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IID00669
 UniprotQ14457
ProteinBeclin-1
GeneBECN1
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
450
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seqdisorder 1-150
 Evidence CD¸ NMR Reference
       Region 1-150 disorder
Seq 93-102 Hetero tetramer : IID01017Complex
 Evidence X-RAY 6hoi F Reference
       Region 6hoi F 93-95 disorder
       Region 6hoi F 96-102 order
 Evidence X-RAY 6hoi G Reference
       Region 6hoi G 93-93 disorder
       Region 6hoi G 94-102 order
Seq 93-105 Hetero hexamer : IID00921Complex
 Evidence X-RAY 6hoj A Reference
       Region 6hoj A 93-95 disorder
       Region 6hoj A 96-105 order
 Evidence X-RAY 6hoj B Reference
       Region 6hoj B 93-94 disorder
       Region 6hoj B 95-104 order
       Region 6hoj B 105-105 disorder
 Evidence X-RAY 6hoj C Reference
       Region 6hoj C 93-95 disorder
       Region 6hoj C 96-105 order
Seq 93-105 Hetero dimer : IID00921Complex
 Evidence X-RAY 6hok A Reference
       Region 6hok A 93-105 order
Seq 105-130 Hetero tetramer : IID00707Complex,IID00720Complex
 Evidence X-RAY 5vay H Reference
       Region 5vay H 105-107 disorder
       Region 5vay H 108-127 order
       Region 5vay H 128-130 disorder
Seq 105-130 Hetero hexamer : IID00720Complex
 Evidence X-RAY 6dco C Reference
       Region 6dco C 105-107 disorder
       Region 6dco C 108-127 order
       Region 6dco C 128-130 disorder
 Evidence X-RAY 6dco D Reference
       Region 6dco D 105-107 disorder
       Region 6dco D 108-128 order
       Region 6dco D 129-130 disorder
Seq 105-130 Hetero hexamer : IID00720Complex
 Evidence X-RAY 6dcn C Reference
       Region 6dcn C 105-106 disorder
       Region 6dcn C 107-127 order
       Region 6dcn C 128-130 disorder
 Evidence X-RAY 6dcn D Reference
       Region 6dcn D 105-106 disorder
       Region 6dcn D 107-127 order
       Region 6dcn D 128-130 disorder
Seq 105-130 Hetero tetramer : IID00707Complex,IID00720Complex
 Evidence X-RAY 5vay G Reference
       Region 5vay G 105-106 disorder
       Region 5vay G 107-127 order
       Region 5vay G 128-130 disorder
Seq 105-130 Hetero tetramer : IID00707Complex,IID00720Complex
 Evidence X-RAY 5vay F Reference
       Region 5vay F 105-107 disorder
       Region 5vay F 108-128 order
       Region 5vay F 129-130 disorder
Seq 105-130 Hetero dimer : P89884
 Evidence X-RAY 3dvu C Reference
       Region 3dvu C 105-105 disorder
       Region 3dvu C 106-129 order
       Region 3dvu C 130-130 disorder
 Evidence X-RAY 3dvu D Reference
       Region 3dvu D 105-128 order
       Region 3dvu D 129-130 disorder
 Evidence X-RAY 4mi8 C Reference
       Region 4mi8 C 107-107 disorder
       Region 4mi8 C 108-127 order
       Region 4mi8 C 128-130 disorder
 Evidence X-RAY 4mi8 D Reference
       Region 4mi8 D 107-127 order
       Region 4mi8 D 128-130 disorder
Seq 105-130 Hetero dimer : IID00707Complex
 Evidence X-RAY 5vau E Reference
       Region 5vau E 105-108 disorder
       Region 5vau E 109-128 order
       Region 5vau E 129-130 disorder
 Evidence X-RAY 5vau F Reference
       Region 5vau F 105-107 disorder
       Region 5vau F 108-128 order
       Region 5vau F 129-130 disorder
 Evidence X-RAY 5vau G Reference
       Region 5vau G 105-107 disorder
       Region 5vau G 108-127 order
       Region 5vau G 128-130 disorder
 Evidence X-RAY 5vau H Reference
       Region 5vau H 105-107 disorder
       Region 5vau H 108-127 order
       Region 5vau H 128-130 disorder
 Evidence X-RAY 5vax E Reference
       Region 5vax E 105-107 disorder
       Region 5vax E 108-129 order
       Region 5vax E 130-130 disorder
 Evidence X-RAY 5vax F Reference
       Region 5vax F 105-107 disorder
       Region 5vax F 108-128 order
       Region 5vax F 129-130 disorder
 Evidence X-RAY 5vax G Reference
       Region 5vax G 105-106 disorder
       Region 5vax G 107-129 order
       Region 5vax G 130-130 disorder
 Evidence X-RAY 5vax H Reference
       Region 5vax H 105-107 disorder
       Region 5vax H 108-128 order
       Region 5vax H 129-130 disorder
Seq 105-130 Hetero tetramer : IID00707Complex,IID00720Complex
 Evidence X-RAY 5vay E Reference
       Region 5vay E 105-107 disorder
       Region 5vay E 108-128 order
       Region 5vay E 129-130 disorder
Seqdisorder 105-140
 Evidence CD Reference
       Region 105-140 disorder
Seq 106-135 Hetero dimer : IID00720Complex
 Evidence X-RAY 2p1l B Reference
       Region 2p1l B 107-128 order
       Region 2p1l B 129-135 disorder
 Evidence X-RAY 2p1l D Reference
       Region 2p1l D 107-128 order
       Region 2p1l D 129-135 disorder
 Evidence X-RAY 2p1l F Reference
