Search Keyword:


Search option:


IID00022
 UniprotP12004
ProteinProliferating cell nuclear antigen
GenePCNA
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
261
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-255 Hetero pentamer : Q15004
 Evidence X-RAY 6eht A Reference
       Region 6eht A 1-254 order
 Evidence X-RAY 6eht B Reference
       Region 6eht B 1-1 disorder
       Region 6eht B 2-254 order
 Evidence X-RAY 6eht C Reference
       Region 6eht C 1-255 order
Seq 1-258 Hetero hexamer :
 Evidence X-RAY 7m5l A Reference
       Region 7m5l A 1-257 order
       Region 7m5l A 258-258 disorder
 Evidence X-RAY 7m5l B Reference
       Region 7m5l B 1-257 order
       Region 7m5l B 258-258 disorder
 Evidence X-RAY 7m5l C Reference
       Region 7m5l C 1-255 order
       Region 7m5l C 256-258 disorder
Seq 1-259 Hetero hexamer : IID00043Complex
 Evidence X-RAY 7kq0 A Reference
       Region 7kq0 A 1-257 order
       Region 7kq0 A 258-259 disorder
 Evidence X-RAY 7kq0 C Reference
       Region 7kq0 C 1-183 order
       Region 7kq0 C 184-184 disorder
       Region 7kq0 C 185-256 order
       Region 7kq0 C 257-259 disorder
 Evidence X-RAY 7kq0 E Reference
       Region 7kq0 E 1-129 order
       Region 7kq0 E 130-130 disorder
       Region 7kq0 E 131-256 order
       Region 7kq0 E 257-259 disorder
Seq 1-259 Hetero hexamer : Q8NFZ0
 Evidence X-RAY 8f5q A Reference
       Region 8f5q A 1-92 order
       Region 8f5q A 93-96 disorder
       Region 8f5q A 97-105 order
       Region 8f5q A 106-108 disorder
       Region 8f5q A 109-123 order
       Region 8f5q A 124-124 disorder
       Region 8f5q A 125-162 order
       Region 8f5q A 163-165 disorder
       Region 8f5q A 166-185 order
       Region 8f5q A 186-191 disorder
       Region 8f5q A 192-254 order
       Region 8f5q A 255-259 disorder
 Evidence X-RAY 8f5q C Reference
       Region 8f5q C 1-92 order
       Region 8f5q C 93-96 disorder
       Region 8f5q C 97-185 order
       Region 8f5q C 186-191 disorder
       Region 8f5q C 192-254 order
       Region 8f5q C 255-259 disorder
 Evidence X-RAY 8f5q E Reference
       Region 8f5q E 1-92 order
       Region 8f5q E 93-95 disorder
       Region 8f5q E 96-122 order
       Region 8f5q E 123-125 disorder
       Region 8f5q E 126-184 order
       Region 8f5q E 185-193 disorder
       Region 8f5q E 194-255 order
       Region 8f5q E 256-259 disorder
Seq 1-259 Hetero pentamer :
 Evidence X-RAY 7m5n A Reference
       Region 7m5n A 1-254 order
       Region 7m5n A 255-259 disorder
 Evidence X-RAY 7m5n B Reference
       Region 7m5n B 1-1 disorder
       Region 7m5n B 2-121 order
       Region 7m5n B 122-122 disorder
       Region 7m5n B 123-255 order
       Region 7m5n B 256-259 disorder
 Evidence X-RAY 7m5n C Reference
       Region 7m5n C 1-85 order
       Region 7m5n C 86-86 disorder
       Region 7m5n C 87-122 order
       Region 7m5n C 123-125 disorder
       Region 7m5n C 126-129 order
       Region 7m5n C 130-130 disorder
       Region 7m5n C 131-188 order
       Region 7m5n C 189-190 disorder
       Region 7m5n C 191-255 order
       Region 7m5n C 256-259 disorder
Seq 1-259 Hetero pentamer :
 Evidence X-RAY 7m5m A Reference
       Region 7m5m A 1-255 order
       Region 7m5m A 256-259 disorder
 Evidence X-RAY 7m5m B Reference
       Region 7m5m B 1-121 order
       Region 7m5m B 122-122 disorder
       Region 7m5m B 123-255 order
       Region 7m5m B 256-259 disorder
 Evidence X-RAY 7m5m C Reference
       Region 7m5m C 1-123 order
       Region 7m5m C 124-124 disorder
       Region 7m5m C 125-255 order
       Region 7m5m C 256-259 disorder
Seq 1-261 Hetero pentamer : Q15004
 Evidence X-RAY 4d2g A Reference
       Region 4d2g A 1-255 order
       Region 4d2g A 256-261 disorder
 Evidence X-RAY 4d2g B Reference
       Region 4d2g B 1-255 order
       Region 4d2g B 256-261 disorder
 Evidence X-RAY 4d2g C Reference
       Region 4d2g C 1-255 order
       Region 4d2g C 256-261 disorder
Seq 1-261 Hetero decamer : IID00043Complex
 Evidence X-RAY 6cbi A Reference
       Region 6cbi A 1-105 order
       Region 6cbi A 106-107 disorder
       Region 6cbi A 108-122 order
       Region 6cbi A 123-124 disorder
