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IID00145
 UniprotP17096
ProteinHigh mobility group protein HMG-I/HMG-Y
GeneHMGA1
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
107
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seqdisorder 1-107
 Evidence CD Reference
       Region 1-107 disorder
Seq 51-75 Monomer :
 Evidence NMR 2ezd A Reference
       Region 2ezd A 51-71 order
 Evidence NMR 2eze A Reference
       Region 2eze A 51-75 order
       Region 2eze A 51-52 high_rmsd
       Region 2eze A 71-75 high_rmsd
Seq 80-89 Monomer :
 Evidence NMR 2ezf A Reference
       Region 2ezf A 80-89 order
 Evidence NMR 2ezg A Reference
       Region 2ezg A 80-89 order
SeqProS verified 51-75 This region is ordered when it binds upon DNA. :
       Region 2ezd A 51-71 order
       Region 2eze A 51-75 order
       Region 1-107 disorder
SeqProS verified 80-89 This region is ordered when it binds upon DNA. :
       Region 2ezg A 80-89 order
       Region 2ezf A 80-89 order
       Region 1-107 disorder
Seqphosphorylation
    99-99 Phosphoserine
    67-67 Phosphothreonine
    67-67 Phosphothreonine
    42-42 Phosphothreonine
    103-103 Phosphoserine; by CK
    102-102 Phosphoserine; by CK
    78-78 Phosphothreonine; by HIPK2 and CDC2
    9-9 Phosphoserine; alternate
    36-36 Phosphoserine; by HIPK2 and CDC2
    39-39 Phosphothreonine
    44-44 Phosphoserine
    49-49 Phosphoserine
    53-53 Phosphothreonine; by HIPK2 and CDC2
    49-49 Phosphoserine
    42-42 Phosphothreonine
    103-103 Phosphoserine; by CK
    102-102 Phosphoserine; by CK
    99-99 Phosphoserine
    78-78 Phosphothreonine; by HIPK2 and CDC2
    53-53 Phosphothreonine; by HIPK2 and CDC2
    44-44 Phosphoserine
    39-39 Phosphothreonine
    36-36 Phosphoserine; by HIPK2 and CDC2
    9-9 Phosphoserine; alternate
Seqacetylation
    2-2 N-acetylserine
    7-7 N6-acetyllysine
    15-15 N6-acetyllysine; alternate
    15-15 N6-acetyllysine; alternate
    7-7 N6-acetyllysine
    2-2 N-acetylserine
 
Prediction
NeProc
Disorder 1-107
ProS 24-30,56-65
AlphaFold
Disorder 1-9,12-23,35-50,67-81,88-107
Order 10-11,24-34,51-66,82-87
SEG 2-9 ,23-34 ,54-68 ,71-106
Function
Function in SwissProt
HMG-I/Y bind preferentially to the minor groove of A+T rich regions in double-stranded DNA. It is suggested that these proteins could function in nucleosome phasing and in the 3'-end processing of mRNA transcripts. They are also involved in the transcription regulation of genes containing, or in close proximity to A+T-rich regions.
Biological Process
Diagram with PDB data
HMGA1/DNASOLUTION STRUCTURE OF A COMPLEX OF THE SECOND DNA BINDING DOMAIN OF HUMAN HMG-I(Y) BOUND TO DNA DODECAMER CONTAINING THE PRDII SITE OF THE INTERFERON-BETA PROMOTER, NMR, MINIMIZED AVERAGE STRUCTURE