       Region 2p1l F 107-128 order
       Region 2p1l F 129-135 disorder
 Evidence X-RAY 2p1l H Reference
       Region 2p1l H 107-128 order
       Region 2p1l H 129-135 disorder
 Evidence NMR 2pon A Reference
       Region 2pon A 106-128 order
       Region 2pon A 128-128 high_rmsd
Seq 141-171 Homo trimer :
 Evidence X-RAY 5efm A Reference
       Region 5efm A 141-156 disorder
       Region 5efm A 157-171 order
Seq 175-265 Homo dimer :
 Evidence X-RAY 5hhe D Reference
       Region 5hhe D 175-265 order
 Evidence X-RAY 5hhe A Reference
       Region 5hhe A 175-265 order
Seq 241-450 Monomer :
 Evidence X-RAY 4ddp A Reference
       Region 4ddp A 241-247 disorder
       Region 4ddp A 248-264 order
       Region 4ddp A 265-268 disorder
       Region 4ddp A 269-386 order
       Region 4ddp A 387-387 disorder
       Region 4ddp A 388-447 order
       Region 4ddp A 448-450 disorder
SeqProS verified 93-105 Hetero tetramer : IID01017Complex
       Region 6hoi F 96-102 order
       Region 6hoi G 94-102 order
       Region 1-150 disorder
SeqProS verified 93-105 Hetero hexamer : IID00921Complex
       Region 6hoj A 96-105 order
       Region 6hoj B 95-104 order
       Region 6hoj C 96-105 order
       Region 1-150 disorder
SeqProS verified 93-105 Hetero dimer : IID00921Complex
       Region 6hok A 93-105 order
       Region 1-150 disorder
SeqProS verified 106-129 Hetero dimer : IID00707Complex
       Region 5vax E 108-129 order
       Region 5vax F 108-128 order
       Region 5vax G 107-129 order
       Region 5vax H 108-128 order
       Region 5vau E 109-128 order
       Region 5vau F 108-128 order
       Region 5vau G 108-127 order
       Region 5vau H 108-127 order
       Region 1-150 disorder
SeqProS verified 106-129 Hetero hexamer : IID00720Complex
       Region 6dcn C 107-127 order
       Region 6dcn D 107-127 order
       Region 1-150 disorder
SeqProS verified 106-129 Hetero hexamer : IID00720Complex
       Region 6dco C 108-127 order
       Region 6dco D 108-128 order
       Region 1-150 disorder
SeqProS verified 106-129 Hetero tetramer : IID00707Complex,IID00720Complex
       Region 5vay H 108-127 order
       Region 1-150 disorder
SeqProS verified 106-129 Hetero dimer : P89884
       Region 4mi8 C 108-127 order
       Region 4mi8 D 107-127 order
       Region 3dvu C 106-129 order
       Region 3dvu D 105-128 order
       Region 1-150 disorder
SeqProS verified 106-129 Hetero dimer : IID00720Complex
       Region 2pon A 106-128 order
       Region 2p1l B 107-128 order
       Region 2p1l D 107-128 order
       Region 2p1l F 107-128 order
       Region 2p1l H 107-128 order
       Region 1-150 disorder
SeqProS verified 106-129 Hetero tetramer : IID00707Complex,IID00720Complex
       Region 5vay F 108-128 order
       Region 1-150 disorder
SeqProS verified 106-129 Hetero tetramer : IID00707Complex,IID00720Complex
       Region 5vay E 108-128 order
       Region 1-150 disorder
SeqProS verified 106-129 Hetero tetramer : IID00707Complex,IID00720Complex
       Region 5vay G 107-127 order
       Region 1-150 disorder
Seqphosphorylation
    119-119 Phosphothreonine; by DAPK1
    96-96 Phosphoserine; by AMPK
    93-93 Phosphoserine; by AMPK
    90-90 Phosphoserine; by AMPK
    30-30 Phosphoserine
    15-15 Phosphoserine
    30-30 Phosphoserine
    90-90 Phosphoserine; by AMPK
    93-93 Phosphoserine; by AMPK
    96-96 Phosphoserine; by AMPK
    119-119 Phosphothreonine; by DAPK1
Seqacetylation
    1-1 N-acetylmethionine
    1-1 N-acetylmethionine
 
Prediction
NeProc
Disorder 1-15,26-113
Order 16-25,114-450
ProS 26-42,65-72,80-91,96-99
AlphaFold
Disorder 1-15,27-116,357-362,387-389,407-409,448-450
Order 16-26,117-356,363-386,390-406,410-447
Pfam Hmmer
PF04111 115-450 1e-235
SEG 55-67 ,141-152 ,178-194
Function
Function in SwissProt
Plays a central role in autophagy (PubMed:18570871, PubMed:21358617, PubMed:23184933, PubMed:23974797, PubMed:28445460, PubMed:25484083, PubMed:37776275). Acts as a core subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2 (PubMed:20643123, PubMed:20208530, PubMed:23974797, PubMed:26783301). Essential for the formation of PI3KC3-C2 but not PI3KC3-C1 PI3K complex forms. Involved in endocytosis (PubMed:25275521). Protects against infection by a neurovirulent strain of Sindbis virus (PubMed:9765397). May play a role in antiviral host defense.
Beclin-1-C 35 kDa localized to mitochondria can promote apoptosis; it induces the mitochondrial translocation of BAX and the release of proapoptotic factors.
Biological Process
Diagram with PDB data
BECN1/BCL2L1Solution structure of the Bcl-xL/Beclin-1 complex