       Region 6cbi A 125-186 order
       Region 6cbi A 187-190 disorder
       Region 6cbi A 191-256 order
       Region 6cbi A 257-261 disorder
 Evidence X-RAY 6cbi B Reference
       Region 6cbi B 1-105 order
       Region 6cbi B 106-107 disorder
       Region 6cbi B 108-121 order
       Region 6cbi B 122-124 disorder
       Region 6cbi B 125-186 order
       Region 6cbi B 187-190 disorder
       Region 6cbi B 191-255 order
       Region 6cbi B 256-261 disorder
 Evidence X-RAY 6cbi C Reference
       Region 6cbi C 1-125 order
       Region 6cbi C 126-128 disorder
       Region 6cbi C 129-185 order
       Region 6cbi C 186-190 disorder
       Region 6cbi C 191-255 order
       Region 6cbi C 256-261 disorder
 Evidence X-RAY 6cbi D Reference
       Region 6cbi D 1-123 order
       Region 6cbi D 124-125 disorder
       Region 6cbi D 126-185 order
       Region 6cbi D 186-189 disorder
       Region 6cbi D 190-255 order
       Region 6cbi D 256-261 disorder
 Evidence X-RAY 6cbi E Reference
       Region 6cbi E 1-255 order
       Region 6cbi E 256-261 disorder
 Evidence X-RAY 6cbi F Reference
       Region 6cbi F 1-106 order
       Region 6cbi F 107-108 disorder
       Region 6cbi F 109-255 order
       Region 6cbi F 256-261 disorder
Seq 1-261 Hetero dimer : Q99P21
 Evidence X-RAY 7efa A Reference
       Region 7efa A 1-256 order
       Region 7efa A 257-261 disorder
Seq 1-261 Homo tetramer :
 Evidence X-RAY 8gl9 A Reference
       Region 8gl9 A 1-94 order
       Region 8gl9 A 95-96 disorder
       Region 8gl9 A 97-105 order
       Region 8gl9 A 106-107 disorder
       Region 8gl9 A 108-163 order
       Region 8gl9 A 164-166 disorder
       Region 8gl9 A 167-185 order
       Region 8gl9 A 186-192 disorder
       Region 8gl9 A 193-254 order
       Region 8gl9 A 255-261 disorder
 Evidence X-RAY 8gl9 B Reference
       Region 8gl9 B 1-93 order
       Region 8gl9 B 94-96 disorder
       Region 8gl9 B 97-105 order
       Region 8gl9 B 106-106 disorder
       Region 8gl9 B 107-162 order
       Region 8gl9 B 163-165 disorder
       Region 8gl9 B 166-185 order
       Region 8gl9 B 186-192 disorder
       Region 8gl9 B 193-254 order
       Region 8gl9 B 255-261 disorder
 Evidence X-RAY 8gl9 C Reference
       Region 8gl9 C 1-1 disorder
       Region 8gl9 C 2-94 order
       Region 8gl9 C 95-96 disorder
       Region 8gl9 C 97-105 order
       Region 8gl9 C 106-107 disorder
       Region 8gl9 C 108-163 order
       Region 8gl9 C 164-166 disorder
       Region 8gl9 C 167-185 order
       Region 8gl9 C 186-192 disorder
       Region 8gl9 C 193-255 order
       Region 8gl9 C 256-261 disorder
 Evidence X-RAY 8gl9 D Reference
       Region 8gl9 D 1-94 order
       Region 8gl9 D 95-96 disorder
       Region 8gl9 D 97-105 order
       Region 8gl9 D 106-106 disorder
       Region 8gl9 D 107-162 order
       Region 8gl9 D 163-165 disorder
       Region 8gl9 D 166-185 order
       Region 8gl9 D 186-192 disorder
       Region 8gl9 D 193-255 order
       Region 8gl9 D 256-261 disorder
Seq 1-261 Hetero dimer : Q5FWF4
 Evidence X-RAY 5yd8 Y Reference
       Region 5yd8 Y 1-82 order
       Region 5yd8 Y 83-86 disorder
       Region 5yd8 Y 87-105 order
       Region 5yd8 Y 106-108 disorder
       Region 5yd8 Y 109-120 order
       Region 5yd8 Y 121-124 disorder
       Region 5yd8 Y 125-254 order
       Region 5yd8 Y 255-261 disorder
 Evidence X-RAY 5yd8 X Reference
       Region 5yd8 X 1-123 order
       Region 5yd8 X 124-124 disorder
       Region 5yd8 X 125-186 order
       Region 5yd8 X 187-192 disorder
       Region 5yd8 X 193-255 order
       Region 5yd8 X 256-261 disorder
 Evidence X-RAY 5yd8 Z Reference
       Region 5yd8 Z 1-185 order
       Region 5yd8 Z 186-192 disorder
       Region 5yd8 Z 193-242 order
       Region 5yd8 Z 243-243 disorder
       Region 5yd8 Z 244-255 order
       Region 5yd8 Z 256-261 disorder
Seq 1-261 Hetero hexamer : IID00880Complex
 Evidence X-RAY 6hvo A Reference
       Region 6hvo A 1-187 order
       Region 6hvo A 188-190 disorder
       Region 6hvo A 191-255 order
       Region 6hvo A 256-261 disorder
 Evidence X-RAY 6hvo B Reference
       Region 6hvo B 1-187 order
