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IID00774
 UniprotP08151
ProteinZinc finger protein GLI1
GeneGLI1
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
1106
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 112-128 Hetero dimer : IID01030Complex
 Evidence X-RAY 4kmd B Reference
       Region 4kmd B 112-118 disorder
       Region 4kmd B 119-128 order
Seq 115-131 Hetero hexadecamer : IID01030Complex,IID90020Complex
 Evidence X-RAY 4blb E Reference
       Region 4blb E 115-119 disorder
       Region 4blb E 120-128 order
       Region 4blb E 129-131 disorder
 Evidence X-RAY 4blb F Reference
       Region 4blb F 115-119 disorder
       Region 4blb F 120-128 order
       Region 4blb F 129-131 disorder
 Evidence X-RAY 4blb G Reference
       Region 4blb G 115-119 disorder
       Region 4blb G 120-127 order
       Region 4blb G 128-131 disorder
 Evidence X-RAY 4blb H Reference
       Region 4blb H 115-119 disorder
       Region 4blb H 120-128 order
       Region 4blb H 129-131 disorder
Seq 234-302 Homo dimer :
 Evidence X-RAY 7t91 A Reference
       Region 7t91 A 234-300 order
       Region 7t91 A 301-302 disorder
 Evidence X-RAY 7t91 B Reference
       Region 7t91 B 234-234 disorder
       Region 7t91 B 235-296 order
       Region 7t91 B 297-302 disorder
Seq 234-388 Monomer :
 Evidence X-RAY 2gli A Reference
       Region 2gli A 234-388 order
Seq 637-645 Hetero tetramer : IID00301Complex
 Evidence X-RAY 5om0 B Reference
       Region 5om0 B 637-644 order
       Region 5om0 B 645-645 disorder
Seqdisorder 637-645
 Evidence X-RAY 5om0 A Reference
       Region 5om0 A 637-645 disorder
SeqProS predicted 119-128 This region is predicted to be disordered by NeProc and AlphaFold (pLDDT < 68.5). Hetero dimer : IID01030Complex
       Region 4kmd B 119-128 order
SeqProS predicted 119-128 This region is predicted to be disordered by NeProc and AlphaFold (pLDDT < 68.5). Hetero hexadecamer : IID01030Complex,IID90020Complex
       Region 4blb E 120-128 order
       Region 4blb F 120-128 order
       Region 4blb G 120-127 order
       Region 4blb H 120-128 order
SeqProS predicted 637-644 This region is predicted to be disordered by NeProc and AlphaFold (pLDDT < 68.5). Hetero tetramer : IID00301Complex
       Region 5om0 B 637-644 order
Seqacetylation
    518-518 N6-acetyllysine
 
Prediction
NeProc
Disorder 1-229,293-298,349-1106
Order 230-292,299-348
ProS 1-22,31-43,80-112,293-298,349-390,448-482,494-508,612-648,653-665,672-699,719-732,776-784,802-811,898-902,1037-1054,1081-1106
AlphaFold
Disorder 1-96,98-233,263-266,278-278,358-358,389-581,583-583,592-890,892-892,909-1106
Order 97-97,234-262,267-277,279-357,359-388,582-582,584-591,891-891,893-908
Pfam Hmmer
PF00096 301-325 4.2e-06
PF00096 331-356 8.5e-05
PF00096 362-387 4.2e-06
SEG 218-234 ,538-560 ,637-656 ,731-767 ,849-865 ,984-996 ,1069-1081
Function
Function in SwissProt
Acts as a transcriptional activator (PubMed:19706761, PubMed:10806483, PubMed:19878745, PubMed:24076122, PubMed:24311597, PubMed:24217340). Binds to the DNA consensus sequence 5'-GACCACCCA-3' (PubMed:2105456, PubMed:8378770, PubMed:24217340). Regulates the transcription of specific genes during normal development (PubMed:19706761). Plays a role in craniofacial development and digital development, as well as development of the central nervous system and gastrointestinal tract. Mediates SHH signaling (PubMed:19706761, PubMed:28973407). Plays a role in cell proliferation and differentiation via its role in SHH signaling (PubMed:11238441, PubMed:28973407).
Acts as a transcriptional activator, but activates a different set of genes than isoform 1. Activates expression of CD24, unlike isoform 1. Mediates SHH signaling. Promotes cancer cell migration.
Biological Process
Diagram with PDB data
GLI1/SUFUCrystal structure of Sufud60-Gli1p
GLI1/SFNCH2 chimera of human 14-3-3 sigma with the Gli1 phosphopeptide around Ser640