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IID00720
 UniprotQ07817
ProteinBcl-2-like protein 1
GeneBCL2L1
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
233
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-26,82-196 Hetero dimer :
 Evidence X-RAY 7yaa A Reference
       Region 7yaa A 1-26 order
       Region 7yaa A 82-196 order
Seq 1-27,83-196 Hetero dimer :
 Evidence X-RAY 7y8d A Reference
       Region 7y8d A 1-1 disorder
       Region 7y8d A 2-27 order
       Region 7y8d A 83-196 order
Seq 1-26,83-197 Hetero dimer : Q9Y5Z4
 Evidence X-RAY 3r85 A Reference
       Region 3r85 A 1-3 disorder
       Region 3r85 A 4-26 order
       Region 3r85 A 83-197 order
 Evidence X-RAY 3r85 B Reference
       Region 3r85 B 1-3 disorder
       Region 3r85 B 4-26 order
       Region 3r85 B 83-197 order
 Evidence X-RAY 3r85 C Reference
       Region 3r85 C 1-2 disorder
       Region 3r85 C 3-26 order
       Region 3r85 C 83-197 order
 Evidence X-RAY 3r85 D Reference
       Region 3r85 D 1-2 disorder
       Region 3r85 D 3-26 order
       Region 3r85 D 83-197 order
Seq 1-26,83-208 Hetero hexamer : IID00669Complex
 Evidence X-RAY 6dcn A Reference
       Region 6dcn A 1-26 order
       Region 6dcn A 83-197 order
       Region 6dcn A 198-208 disorder
 Evidence X-RAY 6dcn B Reference
       Region 6dcn B 1-26 order
       Region 6dcn B 83-197 order
       Region 6dcn B 198-208 disorder
Seq 1-26,83-208 Hetero hexamer : IID00669Complex
 Evidence X-RAY 6dco A Reference
       Region 6dco A 1-26 order
       Region 6dco A 83-198 order
       Region 6dco A 199-208 disorder
 Evidence X-RAY 6dco B Reference
       Region 6dco B 1-26 order
       Region 6dco B 83-198 order
       Region 6dco B 199-208 disorder
Seq 1-26,83-208 Hetero octamer : IID00651Complex
 Evidence X-RAY 4z9v A Reference
       Region 4z9v A 1-26 order
       Region 4z9v A 83-208 order
 Evidence X-RAY 4z9v B Reference
       Region 4z9v B 1-26 order
       Region 4z9v B 83-207 order
       Region 4z9v B 208-208 disorder
Seq 1-44,85-209 Hetero dimer : IID01012Complex
 Evidence NMR 2m04 A Reference
       Region 2m04 A 1-44 order
       Region 2m04 A 27-40 high_rmsd
       Region 2m04 A 85-209 order
       Region 2m04 A 158-169 high_rmsd
Seq 1-44,85-209 Hetero dimer : IID01001Complex
 Evidence NMR 1g5j A Reference
       Region 1g5j A 1-44 order
       Region 1g5j A 85-209 order
Seq 1-44,85-209 Hetero dimer : IID00951Complex
 Evidence X-RAY 4qve A Reference
       Region 4qve A 1-3 disorder
       Region 4qve A 4-25 order
       Region 4qve A 26-44 disorder
       Region 4qve A 85-198 order
       Region 4qve A 199-209 disorder
Seq 1-26,83-209 Homo dodecamer :
 Evidence X-RAY 6uvg A Reference
       Region 6uvg A 1-26 order
       Region 6uvg A 83-197 order
       Region 6uvg A 198-209 disorder
 Evidence X-RAY 6uvg B Reference
       Region 6uvg B 1-26 order
       Region 6uvg B 83-196 order
       Region 6uvg B 197-209 disorder
 Evidence X-RAY 6uvg C Reference
       Region 6uvg C 1-3 disorder
       Region 6uvg C 4-26 order
       Region 6uvg C 83-197 order
       Region 6uvg C 198-209 disorder
 Evidence X-RAY 6uvg D Reference
       Region 6uvg D 1-26 order
       Region 6uvg D 83-195 order
       Region 6uvg D 196-209 disorder
 Evidence X-RAY 6uvg E Reference
       Region 6uvg E 1-26 order
       Region 6uvg E 83-196 order
       Region 6uvg E 197-209 disorder
 Evidence X-RAY 6uvg F Reference
       Region 6uvg F 1-26 order
       Region 6uvg F 83-197 order
       Region 6uvg F 198-209 disorder
 Evidence X-RAY 6uvg G Reference
       Region 6uvg G 1-26 order
       Region 6uvg G 83-196 order
       Region 6uvg G 197-209 disorder
 Evidence X-RAY 6uvg H Reference
       Region 6uvg H 1-26 order
       Region 6uvg H 83-197 order
       Region 6uvg H 198-209 disorder
 Evidence X-RAY 6uvg I Reference
       Region 6uvg I 1-1 disorder
       Region 6uvg I 2-26 order
       Region 6uvg I 83-195 order
       Region 6uvg I 196-209 disorder
 Evidence X-RAY 6uvg J Reference
       Region 6uvg J 1-3 disorder
       Region 6uvg J 4-26 order
       Region 6uvg J 83-110 order
       Region 6uvg J 111-113 disorder
