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IID00020
 UniprotP10275
ProteinAndrogen receptor
GeneAR
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
920
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 20-31,642-920 Hetero dimer :
 Evidence X-RAY 5cj6 A Reference
       Region 5cj6 A 642-671 disorder
       Region 5cj6 A 672-845 order
       Region 5cj6 A 846-849 disorder
       Region 5cj6 A 850-919 order
       Region 5cj6 A 920-920 disorder
 Evidence X-RAY 2q7i A Reference
       Region 2q7i A 664-671 disorder
       Region 2q7i A 672-843 order
       Region 2q7i A 844-851 disorder
       Region 2q7i A 852-920 order
 Evidence X-RAY 2q7k A Reference
       Region 2q7k A 664-671 disorder
       Region 2q7k A 672-844 order
       Region 2q7k A 845-851 disorder
       Region 2q7k A 852-920 order
 Evidence X-RAY 3v49 A Reference
       Region 3v49 A 655-671 disorder
       Region 3v49 A 672-845 order
       Region 3v49 A 846-850 disorder
       Region 3v49 A 851-920 order
 Evidence X-RAY 3v4a A Reference
       Region 3v4a A 672-845 order
       Region 3v4a A 846-850 disorder
       Region 3v4a A 851-920 order
 Evidence X-RAY 1xow A Reference
       Region 1xow A 672-844 order
       Region 1xow A 845-850 disorder
       Region 1xow A 851-920 order
 Evidence X-RAY 5cj6 B Reference
       Region 5cj6 B 21-30 order
 Evidence X-RAY 2q7i B Reference
       Region 2q7i B 20-20 disorder
       Region 2q7i B 21-30 order
 Evidence X-RAY 2q7k B Reference
       Region 2q7k B 20-20 disorder
       Region 2q7k B 21-30 order
 Evidence X-RAY 3v49 B Reference
       Region 3v49 B 21-31 order
 Evidence X-RAY 3v4a B Reference
       Region 3v4a B 21-31 order
 Evidence X-RAY 1xow B Reference
       Region 1xow B 20-20 disorder
       Region 1xow B 21-30 order
Seqdisorder 142-485
 Evidence CD¸fluorescence spectroscopy¸sensitivity to protease digestion Reference
       Region 142-485 disorder
Seq 622-636 Hetero dimer : IID50009Complex
 Evidence X-RAY 3btr B Reference
       Region 3btr B 622-636 order
Seq 655-920 Monomer :
 Evidence X-RAY 2am9 A Reference
       Region 2am9 A 655-670 disorder
       Region 2am9 A 671-920 order
 Evidence X-RAY 2ama A Reference
       Region 2ama A 655-671 disorder
       Region 2ama A 672-844 order
       Region 2ama A 845-850 disorder
       Region 2ama A 851-920 order
 Evidence X-RAY 2amb A Reference
       Region 2amb A 655-671 disorder
       Region 2amb A 672-847 order
       Region 2amb A 848-850 disorder
       Region 2amb A 851-920 order
 Evidence X-RAY 2ax6 A Reference
       Region 2ax6 A 665-671 disorder
       Region 2ax6 A 672-844 order
       Region 2ax6 A 845-849 disorder
       Region 2ax6 A 850-918 order
       Region 2ax6 A 919-920 disorder
 Evidence X-RAY 2ax7 A Reference
       Region 2ax7 A 665-672 disorder
       Region 2ax7 A 673-844 order
       Region 2ax7 A 845-852 disorder
       Region 2ax7 A 853-918 order
       Region 2ax7 A 919-920 disorder
 Evidence X-RAY 2ax8 A Reference
       Region 2ax8 A 665-672 disorder
       Region 2ax8 A 673-844 order
       Region 2ax8 A 845-852 disorder
       Region 2ax8 A 853-918 order
       Region 2ax8 A 919-920 disorder
 Evidence X-RAY 2ax9 A Reference
       Region 2ax9 A 665-672 disorder
       Region 2ax9 A 673-844 order
