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IID50268
 UniprotO88597
ProteinBeclin-1
GeneBecn1
OrganismMus musculus
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
448
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 106-124 Hetero dimer : P89884
 Evidence X-RAY 3bl2 C Reference
       Region 3bl2 C 106-124 order
 Evidence X-RAY 3bl2 D Reference
       Region 3bl2 D 106-124 order
SeqProS possible 106-124 Same region of human homolog (Q14457, 97%identity) is disordered in the free state. Hetero dimer : P89884
       Region 3bl2 C 106-124 order
       Region 3bl2 D 106-124 order
Seqphosphorylation
    14-14 Phosphoserine
    29-29 Phosphoserine
    88-88 Phosphoserine; by AMPK
    91-91 Phosphoserine; by AMPK
    94-94 Phosphoserine; by AMPK
    117-117 Phosphothreonine; by DAPK1
Seqacetylation
    1-1 N-acetylmethionine
 
Prediction
NeProc
Disorder 1-16,29-111
Order 17-28,112-448
ProS 12-16,29-42,76-88
AlphaFold
Disorder 1-15,25-120,123-124,126-130,132-132,170-173,355-359,384-386,446-448
Order 16-24,121-122,125-125,131-131,133-169,174-354,360-383,387-445
Pfam Hmmer
PF04111 113-448 1.7e-232
SEG 139-150 ,176-192
Function
Function in SwissProt
Beclin-1-C 35 kDa localized to mitochondria can promote apoptosis; it induces the mitochondrial translocation of BAX and the release of proapoptotic factors.