       Region 6hvo B 188-190 disorder
       Region 6hvo B 191-255 order
       Region 6hvo B 256-261 disorder
 Evidence X-RAY 6hvo C Reference
       Region 6hvo C 1-185 order
       Region 6hvo C 186-191 disorder
       Region 6hvo C 192-256 order
       Region 6hvo C 257-261 disorder
Seq 1-261 Hetero hexamer : Q5FWF4
 Evidence X-RAY 5mlo A Reference
       Region 5mlo A 1-255 order
       Region 5mlo A 256-261 disorder
 Evidence X-RAY 5mlo C Reference
       Region 5mlo C 1-255 order
       Region 5mlo C 256-261 disorder
 Evidence X-RAY 5mlo E Reference
       Region 5mlo E 1-255 order
       Region 5mlo E 256-261 disorder
Seq 1-261 Hetero hexamer : P26358
 Evidence X-RAY 6k3a A Reference
       Region 6k3a A 1-106 order
       Region 6k3a A 107-108 disorder
       Region 6k3a A 109-121 order
       Region 6k3a A 122-124 disorder
       Region 6k3a A 125-162 order
       Region 6k3a A 163-165 disorder
       Region 6k3a A 166-184 order
       Region 6k3a A 185-192 disorder
       Region 6k3a A 193-257 order
       Region 6k3a A 258-261 disorder
 Evidence X-RAY 6k3a C Reference
       Region 6k3a C 1-106 order
       Region 6k3a C 107-108 disorder
       Region 6k3a C 109-121 order
       Region 6k3a C 122-124 disorder
       Region 6k3a C 125-162 order
       Region 6k3a C 163-165 disorder
       Region 6k3a C 166-184 order
       Region 6k3a C 185-192 disorder
       Region 6k3a C 193-257 order
       Region 6k3a C 258-261 disorder
 Evidence X-RAY 6k3a E Reference
       Region 6k3a E 1-106 order
       Region 6k3a E 107-108 disorder
       Region 6k3a E 109-121 order
       Region 6k3a E 122-124 disorder
       Region 6k3a E 125-162 order
       Region 6k3a E 163-165 disorder
       Region 6k3a E 166-184 order
       Region 6k3a E 185-192 disorder
       Region 6k3a E 193-257 order
       Region 6k3a E 258-261 disorder
Seq 1-261 Hetero hexamer :
 Evidence X-RAY 1vyj A B-chain is a PL (Pogo-Ligase) hybrid peptide that includes p21(141-160). (PMID 15681588) Reference
       Region 1vyj A 1-257 order
       Region 1vyj A 258-261 disorder
 Evidence X-RAY 1vyj C B-chain is a PL (Pogo-Ligase) hybrid peptide that includes p21(141-160). (PMID 15681588) Reference
       Region 1vyj C 1-257 order
       Region 1vyj C 258-261 disorder
 Evidence X-RAY 1vyj E B-chain is a PL (Pogo-Ligase) hybrid peptide that includes p21(141-160). (PMID 15681588) Reference
       Region 1vyj E 1-257 order
       Region 1vyj E 258-261 disorder
Seq 1-261 Hetero hexamer : IID00043Complex
 Evidence X-RAY 1axc A Reference
       Region 1axc A 1-106 order
       Region 1axc A 107-108 disorder
       Region 1axc A 109-186 order
       Region 1axc A 187-190 disorder
       Region 1axc A 191-255 order
       Region 1axc A 256-261 disorder
 Evidence X-RAY 1axc C Reference
       Region 1axc C 1-106 order
       Region 1axc C 107-108 disorder
       Region 1axc C 109-185 order
       Region 1axc C 186-190 disorder
       Region 1axc C 191-255 order
       Region 1axc C 256-261 disorder
 Evidence X-RAY 1axc E Reference
       Region 1axc E 1-188 order
       Region 1axc E 189-190 disorder
       Region 1axc E 191-255 order
       Region 1axc E 256-261 disorder
 Evidence X-RAY 4rjf A Reference
       Region 4rjf A 1-255 order
       Region 4rjf A 256-261 disorder
 Evidence X-RAY 4rjf C Reference
       Region 4rjf C 1-187 order
       Region 4rjf C 188-189 disorder
       Region 4rjf C 190-255 order
       Region 4rjf C 256-261 disorder
 Evidence X-RAY 4rjf E Reference
       Region 4rjf E 1-106 order
       Region 4rjf E 107-108 disorder
       Region 4rjf E 109-186 order
       Region 4rjf E 187-190 disorder
       Region 4rjf E 191-255 order
       Region 4rjf E 256-261 disorder
 Evidence X-RAY 7kq1 A Reference
       Region 7kq1 A 1-257 order
       Region 7kq1 A 258-259 disorder
 Evidence X-RAY 7kq1 C Reference
       Region 7kq1 C 1-257 order
       Region 7kq1 C 258-259 disorder
 Evidence X-RAY 7kq1 E Reference
       Region 7kq1 E 1-259 order
Seq 1-261 Hetero dodecamer : IID01018Complex
 Evidence X-RAY 6qcg A Reference
       Region 6qcg A 1-186 order
       Region 6qcg A 187-190 disorder
       Region 6qcg A 191-255 order
