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Biological Process List
IDStructureTitle
IID00005MDM4/USP7Crystal Structure of the USP7:HdmX(AHSS) complex
IID00005MDM4/SFN14-3-3 sigma in complex with hDMX-367 peptide
IID00006PLSCR1/Kpna2Structure of mammalian importin bound to the non-classical PLSCR1-NLS
IID00007AXIN1/GSK3BCrystal structure of GSK-3/Axin complex bound to phosphorylated N-terminal auto-inhibitory pS9 peptide
IID00012MYC/BIN1NMR STRUCTURE OF THE TUMOR SUPPRESSOR BIN1: ALTERNATIVE SPLICING IN MELANOMA AND INTERACTION WITH C-MYC
IID00012MYC/WDR5Crystal structure of WDR5 in complex with MYC MbIIIb peptide
IID00012MYC/FBXW7/SKP1Structure of the Fbw7-Skp1-MycCdegron complex
IID00013ESR1/SMYD2Structural Basis of Estrogen Receptor Alpha Methylation Mediated by Histone Methyltransferase SmyD2
IID00013ESR1/ESR1/calm1Solution NMR-derived structure of calmodulin bound with ER alpha peptides
IID00013ESR1/SETD7SET7/9-ER-AdoHcy complex
IID00013ESR1/SFN14-3-3 protein interaction with Estrogen Receptor Alpha provides a novel drug target interface
IID00014NR3C1/YWHAZBinary complex of 14-3-3 zeta with Glucocorticoid Receptor (GR) pT524 peptide
IID00015TP53/EP300Structural Basis for the Regulation of p53 Function by p300
IID00015TP53/CREBBPNMR Structure of CBP Bromodomain in complex with p53 peptide
IID00015TP53/SETD7Crystal structure of a ternary complex of the methyltransferase SET9 (also known as SET7/9) with a P53 peptide and SAH
IID00015TP53/SMYD2Structure of SMYD2 in complex with p53 and SAH
IID00015TP53/HMGB1HMGB1-facilitated p53 DNA binding occurs via HMG-box/p53 transactivation domain interaction and is regulated by the acidic tail
IID00015TP53/GTF2H1Solution structure of the complex between p53 transactivation domain 2 and TFIIH p62 PH domain
IID00015TP53/MDM2Crystal Structure of an MDM2/P53 Peptide Complex
IID00015TP53/MDM4Structure of the human Mdmx protein bound to the p53 tumor suppressor transactivation domain
IID00015TP53/S100BSOLUTION STRUCTURE OF THE C-TERMINAL NEGATIVE REGULATORY DOMAIN OF P53 IN A COMPLEX WITH CA2+-BOUND S100B(BB)
IID00015TP53/CCNA2 /CDK2CDK2/CyclinA in complex with an 11-residue recruitment peptide from p53
IID00015TP53/SFNCrystal structure of 14-3-3sigma and a p53 C-terminal 12-mer synthetic phosphopeptide
IID00015TP53/TP53BP1Solution structure of 53BP1 tandem Tudor domains in complex with a p53K382me2 peptide
IID00017RB1/E2F1/TFDP1Structure of the Rb C-terminal domain bound to an E2F1-DP1 heterodimer
IID00017RB1/CCNA1/CDK2CDK2/Cyclin A in complex with an 11-residue recruitment peptide from retinoblastoma-associated protein
IID00017RB1/PPP1CACrystal structure of an Rb C-terminal peptide bound to the catalytic subunit of PP1
IID00023XRCC6/XRCC5/NHEJ1Complex of XLF and heterodimer Ku bound to DNA
IID00027H2AX/MDC1Crystal structure of the MDC1 brct repeat in complex with the histone tail of gamma-H2AX
IID00027H2AX/MCPH1STRUCTURE OF HUMAN MICROCEPHALIN (MCPH1) TANDEM BRCT DOMAINS IN COMPLEX WITH A GAMMA-H2AX PHOSPHOPEPTIDE
IID00027H2AX/MCPH1Structure of human microcephalin (MCPH1) tandem BRCT domains in complex with an H2A.X peptide phosphorylated at Ser139 and Tyr142
IID00035APC/CTNNB1Beta-catenin in complex with a phosphorylated APC 20aa repeat fragment
IID00037AKT2/GSK3BStructure of activated form of PKB kinase domain S474D with GSK3 peptide and AMP-PNP
IID00039CTNNB1/BTRC/SKP1Structure of a beta-TrCP1-Skp1-beta-catenin complex: destruction motif binding and lysine specificity on the SCFbeta-TrCP1 ubiquitin ligase
IID00043CDKN1A/PCNAHuman PCNA
IID00046STAT1/CREBBPNMR structure of the CBP-TAZ2/STAT1-TAD complex
IID00047STAT6/NCOA1Insight into the molecular recognition mechanism of the coactivator NCoA1 by STAT6
IID00048MSH2/MSH6/DNAhuman MutSalpha (MSH2/MSH6) bound to ADP and a G T mispair
IID00048MSH2/MSH3/DNAHuman MutSbeta complexed with an IDL of 4 bases (Loop4) and ADP
IID00049CDKN1B/SKP1/SKP2/CKS1BCrystal structure of Skp1-Skp2-Cks1 in complex with a p27 peptide
IID00049CDKN1B/SFNTernarycomplex of 14-3-3 sigma, p27pT198 phosphopeptide, andWQ136
IID00052GSK3B/AKT1Crystal Structure of Akt-1 complexed with substrate peptide and inhibitor
IID00053STAT2/CrebbpNMR structure of the CBP-TAZ1/STAT2-TAD complex
