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IID00057
 UniprotP62508
ProteinEstrogen-related receptor gamma
GeneESRRG
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
458
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 123-219 Homo trimer :
 Evidence X-RAY 8ifo A Reference
       Region 8ifo A 123-124 disorder
       Region 8ifo A 125-200 order
       Region 8ifo A 201-219 disorder
 Evidence X-RAY 8ifo B Reference
       Region 8ifo B 123-123 disorder
       Region 8ifo B 124-203 order
       Region 8ifo B 204-219 disorder
 Evidence X-RAY 8ifo F Reference
       Region 8ifo F 123-123 disorder
       Region 8ifo F 124-200 order
       Region 8ifo F 201-219 disorder
Seq 174-182 Hetero dimer : IID00301Complex
 Evidence X-RAY 8b4q B Reference
       Region 8b4q B 174-174 disorder
       Region 8b4q B 175-181 order
       Region 8b4q B 182-182 disorder
 Evidence X-RAY 8bjg B Reference
       Region 8bjg B 174-174 disorder
       Region 8bjg B 175-182 order
 Evidence X-RAY 8bjn B Reference
       Region 8bjn B 174-174 disorder
       Region 8bjn B 175-182 order
 Evidence X-RAY 8bm5 B Reference
       Region 8bm5 B 174-174 disorder
       Region 8bm5 B 175-182 order
 Evidence X-RAY 6xxc B Reference
       Region 6xxc B 174-174 disorder
       Region 6xxc B 175-181 order
       Region 6xxc B 182-182 disorder
 Evidence X-RAY 6xy5 B Reference
       Region 6xy5 B 174-174 disorder
       Region 6xy5 B 175-181 order
       Region 6xy5 B 182-182 disorder
 Evidence X-RAY 6y18 B Reference
       Region 6y18 B 174-174 disorder
       Region 6y18 B 175-181 order
       Region 6y18 B 182-182 disorder
 Evidence X-RAY 6y1d B Reference
       Region 6y1d B 174-174 disorder
       Region 6y1d B 175-182 order
 Evidence X-RAY 6y3w B Reference
       Region 6y3w B 174-174 disorder
       Region 6y3w B 175-182 order
Seq 221-458 Homo trimer :
 Evidence X-RAY 6a6k A Reference
       Region 6a6k A 221-234 disorder
       Region 6a6k A 235-455 order
       Region 6a6k A 456-458 disorder
 Evidence X-RAY 6a6k B Reference
       Region 6a6k B 221-233 disorder
       Region 6a6k B 234-455 order
       Region 6a6k B 456-458 disorder
 Evidence X-RAY 6a6k C Reference
       Region 6a6k C 221-235 disorder
       Region 6a6k C 236-437 order
       Region 6a6k C 438-458 disorder
 Evidence X-RAY 5yso A Reference
       Region 5yso A 221-233 disorder
       Region 5yso A 234-455 order
       Region 5yso A 456-458 disorder
 Evidence X-RAY 5yso B Reference
       Region 5yso B 221-232 disorder
       Region 5yso B 233-456 order
       Region 5yso B 457-458 disorder
 Evidence X-RAY 5yso C Reference
       Region 5yso C 221-234 disorder
       Region 5yso C 235-438 order
       Region 5yso C 439-458 disorder
Seq 222-458 Monomer :
 Evidence X-RAY 2p7a A Reference
       Region 2p7a A 229-233 disorder
       Region 2p7a A 234-456 order
       Region 2p7a A 457-458 disorder
 Evidence X-RAY 2p7g A Reference
       Region 2p7g A 229-234 disorder
       Region 2p7g A 235-456 order
       Region 2p7g A 457-458 disorder
 Evidence X-RAY 2p7z A Reference
       Region 2p7z A 229-234 disorder
