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IID00367
 UniprotP20226
ProteinTATA-box-binding protein
GeneTBP
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
339
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 156-339 Monomer :
 Evidence X-RAY 1cdw A Reference
       Region 1cdw A 159-337 order
 Evidence X-RAY 1tgh A Reference
       Region 1tgh A 156-158 disorder
       Region 1tgh A 159-338 order
       Region 1tgh A 339-339 disorder
Seq 159-337 Hetero dimer : IID00314Complex
 Evidence X-RAY 1c9b B Reference
       Region 1c9b B 159-337 order
 Evidence X-RAY 1c9b F Reference
       Region 1c9b F 159-337 order
 Evidence X-RAY 1c9b J Reference
       Region 1c9b J 159-337 order
 Evidence X-RAY 1c9b N Reference
       Region 1c9b N 159-337 order
 Evidence X-RAY 1c9b R Reference
       Region 1c9b R 159-337 order
Seq 159-339 Hetero dimer : Q9HAW0
 Evidence X-RAY 4roc B Reference
       Region 4roc B 159-334 order
       Region 4roc B 335-339 disorder
 Evidence X-RAY 4rod B Reference
       Region 4rod B 159-334 order
       Region 4rod B 335-339 disorder
 Evidence X-RAY 4roe B Reference
       Region 4roe B 159-334 order
       Region 4roe B 335-339 disorder
Seq 159-339 Hetero trimer : IID00206Complex,IID00385Complex
 Evidence X-RAY 1jfi C Reference
       Region 1jfi C 159-338 order
       Region 1jfi C 339-339 disorder
Seq 159-339 Hetero trimer : A6H8Y1,Q9HAW0
 Evidence X-RAY 5n9g B Reference
       Region 5n9g B 159-334 order
       Region 5n9g B 335-339 disorder
 Evidence X-RAY 5n9g G Reference
       Region 5n9g G 159-334 order
       Region 5n9g G 335-339 disorder
Seq 159-339 Hetero tetramer : IID00556Complex
 Evidence X-RAY 1nvp A Reference
       Region 1nvp A 159-338 order
       Region 1nvp A 339-339 disorder
 
Prediction
NeProc
Disorder 1-44,100-158
Order 45-99,159-339
ProS 4-18,27-44
AlphaFold
Disorder 1-52,93-159,339-339
Order 53-92,160-338
Pfam Hmmer
PF00352 160-245 3.2e-39
PF00352 250-336 2e-43
SEG 55-112 ,126-138 ,140-156
Function
Function in SwissProt
The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription (PubMed:33795473). TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC) (PubMed:33795473, PubMed:27193682, PubMed:2194289, PubMed:2363050, PubMed:2374612). The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13 (PubMed:33795473, PubMed:27007846). The TFIID complex structure can be divided into 3 modules TFIID-A, TFIID-B, and TFIID-C (PubMed:33795473). TBP forms the TFIID-A module together with TAF3 and TAF5 (PubMed:33795473). TBP is a general transcription factor that functions at the core of the TFIID complex (PubMed:33795473, PubMed:27193682, PubMed:2194289, PubMed:2363050, PubMed:2374612, PubMed:9836642). During assembly of the core PIC on the promoter, as part of TFIID, TBP binds to and also bends promoter DNA, irrespective of whether the promoter contains a TATA box (PubMed:33795473). Component of a BRF2-containing transcription factor complex that regulates transcription mediated by RNA polymerase III (PubMed:26638071). Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC during RNA polymerase I-dependent transcription (PubMed:15970593). The rate of PIC formation probably is primarily dependent on the rate of association of SL1 with the rDNA promoter (PubMed:15970593). SL1 is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA (PubMed:15970593).