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IID00311
 UniprotP62136
ProteinSerine/threonine-protein phosphatase PP1-alpha catalytic subunit
GenePPP1CA
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
330
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-300 Hetero dimer : Q15435
 Evidence X-RAY 6obp A Reference
       Region 6obp A 1-298 order
       Region 6obp A 299-300 disorder
Seq 1-300 Hetero trimer : IID00017Complex
 Evidence X-RAY 3n5u A Reference
       Region 3n5u A 1-6 disorder
       Region 3n5u A 7-300 order
 Evidence X-RAY 3n5u B Reference
       Region 3n5u B 1-6 disorder
       Region 3n5u B 7-300 order
Seq 1-300 Hetero tetramer : Q15435
 Evidence X-RAY 6obn A Reference
       Region 6obn A 1-298 order
       Region 6obn A 299-300 disorder
 Evidence X-RAY 6obn B Reference
       Region 6obn B 1-6 disorder
       Region 6obn B 7-297 order
       Region 6obn B 298-300 disorder
Seq 1-330 Hetero tetramer : Q8WUF5
 Evidence X-RAY 6dcx A Reference
       Region 6dcx A 1-7 disorder
       Region 6dcx A 8-300 order
       Region 6dcx A 301-317 disorder
       Region 6dcx A 318-324 order
       Region 6dcx A 325-330 disorder
 Evidence X-RAY 6dcx B Reference
       Region 6dcx B 1-7 disorder
       Region 6dcx B 8-298 order
       Region 6dcx B 299-316 disorder
       Region 6dcx B 317-328 order
       Region 6dcx B 329-330 disorder
Seq 1-330 Hetero dimer :
 Evidence X-RAY 4g9j B Reference
       Region 4g9j B 1-6 disorder
       Region 4g9j B 7-300 order
       Region 4g9j B 301-330 disorder
Seq 1-330 Monomer :
 Evidence X-RAY 6alz A Reference
       Region 6alz A 7-299 order
       Region 6alz A 300-300 disorder
 Evidence X-RAY 6alz B Reference
       Region 6alz B 7-299 order
       Region 6alz B 300-300 disorder
 Evidence X-RAY 3e7a A Reference
       Region 3e7a A 7-299 order
       Region 3e7a A 300-300 disorder
 Evidence X-RAY 3e7a B Reference
       Region 3e7a B 7-299 order
       Region 3e7a B 300-300 disorder
 Evidence X-RAY 3e7b A Reference
       Region 3e7b A 7-299 order
       Region 3e7b A 300-300 disorder
 Evidence X-RAY 3e7b B Reference
       Region 3e7b B 7-299 order
       Region 3e7b B 300-300 disorder
 Evidence X-RAY 4mov A Reference
       Region 4mov A 7-299 order
       Region 4mov A 300-300 disorder
 Evidence X-RAY 4mov B Reference
       Region 4mov B 7-22 order
       Region 4mov B 23-24 disorder
       Region 4mov B 25-299 order
       Region 4mov B 300-300 disorder
 Evidence X-RAY 6g0i A Reference
       Region 6g0i A 1-7 disorder
       Region 6g0i A 8-19 order
       Region 6g0i A 20-24 disorder
       Region 6g0i A 25-298 order
       Region 6g0i A 299-330 disorder
 Evidence X-RAY 6g0j A Reference
       Region 6g0j A 1-6 disorder
       Region 6g0j A 7-19 order
       Region 6g0j A 20-24 disorder
       Region 6g0j A 25-298 order
       Region 6g0j A 299-330 disorder
 Evidence X-RAY 6zk6 A Reference
       Region 6zk6 A 1-7 disorder
       Region 6zk6 A 8-298 order
       Region 6zk6 A 299-330 disorder
Seq 1-330 Hetero dimer :
 Evidence X-RAY 4g9j A Reference
       Region 4g9j A 1-8 disorder
       Region 4g9j A 9-300 order
       Region 4g9j A 301-330 disorder
Seq 2-330 Hetero hexamer : IID00905Complex,IID00911Complex
 Evidence X-RAY 7tvf C Reference
       Region 7tvf C 2-5 disorder
       Region 7tvf C 6-299 order
       Region 7tvf C 300-317 disorder
       Region 7tvf C 318-322 order
       Region 7tvf C 323-330 disorder
 Evidence X-RAY 7tvf F Reference
       Region 7tvf F 2-6 disorder
       Region 7tvf F 7-299 order
