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IID00507
 UniprotO60239
ProteinSH3 domain-binding protein 5
GeneSH3BP5
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
455
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-265 Hetero octamer : P62491
 Evidence X-RAY 6djl B Reference
       Region 6djl B 1-40 disorder
       Region 6djl B 41-261 order
       Region 6djl B 262-265 disorder
 Evidence X-RAY 6djl C Reference
       Region 6djl C 1-40 disorder
       Region 6djl C 41-264 order
       Region 6djl C 265-265 disorder
 Evidence X-RAY 6djl D Reference
       Region 6djl D 1-40 disorder
       Region 6djl D 41-264 order
       Region 6djl D 265-265 disorder
 Evidence X-RAY 6djl E Reference
       Region 6djl E 1-38 disorder
       Region 6djl E 39-264 order
       Region 6djl E 265-265 disorder
Seq 10-276 Hetero octamer : P62491
 Evidence X-RAY 6ixv A Reference
       Region 6ixv A 10-41 disorder
       Region 6ixv A 42-265 order
       Region 6ixv A 266-276 disorder
 Evidence X-RAY 6ixv B Reference
       Region 6ixv B 10-38 disorder
       Region 6ixv B 39-264 order
       Region 6ixv B 265-276 disorder
 Evidence X-RAY 6ixv C Reference
       Region 6ixv C 10-40 disorder
       Region 6ixv C 41-262 order
       Region 6ixv C 263-276 disorder
 Evidence X-RAY 6ixv D Reference
       Region 6ixv D 10-41 disorder
       Region 6ixv D 42-267 order
       Region 6ixv D 268-276 disorder
Seq 41-266 Homo dimer :
 Evidence X-RAY 6ixf A Reference
       Region 6ixf A 41-261 order
       Region 6ixf A 262-266 disorder
 Evidence X-RAY 6ixf B Reference
       Region 6ixf B 41-262 order
       Region 6ixf B 263-266 disorder
 Evidence X-RAY 6ixg A Reference
       Region 6ixg A 41-263 order
       Region 6ixg A 264-266 disorder
 Evidence X-RAY 6ixg B Reference
       Region 6ixg B 41-143 order
       Region 6ixg B 144-149 disorder
       Region 6ixg B 150-262 order
       Region 6ixg B 263-266 disorder
Seq 41-266 Monomer :
 Evidence X-RAY 6ixe A Reference
       Region 6ixe A 41-143 order
       Region 6ixe A 144-150 disorder
       Region 6ixe A 151-260 order
       Region 6ixe A 261-266 disorder
Seq 341-350 Hetero dimer : IID00456Complex
 Evidence X-RAY 4h3b B Reference
       Region 4h3b B 341-350 order
 Evidence X-RAY 4h3b D Reference
       Region 4h3b D 341-350 order
SeqProS predicted 341-350 This region is predicted to be disordered by NeProc and AlphaFold (pLDDT < 68.5). Hetero dimer : IID00456Complex
       Region 4h3b B 341-350 order
       Region 4h3b D 341-350 order
Seqphosphorylation
    351-351 Phosphoserine; by MAPK12 and MAPK9
    375-375 Phosphoserine
    376-376 Phosphoserine
    418-418 Phosphoserine
    421-421 Phosphoserine
    421-421 Phosphoserine
    418-418 Phosphoserine
    376-376 Phosphoserine
    375-375 Phosphoserine
    351-351 Phosphoserine; by MAPK12 and MAPK9
 
Prediction
NeProc
Disorder 1-39,257-455
Order 40-256
ProS 36-39,257-275,284-309,352-369,385-402,424-455
AlphaFold
Disorder 1-39,266-455
Order 40-265
Pfam Hmmer
PF05276 37-273 1.2e-156
SEG 23-40 ,320-332 ,403-421
Function
Function in SwissProt
Functions as a guanine nucleotide exchange factor (GEF) with specificity for RAB11A and RAB25 (PubMed:26506309, PubMed:30217979). Inhibits the auto- and transphosphorylation activity of BTK. Plays a negative regulatory role in BTK-related cytoplasmic signaling in B-cells. May be involved in BCR-induced apoptotic cell death.
Biological Process
Diagram with PDB data
SH3BP5/MAPK10Crystal Structure of JNK3 in Complex with SAB Peptide