       Region 2ax9 A 845-852 disorder
       Region 2ax9 A 853-918 order
       Region 2ax9 A 919-920 disorder
 Evidence X-RAY 2axa A Reference
       Region 2axa A 665-672 disorder
       Region 2axa A 673-844 order
       Region 2axa A 845-852 disorder
       Region 2axa A 853-918 order
       Region 2axa A 919-920 disorder
 Evidence X-RAY 1gs4 A Reference
       Region 1gs4 A 671-847 order
       Region 1gs4 A 848-851 disorder
       Region 1gs4 A 852-918 order
 Evidence X-RAY 4hlw A Reference
       Region 4hlw A 665-670 disorder
       Region 4hlw A 671-844 order
       Region 4hlw A 845-850 disorder
       Region 4hlw A 851-920 order
 Evidence X-RAY 2hvc A Reference
       Region 2hvc A 670-919 order
 Evidence X-RAY 4k7a A Reference
       Region 4k7a A 671-844 order
       Region 4k7a A 845-851 disorder
       Region 4k7a A 852-919 order
 Evidence X-RAY 4oea A Reference
       Region 4oea A 671-844 order
       Region 4oea A 845-851 disorder
       Region 4oea A 852-919 order
       Region 4oea A 920-920 disorder
 Evidence X-RAY 4ogh A Reference
       Region 4ogh A 671-671 disorder
       Region 4ogh A 672-844 order
       Region 4ogh A 845-851 disorder
       Region 4ogh A 852-920 order
 Evidence X-RAY 4ojb A Reference
       Region 4ojb A 671-671 disorder
       Region 4ojb A 672-844 order
       Region 4ojb A 845-852 disorder
       Region 4ojb A 853-919 order
       Region 4ojb A 920-920 disorder
 Evidence X-RAY 2oz7 A Reference
       Region 2oz7 A 672-920 order
 Evidence X-RAY 2pio A Reference
       Region 2pio A 670-671 disorder
       Region 2pio A 672-919 order
       Region 2pio A 920-920 disorder
 Evidence X-RAY 2pip L Reference
       Region 2pip L 670-670 disorder
       Region 2pip L 671-919 order
       Region 2pip L 920-920 disorder
 Evidence X-RAY 2piq A Reference
       Region 2piq A 670-670 disorder
       Region 2piq A 671-919 order
       Region 2piq A 920-920 disorder
 Evidence X-RAY 2pir A Reference
       Region 2pir A 670-919 order
       Region 2pir A 920-920 disorder
 Evidence X-RAY 2pit A Reference
       Region 2pit A 670-919 order
       Region 2pit A 920-920 disorder
 Evidence X-RAY 2piu A Reference
       Region 2piu A 670-671 disorder
       Region 2piu A 672-919 order
       Region 2piu A 920-920 disorder
 Evidence X-RAY 2piv A Reference
       Region 2piv A 670-670 disorder
       Region 2piv A 671-919 order
       Region 2piv A 920-920 disorder
 Evidence X-RAY 2piw A Reference
       Region 2piw A 670-671 disorder
       Region 2piw A 672-919 order
       Region 2piw A 920-920 disorder
 Evidence X-RAY 2pix A Reference
       Region 2pix A 670-671 disorder
       Region 2pix A 672-919 order
       Region 2pix A 920-920 disorder
 Evidence X-RAY 2pnu A Reference
       Region 2pnu A 655-670 disorder
       Region 2pnu A 671-845 order
       Region 2pnu A 846-850 disorder
       Region 2pnu A 851-920 order
 Evidence X-RAY 4ql8 A Reference
       Region 4ql8 A 663-671 disorder
       Region 4ql8 A 672-845 order
       Region 4ql8 A 846-852 disorder
       Region 4ql8 A 853-918 order
       Region 4ql8 A 919-920 disorder
 Evidence X-RAY 3rlj A Reference
       Region 3rlj A 672-918 order
 Evidence X-RAY 3rll A Reference
       Region 3rll A 672-672 disorder