IID00062H3C1/YWHAZMolecular basis for the recognitionof phosphorylated and phosphoacetylatedhistone H3 by 14-3-3
IID00064E2F1/CCNA2/CDK2CDK2/CyclinA in complex with a 9 residue recruitment peptide from E2F
IID00064E2F1/RB1Crystal structure of the retinoblastoma tumour suppressor protein bound to E2F peptide
IID00066PRKCE/YWHAZRecognition of an intrachain tandem 14-3-3 binding site within protein kinase C epsilon
IID00069PPP3CA/CALM1Structure of calmodulin bound to its recognition site from calcineurin
IID00069PPP3CA/RCAN1Structure of Calcineurin bound to RCAN1
IID00076TFDP1/GTF2H1Solution structure of the complex between DP1 acidic region and TFIIH p62 PH domain
IID00079IRF3/DNACrystal Structure of IRF-3 bound to the PRDIII-I regulatory element of the human interferon-B enhancer
IID00080POLD3/PCNACrystal structure of hPCNA bound to residues 452-466 of the DNA polymerase-delta-p66 subunit
IID00083NCOA1/RARACrystal structure of RARalpha ligand binding domain in complex with an agonist ligand (Am580) and a coactivator fragment
IID00085HIF1A/VHL/ELOB/ELOCCrystal structure of a hydroxylated HIF-1 alpha peptide bound to the pVHL/elongin-C/elongin-B complex
IID00085HIF1A/HIF1ANFactor Inhibiting HIF-1 alpha in complex with HIF-1 alpha fragment peptide
IID00085HIF1A/EP300NMR Structures of the HIF-1alpha CTAD/p300 CH1 Complex
IID00092CREBBP/NCOA3Structure and dynamics conspire in the evolution of affinity between intrinsically disordered proteins
IID00092CREBBP/IRF3Crystal structure of human phosphorylated IRF-3 bound to CBP
IID00100TCF7L2/CTNNB1CRYSTAL STRUCTURE OF BETA-CATENIN AND HTCF-4
IID00102CTNNBIP1/Ctnnb1Beta-catenin armadillo repeat domain bound to ICAT
IID00110NCOA3/CREBBPStructure and dynamics conspire in the evolution of affinity between intrinsically disordered proteins
IID00110NCOA3/ARCrystal structure of DHT-bound androgen receptor in complex with the first motif of steroid receptor coactivator 3
IID00112ZFYVE9/SMAD2CRYSTAL STRUCTURE OF SMAD2 MH2 DOMAIN BOUND TO THE SMAD-BINDING DOMAIN OF SARA
IID00112ZFYVE9/SMAD3SMAD3 SBD complex
IID00113SMAD3/SMAD3/SMAD4Crystal Structure of the phosphorylated Smad3/Smad4 heterotrimeric complex
IID00113SMAD3/NEDD4LStructure of the second domain of human Nedd4L in complex with a phosphorylated pTPY motif derived from human Smad3
IID00114NEDD4L/YWHAGStructureof 14-3-3 gamma in complex with Nedd4-2 14-3-3 binding motif Ser342
IID00123TP53BP1/TOPBP1Crystal structure of TOPBP1 BRCT4,5 in complex with a 53BP1 phosphopeptide
IID00123TP53BP1/Kpna2Crystal structure of importin-alpha1 bound to the 53BP1 nuclear localization signal (wild-type)
IID00123TP53BP1/SPOPX-ray structure of SPOP MATH domain (S119D) in complex with a 53BP1 peptide
IID00127SMAD2/SMAD2/SMAD4Crystal Structure of the phosphorylated Smad2/Smad4 heterotrimeric complex
IID00130RBL1/E2F5/TFDP1Crystal structure of the E2F5-DP1-p107ternary complex
IID00134NHERF1/MSNMoesin FERM domain bound to EBP50 C-terminal peptide
IID00134NHERF1/RdxCrystal structure of the Radixin FERM domain complexed with the NHERF-1 C-terminal tail peptide
IID00135SMAD7/SMURF2Solution structure of Smurf2 WW3 domain-Smad7 PY peptide complex
IID00137ANXA1An engineered cyclic peptide alleviates symptoms of inflammation in a murine model of inflammatory bowel disease
IID00137ANXA1/S100A11S100C (S100A11),OR CALGIZZARIN, IN COMPLEX WITH ANNEXIN I N-TERMINUS
IID00145HMGA1/DNASOLUTION STRUCTURE OF A COMPLEX OF THE SECOND DNA BINDING DOMAIN OF HUMAN HMG-I(Y) BOUND TO DNA DODECAMER CONTAINING THE PRDII SITE OF THE INTERFERON-BETA PROMOTER, NMR, MINIMIZED AVERAGE STRUCTURE
IID00163MDM2/USP7The Crystal Structure of the N-terminal domain of HAUSP/USP7 complexed with mdm2 peptide 147-150
IID00163MDM2NMR structure of unliganded MDM2
IID00163MDM2/MDM4Crystal Structure of the MDM2-MDMX RING Domain Heterodimer
IID00164XPC/CETN2Solution structure of the C-terminal domain (T94-Y172) of the human centrin 2 in complex with a 17 residues peptide (P1-XPC) from xeroderma pigmentosum group C protein
IID00164XPC/GTF2H1Solution structure of the complex between XPC acidic domain and TFIIH p62 PH domain
IID00165MXD1/Sin3bStructure of the complex of the Mad1-Sin3B interaction domains
