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IID90022
 UniprotP31818
ProteinProtein Nef
Genenef
OrganismSimian immunodeficiency virus (isolate 1A11)
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
263
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 95-235 Hetero tetramer : IID00544Complex
 Evidence X-RAY 3ik5 C Reference
       Region 3ik5 C 95-99 disorder
       Region 3ik5 C 100-181 order
       Region 3ik5 C 182-199 disorder
       Region 3ik5 C 200-234 order
       Region 3ik5 C 235-235 disorder
 Evidence X-RAY 3ik5 A Reference
       Region 3ik5 A 95-99 disorder
       Region 3ik5 A 100-180 order
       Region 3ik5 A 181-196 disorder
       Region 3ik5 A 197-234 order
       Region 3ik5 A 235-235 disorder
 
Prediction
NeProc
Disorder 1-64,71-75,258-263
Order 65-70,76-257
ProS 1-6,13-34,47-64,71-75
AlphaFold
Disorder 1-14,22-104,182-203,259-263
Order 15-21,105-181,204-258
Pfam Hmmer
PF00469 2-235 2.9e-150
SEG 88-96
Function
Function in SwissProt
Interferes with TCR signaling from the cell membrane. Interacts with CD247/TCRZ (TCR zeta chain) and exert potent down-regulation of cell surface TCR/CD3 complexes.