       Region 3rll A 673-844 order
       Region 3rll A 845-852 disorder
       Region 3rll A 853-918 order
 Evidence X-RAY 5t8e A Reference
       Region 5t8e A 672-920 order
 Evidence X-RAY 5t8j A Reference
       Region 5t8j A 672-920 order
 Evidence X-RAY 5v8q A Reference
       Region 5v8q A 672-920 order
 Evidence X-RAY 5vo4 A Reference
       Region 5vo4 A 671-844 order
       Region 5vo4 A 845-849 disorder
       Region 5vo4 A 850-920 order
 Evidence X-RAY 1xq3 A Reference
       Region 1xq3 A 672-844 order
       Region 1xq3 A 845-850 disorder
       Region 1xq3 A 851-920 order
 Evidence X-RAY 2yhd A Reference
       Region 2yhd A 672-920 order
 Evidence X-RAY 2ylo A Reference
       Region 2ylo A 665-670 disorder
       Region 2ylo A 671-920 order
 Evidence X-RAY 2ylp A Reference
       Region 2ylp A 665-671 disorder
       Region 2ylp A 672-920 order
 Evidence X-RAY 2ylq A Reference
       Region 2ylq A 665-671 disorder
       Region 2ylq A 672-920 order
 Evidence X-RAY 1z95 A Reference
       Region 1z95 A 673-844 order
       Region 1z95 A 845-852 disorder
       Region 1z95 A 853-918 order
 Evidence X-RAY 3zqt A Reference
       Region 3zqt A 665-670 disorder
       Region 3zqt A 671-920 order
 Evidence X-RAY 3b5r A Reference
       Region 3b5r A 672-918 order
       Region 3b5r A 919-920 disorder
 Evidence X-RAY 3b65 A Reference
       Region 3b65 A 672-918 order
       Region 3b65 A 919-920 disorder
 Evidence X-RAY 3b66 A Reference
       Region 3b66 A 672-918 order
       Region 3b66 A 919-920 disorder
 Evidence X-RAY 3b67 A Reference
       Region 3b67 A 672-918 order
       Region 3b67 A 919-920 disorder
 Evidence X-RAY 3b68 A Reference
       Region 3b68 A 672-918 order
       Region 3b68 A 919-920 disorder
 Evidence X-RAY 1e3g A Reference
       Region 1e3g A 658-669 disorder
       Region 1e3g A 670-919 order
       Region 1e3g A 920-920 disorder
Seq 664-920 Hetero dimer :
 Evidence X-RAY 1xj7 A Reference
       Region 1xj7 A 664-919 order
       Region 1xj7 A 920-920 disorder
Seq 664-920 Hetero dimer : IID00082Complex
 Evidence X-RAY 2q7j A Reference
       Region 2q7j A 664-671 disorder
       Region 2q7j A 672-844 order
       Region 2q7j A 845-846 disorder
       Region 2q7j A 847-920 order
 Evidence X-RAY 2q7l A Reference
       Region 2q7l A 664-671 disorder
       Region 2q7l A 672-844 order
       Region 2q7l A 845-846 disorder
       Region 2q7l A 847-920 order
 Evidence X-RAY 1t63 A Reference
       Region 1t63 A 670-919 order
Seq 669-920 Hetero tetramer : Q8TBC4
 Evidence X-RAY 5jjm A Reference
       Region 5jjm A 669-920 order
 Evidence X-RAY 5jjm B Reference
       Region 5jjm B 669-669 disorder
       Region 5jjm B 670-920 order
 Evidence X-RAY 5jjm C Reference
       Region 5jjm C 669-918 order
       Region 5jjm C 919-920 disorder
 Evidence X-RAY 5jjm D Reference
       Region 5jjm D 669-669 disorder
       Region 5jjm D 670-918 order
       Region 5jjm D 919-920 disorder
Seq 670-920 Hetero dimer : IID00074Complex
 Evidence X-RAY 1t5z A Reference
       Region 1t5z A 670-919 order
       Region 1t5z A 920-920 disorder
Seq 670-920 Hetero dimer : IID00082Complex
 Evidence X-RAY 1t65 A Reference
       Region 1t65 A 670-920 order
Seq 670-920 Hetero dimer :
 Evidence X-RAY 2pkl A Reference
