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IID00451
 UniprotP35637
ProteinRNA-binding protein FUS
GeneFUS
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
526
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-526 Hetero hexamer : IID00094Complex
 Evidence X-RAY 5yvg X Reference
       Region 5yvg X 1-508 disorder
       Region 5yvg X 509-526 order
 Evidence X-RAY 5yvg Y Reference
       Region 5yvg Y 1-512 disorder
       Region 5yvg Y 513-526 order
Seq 2-214 Homo nonamer :
 Evidence NMR 5w3n A Reference
       Region 5w3n A 2-36 disorder
       Region 5w3n A 37-97 order
       Region 5w3n A 37-40 high_rmsd
       Region 5w3n A 56-59 high_rmsd
       Region 5w3n A 98-214 disorder
 Evidence NMR 5w3n B Reference
       Region 5w3n B 2-36 disorder
       Region 5w3n B 37-97 order
       Region 5w3n B 37-40 high_rmsd
       Region 5w3n B 56-59 high_rmsd
       Region 5w3n B 98-214 disorder
 Evidence NMR 5w3n C Reference
       Region 5w3n C 2-36 disorder
       Region 5w3n C 37-97 order
       Region 5w3n C 37-41 high_rmsd
       Region 5w3n C 56-59 high_rmsd
       Region 5w3n C 98-214 disorder
 Evidence NMR 5w3n D Reference
       Region 5w3n D 2-36 disorder
       Region 5w3n D 37-97 order
       Region 5w3n D 37-41 high_rmsd
       Region 5w3n D 56-59 high_rmsd
       Region 5w3n D 98-214 disorder
 Evidence NMR 5w3n E Reference
       Region 5w3n E 2-36 disorder
       Region 5w3n E 37-97 order
       Region 5w3n E 37-41 high_rmsd
       Region 5w3n E 56-59 high_rmsd
       Region 5w3n E 98-214 disorder
 Evidence NMR 5w3n F Reference
       Region 5w3n F 2-36 disorder
       Region 5w3n F 37-97 order
       Region 5w3n F 37-41 high_rmsd
       Region 5w3n F 56-59 high_rmsd
       Region 5w3n F 98-214 disorder
 Evidence NMR 5w3n G Reference
       Region 5w3n G 2-36 disorder
       Region 5w3n G 37-97 order
       Region 5w3n G 37-41 high_rmsd
       Region 5w3n G 56-59 high_rmsd
       Region 5w3n G 98-214 disorder
 Evidence NMR 5w3n H Reference
       Region 5w3n H 2-36 disorder
       Region 5w3n H 37-97 order
       Region 5w3n H 37-41 high_rmsd
       Region 5w3n H 56-59 high_rmsd
       Region 5w3n H 98-214 disorder
 Evidence NMR 5w3n I Reference
       Region 5w3n I 2-36 disorder
       Region 5w3n I 37-97 order
       Region 5w3n I 37-41 high_rmsd
       Region 5w3n I 56-59 high_rmsd
       Region 5w3n I 98-214 disorder
Seq 37-42 Monomer :
 Evidence X-RAY 6bwz A Reference
       Region 6bwz A 37-42 order
Seq 54-59 Monomer :
 Evidence X-RAY 5xrr A Reference
       Region 5xrr A 54-59 order
Seq 54-61 Homo decamer :
 Evidence X-RAY 6bxv A Reference
       Region 6bxv A 54-61 order
Seq 260-390 Monomer :
 Evidence NMR 2la6 A Reference
       Region 2la6 A 282-370 order
       Region 2la6 A 282-282 high_rmsd
 Evidence NMR 2lcw A Reference
       Region 2lcw A 278-385 order
       Region 2lcw A 278-281 high_rmsd
       Region 2lcw A 328-329 high_rmsd
       Region 2lcw A 371-385 high_rmsd
 Evidence NMR 6gbm B Reference
       Region 6gbm B 280-377 order
 Evidence NMR 6snj A Reference
       Region 6snj A 260-390 order
       Region 6snj A 387-390 high_rmsd
Seq 371-526 Hetero trimer : IID00094Complex
 Evidence X-RAY 5yvh B Reference
       Region 5yvh B 371-507 disorder
       Region 5yvh B 508-526 order
Seq 419-454 Monomer :
 Evidence NMR 6g99 B Reference
       Region 6g99 B 419-454 order
Seq 456-526 Hetero trimer : IID00094Complex
 Evidence X-RAY 5yvi B Reference