       Region 7tvf F 300-330 disorder
Seq 7-300 Hetero hexamer : IID00905Complex,IID00911Complex
 Evidence X-RAY 7txh C Reference
       Region 7txh C 7-298 order
       Region 7txh C 299-300 disorder
 Evidence X-RAY 7txh F Reference
       Region 7txh F 7-298 order
       Region 7txh F 299-300 disorder
Seq 7-300 Hetero dimer : Q00756
 Evidence X-RAY 6dno A Reference
       Region 6dno A 7-300 order
Seq 7-300 Hetero trimer : O60927,Q15435
 Evidence X-RAY 8u5g A Reference
       Region 8u5g A 7-300 order
Seq 7-300 Hetero dimer : IID50266Complex
 Evidence X-RAY 4moy A Reference
       Region 4moy A 7-300 order
 Evidence X-RAY 4mp0 A Reference
       Region 4mp0 A 7-300 order
 Evidence X-RAY 4mp0 C Reference
       Region 4mp0 C 7-297 order
       Region 4mp0 C 298-300 disorder
Seq 7-300 Hetero dodecamer : Q9C0D0
 Evidence X-RAY 6zee A Reference
       Region 6zee A 7-299 order
       Region 6zee A 300-300 disorder
 Evidence X-RAY 6zee B Reference
       Region 6zee B 7-299 order
       Region 6zee B 300-300 disorder
 Evidence X-RAY 6zee I Reference
       Region 6zee I 7-299 order
       Region 6zee I 300-300 disorder
 Evidence X-RAY 6zee K Reference
       Region 6zee K 7-299 order
       Region 6zee K 300-300 disorder
 Evidence X-RAY 6zee P Reference
       Region 6zee P 7-299 order
       Region 6zee P 300-300 disorder
 Evidence X-RAY 6zee Q Reference
       Region 6zee Q 7-299 order
       Region 6zee Q 300-300 disorder
Seq 7-300 Hetero dimer : IID00984Complex
 Evidence X-RAY 5ioh A Reference
       Region 5ioh A 7-299 order
       Region 5ioh A 300-300 disorder
 Evidence X-RAY 5ioh C Reference
       Region 5ioh C 7-300 order
Seq 7-300 Hetero tetramer : Q05C46
 Evidence X-RAY 6czo A Reference
       Region 6czo A 7-298 order
       Region 6czo A 299-300 disorder
 Evidence X-RAY 6czo C Reference
       Region 6czo C 7-298 order
       Region 6czo C 299-300 disorder
Seq 7-300 Hetero dimer : Q9UQK1
 Evidence X-RAY 7qfb A Reference
       Region 7qfb A 7-19 order
       Region 7qfb A 20-28 disorder
       Region 7qfb A 29-300 order
Seq 7-300 Hetero tetramer : Q9UQK1
 Evidence X-RAY 7qm2 A Reference
       Region 7qm2 A 7-19 order
       Region 7qm2 A 20-28 disorder
       Region 7qm2 A 29-299 order
       Region 7qm2 A 300-300 disorder
 Evidence X-RAY 7qm2 C Reference
       Region 7qm2 C 7-19 order
       Region 7qm2 C 20-28 disorder
       Region 7qm2 C 29-299 order
       Region 7qm2 C 300-300 disorder
Seq 7-300 Hetero tetramer : Q9C0D0
 Evidence X-RAY 6zef A Reference
       Region 6zef A 7-299 order
       Region 6zef A 300-300 disorder
 Evidence X-RAY 6zef B Reference
       Region 6zef B 7-299 order
       Region 6zef B 300-300 disorder
Seq 7-300 Hetero tetramer : O60927
 Evidence X-RAY 8dwk A Reference
       Region 8dwk A 7-299 order
       Region 8dwk A 300-300 disorder
 Evidence X-RAY 8dwk B Reference
       Region 8dwk B 7-299 order
       Region 8dwk B 300-300 disorder
 Evidence X-RAY 8dwl A Reference
       Region 8dwl A 7-299 order
       Region 8dwl A 300-300 disorder
 Evidence X-RAY 8dwl C Reference
       Region 8dwl C 7-299 order
       Region 8dwl C 300-300 disorder
Seq 7-300 Hetero dimer : IID00763Complex
 Evidence X-RAY 4xpn A Reference
       Region 4xpn A 7-299 order
       Region 4xpn A 300-300 disorder
 Evidence X-RAY 4xpn C Reference
       Region 4xpn C 7-299 order
       Region 4xpn C 300-300 disorder
Seq 7-300 Hetero tetramer : Q14684
 Evidence X-RAY 7t0y A Reference
       Region 7t0y A 7-300 order
 Evidence X-RAY 7t0y C Reference