       Region 2pkl A 670-670 disorder
       Region 2pkl A 671-919 order
       Region 2pkl A 920-920 disorder
Seq 671-919 Hetero dimer : IID00110Complex
 Evidence X-RAY 3l3z A Reference
       Region 3l3z A 671-846 order
       Region 3l3z A 847-847 disorder
       Region 3l3z A 848-919 order
Seq 671-919 Hetero dimer : IID00110Complex
 Evidence X-RAY 3l3x A Reference
       Region 3l3x A 671-919 order
Seq 671-920 Hetero dimer :
 Evidence X-RAY 4oha A Reference
       Region 4oha A 671-671 disorder
       Region 4oha A 672-844 order
       Region 4oha A 845-851 disorder
       Region 4oha A 852-920 order
Seq 671-920 Hetero dimer :
 Evidence X-RAY 4okx A Reference
       Region 4okx A 671-671 disorder
       Region 4okx A 672-844 order
       Region 4okx A 845-852 disorder
       Region 4okx A 853-919 order
       Region 4okx A 920-920 disorder
Seq 671-920 Hetero dimer :
 Evidence X-RAY 4okw A Reference
       Region 4okw A 671-671 disorder
       Region 4okw A 672-844 order
       Region 4okw A 845-852 disorder
       Region 4okw A 853-918 order
       Region 4okw A 919-920 disorder
Seq 671-920 Hetero dimer : P41223
 Evidence X-RAY 4oed A Reference
       Region 4oed A 671-844 order
       Region 4oed A 845-851 disorder
       Region 4oed A 852-919 order
       Region 4oed A 920-920 disorder
 Evidence X-RAY 4oh6 A Reference
       Region 4oh6 A 671-671 disorder
       Region 4oh6 A 672-844 order
       Region 4oh6 A 845-851 disorder
       Region 4oh6 A 852-920 order
 Evidence X-RAY 4okb A Reference
       Region 4okb A 671-671 disorder
       Region 4okb A 672-844 order
       Region 4okb A 845-852 disorder
       Region 4okb A 853-919 order
       Region 4okb A 920-920 disorder
Seq 671-920 Hetero dimer :
 Evidence X-RAY 4ok1 A Reference
       Region 4ok1 A 671-919 order
       Region 4ok1 A 920-920 disorder
Seq 671-920 Hetero dimer :
 Evidence X-RAY 4ofu A Reference
       Region 4ofu A 671-671 disorder
       Region 4ofu A 672-844 order
       Region 4ofu A 845-851 disorder
       Region 4ofu A 852-919 order
       Region 4ofu A 920-920 disorder
Seq 671-920 Hetero dimer :
 Evidence X-RAY 4oez A Reference
       Region 4oez A 671-844 order
       Region 4oez A 845-851 disorder
       Region 4oez A 852-919 order
       Region 4oez A 920-920 disorder
Seq 671-920 Hetero dimer :
 Evidence X-RAY 4ofr A Reference
       Region 4ofr A 671-671 disorder
       Region 4ofr A 672-844 order
       Region 4ofr A 845-849 disorder
       Region 4ofr A 850-919 order
       Region 4ofr A 920-920 disorder
Seq 671-920 Hetero dimer :
 Evidence X-RAY 4oil A Reference
       Region 4oil A 671-844 order
       Region 4oil A 845-851 disorder
       Region 4oil A 852-919 order
       Region 4oil A 920-920 disorder
Seq 671-920 Hetero dimer :
 Evidence X-RAY 4oey A Reference
       Region 4oey A 671-671 disorder
       Region 4oey A 672-844 order
       Region 4oey A 845-851 disorder
       Region 4oey A 852-919 order
       Region 4oey A 920-920 disorder
Seq 671-920 Hetero dimer :
 Evidence X-RAY 4oiu A Reference
       Region 4oiu A 671-844 order
       Region 4oiu A 845-851 disorder
       Region 4oiu A 852-919 order
       Region 4oiu A 920-920 disorder
Seq 671-920 Hetero dimer :
 Evidence X-RAY 4olm A Reference
