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IID00990
 UniprotQ86V97
ProteinKelch repeat and BTB domain-containing protein 6
GeneKBTBD6
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
674
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 663-673 Hetero dimer : IID00921Complex
 Evidence X-RAY 4xc2 E Reference
       Region 4xc2 E 663-673 order
 Evidence X-RAY 4xc2 F Reference
       Region 4xc2 F 663-673 order
 Evidence X-RAY 4xc2 G Reference
       Region 4xc2 G 663-673 order
 Evidence X-RAY 4xc2 H Reference
       Region 4xc2 H 663-673 order
 
Prediction
NeProc
Disorder 1-36,310-330,649-654
Order 37-309,331-648,655-674
ProS 324-330
AlphaFold
Disorder 1-35,207-211,302-302,304-332,376-380,382-382,579-579,600-603,632-674
Order 36-206,212-301,303-303,333-375,381-381,383-578,580-599,604-631
Pfam Hmmer
173->279 53-168 424->471
SEG 214-232 ,310-329 ,631-643 ,650-666
Function
Function in SwissProt
As part of the CUL3(KBTBD6/7) E3 ubiquitin ligase complex functions as a substrate adapter for the RAC1 guanine exchange factor (GEF) TIAM1, mediating its 'Lys-48' ubiquitination and proteasomal degradation (PubMed:25684205). By controlling this ubiquitination, regulates RAC1 signal transduction and downstream biological processes including the organization of the cytoskeleton, cell migration and cell proliferation (PubMed:25684205). Ubiquitination of TIAM1 requires the membrane-associated protein GABARAP which may restrict locally the activity of the complex (PubMed:25684205).
Biological Process
Diagram with PDB data
KBTBD6/GABARAPCrystal structure of GABARAP in complex with KBTBD6 LIR peptide