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IID00914
 UniprotO15226
ProteinNF-kappa-B-repressing factor
GeneNKRF
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
690
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 541-603 Hetero dimer : O43143
 Evidence X-RAY 6sh6 B Reference
       Region 6sh6 B 541-552 disorder
       Region 6sh6 B 553-593 order
       Region 6sh6 B 594-603 disorder
 Evidence X-RAY 6sh7 B Reference
       Region 6sh7 B 541-550 disorder
       Region 6sh7 B 551-596 order
       Region 6sh7 B 597-603 disorder
SeqProS predicted 576-587 This region is predicted to be disordered by NeProc and AlphaFold (pLDDT < 68.5). Hetero dimer : O43143
       Region 6sh7 B 551-596 order
       Region 6sh6 B 553-593 order
Seqphosphorylation
    618-618 Phosphoserine
 
Prediction
NeProc
Disorder 1-167,300-328,396-433,526-587
Order 168-299,329-395,434-525,588-690
ProS 1-23,53-64,309-312,396-414,526-537,548-587
AlphaFold
Disorder 1-161,188-195,231-237,303-305,314-336,413-437,523-528,538-549,576-599,689-690
Order 162-187,196-230,238-302,306-313,337-412,438-522,529-537,550-575,600-688
Pfam Hmmer
451->511 349-409 551->594
SEG 142-165
Function
Function in SwissProt
Enhances the ATPase activity of DHX15 by acting like a brace that tethers mobile sections of DHX15 together, stabilizing a functional conformation with high RNA affinity of DHX15 (PubMed:12381793). Involved in the constitutive silencing of the interferon beta promoter, independently of the virus-induced signals, and in the inhibition of the basal and cytokine-induced iNOS promoter activity (PubMed:12381793). Also involved in the regulation of IL-8 transcription (PubMed:12381793). May also act as a DNA-binding transcription regulator: interacts with a specific negative regulatory element (NRE) 5'-AATTCCTCTGA-3' to mediate transcriptional repression of certain NK-kappa-B responsive genes (PubMed:10562553).
Biological Process
Diagram with PDB data
NKRF/DHX15Crystal structure of the human DEAH-helicase DHX15 in complex with the NKRF G-patch