IID00168STK4/MOB1Ahuman MOB1A bound to MST1 phosphorylated T367 peptide
IID00169REST/CTDSP1Structure of Scp1 D96N bound to REST-pS861/4 peptide
IID00169REST/Sin3bSolution structure of the NRSF/REST-mSin3B PAH1 complex
IID00171E2F2/RB1Structure of Rb tumor suppressor bound to the transactivation domain of E2F-2
IID00174SMAD1/YAP1Structure of the first WW domain of human YAP in complex with a phosphorylated human Smad1 derived peptide
IID00174SMAD1/STUB1Crystal structure of the TPR domain of CHIP complexed with phosphorylated Smad1 peptide
IID00175POU2AF1/POU2F1/DNACRYSTAL STRUCTURE OF A TERNARY COMPLEX CONTAINING AN OCA-B PEPTIDE, THE OCT-1 POU DOMAIN, AND AN OCTAMER ELEMENT
IID00179CITED2/EP300Structural basis for negative regulation of hypoxia-inducible factor-1alpha by CITED2
IID00181BRIP1/BRCA1Crystal Structure of the Brca1 BRCT Domains in Complex with the Phosphorylated Interacting Region from Bach1 Helicase
IID00183CABIN1/MEF2BStructural basis of sequence-specific recruitment of histone deacetylases by Myocyte Enhancer Factor-2
IID00187PQBP1/TXNL4ACrystal structure of U5-15kD in a complex with PQBP1
IID00196XPA/ERCC1Solution structure of a ERCC1-XPA heterodimer
IID00198CDC25C/PLK1Molecular and structural basis of polo-like kinase 1 substrate recognition: Implications in centrosomal localization
IID00198CDC25C/YWHAZThe molecular tweezer CLR01 stabilizes a disordered protein-protein interface
IID00210AKAP13/Prkar2aDocking and dimerization domain (D/D) of the Type II-alpha regulatory subunity of protein kinase A (PKA) in complex with a peptide from an A-kinase anchoring protein
IID00210AKAP13/RHOAAKAP13 (AKAP-Lbc) RhoGEF domain in complex with RhoA
IID00212NHERF2/RdxCrystal structure of the Radixin FERM domain complexed with the NHERF-2 C-terminal tail peptide
IID00218VPS36/SNF8/VPS25/VPS25Integrated structural and functional model of the human ESCRT-II complex
IID00222TCF12/RUNX1T1Complex structure of AML1-ETO NHR2 domain with HEB fragment
IID00222TCF12/RUNX1T1Complex structure of AML1-ETO NHR2 domain with HEB fragment
IID00227MAPK8IP1/MAPK10Crystal Structure of JNK3 in Complex with JIP1 Peptide
IID00227MAPK8IP1/MAPK8Discovery of Potent, Highly Selective, and Orally Bioavailable Pyridine Carboxamide C-jun NH2-terminal Kinase Inhibitors
IID00230CHMP3/CHMP2ACHMP2A-CHMP3 heterodimer (430 Angstrom diameter)
IID00230CHMP3/STAMBPStructural basis for AMSH-ESCRT-III CHMP3 interaction
IID00233AKAP5/CALM1Crystal Structure of AKAP79 calmodulin binding domain peptide in complex with Ca2+/Calmodulin
IID00233AKAP5/PPP3CA/PPP3R1Crystal Structure of Calcineurin in Complex with AKAP79 Peptide
IID00233AKAP5/Prkar2aDocking and dimerization domain (D/D) of the regulatory subunit of the Type II-alpha cAMP-dependent protein kinase A associated with a Peptide derived from an A-kinase anchoring protein (AKAP)
IID00237BRCA2/RAD51Crystal structure of a RAD51-BRCA2 BRC repeat complex
IID00240MEF2A/MAPK14CRYSTAL STRUCTURE OF MAP KINASE P38 COMPLEXED TO THE DOCKING SITE ON ITS NUCLEAR SUBSTRATE MEF2A
IID00240MEF2A/EP300Crystal structure of the p300 TAZ2 domain bound to MEF2 on DNA
IID00249PALB2/BRCA2Crystal Structure of a PALB2 / BRCA2 complex
IID00250EHMT2/CBX3Crystal structure of the complex of human chromobox homolog 3 (CBX3) with peptide
IID00262EGFR/CBLCrystal structure of c-Cbl-TKB domain complexed with its binding motif in EGF receptor'
IID00277PAK1Crystal structure of PAK1 kinase domain with ruthenium complex lambda-FL172
IID00282LDB1/LMO2/TCF3/TAL1/DNAStructure of the SCL:E47:LMO2:LDB1 complex bound to DNA
IID00286ERRFI1/EGFRcrystal structure of EGFR kinase domain in complex with Mitogen-inducible gene 6 protein
IID00286ERRFI1/EGFRCrystal structure of the complex between the EGFR kinase domain and a Mig6 peptide
IID00292RAF1/YWHAZHuman 14-3-3 isoform zeta in complex with a diphoyphorylated C-RAF peptide and Cotylenin A
IID00293ERBB2/PTPN18PTPN18 in complex with HER2-pY1248 phosphor-peptides
IID00293ERBB2/ERBINThe Structure of ERBIN PDZ domain bound to the Carboxy-terminal tail of the ErbB2 Receptor
IID00293ERBB2/PLCG1Phospholipase C gamma-1 C-terminal SH2 domain bound to a phosphopeptide derived from the receptor tyrosine kinase ErbB2
