero dimer 1wa7A P07948 IID00701 1wa7B P22575 IID90036 1wa7B-1wa7A 227-249 1-226,250-256