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IID00584
 UniprotQ9BQB4
ProteinSclerostin
GeneSOST
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
213
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 24-177 Hetero tetramer : IID00531Complex
 Evidence X-RAY 6l6r D Reference
       Region 6l6r D 24-77 disorder
       Region 6l6r D 78-121 order
       Region 6l6r D 122-130 disorder
       Region 6l6r D 131-177 order
 Evidence X-RAY 6l6r C Reference
       Region 6l6r C 24-77 disorder
       Region 6l6r C 78-121 order
       Region 6l6r C 122-128 disorder
       Region 6l6r C 129-177 order
Seq 25-213 Monomer :
 Evidence NMR 2k8p A Reference
       Region 2k8p A 25-79 disorder
       Region 2k8p A 25-78 high_rmsd
       Region 2k8p A 80-109 order
       Region 2k8p A 110-137 disorder
       Region 2k8p A 112-131 high_rmsd
       Region 2k8p A 138-168 order
       Region 2k8p A 169-213 disorder
       Region 2k8p A 171-213 high_rmsd
Seq 115-121 Hetero dimer : IID00531Complex
 Evidence X-RAY 3sov Z Reference
       Region 3sov Z 115-121 order
SeqProS verified 110-121 Hetero tetramer : IID00531Complex
       Region 6l6r C 78-121 order
       Region 6l6r D 78-121 order
       Region 2k8p A 110-137 disorder
SeqProS verified 115-121 Hetero dimer : IID00531Complex
       Region 3sov Z 115-121 order
       Region 2k8p A 110-137 disorder
 
Prediction
NeProc
Disorder 1-67,174-213
Order 68-173
ProS 1-43,58-67,174-180,205-213
AlphaFold
Disorder 1-3,19-57,59-64,66-77,112-130,175-213
Order 4-18,58-58,65-65,78-111,131-174
Pfam Hmmer
PF05463 1-210 9.6e-159
SEG 3-14 ,35-51 ,193-204
Function
Function in SwissProt
Negative regulator of bone growth that acts through inhibition of Wnt signaling and bone formation.
Biological Process
Diagram with PDB data
SOST/LRP6The structure of a beta propeller domain in complex with peptide S