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IID50464
 UniprotQ8VDC1
ProteinFYVE and coiled-coil domain-containing protein 1
GeneFyco1
OrganismMus musculus
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
1437
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1235-1253 Hetero tetramer : IID50469Complex
 Evidence X-RAY 5wrd C Reference
       Region 5wrd C 1235-1253 order
 Evidence X-RAY 5wrd D Reference
       Region 5wrd D 1235-1253 order
SeqProS predicted 1235-1253 This region is predicted to be disordered by NeProc and AlphaFold (pLDDT < 68.5). Hetero tetramer : IID50469Complex
       Region 5wrd C 1235-1253 order
       Region 5wrd D 1235-1253 order
 
Prediction
NeProc
Disorder 1-7,182-224,274-294,323-334,363-390,440-449,548-567,631-644,715-729,807-814,857-877,1068-1078,1114-1131,1187-1312
Order 8-181,225-273,295-322,335-362,391-439,450-547,568-630,645-714,730-806,815-856,878-1067,1079-1113,1132-1186,1313-1437
ProS 203-219,274-281,288-294,323-334,363-390,440-449,548-567,631-644,715-729,807-814,857-877,1068-1078,1114-1131,1187-1194,1231-1252,1279-1312
AlphaFold
Disorder 1-7,63-64,81-85,166-168,179-236,238-238,270-388,390-391,539-539,541-582,584-584,708-730,927-927,929-967,1123-1134,1172-1176,1190-1294,1429-1437
Order 8-62,65-80,86-165,169-178,237-237,239-269,389-389,392-538,540-540,583-583,585-707,731-926,928-928,968-1122,1135-1171,1177-1189,1295-1428
SEG 196-206 ,355-367 ,418-432 ,479-498 ,500-513 ,579-590 ,684-698 ,906-931 ,937-953 ,1190-1206
Function
Function in SwissProt
May mediate microtubule plus end-directed vesicle transport.
Biological Process
Diagram with PDB data
Fyco1/Map1lc3bCrystal structure of LC3B in complex with FYCO1 LIR