IID00293ERBB2/GRB7Water refined solution structure of the human Grb7-SH2 domain in complex with the 10 amino acid peptide pY1139
IID00293ERBB2/PTPN18Structural basis of PTPN18 fingerprint on distinct HER2 tyrosine phosphorylation sites
IID00294APP/APBB1Crystal structure of theintracellular domain of human APP in complex with Fe65-PTB2
IID00304YAP1/SFN14-3-3 sigma in complex with YAP pS127-peptide
IID00326PHF12/MORF4L1Structural Basis for Molecular Interactions Involving MRG Domains: Implications in Chromatin Biology
IID00327UHRF1/USP7Crystal structure of USP7 in complex with UHRF1
IID00327UHRF1Crystal structure of UHRF1 TTD domain in complex with the polybasic region
IID00332MBD1/DNASolution Structure of the Methyl-CpG-Binding Domain of Human MBD1 in Complex with Methylated DNA
IID00334VPS4A/CHMP6NMR structure of VPS4A-MIT-CHMP6
IID00348OPTN/MAP1LC3BLC3B OPTN-LIR Ptotcomplex structure
IID00352SELPLG/SELPP-SELECTIN LECTIN/EGF DOMAINS COMPLEXED WITH PSGL-1 PEPTIDE
IID00363SNAI1/KDM1A/RCOR1Crystal structure of LSD1-CoREST in complex with a N-terminal SNAIL peptide
IID00398DAXX/SUMO1Phosphorylation of SUMO-interacting motif by CK2 enhances Daxx SUMO binding activity
IID00410S100B/S100BCALCIUM FORM OF HUMAN S100B, NMR, 20 STRUCTURES
IID00427RFXANK/FRX5Crystal Structure of the Peptide Bound Complex of the Ankyrin Repeat Domains of Human RFXANK
IID00433FOXO3/YWHAECrystal Structure of 14-3-3 epsilon with FOXO3a peptide
IID00435NFATC1/PPP3CA/PPP3R1Structure of Calcineurin in complex with NFATc1 LxVP peptide
IID00440HSPA8/ DNAJB1Crystal structure of human Hsp40 Hdj1 peptide-binding domain complexed with a C-terminal peptide of Hsp70
IID00441ATF2/MAPK10Crystal Structure of JNK3 in Complex with ATF2 Peptide
IID00441ATF2/MAPK8Crystal structure of JNK1 in complex with ATF2(19-58)
IID00441ATF2/MAPK14Crystal structure of double-phosphorylated p38alpha with ATF2(83-102)
IID00442CREB1/CRBBP/KMT2AAllosteric communication in the KIXdomain proceeds through dynamic re-packing of the hydrophobic core
IID00443EIF2AK2/EIF2S1PKR kinase domain- eIF2alpha- AMP-PNP complex.
IID00451FUS/TNPO1Crystal structure of Karyopherin beta2 in complex with FUS(full length)
IID00455MAP2K6/MAPK14Crystal structure of human p38alpha complexed with a MAPK docking peptide
IID00457HDAC4/YWHAGCrystal structure of 14-3-3 GAMMA
IID00457HDAC4/ANKRA2Crystal Structure of the Peptide Bound Complex of the Ankyrin Repeat Domains of Human ANKRA2
IID00457HDAC4/RFXANKCrystal structure of RFXANK
IID00458MLF1/YWHAECrystal structure of 14-3-3 epsilon with Mlf1 peptide
IID00460FOXO4Stress signals in FOXO regulation
IID00464FOXO1/SFN14-3-3 sigma in complex with FOXO1 pT24 peptide
IID00466NEATC3/MAPK8Linear binding motifs for JNK and for calcineurin antagonistically control the nuclear shuttling of NFAT4
IID00470NFATC2/FOXP3/DNAStructure of a domain-swapped FOXP3 dimer
IID00470NFATC2/FOXP2/DNAStructure of the DNA binding domains of NFAT and FOXP2 bound specifically to DNA.
IID00470NFATC2/FOS/JUN/DNASTRUCTURE OF THE DNA BINDING DOMAINS OF NFAT, FOS AND JUN BOUND TO DNA
IID00484FANCM/CENPS/CENPXThe crystal structure of FANCM bound MHF complex
IID00484FANCM/RMI1/RMI2Crystal structure of the RMI core complex with MM2 peptide from FANCM
IID00507SH3BP5/MAPK10Crystal Structure of JNK3 in Complex with SAB Peptide
IID00510ATP2B4/calm1NMRSOLUTION STRUCTURE OF A COMPLEX OF CALMODULIN WITH A BINDING PEPTIDE OF THECA2+-PUMP
IID00522GAB2/GRB2Grb2 SH3C (3)
IID00528SPRY2/CBLCrystal structure of c-Cbl-TKB domain complexed with its binding motif in Sprouty2
IID00532DKK1/LRP6The structure of the first YWTD beta propeller domain of LRP6 in complex with a DKK1 peptide
IID00532DKK1/LRP6/KREMEN1Wnt modulator Kremen in complex with DKK1 (CRD2) and LRP6 (PE3PE4)
IID00540CFTR/YWHAZCrystal structure of human 14-3-3 zeta in complex with CFTR R-domain peptide pS753-pS768
IID00540CFTR/GOPCPDZ Domain of CAL (Cystic Fibrosis Transmembrane Regulator-Associated Ligand)
IID00541TCF3/EP300Solution NMR structure of the p300 Taz2:ETAD1 complex
IID00553ZAP70/CBL/UBE2D2Structure of modified phosphoTyr371-c-Cbl-UbcH5B-ZAP-70 complex
IID00553ZAP70/CBLB/UBE2D2Structure of phosphoTyr363-Cbl-b - UbcH5B-Ub - ZAP-70 peptide complex
