Search Keyword:


Search option:


IID00282
 UniprotQ86U70
ProteinLIM domain-binding protein 1
GeneLDB1
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
411
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 56-285 Hetero tetramer : P81877,Q9BRQ0
 Evidence X-RAY 8hib V Reference
       Region 8hib V 56-64 disorder
       Region 8hib V 65-280 order
       Region 8hib V 281-285 disorder
Seq 56-285 Hetero trimer : P81877
 Evidence X-RAY 6tyd V Reference
       Region 6tyd V 56-63 disorder
       Region 6tyd V 64-282 order
       Region 6tyd V 283-285 disorder
Seqdisorder 231-294
 Evidence X-RAY 8ssu A Reference
       Region 8ssu A 231-294 disorder
Seq 334-368 Hetero dimer : IID00268Complex
 Evidence X-RAY 2xjy B Reference
       Region 2xjy B 334-368 order
 Evidence X-RAY 2xjz I Reference
       Region 2xjz I 334-335 disorder
       Region 2xjz I 336-364 order
       Region 2xjz I 365-368 disorder
 Evidence X-RAY 2xjz L Reference
       Region 2xjz L 334-335 disorder
       Region 2xjz L 336-364 order
       Region 2xjz L 365-368 disorder
 Evidence X-RAY 2xjz M Reference
       Region 2xjz M 334-335 disorder
       Region 2xjz M 336-361 order
       Region 2xjz M 362-368 disorder
 Evidence X-RAY 2xjz J Reference
       Region 2xjz J 334-363 order
       Region 2xjz J 364-368 disorder
 Evidence X-RAY 2xjz K Reference
       Region 2xjz K 334-335 disorder
       Region 2xjz K 336-356 order
       Region 2xjz K 357-368 disorder
Seq 336-375 Hetero tetramer : IID00268Complex
 Evidence X-RAY 2ypa D Reference
       Region 2ypa D 336-365 order
       Region 2ypa D 366-375 disorder
Seq 401-411 Hetero dimer : IID00301Complex
 Evidence X-RAY 7ob5 P Reference
       Region 7ob5 P 401-402 disorder
       Region 7ob5 P 403-411 order
 Evidence X-RAY 7ob8 B Reference
       Region 7ob8 B 401-408 disorder
       Region 7ob8 B 409-411 order
SeqProS possible 336-368 Same region of mouse homolog (P70662, 99%identity) is disordered in the free state. Hetero tetramer : IID00268Complex
       Region 2ypa D 336-365 order
SeqProS possible 336-368 Same region of mouse homolog (P70662, 99%identity) is disordered in the free state. Hetero dimer : IID00268Complex
       Region 2xjz I 336-364 order
       Region 2xjz J 334-363 order
       Region 2xjz K 336-356 order
       Region 2xjz L 336-364 order
       Region 2xjz M 336-361 order
       Region 2xjy B 334-368 order
SeqProS predicted 403-411 This region is predicted to be disordered by NeProc and AlphaFold (pLDDT < 68.5). Hetero dimer : IID00301Complex
       Region 7ob8 B 409-411 order
       Region 7ob5 P 403-411 order
Seqphosphorylation
    302-302 Phosphoserine
    265-265 Phosphoserine
    61-61 Phosphothreonine
    302-302 Phosphoserine
    265-265 Phosphoserine
    61-61 Phosphothreonine
Seqacetylation
    2-2 N-acetylserine
    2-2 N-acetylserine
 
Prediction
NeProc
Disorder 1-62,222-231,268-411
Order 63-214,232-267
ProS 1-8,228-231,268-284
AlphaFold
Disorder 1-64,285-411
Order 65-284
Pfam Hmmer
PF01803 37-411 1e-298
SEG 300-323 ,391-404
Function
Function in SwissProt
Binds to the LIM domain of a wide variety of LIM domain-containing transcription factors. May regulate the transcriptional activity of LIM-containing proteins by determining specific partner interactions. Plays a role in the development of interneurons and motor neurons in cooperation with LHX3 and ISL1. Acts synergistically with LHX1/LIM1 in axis formation and activation of gene expression. Acts with LMO2 in the regulation of red blood cell development, maintaining erythroid precursors in an immature state.
Biological Process
Diagram with PDB data
LDB1/LMO2/TCF3/TAL1/DNAStructure of the SCL:E47:LMO2:LDB1 complex bound to DNA