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IID00231
 UniprotO00268
ProteinTranscription initiation factor TFIID subunit 4
GeneTAF4
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
1085
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 575-688 Homo hexamer :
 Evidence X-RAY 2p6v A Reference
       Region 2p6v A 575-582 disorder
       Region 2p6v A 583-679 order
       Region 2p6v A 680-688 disorder
Seq 872-945 Hetero dimer : IID00248Complex
 Evidence X-RAY 1h3o A Reference
       Region 1h3o A 872-919 order
       Region 1h3o A 920-945 disorder
 Evidence X-RAY 1h3o C Reference
       Region 1h3o C 872-919 order
       Region 1h3o C 920-945 disorder
Seqphosphorylation
    109-109 Phosphoserine
    109-109 Phosphoserine
 
Prediction
NeProc
Disorder 1-847,978-990,1004-1050
Order 848-977,991-1003,1051-1085
ProS 1-32,454-467,673-677,813-820,826-831,841-847,978-990,1004-1021
AlphaFold
Disorder 1-17,35-451,477-586,680-832,855-869,972-979,981-981,1014-1054
Order 18-34,452-476,587-679,833-854,870-971,980-980,982-1013,1055-1085
Pfam Hmmer
PF07531 590-687 1.7e-61
PF05236 834-1085 9.9e-132
SEG 28-44 ,65-130 ,132-195 ,201-214 ,222-234 ,246-278 ,281-342 ,352-363 ,381-407 ,437-450 ,464-500 ,579-589 ,676-692 ,803-821 ,1023-1047
Function
Function in SwissProt
The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription (PubMed:33795473). TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC) (PubMed:33795473). The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13 (PubMed:33795473, PubMed:10594036, PubMed:8942982). TAF4 may maintain an association between the TFIID and TFIIA complexes, while bound to the promoter, together with TBP, during PIC assembly (PubMed:33795473). Potentiates transcriptional activation by the AF-2S of the retinoic acid, vitamin D3 and thyroid hormone (PubMed:9192867).