IID00563MTA1/HDAC1The structure of HDAC1 in complex with the dimeric ELM2-SANT domain of MTA1 from the NuRD complex
IID00564EIF4EBP2NMR structure of Phosphorylated 4E-BP2
IID00565HDAC1/RBL1p107 pocket domain complexed with HDAC1 peptide
IID00584SOST/LRP6The structure of a beta propeller domain in complex with peptide S
IID00596CYBA/NCF1Solution Structure Of The P22Phox-P47Phox Complex
IID00598MTOR/MLST8/AKT1S1Crystal structure of mTOR(deltaN)-mLST8-PRAS40(alpha-helix & beta-strand) complex
IID00613STK11/CAB39/STRADAStructure of the heterotrimeric LKB1-STRADalpha-MO25alpha complex
IID00613STK11/YWHAZStructure of the LKB1 and 14-3-3 complex
IID00615ITGA4/YWHAZ14-3-3-zeta in complex with S1011 phosphorylated integrin alpha-4 peptide
IID00615ITGA4/Ap2m1Mu2 adaptin subunit of the AP2 adaptor (C-terminal domain) complexed with Integrin alpha4 internalisation peptide QYKSILQE
IID00616ITGB7/ FLNACrystal structure of the filamin A repeat 21 complexed with the integrin beta7 cytoplasmic tail peptide
IID00617PTPN7/MAPK1Crystal structure of HePTP in complex with a monophosphorylated Erk2 peptide
IID00619KHDRBS1/APCCrystal structure of the complex between the armadillo repeat domain of adenomatous polyposis coli and the tyrosine-rich domain of Sam68
IID00622TCF4/CREBBPThe structure of E-protein activation domain 1 bound to the KIX domain of CBP/p300 elucidates leukemia induction by E2A-PBX1
IID00626SOX2/POU2F1/DNATERNARY COMPLEX OF THE DNA BINDING DOMAINS OF THE OCT1 AND SOX2 TRANSCRIPTION FACTORS WITH A 19MER OLIGONUCLEOTIDE FROM THE HOXB1 REGULATORY ELEMENT
IID00626SOX2/KPNA4SOX2 bound to Importin-alpha 3
IID00629EPAS1/VHL/ELOB/ELOCCrystal structure of HIF-2alpha-pVHL-elongin B-elongin C
IID00629EPAS1/EGLN1HIF PROLYL HYDROXYLASE 2 (PHD2/EGLN1) IN COMPLEX WITH N-OXALYLGLYCINE (NOG) AND HIF-2 ALPHA CODD (523-542)
IID00641SUPT5H/RTF1Crystal Structure of Human Rtf1 Plus3 Domain in Complex with Spt5 CTR Phosphopeptide
IID00655ZFP36/CNOT1Crystal structure of human CNOT1 MIF4G domain in complex with a TTP peptide
IID00661PRKAA2/PRKAB1/PRKAG1Structure of full length human AMPK in complex with a small molecule activator, a benzimidazole derivative (991)
IID00666PPP1R8/PPP1CACrystal Structure of the first Nuclear PP1 holoenzyme
IID00669BECN1/BCL2L1Solution structure of the Bcl-xL/Beclin-1complex
IID00679MKNK1/MAPK1Crystal structure of human ERK2 complexed with a MAPK docking peptide
IID00690TERT/KPNA1The crystal structure of human Importin alpha 5 with TERT NLS peptide
IID00698FYNFyn SH2 domain in complex with thenatural inhibitory phosphotyrosinepeptide
IID00700ANXA2/S100A4Crystal structure of Annexin A2 complexed with S100A4
IID00700ANXA2/S100A10P11 (S100A10), LIGAND OF ANNEXIN II IN COMPLEX WITH ANNEXIN II N-TERMINUS
IID00700ANXA2Crystal structure of Tyr24 phosphorylated Annexin A2 at 2.9 A resolution
IID00704MET/GRB2DIMER FORMATION THROUGH DOMAIN SWAPPING IN THE CRYSTAL STRUCTURE OF THE GRB2-SH2 AC-PYVNV COMPLEX
IID00704MET/HGFCryo-EM structure of 2:2 c-MET/HGF holo-complex
IID00704MET/CBLCrystal structure of c-Cbl-TKB domain complexed with its binding motif in c-Met
IID00708SRCCRYSTAL STRUCTURE OF HUMAN TYROSINE-PROTEIN KINASE C-SRC, IN COMPLEX WITH AMP-PNP
IID00714SYK/CBLCrystal structure of c-Cbl-TKB domain complexed with its binding motif in Syk
IID00721STK3/MOB1AStructural basis for Mob1-dependent activation of the core Mst-Lats kinase cascade in Hippo signaling
IID00721STK3/SLMAPStructure of human SLMAP FHA domain in complex with pMST2
IID00724HLTF/S100A10/ANXA2Crystal Structure of p11-Annexin A2(N-terminal) Fusion Protein in Complex with SMARCA3 Peptide
IID00725SUZ12/RBBP4/PHF19/JARID2Crystal Structure of a SUZ12-RBBP4-PHF19-JARID2 Heterotetrameric Complex
IID00726RPS6KA1/MAPK1Heterodimeric structure of ERK2 and RSK1
IID00726RPS6KA1/S100BS100B-RSK1 crystal structure C
IID00727EZH2/EED/SUZ12/H3C1/JARID2Structure of Human Polycomb Repressive Complex 2 (PRC2) with oncogenic histone H3K27M peptide
IID00736CCDC8/ANKRA2Crystalstructure of ANKRA2-CCDC8 complex
IID00737MOB1A/LATS1pMob1-Lats1 complex
IID00743DCAF1/Nf2Crystal structure of the Merlin FERM/DCAF1 complex
IID00743DCAF1/DDB1/CUL4A/RBX1Cryo-EM Structure of the DDB1-DCAF1-CUL4A-RBX1 Complex