       Region 2p7z A 235-441 order
       Region 2p7z A 442-458 disorder
 Evidence X-RAY 6i61 A Reference
       Region 6i61 A 222-233 disorder
       Region 6i61 A 234-457 order
       Region 6i61 A 458-458 disorder
 Evidence X-RAY 6i62 A Reference
       Region 6i62 A 222-233 disorder
       Region 6i62 A 234-457 order
       Region 6i62 A 458-458 disorder
 Evidence X-RAY 6i63 A Reference
       Region 6i63 A 222-233 disorder
       Region 6i63 A 234-458 order
 Evidence X-RAY 6i64 A Reference
       Region 6i64 A 222-233 disorder
       Region 6i64 A 234-457 order
       Region 6i64 A 458-458 disorder
 Evidence X-RAY 6i65 A Reference
       Region 6i65 A 222-233 disorder
       Region 6i65 A 234-457 order
       Region 6i65 A 458-458 disorder
 Evidence X-RAY 6i66 A Reference
       Region 6i66 A 222-233 disorder
       Region 6i66 A 234-456 order
       Region 6i66 A 457-458 disorder
 Evidence X-RAY 6i67 A Reference
       Region 6i67 A 222-233 disorder
       Region 6i67 A 234-458 order
 Evidence X-RAY 6k3n A Reference
       Region 6k3n A 232-458 order
Seq 222-458 Homo dimer :
 Evidence X-RAY 2e2r A Reference
       Region 2e2r A 222-231 disorder
       Region 2e2r A 232-458 order
 Evidence X-RAY 2ewp A Reference
       Region 2ewp A 233-456 order
       Region 2ewp A 457-458 disorder
 Evidence X-RAY 2ewp B Reference
       Region 2ewp B 233-456 order
       Region 2ewp B 457-458 disorder
 Evidence X-RAY 2ewp C Reference
       Region 2ewp C 233-233 disorder
       Region 2ewp C 234-456 order
       Region 2ewp C 457-458 disorder
 Evidence X-RAY 2ewp D Reference
       Region 2ewp D 233-234 disorder
       Region 2ewp D 235-455 order
       Region 2ewp D 456-458 disorder
 Evidence X-RAY 2ewp E Reference
       Region 2ewp E 233-236 disorder
       Region 2ewp E 237-403 order
       Region 2ewp E 404-408 disorder
       Region 2ewp E 409-455 order
       Region 2ewp E 456-458 disorder
 Evidence X-RAY 2gp7 A Reference
       Region 2gp7 A 229-234 disorder
       Region 2gp7 A 235-458 order
 Evidence X-RAY 2gp7 B Reference
       Region 2gp7 B 229-233 disorder
       Region 2gp7 B 234-458 order
 Evidence X-RAY 2gp7 C Reference
       Region 2gp7 C 229-234 disorder
       Region 2gp7 C 235-458 order
 Evidence X-RAY 2gp7 D Reference
       Region 2gp7 D 229-234 disorder
       Region 2gp7 D 235-458 order
 Evidence X-RAY 2gpu A Reference
       Region 2gpu A 229-233 disorder
       Region 2gpu A 234-455 order
       Region 2gpu A 456-458 disorder
 Evidence X-RAY 1vjb A Reference
       Region 1vjb A 229-233 disorder
       Region 1vjb A 234-441 order
       Region 1vjb A 442-458 disorder
 Evidence X-RAY 1vjb B Reference
       Region 1vjb B 229-232 disorder
       Region 1vjb B 233-442 order
       Region 1vjb B 443-458 disorder
 Evidence X-RAY 2zas A Reference
       Region 2zas A 222-231 disorder
       Region 2zas A 232-458 order
 Evidence X-RAY 2zbs A Reference
       Region 2zbs A 222-231 disorder
       Region 2zbs A 232-458 order
 Evidence X-RAY 2zkc A Reference
       Region 2zkc A 222-231 disorder
       Region 2zkc A 232-457 order
       Region 2zkc A 458-458 disorder
