Search Keyword:


Search option:


IID00904
 UniprotQ9NRQ2
ProteinPhospholipid scramblase 4
GenePLSCR4
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
329
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 271-283 Hetero dimer : IID50009Complex
 Evidence X-RAY 3q5u B Reference
       Region 3q5u B 271-272 disorder
       Region 3q5u B 273-280 order
       Region 3q5u B 281-283 disorder
SeqProS possible 273-280 Nuclear Localization Signal (NLS) Hetero dimer : IID50009Complex
       Region 3q5u B 273-280 order
Seqphosphorylation
    88-88 Phosphotyrosine; by ABL
    83-83 Phosphotyrosine; by ABL
 
Prediction
NeProc
Disorder 1-106,325-329
Order 107-324
ProS 1-10,24-43,68-71,78-87
AlphaFold
Disorder 1-95,129-139,162-168,170-170,195-201,251-255,281-288,322-329
Order 96-128,140-161,169-169,171-194,202-250,256-280,289-321
Pfam Hmmer
PF03803 100-322 1.9e-134
SEG 22-31 ,39-55 ,191-203
Function
Function in SwissProt
May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. May play a central role in the initiation of fibrin clot formation, in the activation of mast cells and in the recognition of apoptotic and injured cells by the reticuloendothelial system.
Biological Process
Diagram with PDB data
PLSCR4/Kpna2A minimal NLS from human scramblase 4 complexed with importin alpha