       Region 6qcg A 256-261 disorder
 Evidence X-RAY 6qcg B Reference
       Region 6qcg B 1-255 order
       Region 6qcg B 256-261 disorder
 Evidence X-RAY 6qcg C Reference
       Region 6qcg C 1-185 order
       Region 6qcg C 186-190 disorder
       Region 6qcg C 191-255 order
       Region 6qcg C 256-261 disorder
 Evidence X-RAY 6qcg D Reference
       Region 6qcg D 1-185 order
       Region 6qcg D 186-190 disorder
       Region 6qcg D 191-255 order
       Region 6qcg D 256-261 disorder
 Evidence X-RAY 6qcg E Reference
       Region 6qcg E 1-255 order
       Region 6qcg E 256-261 disorder
 Evidence X-RAY 6qcg F Reference
       Region 6qcg F 1-255 order
       Region 6qcg F 256-261 disorder
Seq 1-261 Hetero hexamer : IID00080Complex
 Evidence X-RAY 1u76 A Reference
       Region 1u76 A 1-186 order
       Region 1u76 A 187-190 disorder
       Region 1u76 A 191-257 order
       Region 1u76 A 258-261 disorder
 Evidence X-RAY 1u76 C Reference
       Region 1u76 C 1-107 order
       Region 1u76 C 108-108 disorder
       Region 1u76 C 109-185 order
       Region 1u76 C 186-190 disorder
       Region 1u76 C 191-257 order
       Region 1u76 C 258-261 disorder
 Evidence X-RAY 1u76 E Reference
       Region 1u76 E 1-186 order
       Region 1u76 E 187-192 disorder
       Region 1u76 E 193-259 order
       Region 1u76 E 260-261 disorder
Seq 1-261 Hetero hexamer : Q15004
 Evidence X-RAY 6gws A Reference
       Region 6gws A 1-255 order
       Region 6gws A 256-261 disorder
 Evidence X-RAY 6gws B Reference
       Region 6gws B 1-255 order
       Region 6gws B 256-261 disorder
 Evidence X-RAY 6gws C Reference
       Region 6gws C 1-255 order
       Region 6gws C 256-261 disorder
Seq 1-261 Hetero hexamer :
 Evidence X-RAY 2zvl A Reference
       Region 2zvl A 1-95 order
       Region 2zvl A 96-96 disorder
       Region 2zvl A 97-184 order
       Region 2zvl A 185-193 disorder
       Region 2zvl A 194-255 order
       Region 2zvl A 256-261 disorder
 Evidence X-RAY 2zvl B Reference
       Region 2zvl B 1-185 order
       Region 2zvl B 186-193 disorder
       Region 2zvl B 194-255 order
       Region 2zvl B 256-261 disorder
 Evidence X-RAY 2zvl C Reference
       Region 2zvl C 1-185 order
       Region 2zvl C 186-193 disorder
       Region 2zvl C 194-255 order
       Region 2zvl C 256-261 disorder
Seq 1-261 Hetero hexamer :
 Evidence X-RAY 1vyj G B-chain is a PL (Pogo-Ligase) hybrid peptide that includes p21(141-160). (PMID 15681588) Reference
       Region 1vyj G 1-260 order
       Region 1vyj G 261-261 disorder
 Evidence X-RAY 1vyj I B-chain is a PL (Pogo-Ligase) hybrid peptide that includes p21(141-160). (PMID 15681588) Reference
       Region 1vyj I 1-257 order
       Region 1vyj I 258-261 disorder
 Evidence X-RAY 1vyj K B-chain is a PL (Pogo-Ligase) hybrid peptide that includes p21(141-160). (PMID 15681588) Reference
       Region 1vyj K 1-257 order
       Region 1vyj K 258-261 disorder
Seq 1-261 Hetero hexamer : IID00043Complex
 Evidence X-RAY 5e0u A Reference
       Region 5e0u A 1-255 order
       Region 5e0u A 256-261 disorder
 Evidence X-RAY 5e0u B Reference
       Region 5e0u B 1-255 order
       Region 5e0u B 256-261 disorder
 Evidence X-RAY 5e0u C Reference
       Region 5e0u C 1-255 order
       Region 5e0u C 256-261 disorder
Seq 1-261 Hetero hexamer : Q5T890
 Evidence X-RAY 8cob A Reference
       Region 8cob A 1-92 order
       Region 8cob A 93-96 disorder
       Region 8cob A 97-186 order
       Region 8cob A 187-190 disorder
       Region 8cob A 191-255 order
       Region 8cob A 256-261 disorder
 Evidence X-RAY 8cob C Reference
       Region 8cob C 1-185 order
       Region 8cob C 186-191 disorder
       Region 8cob C 192-255 order
       Region 8cob C 256-261 disorder
 Evidence X-RAY 8cob E Reference
       Region 8cob E 1-93 order
       Region 8cob E 94-96 disorder
       Region 8cob E 97-187 order
       Region 8cob E 188-190 disorder
       Region 8cob E 191-255 order
       Region 8cob E 256-261 disorder
Seq 1-261 Homo trimer :
 Evidence X-RAY 5e0t A Reference
       Region 5e0t A 1-185 order
       Region 5e0t A 186-192 disorder
       Region 5e0t A 193-255 order