       Region 7t0y C 7-300 order
Seq 7-300 Homo dimer :
 Evidence X-RAY 6obq A Reference
       Region 6obq A 7-299 order
       Region 6obq A 300-300 disorder
 Evidence X-RAY 6obq B Reference
       Region 6obq B 7-299 order
       Region 6obq B 300-300 disorder
 Evidence X-RAY 6obr A Reference
       Region 6obr A 7-299 order
       Region 6obr A 300-300 disorder
 Evidence X-RAY 6obr B Reference
       Region 6obr B 7-299 order
       Region 6obr B 300-300 disorder
 Evidence X-RAY 6obs A Reference
       Region 6obs A 7-299 order
       Region 6obs A 300-300 disorder
 Evidence X-RAY 6obs B Reference
       Region 6obs B 7-299 order
       Region 6obs B 300-300 disorder
 Evidence X-RAY 6obu A Reference
       Region 6obu A 7-299 order
       Region 6obu A 300-300 disorder
 Evidence X-RAY 6obu B Reference
       Region 6obu B 7-299 order
       Region 6obu B 300-300 disorder
Seq 7-304 Hetero hexamer : IID00893Complex,Q9C0D0
 Evidence X-RAY 6zeg A Reference
       Region 6zeg A 7-299 order
       Region 6zeg A 300-304 disorder
 Evidence X-RAY 6zeg B Reference
       Region 6zeg B 7-299 order
       Region 6zeg B 300-304 disorder
Seq 7-304 Hetero hexamer : IID00893Complex,Q9C0D0
 Evidence X-RAY 6zei A Reference
       Region 6zei A 7-299 order
       Region 6zei A 300-304 disorder
 Evidence X-RAY 6zei B Reference
       Region 6zei B 7-299 order
       Region 6zei B 300-304 disorder
Seq 7-304 Hetero hexamer : Q13813,Q9C0D0
 Evidence X-RAY 6zeh A Reference
       Region 6zeh A 7-298 order
       Region 6zeh A 299-304 disorder
 Evidence X-RAY 6zeh B Reference
       Region 6zeh B 7-298 order
       Region 6zeh B 299-304 disorder
Seq 7-304 Hetero dodecamer : Q9C0D0
 Evidence X-RAY 6zej A Reference
       Region 6zej A 7-298 order
       Region 6zej A 299-304 disorder
 Evidence X-RAY 6zej D Reference
       Region 6zej D 7-299 order
       Region 6zej D 300-304 disorder
 Evidence X-RAY 6zej F Reference
       Region 6zej F 7-298 order
       Region 6zej F 299-304 disorder
 Evidence X-RAY 6zej I Reference
       Region 6zej I 7-299 order
       Region 6zej I 300-304 disorder
 Evidence X-RAY 6zej L Reference
       Region 6zej L 7-299 order
       Region 6zej L 300-304 disorder
 Evidence X-RAY 6zej O Reference
       Region 6zej O 7-299 order
       Region 6zej O 300-304 disorder
Seq 7-307 Hetero dimer : IID00666Complex
 Evidence X-RAY 3v4y A Reference
       Region 3v4y A 7-299 order
       Region 3v4y A 300-307 disorder
 Evidence X-RAY 3v4y C Reference
       Region 3v4y C 7-300 order
       Region 3v4y C 301-307 disorder
 Evidence X-RAY 3v4y E Reference
       Region 3v4y E 7-299 order
       Region 3v4y E 300-307 disorder
 Evidence X-RAY 3v4y G Reference
       Region 3v4y G 7-298 order
       Region 3v4y G 299-307 disorder
Seq 7-330 Hetero trimer : IID50060Complex
 Evidence X-RAY 3hvq A Reference
       Region 3hvq A 7-300 order
       Region 3hvq A 301-330 disorder
 Evidence X-RAY 3hvq B Reference
       Region 3hvq B 7-300 order
       Region 3hvq B 301-330 disorder
Seq 7-330 Hetero dimer : IID50058Complex
 Evidence X-RAY 3egg B Reference
       Region 3egg B 7-300 order
       Region 3egg B 301-330 disorder
 Evidence X-RAY 3egh B Reference
       Region 3egh B 7-300 order
       Region 3egh B 301-330 disorder
Seq 7-330 Hetero dimer : IID50058Complex
 Evidence X-RAY 3egg A Reference
       Region 3egg A 7-300 order
       Region 3egg A 301-330 disorder
 Evidence X-RAY 3egh A Reference
       Region 3egh A 7-300 order
       Region 3egh A 301-330 disorder
