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IID00435
 UniprotO95644
ProteinNuclear factor of activated T-cells, cytoplasmic 1
GeneNFATC1
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
943
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 384-400 Hetero trimer : IID00060Complex,IID00069Complex
 Evidence X-RAY 5sve C Reference
       Region 5sve C 384-390 order
       Region 5sve C 391-400 disorder
Seq 414-591 Monomer :
 Evidence NMR 1a66 A Reference
       Region 1a66 A 414-591 order
       Region 1a66 A 414-421 high_rmsd
       Region 1a66 A 454-456 high_rmsd
       Region 1a66 A 591-591 high_rmsd
 Evidence NMR 1nfa A Reference
       Region 1nfa A 416-539 order
       Region 1nfa A 416-424 high_rmsd
       Region 1nfa A 443-448 high_rmsd
       Region 1nfa A 540-555 disorder
       Region 1nfa A 540-555 high_rmsd
       Region 1nfa A 556-591 order
       Region 1nfa A 588-591 high_rmsd
SeqProS predicted 384-390 This region is predicted to be disordered by NeProc and AlphaFold (pLDDT < 68.5). Hetero trimer : IID00060Complex,IID00069Complex
       Region 5sve C 384-390 order
SeqProS verified 540-555 :
       Region 1a66 A 414-591 order
       Region 1nfa A 540-555 disorder
Seqphosphorylation
    294-294 Phosphoserine; by PKA
    269-269 Phosphoserine; by PKA
    245-245 Phosphoserine; by PKA
    237-237 Phosphoserine
    233-233 Phosphoserine
    294-294 Phosphoserine; by PKA
    269-269 Phosphoserine; by PKA
    245-245 Phosphoserine; by PKA
    237-237 Phosphoserine
    233-233 Phosphoserine
 
Prediction
NeProc
Disorder 1-431,436-451,702-943
Order 432-435,452-701
ProS 4-27,41-55,64-72,97-127,139-139,141-143,154-168,179-198,203-214,248-252,268-272,285-301,316-342,368-390,401-431,436-451,702-707,910-943
AlphaFold
Disorder 1-118,120-309,319-410,549-555,590-594,698-925,937-943
Order 119-119,310-318,411-548,556-589,595-697,926-936
Pfam Hmmer
PF00554 428-588 2e-61
PF01833 596-694 4.3e-20
SEG 151-162 ,168-200 ,275-291 ,811-830 ,841-853
Function
Function in SwissProt
Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 or IL-4 gene transcription. Also controls gene expression in embryonic cardiac cells. Could regulate not only the activation and proliferation but also the differentiation and programmed death of T-lymphocytes as well as lymphoid and non-lymphoid cells (PubMed:10358178). Required for osteoclastogenesis and regulates many genes important for osteoclast differentiation and function (By similarity).
Biological Process
Diagram with PDB data
NFATC1/PPP3CA/PPP3R1Structure of Calcineurin in complex with NFATc1 LxVP peptide