IID00745IKBKG/IKBKBNEMO/IKKb association domain structure
IID00750HSPB6/SFNHuman 14-3-3 sigma complexed with long HSPB6 phosphopeptide
IID00751HGS/STAMHuman ESCRT-0 Core Complex
IID00752AURKA/TPX2Crystal structure of Aurora-A bound to a hydrocarbon-stapled proteomimetic of TPX2
IID00753TP73/MDM2Structure of complex of MDM2(3-109) and P73 TAD(10-25)
IID00753TP73/EP300Solution structure of p300Taz2-p73TA1
IID00753TP73/BCL2L1Solution structure of BCL-XL bound to P73-TAD peptide
IID00758TBC1D4/SFN14-3-3 sigma with AS160 binding site pT642
IID00759NBN/MRE11Human Mre11-Nbs1 complex
IID00760VPS4B/CHMP2BVPS4B MIT-CHMP2B Complex
IID00765LATS1/NF2Human neurofibromin 2/merlin residues 1-339 in complex with LATS1
IID00765LATS1/YAP1NMR structure of YAP1-2 WW1 domain with LATS1 PPxY motif complex
IID00766MYCN/AURKACrystal structure of Aurora-A kinase in complex with N-Myc
IID00770LCKSH3-SH2 DOMAIN FRAGMENT OF HUMAN P56-LCK TYROSINE KINASE COMPLEXED WITH THE 10 RESIDUE SYNTHETIC PHOSPHOTYROSYL PEPTIDE TEGQPYQPQPA
IID00770LCK/CD4/Zn2+Solution structure of T-cell surface glycoprotein CD4 and Proto-oncogene tyrosine-protein kinase LCK fragments
IID00770LCK/CD8A/Zn2+Solution structure of T-cell surface glycoprotein CD8 alpha chain and Proto-oncogene tyrosine-protein kinase LCK fragments
IID00773RHO/SAGCrystal structure of rhodopsin bound to visual arrestin determined by X-ray free electron laser
IID00774GLI1/SUFUCrystal structure of Sufud60-Gli1p
IID00774GLI1/SFNCH2 chimera of human 14-3-3 sigma with the Gli1 phosphopeptide around Ser640
IID00792PLN/SFN14-3-3 Sigma in complex with phosphorylated PLN peptide
IID00803CASP2/YWHAGStructure of 14-3-3 gamma in complex with double phosphorylated caspase-2 peptide on Ser139 and Ser164
IID00805STAR/SFNHuman 14-3-3 sigma fused to the StARD1 peptide including phosphoserine-195
IID00810ATXN1/SFNCrystal structure of 14-3-3 sigma in complex with Ataxin-1 Ser776 phosphopeptide
IID00814MAX/MYC/DNACrystal structure of Myc-Max recognizing DNA
IID00815RND3/YWHAZ14-3-3 interaction with Rnd3 prenyl-phosphorylation motif
IID00824AHNAK/ANXA2/S100A10The crystal structure of an AHNAK peptide in complex with the S100A10/AnxA2 heterotetramer
IID00842AMOT/NEDD4LStructure of Nedd4L WW3 domain
IID00842AMOT/WWC1Crystal Structure of KIBRA and Angiomotin complex
IID00842AMOT/SFNCrystal structure of 14-3-3 sigma in complex with 20mer Amot-p130 peptide
IID00849TEX14/CEP55Structure basis of inactivating cell abscission with chimera peptide 1
IID00852PDCD6IP/CEP55Structure basis of inactivating cell abscission with chimera peptide 2
IID00856JARID2/EEDCrystal structure of EED in complex with a trimethylated Jarid2 peptide
IID00860CHMP4C/PDCD6IPALIX BRO1 CHMP4C complex
IID00862CHMP6/VPS25Crystal structure of the human VPS25-VPS20 subcomplex
IID00863AURKB/INCENPHuman Aurora B Kinase in complex with INCENP and VX-680
IID00868TSG101/HGSCrystal Structure of the Tsg101 UEV domain in complex with a human HRS PSAP peptide
IID00870ANP32E/H2AZ1/H2BC11Crystal structure of a human Anp32e-H2A.Z-H2B complex
IID00874WWTR1/SFN14-3-3 sigma in complex with TAZ pS89 peptide
IID00874WWTR1Phase separation of TAZ compartmentalizes the transcription machinery to promote gene expression
IID00875TP63/EP300Solution Structure of p300Taz2-p63TA
IID00875TP63/CSNK1DCrystal structure of Casein Kinase I delta (CK1d) in complex with triple phosphorylated p63 PAD3P peptide
IID00884LATS2/NF2Crystal structure of Merlin-FERM and Lats2
IID00889DAPK2Crystal structure of DAPK2 S308A Calcium/Calmodulin complex
IID00889DAPK2/YWHAGStructure of 14-3-3 gamma in complex with DAPK2 peptide containing the 14-3-3 binding motif
IID00894AURKC/INCENPHuman AURKC INCENP complex bound to BRD-7880
IID00898TACC3/AURKAAurora-A in complex with TACC3
IID00902NEK9/DYNLLStructure of LC8 in complex with Nek9 peptide
IID00904PLSCR4/Kpna2Aminimal NLS from human scramblase 4 complexed with importin alpha
IID00913PER2/CSNK1DHuman Casein kinase 1 delta in complex with phosphorylated human PERIOD2 FASP peptide
IID00914NKRF/DHX15Crystal structure of the human DEAH-helicase DHX15 in complex with the NKRF G-patch
IID00935SDC4/SDCBPCrystal structure of the complex of PDZ2 of syntenin with a syndecan-4 peptide.
