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IID00248
 UniprotQ16514
ProteinTranscription initiation factor TFIID subunit 12
GeneTAF12
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
161
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 57-128 Hetero dimer : IID00231Complex
 Evidence X-RAY 1h3o B Reference
       Region 1h3o B 57-128 order
 Evidence X-RAY 1h3o D Reference
       Region 1h3o D 57-128 order
Seqphosphorylation
    43-43 Phosphothreonine
    51-51 Phosphoserine
    59-59 Phosphothreonine
    43-43 Phosphothreonine
    51-51 Phosphoserine
    59-59 Phosphothreonine
 
Prediction
NeProc
Disorder 1-54,156-161
Order 55-155
ProS 1-4,156-161
AlphaFold
Disorder 1-26,28-54,132-141,161-161
Order 27-27,55-131,142-160
Pfam Hmmer
PF03847 59-126 4.1e-49
Function
Function in SwissProt
The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription (PubMed:33795473). TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC) (PubMed:33795473). The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13 (PubMed:33795473). Component of the TATA-binding protein-free TAF complex (TFTC), the PCAF histone acetylase complex and the STAGA transcription coactivator-HAT complex (PubMed:10373431, PubMed:7729427, PubMed:8598932, PubMed:8663456, PubMed:9674425, PubMed:9885574).