       Region 5e0t A 256-261 disorder
 Evidence X-RAY 5e0t B Reference
       Region 5e0t B 1-185 order
       Region 5e0t B 186-191 disorder
       Region 5e0t B 192-259 order
       Region 5e0t B 260-261 disorder
 Evidence X-RAY 5e0t C Reference
       Region 5e0t C 1-186 order
       Region 5e0t C 187-190 disorder
       Region 5e0t C 191-256 order
       Region 5e0t C 257-261 disorder
 Evidence X-RAY 5mom A Reference
       Region 5mom A 1-185 order
       Region 5mom A 186-192 disorder
       Region 5mom A 193-258 order
 Evidence X-RAY 5mom B Reference
       Region 5mom B 1-185 order
       Region 5mom B 186-192 disorder
       Region 5mom B 193-256 order
       Region 5mom B 257-258 disorder
 Evidence X-RAY 5mom C Reference
       Region 5mom C 1-185 order
       Region 5mom C 186-192 disorder
       Region 5mom C 193-255 order
       Region 5mom C 256-258 disorder
 Evidence X-RAY 3vkx A Reference
       Region 3vkx A 1-185 order
       Region 3vkx A 186-192 disorder
       Region 3vkx A 193-255 order
       Region 3vkx A 256-261 disorder
 Evidence X-RAY 1vym A Reference
       Region 1vym A 1-255 order
       Region 1vym A 256-261 disorder
 Evidence X-RAY 1vym B Reference
       Region 1vym B 1-255 order
       Region 1vym B 256-261 disorder
 Evidence X-RAY 1vym C Reference
       Region 1vym C 1-255 order
       Region 1vym C 256-261 disorder
 Evidence X-RAY 1w60 A Reference
       Region 1w60 A 1-255 order
       Region 1w60 A 256-261 disorder
 Evidence X-RAY 1w60 B Reference
       Region 1w60 B 1-255 order
       Region 1w60 B 256-261 disorder
 Evidence X-RAY 3wgw A Reference
       Region 3wgw A 1-185 order
       Region 3wgw A 186-192 disorder
       Region 3wgw A 193-255 order
       Region 3wgw A 256-261 disorder
 Evidence X-RAY 3wgw B Reference
       Region 3wgw B 1-186 order
       Region 3wgw B 187-192 disorder
       Region 3wgw B 193-255 order
       Region 3wgw B 256-261 disorder
 Evidence X-RAY 8e84 A Reference
       Region 8e84 A 1-124 order
       Region 8e84 A 125-130 disorder
       Region 8e84 A 131-188 order
       Region 8e84 A 189-191 disorder
       Region 8e84 A 192-255 order
       Region 8e84 A 256-261 disorder
 Evidence X-RAY 8e84 B Reference
       Region 8e84 B 1-121 order
       Region 8e84 B 122-124 disorder
       Region 8e84 B 125-185 order
       Region 8e84 B 186-190 disorder
       Region 8e84 B 191-255 order
       Region 8e84 B 256-261 disorder
 Evidence X-RAY 8e84 C Reference
       Region 8e84 C 1-122 order
       Region 8e84 C 123-125 disorder
       Region 8e84 C 126-186 order
       Region 8e84 C 187-192 disorder
       Region 8e84 C 193-254 order
       Region 8e84 C 255-261 disorder
 Evidence X-RAY 6fcm A Reference
       Region 6fcm A 1-185 order
       Region 6fcm A 186-190 disorder
       Region 6fcm A 191-255 order
       Region 6fcm A 256-261 disorder
 Evidence X-RAY 6fcm C Reference
       Region 6fcm C 1-187 order
       Region 6fcm C 188-189 disorder
       Region 6fcm C 190-256 order
       Region 6fcm C 257-261 disorder
 Evidence X-RAY 6fcm E Reference
       Region 6fcm E 1-186 order
       Region 6fcm E 187-190 disorder
       Region 6fcm E 191-255 order
       Region 6fcm E 256-261 disorder
 Evidence X-RAY 6fcn A Reference
       Region 6fcn A 1-185 order
       Region 6fcn A 186-189 disorder
       Region 6fcn A 190-256 order
       Region 6fcn A 257-261 disorder
 Evidence X-RAY 6fcn C Reference
       Region 6fcn C 1-187 order
       Region 6fcn C 188-191 disorder
       Region 6fcn C 192-256 order
       Region 6fcn C 257-261 disorder
 Evidence X-RAY 6fcn E Reference
       Region 6fcn E 1-186 order
       Region 6fcn E 187-190 disorder
       Region 6fcn E 191-255 order
       Region 6fcn E 256-261 disorder
 Evidence X-RAY 6gis A Reference
       Region 6gis A 1-185 order
       Region 6gis A 186-191 disorder
       Region 6gis A 192-254 order
       Region 6gis A 255-261 disorder
 Evidence X-RAY 6gis B Reference
       Region 6gis B 1-185 order
       Region 6gis B 186-190 disorder
       Region 6gis B 191-254 order
       Region 6gis B 255-261 disorder
 Evidence X-RAY 6gis C Reference
       Region 6gis C 1-185 order