Seq 7-330 Hetero trimer : IID50058Complex
 Evidence X-RAY 3egh A Reference
       Region 3egh A 7-300 order
       Region 3egh A 301-330 disorder
 Evidence X-RAY 3egh B Reference
       Region 3egh B 7-300 order
       Region 3egh B 301-330 disorder
Seq 7-330 Hetero tetramer : IID00124Complex
 Evidence X-RAY 6ghm A Reference
       Region 6ghm A 7-20 order
       Region 6ghm A 21-25 disorder
       Region 6ghm A 26-300 order
       Region 6ghm A 301-316 disorder
       Region 6ghm A 317-324 order
       Region 6ghm A 325-330 disorder
 Evidence X-RAY 6ghm B Reference
       Region 6ghm B 7-22 order
       Region 6ghm B 23-28 disorder
       Region 6ghm B 29-298 order
       Region 6ghm B 299-316 disorder
       Region 6ghm B 317-324 order
       Region 6ghm B 325-330 disorder
SeqProS verified 317-324 Hetero tetramer : IID00124Complex
       Region 6ghm A 317-324 order
       Region 6ghm B 317-324 order
       Region 6g0i A 299-330 disorder
SeqProS verified 317-328 Hetero tetramer : Q8WUF5
       Region 6dcx A 318-324 order
       Region 6dcx B 317-328 order
       Region 6g0i A 299-330 disorder
SeqProS verified 318-322 Hetero hexamer : IID00905Complex,IID00911Complex
       Region 7tvf C 318-322 order
       Region 6g0i A 299-330 disorder
Seqphosphorylation
    325-325 Phosphoserine
    320-320 Phosphothreonine
    306-306 Phosphotyrosine
    22-22 Phosphoserine
    2-2 Phosphoserine
    306-306 Phosphotyrosine
    320-320 Phosphothreonine
    325-325 Phosphoserine
    22-22 Phosphoserine
    2-2 Phosphoserine
Seqacetylation
    305-305 N6-acetyllysine
    2-2 N-acetylserine
    305-305 N6-acetyllysine
    2-2 N-acetylserine
 
Prediction
NeProc
Disorder 1-5,304-330
Order 6-303
ProS 304-310
AlphaFold
Disorder 1-5,300-330
Order 6-299
Pfam Hmmer
PF00149 57-252 2.6e-44
Function
Function in SwissProt
Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca(2+)/calmodulin dependent protein kinase II. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. Regulates NEK2 function in terms of kinase activity and centrosome number and splitting, both in the presence and absence of radiation-induced DNA damage. Regulator of neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development. In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. May dephosphorylate CSNK1D and CSNK1E. Dephosphorylates the 'Ser-418' residue of FOXP3 in regulatory T-cells (Treg) from patients with rheumatoid arthritis, thereby inactivating FOXP3 and rendering Treg cells functionally defective (PubMed:23396208). Dephosphorylates CENPA (PubMed:25556658). Dephosphorylates the 'Ser-139' residue of ATG16L1 causing dissociation of ATG12-ATG5-ATG16L1 complex, thereby inhibiting autophagy (PubMed:26083323).
(Microbial infection) Necessary for alphaviruses replication.
Biological Process
See also
Diagram with PDB data
AXIN1/GSK3BCrystal structure of GSK-3/Axin complex bound to phosphorylated N-terminal auto-inhibitory pS9 peptide
Ppp1r9b/PPP1CACrystal structure of a complex between Protein Phosphatase 1 alpha (PP1) and the PP1 binding and PDZ domains of Spinophilin
Ppp1r9a/PPP1CACrystal structure of a complex between Protein Phosphatase 1 alpha (PP1) and the PP1 binding and PDZ domains of Neurabin
Pnuts/Ppp1r10Structure of a second nuclear PP1 Holoenzyme, crystal form 1
RAF1/YWHAZHuman 14-3-3 isoform zeta in complex with a diphoyphorylated C-RAF peptide and Cotylenin A
RB1/PPP1CACrystal structure of an Rb C-terminal peptide bound to the catalytic subunit of PP1
PPP1R8/PPP1CACrystal Structure of the first Nuclear PP1 holoenzyme