 Evidence X-RAY 6knr A Reference
       Region 6knr A 222-234 disorder
       Region 6knr A 235-456 order
       Region 6knr A 457-458 disorder
 Evidence X-RAY 6knr B Reference
       Region 6knr B 222-232 disorder
       Region 6knr B 233-457 order
       Region 6knr B 458-458 disorder
Seq 229-458 Hetero nonamer : IID00109Complex
 Evidence X-RAY 2gpv A Reference
       Region 2gpv A 229-231 disorder
       Region 2gpv A 232-455 order
       Region 2gpv A 456-458 disorder
 Evidence X-RAY 2gpv B Reference
       Region 2gpv B 229-232 disorder
       Region 2gpv B 233-455 order
       Region 2gpv B 456-458 disorder
 Evidence X-RAY 2gpv C Reference
       Region 2gpv C 229-232 disorder
       Region 2gpv C 233-455 order
       Region 2gpv C 456-458 disorder
 Evidence X-RAY 2gpv D Reference
       Region 2gpv D 229-232 disorder
       Region 2gpv D 233-441 order
       Region 2gpv D 442-458 disorder
 Evidence X-RAY 2gpv E Reference
       Region 2gpv E 229-233 disorder
       Region 2gpv E 234-441 order
       Region 2gpv E 442-458 disorder
 Evidence X-RAY 2gpv F Reference
       Region 2gpv F 229-232 disorder
       Region 2gpv F 233-440 order
       Region 2gpv F 441-458 disorder
Seq 229-458 Hetero tetramer : IID00050Complex
 Evidence X-RAY 2gpo A Reference
       Region 2gpo A 229-234 disorder
       Region 2gpo A 235-458 order
 Evidence X-RAY 2gpp A Reference
       Region 2gpp A 229-232 disorder
       Region 2gpp A 233-457 order
       Region 2gpp A 458-458 disorder
 Evidence X-RAY 2gpp B Reference
       Region 2gpp B 229-232 disorder
       Region 2gpp B 233-456 order
       Region 2gpp B 457-458 disorder
Seq 229-458 Hetero tetramer : IID00083Complex
 Evidence X-RAY 1kv6 A Reference
       Region 1kv6 A 229-234 disorder
       Region 1kv6 A 235-456 order
       Region 1kv6 A 457-458 disorder
 Evidence X-RAY 1kv6 B Reference
       Region 1kv6 B 229-234 disorder
       Region 1kv6 B 235-456 order
       Region 1kv6 B 457-458 disorder
 Evidence X-RAY 1tfc A Reference
       Region 1tfc A 229-232 disorder
       Region 1tfc A 233-458 order
 Evidence X-RAY 1tfc B Reference
       Region 1tfc B 229-232 disorder
       Region 1tfc B 233-457 order
       Region 1tfc B 458-458 disorder
Seq 314-321 Hetero dimer : IID00301Complex
 Evidence X-RAY 6y58 P Reference
       Region 6y58 P 314-315 disorder
       Region 6y58 P 316-321 order
Seqphosphorylation
    45-45 Phosphoserine
    45-45 Phosphoserine
 
Prediction
NeProc
Disorder 1-124,199-233
Order 125-198,234-458
ProS 1-33,40-50,199-206
AlphaFold
Disorder 1-125,201-234
Order 126-200,235-458
Pfam Hmmer
PF00105 126-201 6.2e-51
PF00104 273-453 1.1e-57
SEG 57-70
Function
Function in SwissProt
Orphan receptor that acts as a transcription activator in the absence of bound ligand. Binds specifically to an estrogen response element and activates reporter genes controlled by estrogen response elements (By similarity). Induces the expression of PERM1 in the skeletal muscle.
Biological Process
See also
Diagram with PDB data
NCOA1/RARACrystal structure of RARalpha ligand binding domain in complex with an agonist ligand (Am580) and a coactivator fragment