       Region 6gis C 186-192 disorder
       Region 6gis C 193-253 order
       Region 6gis C 254-261 disorder
Seq 1-261 Homo tetramer :
 Evidence X-RAY 8gla A Reference
       Region 8gla A 1-1 disorder
       Region 8gla A 2-93 order
       Region 8gla A 94-96 disorder
       Region 8gla A 97-105 order
       Region 8gla A 106-109 disorder
       Region 8gla A 110-164 order
       Region 8gla A 165-166 disorder
       Region 8gla A 167-184 order
       Region 8gla A 185-192 disorder
       Region 8gla A 193-254 order
       Region 8gla A 255-261 disorder
 Evidence X-RAY 8gla B Reference
       Region 8gla B 1-82 order
       Region 8gla B 83-83 disorder
       Region 8gla B 84-162 order
       Region 8gla B 163-166 disorder
       Region 8gla B 167-185 order
       Region 8gla B 186-193 disorder
       Region 8gla B 194-253 order
       Region 8gla B 254-261 disorder
 Evidence X-RAY 8gla C Reference
       Region 8gla C 1-1 disorder
       Region 8gla C 2-92 order
       Region 8gla C 93-96 disorder
       Region 8gla C 97-105 order
       Region 8gla C 106-108 disorder
       Region 8gla C 109-121 order
       Region 8gla C 122-122 disorder
       Region 8gla C 123-162 order
       Region 8gla C 163-166 disorder
       Region 8gla C 167-185 order
       Region 8gla C 186-192 disorder
       Region 8gla C 193-198 order
       Region 8gla C 199-199 disorder
       Region 8gla C 200-255 order
       Region 8gla C 256-261 disorder
 Evidence X-RAY 8gla D Reference
       Region 8gla D 1-1 disorder
       Region 8gla D 2-105 order
       Region 8gla D 106-106 disorder
       Region 8gla D 107-154 order
       Region 8gla D 155-155 disorder
       Region 8gla D 156-164 order
       Region 8gla D 165-166 disorder
       Region 8gla D 167-184 order
       Region 8gla D 185-192 disorder
       Region 8gla D 193-255 order
       Region 8gla D 256-261 disorder
Seq 1-261 Hetero hexamer : IID00044Complex
 Evidence X-RAY 1ul1 A Reference
       Region 1ul1 A 1-186 order
       Region 1ul1 A 187-189 disorder
       Region 1ul1 A 190-259 order
       Region 1ul1 A 260-261 disorder
 Evidence X-RAY 1ul1 B Reference
       Region 1ul1 B 1-258 order
       Region 1ul1 B 259-261 disorder
 Evidence X-RAY 1ul1 C Reference
       Region 1ul1 C 1-255 order
       Region 1ul1 C 256-261 disorder
Seq 1-261 Hetero tetramer : Q96PU4
 Evidence X-RAY 5yco A Reference
       Region 5yco A 1-187 order
       Region 5yco A 188-192 disorder
       Region 5yco A 193-255 order
       Region 5yco A 256-261 disorder
 Evidence X-RAY 5yco C Reference
       Region 5yco C 1-185 order
       Region 5yco C 186-192 disorder
       Region 5yco C 193-255 order
       Region 5yco C 256-261 disorder
 Evidence X-RAY 5yco D Reference
       Region 5yco D 1-187 order
       Region 5yco D 188-192 disorder
       Region 5yco D 193-255 order
       Region 5yco D 256-261 disorder
 Evidence X-RAY 5yco B Reference
       Region 5yco B 1-187 order
       Region 5yco B 188-192 disorder
       Region 5yco B 193-255 order
       Region 5yco B 256-261 disorder
Seq 1-261 Hetero hexamer :
 Evidence X-RAY 2zvl D Reference
       Region 2zvl D 1-185 order
       Region 2zvl D 186-193 disorder
       Region 2zvl D 194-255 order
       Region 2zvl D 256-261 disorder
 Evidence X-RAY 2zvl E Reference
       Region 2zvl E 1-93 order
       Region 2zvl E 94-95 disorder
       Region 2zvl E 96-184 order
       Region 2zvl E 185-193 disorder
       Region 2zvl E 194-255 order
       Region 2zvl E 256-261 disorder
 Evidence X-RAY 2zvl F Reference
       Region 2zvl F 1-93 order
       Region 2zvl F 94-96 disorder
       Region 2zvl F 97-184 order
       Region 2zvl F 185-193 disorder
       Region 2zvl F 194-255 order
       Region 2zvl F 256-261 disorder
Seq 1-261 Hetero hexamer : Q9NZJ0
 Evidence X-RAY 6qc0 A Reference
       Region 6qc0 A 1-188 order
       Region 6qc0 A 189-191 disorder
       Region 6qc0 A 192-257 order
       Region 6qc0 A 258-261 disorder
 Evidence X-RAY 6qc0 C Reference
       Region 6qc0 C 1-255 order
       Region 6qc0 C 256-261 disorder
 Evidence X-RAY 6qc0 E Reference
       Region 6qc0 E 1-255 order
       Region 6qc0 E 256-261 disorder
