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IID00119
 UniprotP09651
ProteinHeterogeneous nuclear ribonucleoprotein A1
GeneHNRNPA1
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
372
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-196 Monomer :
 Evidence X-RAY 1ha1 A Reference
       Region 1ha1 A 1-8 disorder
       Region 1ha1 A 9-93 order
       Region 1ha1 A 94-99 disorder
       Region 1ha1 A 100-181 order
       Region 1ha1 A 182-184 disorder
 Evidence X-RAY 1l3k A Reference
       Region 1l3k A 1-7 disorder
       Region 1l3k A 8-91 order
       Region 1l3k A 92-102 disorder
       Region 1l3k A 103-181 order
       Region 1l3k A 182-196 disorder
 Evidence NMR 2lyv A Reference
       Region 2lyv A 2-196 order
       Region 2lyv A 2-4 high_rmsd
       Region 2lyv A 187-196 high_rmsd
 Evidence X-RAY 1pgz A Reference
       Region 1pgz A 2-7 disorder
       Region 1pgz A 8-190 order
       Region 1pgz A 191-196 disorder
 Evidence X-RAY 1po6 A Reference
       Region 1po6 A 8-190 order
 Evidence X-RAY 1u1k A Reference
       Region 1u1k A 1-7 disorder
       Region 1u1k A 8-190 order
       Region 1u1k A 191-196 disorder
 Evidence X-RAY 1u1l A Reference
       Region 1u1l A 1-7 disorder
       Region 1u1l A 8-190 order
       Region 1u1l A 191-196 disorder
 Evidence X-RAY 1u1m A Reference
       Region 1u1m A 1-7 disorder
       Region 1u1m A 8-190 order
       Region 1u1m A 191-196 disorder
 Evidence X-RAY 1u1n A Reference
       Region 1u1n A 1-7 disorder
       Region 1u1n A 8-190 order
       Region 1u1n A 191-196 disorder
 Evidence X-RAY 1u1o A Reference
       Region 1u1o A 1-7 disorder
       Region 1u1o A 8-190 order
       Region 1u1o A 191-196 disorder
 Evidence X-RAY 1u1p A Reference
       Region 1u1p A 1-7 disorder
       Region 1u1p A 8-190 order
       Region 1u1p A 191-196 disorder
 Evidence X-RAY 1u1q A Reference
       Region 1u1q A 1-7 disorder
       Region 1u1q A 8-190 order
       Region 1u1q A 191-196 disorder
 Evidence X-RAY 1u1r A Reference
       Region 1u1r A 1-7 disorder
       Region 1u1r A 8-190 order
       Region 1u1r A 191-196 disorder
 Evidence X-RAY 1up1 A Reference
       Region 1up1 A 3-6 disorder
       Region 1up1 A 7-92 order
       Region 1up1 A 93-98 disorder
       Region 1up1 A 99-182 order
       Region 1up1 A 183-184 disorder
 Evidence X-RAY 2up1 A Reference
       Region 2up1 A 8-190 order
 Evidence X-RAY 4yoe A Reference
       Region 4yoe A 1-7 disorder
       Region 4yoe A 8-188 order
       Region 4yoe A 189-196 disorder
Seq 2-97 Monomer :
 Evidence NMR 5mpg A Reference
       Region 5mpg A 2-97 order
       Region 5mpg A 2-7 high_rmsd
       Region 5mpg A 97-97 high_rmsd
Seq 2-188 Homo dimer :
 Evidence X-RAY 6dcl A Reference
       Region 6dcl A 2-6 disorder
       Region 6dcl A 7-188 order
 Evidence X-RAY 6dcl B Reference
       Region 6dcl B 2-7 disorder
       Region 6dcl B 8-139 order
       Region 6dcl B 140-144 disorder
       Region 6dcl B 145-183 order
       Region 6dcl B 184-188 disorder
Seq 95-196 Monomer :
 Evidence NMR 5mpl A Reference
       Region 5mpl A 95-196 order
       Region 5mpl A 95-96 high_rmsd
       Region 5mpl A 192-196 high_rmsd
Seq 209-217 Monomer :
 Evidence X-RAY 5zgd A Reference
       Region 5zgd A 209-217 order
Seq 234-240 Homo dimer :
 Evidence X-RAY 5zgl A Reference
       Region 5zgl A 234-240 order
 Evidence X-RAY 5zgl B Reference
       Region 5zgl B 234-240 order
