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IID00252
 UniprotQ9HAU5
ProteinRegulator of nonsense transcripts 2
GeneUPF2
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
1272
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 121-486 Homo dimer :
 Evidence X-RAY 4cem A Reference
       Region 4cem A 121-428 order
       Region 4cem A 429-486 disorder
 Evidence X-RAY 4cem B Reference
       Region 4cem B 121-429 order
       Region 4cem B 430-486 disorder
Seq 455-757 Monomer :
 Evidence X-RAY 4cek A Reference
       Region 4cek A 455-456 disorder
       Region 4cek A 457-480 order
       Region 4cek A 481-530 disorder
       Region 4cek A 531-534 order
       Region 4cek A 535-536 disorder
       Region 4cek A 537-551 order
       Region 4cek A 552-558 disorder
       Region 4cek A 559-655 order
       Region 4cek A 656-657 disorder
       Region 4cek A 658-757 order
Seq 768-1015 Hetero dimer : IID00251Complex
 Evidence X-RAY 1uw4 D Reference
       Region 1uw4 D 768-1015 order
Seq 768-1015 Hetero tetramer : IID00251Complex
 Evidence X-RAY 1uw4 B Reference
       Region 1uw4 B 768-1015 order
Seq 1105-1198 Hetero dimer : IID00325Complex
 Evidence X-RAY 2wjv D Reference
       Region 2wjv D 1105-1128 order
       Region 2wjv D 1129-1166 disorder
       Region 2wjv D 1167-1175 order
       Region 2wjv D 1176-1180 disorder
       Region 2wjv D 1181-1198 order
 Evidence X-RAY 2wjv E Reference
       Region 2wjv E 1105-1129 order
       Region 2wjv E 1130-1166 disorder
       Region 2wjv E 1167-1198 order
Seqdisorder 1105-1227
 Evidence NMR Reference
       Region 1105-1227 disorder
SeqProS verified 1105-1129,1167-1198 Hetero dimer : IID00325Complex
       Region 2wjv D 1105-1128 order
       Region 2wjv E 1105-1129 order
       Region 2wjv E 1167-1198 order
       Region 2wjv D 1167-1175 order
       Region 2wjv D 1181-1198 order
       Region 1105-1227 disorder
Seqphosphorylation
    1088-1088 Phosphothreonine
    1088-1088 Phosphothreonine
 
Prediction
NeProc
Disorder 1-56,429-456,511-563,1009-1172,1205-1272
Order 57-428,457-510,564-758,768-1008,1173-1204
ProS 1-28,435-443,521-525,1009-1017,1091-1100,1112-1118,1138-1145,1169-1172,1205-1225,1240-1249,1255-1268
AlphaFold
Disorder 1-63,65-65,68-68,386-387,389-389,430-457,484-561,759-766,1015-1107,1124-1125,1127-1167,1176-1177,1180-1180,1232-1232,1234-1272
Order 64-64,66-67,69-385,388-388,390-429,458-483,562-758,767-1014,1108-1123,1126-1126,1168-1175,1178-1179,1181-1231,1233-1233
Pfam Hmmer
PF02854 168-431 4.9e-07
PF02854 569-758 1.4e-34
PF02854 776-986 2e-59
PF04050 1036-1218 4.8e-121
SEG 54-126 ,516-557 ,1025-1044 ,1046-1075 ,1080-1094 ,1153-1162 ,1201-1208
Function
Function in SwissProt
Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by associating with the nuclear exon junction complex (EJC). Recruited by UPF3B associated with the EJC core at the cytoplasmic side of the nuclear envelope and the subsequent formation of an UPF1-UPF2-UPF3 surveillance complex (including UPF1 bound to release factors at the stalled ribosome) is believed to activate NMD. In cooperation with UPF3B stimulates both ATPase and RNA helicase activities of UPF1. Binds spliced mRNA.