       Region 4olm A 671-671 disorder
       Region 4olm A 672-844 order
       Region 4olm A 845-852 disorder
       Region 4olm A 853-919 order
       Region 4olm A 920-920 disorder
Seq 671-920 Hetero dimer :
 Evidence X-RAY 4oj9 A Reference
       Region 4oj9 A 671-919 order
       Region 4oj9 A 920-920 disorder
Seq 671-920 Hetero dimer :
 Evidence X-RAY 4okt A Reference
       Region 4okt A 671-844 order
       Region 4okt A 845-845 disorder
       Region 4okt A 846-919 order
       Region 4okt A 920-920 disorder
Seq 671-920 Hetero dimer :
 Evidence X-RAY 4oh5 A Reference
       Region 4oh5 A 671-671 disorder
       Region 4oh5 A 672-844 order
       Region 4oh5 A 845-851 disorder
       Region 4oh5 A 852-920 order
Seq 672-919 Hetero dimer : IID00081Complex
 Evidence X-RAY 2z4j A Reference
       Region 2z4j A 672-919 order
Seq 672-920 Hetero dimer :
 Evidence X-RAY 2ao6 A Reference
       Region 2ao6 A 672-844 order
       Region 2ao6 A 845-850 disorder
       Region 2ao6 A 851-919 order
       Region 2ao6 A 920-920 disorder
SeqProS predicted 622-636 The unbound state of this region is predicted to be disordered by DICHOT and Foldindex Hetero dimer : IID50009Complex
       Region 3btr B 622-636 order
Seqphosphorylation
    916-916 Phosphotyrosine; by CSK
    651-651 Phosphoserine; by STK4/MST1
    535-535 Phosphotyrosine; by CSK
    552-552 Phosphotyrosine; by CSK
    395-395 Phosphotyrosine; by CSK
    365-365 Phosphotyrosine; by CSK and TNK2
    364-364 Phosphotyrosine; by CSK
    359-359 Phosphotyrosine; by CSK
    348-348 Phosphotyrosine; by CSK
    309-309 Phosphotyrosine; by CSK
    269-269 Phosphotyrosine; by CSK and TNK2
    258-258 Phosphoserine
    225-225 Phosphotyrosine; by CSK
    96-96 Phosphoserine
    83-83 Phosphoserine; by CDK9
    83-83 Phosphoserine; by CDK9
    96-96 Phosphoserine
    225-225 Phosphotyrosine; by CSK
    258-258 Phosphoserine
    269-269 Phosphotyrosine; by CSK and TNK2
    309-309 Phosphotyrosine; by CSK
    348-348 Phosphotyrosine; by CSK
    359-359 Phosphotyrosine; by CSK
    364-364 Phosphotyrosine; by CSK
    365-365 Phosphotyrosine; by CSK and TNK2
    395-395 Phosphotyrosine; by CSK
    535-535 Phosphotyrosine; by CSK
    552-552 Phosphotyrosine; by CSK
    651-651 Phosphoserine; by STK4/MST1
    916-916 Phosphotyrosine; by CSK
 
Prediction
NeProc
Disorder 40-51,84-552,628-671
Order 1-39,52-83,555-627,672-847,854-920
ProS 106-110,246-252,261-267,289-293,317-323,334-366,385-422,435-449,500-520,526-538,549-552,628-642
AlphaFold
Disorder 1-21,30-54,79-557,628-672,920-920
Order 22-29,55-78,558-627,673-919
Pfam Hmmer
PF00105 558-633 3e-42
PF00104 710-899 1.5e-44
SEG 44-91 ,150-162 ,192-199 ,203-217 ,319-341 ,374-384 ,416-434 ,451-473 ,642-657
Function
Function in SwissProt
Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins. Transcription activation is down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3.
Isoform 3 and isoform 4 lack the C-terminal ligand-binding domain and may therefore constitutively activate the transcription of a specific set of genes independently of steroid hormones.
Biological Process
See also
Diagram with PDB data
NCOA3/ARCrystal structure of DHT-bound androgen receptor in complex with the first motif of steroid receptor coactivator 3