       Region 5yvi B 456-507 disorder
       Region 5yvi B 508-526 order
Seq 476-526 Hetero trimer : IID00094Complex
 Evidence X-RAY 7cyl B Reference
       Region 7cyl B 476-506 disorder
       Region 7cyl B 507-526 order
Seq 495-526 Hetero dimer : IID00094Complex
 Evidence X-RAY 4fq3 B Reference
       Region 4fq3 B 495-507 disorder
       Region 4fq3 B 508-526 order
Seq 498-526 Hetero trimer : IID00094Complex
 Evidence X-RAY 4fdd B Reference
       Region 4fdd B 498-506 disorder
       Region 4fdd B 507-526 order
SeqProS verified 37-97 :
       Region 5xrr A 54-59 order
       Region 5yvg X 1-508 disorder
SeqProS verified 37-97 :
       Region 6bwz A 37-42 order
       Region 5yvg X 1-508 disorder
SeqProS verified 37-97 Homo decamer :
       Region 6bxv A 54-61 order
       Region 5yvg X 1-508 disorder
SeqProS verified 37-97 Homo nonamer :
       Region 5w3n A 37-97 order
       Region 5w3n B 37-97 order
       Region 5w3n C 37-97 order
       Region 5w3n D 37-97 order
       Region 5w3n E 37-97 order
       Region 5w3n F 37-97 order
       Region 5w3n G 37-97 order
       Region 5w3n H 37-97 order
       Region 5w3n I 37-97 order
       Region 5yvg X 1-508 disorder
SeqProS possible 521-526 Nuclear Localization Signal (NLS) Hetero trimer : IID00094Complex
       Region 4fdd B 507-526 order
SeqProS possible 521-526 Nuclear Localization Signal (NLS) Hetero trimer : IID00094Complex
       Region 5yvi B 508-526 order
SeqProS possible 521-526 Nuclear Localization Signal (NLS) Hetero trimer : IID00094Complex
       Region 7cyl B 507-526 order
SeqProS possible 521-526 Nuclear Localization Signal (NLS) Hetero trimer : IID00094Complex
       Region 5yvh B 508-526 order
SeqProS possible 521-526 Nuclear Localization Signal (NLS) Hetero dimer : IID00094Complex
       Region 4fq3 B 508-526 order
SeqProS possible 521-526 Nuclear Localization Signal (NLS) Hetero hexamer : IID00094Complex
       Region 5yvg X 509-526 order
Seqphosphorylation
    286-286 Phosphothreonine
    340-340 Phosphoserine
    277-277 Phosphoserine
    221-221 Phosphoserine
    42-42 Phosphoserine; by ATM
    30-30 Phosphoserine
    26-26 Phosphoserine
 
Prediction
NeProc
Disorder 1-281,372-526
Order 282-371
ProS 1-6,79-83,140-144,205-216,227-281,387-455,466-473,482-526
AlphaFold
Disorder 1-282,371-421,454-523
Order 283-370,422-453,524-526
Pfam Hmmer
PF00076 287-366 1.9e-15
PF00641 422-453 2.1e-12
SEG 17-104 ,106-261 ,371-425 ,450-507
Function
Function in SwissProt
DNA/RNA-binding protein that plays a role in various cellular processes such as transcription regulation, RNA splicing, RNA transport, DNA repair and damage response (PubMed:27731383). Binds to nascent pre-mRNAs and acts as a molecular mediator between RNA polymerase II and U1 small nuclear ribonucleoprotein thereby coupling transcription and splicing (PubMed:26124092). Binds also its own pre-mRNA and autoregulates its expression; this autoregulation mechanism is mediated by non-sense-mediated decay (PubMed:24204307). Plays a role in DNA repair mechanisms by promoting D-loop formation and homologous recombination during DNA double-strand break repair (PubMed:10567410). In neuronal cells, plays crucial roles in dendritic spine formation and stability, RNA transport, mRNA stability and synaptic homeostasis (By similarity).
Biological Process
Diagram with PDB data
FUS/TNPO1Crystal structure of Karyopherin beta2 in complex with FUS(full length)