Seq 243-248 Homo decamer :
 Evidence X-RAY 6bxx A Reference
       Region 6bxx A 243-248 order
Seq 309-357 Hetero hexamer : IID00094Complex
 Evidence X-RAY 2h4m C Reference
       Region 2h4m C 309-318 disorder
       Region 2h4m C 319-341 order
       Region 2h4m C 342-357 disorder
 Evidence X-RAY 2h4m D Reference
       Region 2h4m D 309-314 disorder
       Region 2h4m D 315-341 order
       Region 2h4m D 342-357 disorder
SeqProS verified 182-190 This region is ordered in the complex with ssDNA. :
       Region 2up1 A 8-190 order
       Region 1po6 A 8-190 order
       Region 1l3k A 182-196 disorder
SeqProS possible 209-217 amyloid core, same region of the homolog (P22626) is disordered in the free state. :
       Region 5zgd A 209-217 order
SeqProS possible 234-240 amyloid core, same region of the homolog (P22626) is disordered in the free state. Homo dimer :
       Region 5zgl A 234-240 order
       Region 5zgl B 234-240 order
SeqProS possible 243-248 fibrils, same region of the homolog (P22626) is disordered in the free state. Homo decamer :
       Region 6bxx A 243-248 order
SeqProS possible 315-341 Nuclear Localization Signal (NLS) Hetero hexamer : IID00094Complex
       Region 2h4m C 319-341 order
       Region 2h4m D 315-341 order
Seqphosphorylation
    368-368 Phosphoserine
    365-365 Phosphoserine
    364-364 Phosphoserine; by MKNK2
    363-363 Phosphoserine; by MKNK2
    362-362 Phosphoserine; by MKNK2
    361-361 Phosphoserine
    337-337 Phosphoserine
    199-199 Phosphoserine
    192-192 Phosphoserine; by MKNK2
    22-22 Phosphoserine
    6-6 Phosphoserine
    4-4 Phosphoserine
    2-2 Phosphoserine
    2-2 Phosphoserine
    4-4 Phosphoserine
    6-6 Phosphoserine
    22-22 Phosphoserine
    192-192 Phosphoserine; by MKNK2
    199-199 Phosphoserine
    337-337 Phosphoserine
    361-361 Phosphoserine
    362-362 Phosphoserine; by MKNK2
    363-363 Phosphoserine; by MKNK2
    364-364 Phosphoserine; by MKNK2
    365-365 Phosphoserine
    368-368 Phosphoserine
Seqacetylation
    350-350 N6-acetyllysine; alternate
    3-3 N6-acetyllysine; alternate
    2-2 N-acetylserine; in Heterogeneous nuclear ribonucleoprotein A1
    1-1 N-acetylmethionine
    1-1 N-acetylmethionine
    2-2 N-acetylserine; in Heterogeneous nuclear ribonucleoprotein A1
    3-3 N6-acetyllysine; alternate
    350-350 N6-acetyllysine; alternate
 
Prediction
NeProc
Disorder 1-10,94-102,183-372
Order 11-93,103-182
ProS 6-10,94-102,198-358,365-372
AlphaFold
Disorder 1-8,190-372
Order 9-189
Pfam Hmmer
PF00076 16-86 9.4e-24
PF00076 107-177 7.7e-25
SEG 190-320 ,330-345 ,355-369
Function
Function in SwissProt
Involved in the packaging of pre-mRNA into hnRNP particles, transport of poly(A) mRNA from the nucleus to the cytoplasm and modulation of splice site selection (PubMed:17371836). Plays a role in the splicing of pyruvate kinase PKM by binding repressively to sequences flanking PKM exon 9, inhibiting exon 9 inclusion and resulting in exon 10 inclusion and production of the PKM M2 isoform (PubMed:20010808). Binds to the IRES and thereby inhibits the translation of the apoptosis protease activating factor APAF1 (PubMed:31498791). May bind to specific miRNA hairpins (PubMed:28431233).
(Microbial infection) May play a role in HCV RNA replication.
(Microbial infection) Cleavage by Enterovirus 71 protease 3C results in increased translation of apoptosis protease activating factor APAF1, leading to apoptosis.