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IID00676
 UniprotQ96F24
ProteinNuclear receptor-binding factor 2
GeneNRBF2
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
287
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 4-86 Monomer :
 Evidence X-RAY 4zey A Reference
       Region 4zey A 4-86 order
Seqphosphorylation
    113-113 Phosphoserine
    268-268 Phosphoserine
 
Prediction
NeProc
Disorder 1-5,75-160,210-258
Order 6-74,161-209,259-287
ProS 1-5,75-89,107-112,127-160,210-233,245-258
AlphaFold
Disorder 1-4,97-139,147-147,149-160,209-259,261-261,264-264,267-287
Order 5-96,140-146,148-148,161-208,260-260,262-263,265-266
Function
Function in SwissProt
Involved in starvation-induced autophagy probably by its association with PI3K complex I (PI3KC3-C1). However, effects has been described variably. Involved in the induction of starvation-induced autophagy (PubMed:24785657). Stabilzes PI3KC3-C1 assembly and enhances ATG14-linked lipid kinase activity of PIK3C3 (By similarity). Proposed to negatively regulate basal and starvation-induced autophagy and to inhibit PIK3C3 activity by modulating interactions in PI3KC3-C1 (PubMed:25086043). May be involved in autophagosome biogenesis (PubMed:25086043). May play a role in neural progenitor cell survival during differentiation.