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IID50427
 UniprotP09959
ProteinRegulatory protein SWI6
GeneSWI6
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c)
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
803
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 2-126 Homo dimer :
 Evidence X-RAY 2xfv A Reference
       Region 2xfv A 2-109 order
       Region 2xfv A 110-126 disorder
 Evidence X-RAY 2xfv B Reference
       Region 2xfv B 2-109 order
       Region 2xfv B 110-126 disorder
Seq 155-164 Hetero trimer : IID50448Complex
 Evidence X-RAY 5xw5 C Reference
       Region 5xw5 C 155-156 disorder
       Region 5xw5 C 157-164 order
Seq 188-512 Homo dimer :
 Evidence X-RAY 1sw6 A Reference
       Region 1sw6 A 188-211 disorder
       Region 1sw6 A 212-259 order
       Region 1sw6 A 260-290 disorder
       Region 1sw6 A 291-430 order
       Region 1sw6 A 431-446 disorder
       Region 1sw6 A 447-512 order
 Evidence X-RAY 1sw6 B Reference
       Region 1sw6 B 188-211 disorder
       Region 1sw6 B 212-258 order
       Region 1sw6 B 259-290 disorder
       Region 1sw6 B 291-430 order
       Region 1sw6 B 431-445 disorder
       Region 1sw6 B 446-512 order
SeqProS predicted 157-164 This region is predicted to be disordered by AlphaFold (pLDDT <68.5) and NeProc. Hetero trimer : IID50448Complex
       Region 5xw5 C 157-164 order
Seqphosphorylation
    149-149 Phosphoserine
    160-160 Phosphoserine; by CDC28
    176-176 Phosphoserine
    547-547 Phosphoserine
    182-182 Phosphothreonine
    179-179 Phosphothreonine
 
Prediction
NeProc
Disorder 110-289,439-444,517-559,644-718,779-803
Order 1-109,290-438,445-516,560-643,719-778
ProS 251-257,439-444,558-559,644-648,653-667,718-718,779-803
AlphaFold
Disorder 1-1,10-16,44-56,103-103,105-211,223-227,260-290,402-402,431-446,512-556,644-668,670-670,673-673,686-686,692-692,695-695,698-698,701-701,704-716,774-774,777-778,780-798,800-803
Order 2-9,17-43,57-102,104-104,212-222,228-259,291-401,403-430,447-511,557-643,669-669,671-672,674-685,687-691,693-694,696-697,699-700,702-703,717-773,775-776,779-779,799-799
SEG 88-101 ,104-118 ,197-208 ,270-288 ,583-592 ,631-641
Function
Function in SwissProt
Part of a complex involved in cell-cycle-dependent transcription. SWI4 and SWI6 are required for formation of the cell-cycle box factor-DNA complex. The repeated element in the upstream region of HO (5'-CACGAAAA-3') is called the cell cycle box (CCB).
Biological Process
Diagram with PDB data
SWI6/CDC14Crystal structure of budding yeast Cdc14p (C283S) bound to a Swi6p phosphopeptide