Seq 1-261 Hetero tetramer : IID00044Complex
 Evidence X-RAY 5e0v A Reference
       Region 5e0v A 1-187 order
       Region 5e0v A 188-193 disorder
       Region 5e0v A 194-255 order
       Region 5e0v A 256-261 disorder
 Evidence X-RAY 5e0v B Reference
       Region 5e0v B 1-185 order
       Region 5e0v B 186-193 disorder
       Region 5e0v B 194-255 order
       Region 5e0v B 256-261 disorder
Seq 1-261 Hetero hexamer : Q0MQR4
 Evidence X-RAY 5mav A Reference
       Region 5mav A 1-186 order
       Region 5mav A 187-190 disorder
       Region 5mav A 191-255 order
       Region 5mav A 256-261 disorder
 Evidence X-RAY 5mav C Reference
       Region 5mav C 1-186 order
       Region 5mav C 187-190 disorder
       Region 5mav C 191-255 order
       Region 5mav C 256-261 disorder
 Evidence X-RAY 5mav E Reference
       Region 5mav E 1-186 order
       Region 5mav E 187-190 disorder
       Region 5mav E 191-255 order
       Region 5mav E 256-261 disorder
 Evidence X-RAY 5mav B Reference
       Region 5mav B 1-185 order
       Region 5mav B 186-190 disorder
       Region 5mav B 191-255 order
       Region 5mav B 256-261 disorder
 Evidence X-RAY 5mav D Reference
       Region 5mav D 1-2 disorder
       Region 5mav D 3-91 order
       Region 5mav D 92-97 disorder
       Region 5mav D 98-186 order
       Region 5mav D 187-190 disorder
       Region 5mav D 191-255 order
       Region 5mav D 256-261 disorder
 Evidence X-RAY 5mav F Reference
       Region 5mav F 1-186 order
       Region 5mav F 187-191 disorder
       Region 5mav F 192-255 order
       Region 5mav F 256-261 disorder
Seq 1-261 Hetero hexamer : Q5FWF4
 Evidence X-RAY 5mlw A Reference
       Region 5mlw A 1-186 order
       Region 5mlw A 187-188 disorder
       Region 5mlw A 189-255 order
       Region 5mlw A 256-261 disorder
 Evidence X-RAY 5mlw C Reference
       Region 5mlw C 1-185 order
       Region 5mlw C 186-192 disorder
       Region 5mlw C 193-255 order
       Region 5mlw C 256-261 disorder
 Evidence X-RAY 5mlw E Reference
       Region 5mlw E 1-189 order
       Region 5mlw E 190-192 disorder
       Region 5mlw E 193-256 order
       Region 5mlw E 257-261 disorder
Seq 1-261 Hetero hexamer : IID00044Complex
 Evidence X-RAY 1u7b A Reference
       Region 1u7b A 1-186 order
       Region 1u7b A 187-190 disorder
       Region 1u7b A 191-255 order
       Region 1u7b A 256-261 disorder
Seq 1-261 Hetero hexamer :
 Evidence X-RAY 2zvk A Reference
       Region 2zvk A 1-185 order
       Region 2zvk A 186-194 disorder
       Region 2zvk A 195-255 order
       Region 2zvk A 256-261 disorder
 Evidence X-RAY 2zvk B Reference
       Region 2zvk B 1-162 order
       Region 2zvk B 163-166 disorder
       Region 2zvk B 167-185 order
       Region 2zvk B 186-192 disorder
       Region 2zvk B 193-254 order
       Region 2zvk B 255-261 disorder
 Evidence X-RAY 2zvk C Reference
       Region 2zvk C 1-183 order
       Region 2zvk C 184-193 disorder
       Region 2zvk C 194-257 order
       Region 2zvk C 258-261 disorder
Seq 1-261 Hetero hexamer : Q9H040
 Evidence X-RAY 5iy4 A Reference
       Region 5iy4 A 1-186 order
       Region 5iy4 A 187-191 disorder
       Region 5iy4 A 192-255 order
       Region 5iy4 A 256-261 disorder
 Evidence X-RAY 5iy4 C Reference
       Region 5iy4 C 1-186 order
       Region 5iy4 C 187-190 disorder
       Region 5iy4 C 191-255 order
       Region 5iy4 C 256-261 disorder
 Evidence X-RAY 5iy4 E Reference
       Region 5iy4 E 1-186 order
       Region 5iy4 E 187-191 disorder
       Region 5iy4 E 192-255 order
       Region 5iy4 E 256-261 disorder
Seq 1-261 Hetero hexamer :
 Evidence X-RAY 2zvm A Reference
       Region 2zvm A 1-186 order
       Region 2zvm A 187-193 disorder
       Region 2zvm A 194-255 order
       Region 2zvm A 256-261 disorder
 Evidence X-RAY 2zvm B Reference
       Region 2zvm B 1-185 order
       Region 2zvm B 186-193 disorder
       Region 2zvm B 194-255 order
       Region 2zvm B 256-261 disorder
 Evidence X-RAY 2zvm C Reference
       Region 2zvm C 1-186 order
       Region 2zvm C 187-193 disorder
       Region 2zvm C 194-256 order
       Region 2zvm C 257-261 disorder