IID00947PDX1/SPOPCo-crystal structure of SPOP MATH domain and human Pdx1 fragment
IID00974GRIN2B/CAMK2ACocrystal structure of human CaMKII-alpha (CAMK2A)kinase domain and GluN2B(S1303D)
IID00976CAMK2D/CALM12.65 Angstrom crystal structure of Ca/CaM:CaMKIIdelta peptide complex
IID00978TNIP1/RB1CC1crystal structure of FIP200 claw/TNIP1_FIR_pS122pS123
IID00982MYLK/CALM1Calmodulin complexed with calmodulin-binding peptide from smooth muscle myosin light chain kinase
IID00985CRTC1/YWHAZCRTC1 pSer151 peptide in complex with 14-3-3 zeta
IID00985CRTC1CRTCs are controlled by calcium signaling via calcineurin
IID00990KBTBD6/GABARAPCrystal structure of GABARAP in complex with KBTBD6 LIR peptide
IID00992FUNDC1/MAP1LC3BLC3B-FUNDC1 complex
IID01011FYCO1/MAP1LC3BCrystal structure of LC3-LIR peptide complex
IID01012BBC3/BCL2L1Solution structure of BCL-xL in complex with PUMA BH3 peptide
IID01022DISC1/SKP1/FBXW7Crystal structure of the Skp1-FBXW7-DISC1 complex
IID01024HYPK/NAA10/NAA15The Human NatA (Naa10/Naa15) amino-terminal acetyltransferase complex bound to HYPK
IID01027STK26/CAB39Crystal structure of MST4-MO25 complex with WSF motif
IID01040TX264/GABARAPCrystal structure of GABARAP complexed with the TEX264 LIR phosphorylated at Ser271 and Ser272
IID50003Cdh1/Ctnnb1BETA-CATENIN/E-CADHERIN COMPLEX
IID50004Creb1/CrebbpKIX DOMAIN OF MOUSE CBP (CREB BINDING PROTEIN) IN COMPLEX WITH PHOSPHORYLATED KINASE INDUCIBLE DOMAIN (PKID) OF RAT CREB (CYCLIC AMP RESPONSE ELEMENT BINDING PROTEIN), NMR 17 STRUCTURES
IID50006Lef1/Ctnnb1Structure of beta-catenin with phosphorylated Lef-1
IID50006Lef1/DNALEF1 HMG DOMAIN (FROM MOUSE), COMPLEXED WITH DNA (15BP), NMR, 12 STRUCTURES
IID50008Crebbp/NCOA3Mutual Synergistic Folding in the Interaction Between Nuclear Receptor Coactivators CBP and ACTR
IID50008Crebbp/TP53Structure of CBP nuclear coactivator binding domain in complex with p53 TAD
IID50013AANAT/YWHAZCRYSTALSTRUCTURE OF THE 14-3-3 ZETA:SEROTONIN N-ACETYLTRANSFERASE COMPLEX
IID50019s100b/s100bCa2+-S100B, refined with RDCs
IID50022S100B/S100BTHE 2.0 A STRUCTURE OF HOLO S100B FROM BOVINE BRAIN
IID50049Ldb1/Lmo2/Gata1haddock model of GATA1NF:Lmo2LIM2-Ldb1LID
IID50054Camk1/CALM1Solution structure of Ca2+/calmodulin complexed with a peptide representing the calmodulin-binding domain of calmodulin kinase I
IID50056Mapk8ip1/MAPK8Structural basis for the selective inhibition of JNK1 by the scaffolding protein JIP1 and SP600125
IID50058Ppp1r9b/PPP1CACrystal structure of a complex between Protein Phosphatase 1 alpha (PP1) and the PP1 binding and PDZ domains of Spinophilin
IID50060Ppp1r9a/PPP1CACrystal structure of a complex between Protein Phosphatase 1 alpha (PP1) and the PP1 binding and PDZ domains of Neurabin
IID50077mdm2NMR Structure of a Complex Between MDM2 and a Small Molecule Inhibitor
IID50084Ncoa1/ESR1Crystal structure of ERa LBDin complex with RU100132
IID50088Sap25/Sin3aSolution structure of the mSin3A PAH1-SAP25 SID complex
IID50094mdm4/TP53Structure of the human Mdmx protein bound to the p53 tumor suppressor transactivation domain
IID50097Hbp1/Sin3aSolution Structure of HBP1 SID-mSin3A PAH2 Complex
IID50119Icam2/RdxCrystal structure of the radxin FERM domain complexed with the ICAM-2 cytoplasmic peptide
IID50120Selplg/RdxCrystal Structure Analysis of the radixin FERM domain complexed with adhesion molecule PSGL-1
IID50177Camkk1/calm1CALMODULIN/RAT CA2+/CALMODULIN DEPENDENT PROTEIN KINASE FRAGMENT
IID50191Map2k3/Mapk14CRYSTAL STRUCTURE OF MAP KINASE P38 COMPLEXED TO THE DOCKING SITE ON ITS ACTIVATOR MKK3B
IID50194Pip5k1c/Tln1Structural basis for phosphatidylinositol phosphate kinase type I-gamma binding to talin at focal adhesions
IID50197MYLK2/CALM1SOLUTION STRUCTURE OF A CALMODULIN-TARGET PEPTIDE COMPLEX BY MULTIDIMENSIONAL NMR
IID50199Cd44/RdxCrystal structure of the mouse radxin FERM domain complexed with the mouse CD44 cytoplasmic peptide
IID50200Spn/RdxCrystal Structure Analysis of the radixin FERM domain complexed with adhesion molecule CD43
IID50223SWR1/HTZ1/HTB1Crystal structure of yeast Swr1-Z domain in complex with H2A.Z-H2B dimer
IID50229Mme/RdxCrystal structure of the Radixin FERM domain complexed with the NEP cytoplasmic tail
IID50236Gsk3bAKT1 protein kinase phosphorylates and deactivates GSK3B
IID50239nbs1/rad32Crystal structure of an unfused Mre11-Nbs1 complex with two manganese ions per active site
IID50247RHO/SAGNMR structures of phosphorylated carboxy terminus of bovine rhodopsin in arrestin-bound state
IID50261Sox2/POU2F1/DNACrystal structure of a POU/HMG/DNA ternary complex
IID50266Pnuts/Ppp1r10Structure of a second nuclear PP1 Holoenzyme, crystal form 1
IID50272Zfp36Not1is required for TTP-mediated mRNA deadenylation and decay.
