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IID00313
 UniprotP81274
ProteinG-protein-signaling modulator 2
GeneGPSM2
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
684
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 20-421 Hetero dimer : Q14CM0
 Evidence X-RAY 4wnd A Reference
       Region 4wnd A 20-161 order
       Region 4wnd A 162-169 disorder
       Region 4wnd A 170-356 order
       Region 4wnd A 357-421 disorder
 Evidence X-RAY 4wne A Reference
       Region 4wne A 20-159 order
       Region 4wne A 160-169 disorder
       Region 4wne A 170-354 order
       Region 4wne A 355-421 disorder
 Evidence X-RAY 4wnf A Reference
       Region 4wnf A 20-162 order
       Region 4wnf A 163-163 disorder
       Region 4wnf A 164-274 order
       Region 4wnf A 275-421 disorder
 Evidence X-RAY 4wng A Reference
       Region 4wng A 20-160 order
       Region 4wng A 161-167 disorder
       Region 4wng A 168-354 order
       Region 4wng A 355-421 disorder
Seq 20-421 Hetero dimer : IID00323Complex
 Evidence X-RAY 3sf4 A Reference
       Region 3sf4 A 20-160 order
       Region 3sf4 A 161-167 disorder
       Region 3sf4 A 168-381 order
       Region 3sf4 A 382-421 disorder
 Evidence X-RAY 3sf4 B Reference
       Region 3sf4 B 20-25 disorder
       Region 3sf4 B 26-160 order
       Region 3sf4 B 161-166 disorder
       Region 3sf4 B 167-381 order
       Region 3sf4 B 382-421 disorder
 Evidence X-RAY 3sf4 C Reference
       Region 3sf4 C 20-21 disorder
       Region 3sf4 C 22-159 order
       Region 3sf4 C 160-166 disorder
       Region 3sf4 C 167-374 order
       Region 3sf4 C 375-421 disorder
Seq 22-357 Hetero tetramer : P55196
 Evidence X-RAY 5a6c A Reference
       Region 5a6c A 22-165 order
       Region 5a6c A 166-169 disorder
       Region 5a6c A 170-357 order
 Evidence X-RAY 5a6c B Reference
       Region 5a6c B 22-165 order
       Region 5a6c B 166-169 disorder
       Region 5a6c B 170-357 order
Seqphosphorylation
    607-607 Phosphoserine; by PKG
    501-501 Phosphoserine; by PKC
    541-541 Phosphoserine
    565-565 Phosphoserine
    486-486 Phosphothreonine
    483-483 Phosphoserine
    408-408 Phosphoserine
    352-352 Phosphoserine; by PKG
    132-132 Phosphoserine; by PKG
    132-132 Phosphoserine; by PKG
    352-352 Phosphoserine; by PKG
    408-408 Phosphoserine
    483-483 Phosphoserine
    486-486 Phosphothreonine
    501-501 Phosphoserine; by PKC
    541-541 Phosphoserine
    565-565 Phosphoserine
    607-607 Phosphoserine; by PKG
 
Prediction
NeProc
Disorder 434-684
Order 1-160,165-433
ProS 434-474,485-514,541-577,591-615,624-653,662-677
AlphaFold
Disorder 1-20,160-170,377-684
Order 21-159,171-376
Pfam Hmmer
PF00515 102-135 1.5e-06
PF00515 242-275 1.1e-05
PF00515 282-315 4.2e-05
PF02188 489-511 5.8e-12
PF02188 544-566 3.9e-09
PF02188 594-616 6.9e-12
PF02188 628-650 7.3e-11
SEG 518-526
Function
Function in SwissProt
Plays an important role in mitotic spindle pole organization via its interaction with NUMA1 (PubMed:11781568, PubMed:15632202, PubMed:21816348). Required for cortical dynein-dynactin complex recruitment during metaphase (PubMed:22327364). Plays a role in metaphase spindle orientation (PubMed:22327364). Plays also an important role in asymmetric cell divisions (PubMed:21816348). Has guanine nucleotide dissociation inhibitor (GDI) activity towards G(i) alpha proteins, such as GNAI1 and GNAI3, and thereby regulates their activity.