Seq 1-261 Hetero hexamer : IID00600Complex
 Evidence X-RAY 3p87 A Reference
       Region 3p87 A 1-94 order
       Region 3p87 A 95-96 disorder
       Region 3p87 A 97-184 order
       Region 3p87 A 185-193 disorder
       Region 3p87 A 194-256 order
       Region 3p87 A 257-261 disorder
 Evidence X-RAY 3p87 C Reference
       Region 3p87 C 1-94 order
       Region 3p87 C 95-96 disorder
       Region 3p87 C 97-184 order
       Region 3p87 C 185-193 disorder
       Region 3p87 C 194-256 order
       Region 3p87 C 257-261 disorder
 Evidence X-RAY 3p87 E Reference
       Region 3p87 E 1-94 order
       Region 3p87 E 95-96 disorder
       Region 3p87 E 97-184 order
       Region 3p87 E 185-193 disorder
       Region 3p87 E 194-256 order
       Region 3p87 E 257-261 disorder
 Evidence X-RAY 3p87 B Reference
       Region 3p87 B 1-94 order
       Region 3p87 B 95-96 disorder
       Region 3p87 B 97-184 order
       Region 3p87 B 185-193 disorder
       Region 3p87 B 194-256 order
       Region 3p87 B 257-261 disorder
 Evidence X-RAY 3p87 D Reference
       Region 3p87 D 1-94 order
       Region 3p87 D 95-96 disorder
       Region 3p87 D 97-184 order
       Region 3p87 D 185-193 disorder
       Region 3p87 D 194-256 order
       Region 3p87 D 257-261 disorder
 Evidence X-RAY 3p87 F Reference
       Region 3p87 F 1-94 order
       Region 3p87 F 95-96 disorder
       Region 3p87 F 97-184 order
       Region 3p87 F 185-193 disorder
       Region 3p87 F 194-256 order
       Region 3p87 F 257-261 disorder
Seq 1-261 Hetero pentamer :
 Evidence X-RAY 3tbl A Reference
       Region 3tbl A 1-186 order
       Region 3tbl A 187-192 disorder
       Region 3tbl A 193-256 order
       Region 3tbl A 257-261 disorder
 Evidence X-RAY 3tbl B Reference
       Region 3tbl B 1-186 order
       Region 3tbl B 187-191 disorder
       Region 3tbl B 192-256 order
       Region 3tbl B 257-261 disorder
 Evidence X-RAY 3tbl C Reference
       Region 3tbl C 1-185 order
       Region 3tbl C 186-191 disorder
       Region 3tbl C 192-258 order
       Region 3tbl C 259-261 disorder
Seq 2-254 Hetero hexamer : Q9BWF2
 Evidence X-RAY 4ztd A Reference
       Region 4ztd A 2-254 order
 Evidence X-RAY 4ztd B Reference
       Region 4ztd B 2-254 order
 Evidence X-RAY 4ztd C Reference
       Region 4ztd C 2-253 order
       Region 4ztd C 254-254 disorder
Seqphosphorylation
    211-211 Phosphotyrosine; by EGFR
    211-211 Phosphotyrosine; by EGFR
Seqacetylation
    248-248 N6-acetyllysine
    80-80 N6-acetyllysine
    77-77 N6-acetyllysine
    14-14 N6-acetyllysine
    248-248 N6-acetyllysine
    80-80 N6-acetyllysine
    77-77 N6-acetyllysine
    14-14 N6-acetyllysine
 
Prediction
NeProc
Disorder 258-261
Order 1-257
AlphaFold
Disorder 257-261
Order 1-256
Pfam Hmmer
PF00705 1-125 1.2e-93
PF02747 127-254 6e-97
Function
Function in SwissProt
Auxiliary protein of DNA polymerase delta and epsilon, is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand (PubMed:35585232). Induces a robust stimulatory effect on the 3'-5' exonuclease and 3'-phosphodiesterase, but not apurinic-apyrimidinic (AP) endonuclease, APEX2 activities. Has to be loaded onto DNA in order to be able to stimulate APEX2. Plays a key role in DNA damage response (DDR) by being conveniently positioned at the replication fork to coordinate DNA replication with DNA repair and DNA damage tolerance pathways (PubMed:24939902). Acts as a loading platform to recruit DDR proteins that allow completion of DNA replication after DNA damage and promote postreplication repair: Monoubiquitinated PCNA leads to recruitment of translesion (TLS) polymerases, while 'Lys-63'-linked polyubiquitination of PCNA is involved in error-free pathway and employs recombination mechanisms to synthesize across the lesion (PubMed:24695737).
Biological Process
See also
Diagram with PDB data
XPA/ERCC1Solution structure of a ERCC1-XPA heterodimer
CDKN1A/PCNAHuman PCNA
MSH2/MSH6/DNAhuman MutSalpha (MSH2/MSH6) bound to ADP and a G T mispair
MSH2/MSH3/DNAHuman MutSbeta complexed with an IDL of 4 bases (Loop4) and ADP
POLD3/PCNACrystal structure of hPCNA bound to residues 452-466 of the DNA polymerase-delta-p66 subunit