IID50275SIC1/SKP1/CDC4Crystal Structure of ScSkp1-ScCdc4-pSic1 peptide complex
IID50275SIC1/CDC14Structure of Cdc14 bound to SIC1 PxL motif
IID50281Yap1/Tead4Structural basis of YAP recognition by TEAD4 in the Hippo pathway
IID50297CTHT_0053230/CTHT_0029920/CTHT_0006210/H3C1/H3C1Structure of ctPRC2 in complex with H3K27me3 and H3K27M
IID50311ANXA1X-RAY STRUCTURE OF FULL-LENGTH ANNEXIN 1
IID50313SPT16/HTB1/HTA1SPT16-H2A-H2B FACT HISTONE Complex
IID50341Fanci/Fancd2Structure of the FANCI-FANCD2 complex
IID50357ANXA4ANNEXIN IV
IID50361S100A11Solution Structure of Rabbit apo-S100A11 (19 models)
IID50362STP22/VPS27Crystal structure of the yeast vps23 UEV domain in complex with a vps27 PSDP peptide
IID50368VPS27/HSE1The Vps27/Hse1 complex is a GAT domain-based scaffold for ubiquitin-dependent sorting
IID50372VPS4/VTA1/DID4Vps4p-Vta1p complex with peptide binding to the central pore of Vps4p
IID50373Arnt/Epas1/DNACrystal Structure of the Heterodimeric HIF-2a:ARNT Complex with HRE DNA
IID50381Epas1/Arnt/DNACrystal Structure of the Heterodimeric HIF-2a:ARNT Complex with HRE DNA
IID50385VPS20ESCRT-III recruitment
IID50387VPS36/SNF8/VPS25/VPS25The crystal structure of endosomal complex ESCRT-II (VPS22/VPS25/VPS36)
IID50395aurkb-a/incenp-aMechanism of Aurora-B activation by INCENP and inhibition by Hesperadin.
IID50396tpx2-a/KPNA2TPX2:importin-alpha complex
IID50398Ddn/Wwc1Structure of KIBRA and Dendrin Complex
IID50398Ddn/Magi2Crystal structure of MAGI2-Dendrin complex
IID50399Mob1b/Lats1Complex of LATS1 and phosphomimetic MOB1b
IID50408Nek9/NEK7Structural mechanism of Nek7 activation by Nek9-induced dimerisation
IID50409UVR8/COP1Crystal structure of an Arabidopsis WD40 domain in complex with photoreceptor
IID50426Camk2b/CALM1Crystal structure of CaM-peptide complex containing AzF at position 108
IID50427SWI6/CDC14Crystal structure of budding yeast Cdc14p (C283S) bound to a Swi6p phosphopeptide
IID50428Camk2a/CALMMOTIONS OF CALMODULIN-SINGLE-CONFORMER REFINEMENT
IID50436Sdc4/SdcbpThe complex structure of syntenin-1 PDZ domain with c-terminal extension
IID50446PDX1/SPOPCo-crystal structure of SPOP MATH domain and hamster Pdx1 fragment
IID50455Tiam1/CAMK2ACocrystal structure of human CaMKII-alpha (CAMK2A)kinase domain and Tiam1 in complex with ATP
IID50464Fyco1/Map1lc3bCrystal structure of LC3B in complex with FYCO1 LIR
IID90002LT_SV40/Kpna2MOUSE IMPORTIN ALPHA-SV40 LARGE T ANTIGEN NLS PEPTIDE COMPLEX
IID90002LT_SV40/RB1RETINOBLASTOMA POCKET COMPLEXED WITH SV40 LARGE T ANTIGEN
IID90003E1A_ADE05/RB1Structure of the retinoblastoma protein pocket domain in complex with adenovirus E1A CR1 domain
IID90003E1A_ADE05/CREBBPNMR structure of CBP TAZ2 and adenoviral E1A complex
IID90033tat/CCNT1/CDK9/AFF4/RNA(TAR)HIV-1 TAR loop in complex with Tat:AFF4:P-TEFb
IID90035tat/SIRT3Crystalstructure of human Sirt3 in complex with an inhibiting HIV1 Tat-37-59 peptide
IID90038tat/CCNT1/CDK9/AFF4/RNA(TAR)HIV-1 TAR loop in complex with Tat:AFF4:P-TEFb
IID90039tat/CCNT1/CDK9/AFF4crystal structure of P-TEFb complex with AFF4 and Tat
IID90040cas9/RNA/DNACrystal structure of catalytically-active Streptococcus pyogenes CRISPR-Cas9 in complex with single-guided RNA and double-stranded DNA primed for target DNA cleavage
IID90040cas9/RNA/acrIIA4Crystal structure of SpyCas9-sgRNA-AcrIIA4 ternary complex
IID90041E7/RB1RB POCKET BOUND TO E7 LXCXE MOTIF
IID90041E7/RBL1p107 pocket domain in complex with HPV E7 peptide