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IID00626  Transcription factor SOX-2 (Homo sapiens) P48431
  :order  :disorder  :conflict  :PDB cluster  :ProS  :SCOP Domain  :Pfam Domain
Networkxml
Experiment
317
fasta
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 39-118 Monomer :
 Evidence NMR 2le4 A C terminus of the Sox2-HMG domain is described to be disordered in the free state (PubMed=12923055). Reference
       Region 2le4 A 39-104 order
       Region 2le4 A 39-42 high_rmsd
       Region 2le4 A 105-118 disorder
       Region 2le4 A 105-118 high_rmsd
Seq 39-121 Hetero dimer : IID00144Complex
 Evidence NMR 1o4x B Reference
       Region 1o4x B 39-115 order
       Region 1o4x B 116-121 disorder
SeqProS verified 105-115 This region is ordered when it binds upon DNA. Hetero dimer : IID00144Complex
       Region 1o4x B 39-115 order
       Region 2le4 A 105-118 disorder
Seqphosphorylation
    251-251 Phosphoserine
 
Prediction
DICHOT
Disorder 1-38,118-317
Known Domain 39-117
SCOPe RPS-Blast
     1lefA 41-124 3e-41 a.21.1.1 High mobility group protein 1, HMG1
SCOP Hmmer
     1cg7A_ 34-113 6.3e-32 a.21.1.1 High mobility gr...
Pfam RPS-Blast
     PF00505 42-109 2e-16 HMG (high mobility group) bo...
     PF12336 110-200 1e-11 SOX transcription factor
Pfam Hmmer
    PF00505 41-109 3e-31 HMG (high mobility group) box
    PF12336 110-200 5.3e-42 SOX transcription factor