       Region 6uvg J 114-195 order
       Region 6uvg J 196-209 disorder
 Evidence X-RAY 6uvg K Reference
       Region 6uvg K 1-26 order
       Region 6uvg K 83-197 order
       Region 6uvg K 198-209 disorder
 Evidence X-RAY 6uvg L Reference
       Region 6uvg L 1-26 order
       Region 6uvg L 83-107 order
       Region 6uvg L 108-111 disorder
       Region 6uvg L 112-195 order
       Region 6uvg L 196-209 disorder
Seq 1-44,85-209 Homo hexamer :
 Evidence X-RAY 4ppi A Reference
       Region 4ppi A 1-2 disorder
       Region 4ppi A 3-25 order
       Region 4ppi A 26-44 disorder
       Region 4ppi A 85-196 order
       Region 4ppi A 197-209 disorder
Seq 1-26,83-209 Hetero tetramer : IID01012Complex
 Evidence X-RAY 4bpk A Reference
       Region 4bpk A 1-26 order
       Region 4bpk A 83-195 order
       Region 4bpk A 196-209 disorder
 Evidence X-RAY 4bpk B Reference
       Region 4bpk B 1-1 disorder
       Region 4bpk B 2-26 order
       Region 4bpk B 83-195 order
       Region 4bpk B 196-209 disorder
Seq 1-44,85-209 Hetero trimer : Q07812
 Evidence X-RAY 3pl7 A Reference
       Region 3pl7 A 1-2 disorder
       Region 3pl7 A 3-28 order
       Region 3pl7 A 29-41 disorder
       Region 3pl7 A 42-44 order
       Region 3pl7 A 85-196 order
       Region 3pl7 A 197-209 disorder
 Evidence X-RAY 3pl7 B Reference
       Region 3pl7 B 1-3 disorder
       Region 3pl7 B 4-29 order
       Region 3pl7 B 30-41 disorder
       Region 3pl7 B 42-44 order
       Region 3pl7 B 85-196 order
       Region 3pl7 B 197-209 disorder
Seq 1-44,85-209 Hetero hexamer :
 Evidence X-RAY 7xgf B Reference
       Region 7xgf B 1-28 order
       Region 7xgf B 29-38 disorder
       Region 7xgf B 39-44 order
       Region 7xgf B 85-201 order
       Region 7xgf B 202-209 disorder
 Evidence X-RAY 7xgf C Reference
       Region 7xgf C 1-30 order
       Region 7xgf C 31-39 disorder
       Region 7xgf C 40-44 order
       Region 7xgf C 85-197 order
       Region 7xgf C 198-209 disorder
 Evidence X-RAY 7xgf E Reference
       Region 7xgf E 1-28 order
       Region 7xgf E 29-38 disorder
       Region 7xgf E 39-44 order
       Region 7xgf E 85-201 order
       Region 7xgf E 202-209 disorder
 Evidence X-RAY 7xgf F Reference
       Region 7xgf F 1-3 disorder
       Region 7xgf F 4-30 order
       Region 7xgf F 31-39 disorder
       Region 7xgf F 40-44 order
       Region 7xgf F 85-196 order
       Region 7xgf F 197-209 disorder
Seq 1-44,83-209 Hetero dimer : IID00669Complex
 Evidence X-RAY 2p1l A Reference
       Region 2p1l A 1-1 disorder
       Region 2p1l A 2-26 order
       Region 2p1l A 83-198 order
       Region 2p1l A 199-209 disorder
 Evidence X-RAY 2p1l C Reference
       Region 2p1l C 1-1 disorder
       Region 2p1l C 2-26 order
       Region 2p1l C 83-198 order
       Region 2p1l C 199-209 disorder
 Evidence X-RAY 2p1l E Reference
       Region 2p1l E 1-1 disorder
       Region 2p1l E 2-26 order
       Region 2p1l E 83-198 order
       Region 2p1l E 199-209 disorder
 Evidence X-RAY 2p1l G Reference
       Region 2p1l G 1-1 disorder
       Region 2p1l G 2-26 order
       Region 2p1l G 83-198 order
       Region 2p1l G 199-209 disorder
 Evidence NMR 2pon B Reference
       Region 2pon B 1-44 order
       Region 2pon B 32-35 high_rmsd
       Region 2pon B 85-196 order
Seq 1-209 Hetero trimer : IID01012Complex
 Evidence X-RAY 4hnj A Reference
       Region 4hnj A 1-24 order
       Region 4hnj A 25-80 disorder
       Region 4hnj A 81-196 order
       Region 4hnj A 197-209 disorder
 Evidence X-RAY 4hnj B Reference
       Region 4hnj B 1-32 order
       Region 4hnj B 33-81 disorder
       Region 4hnj B 82-105 order
       Region 4hnj B 106-120 disorder
       Region 4hnj B 121-131 order
       Region 4hnj B 132-134 disorder
       Region 4hnj B 135-195 order
       Region 4hnj B 196-209 disorder
Seq 1-26,83-209 Homo trimer :
 Evidence X-RAY 6uve A Reference
       Region 6uve A 1-26 order
       Region 6uve A 83-104 order
       Region 6uve A 105-112 disorder
       Region 6uve A 113-196 order
       Region 6uve A 197-209 disorder
 Evidence X-RAY 6uve B Reference
       Region 6uve B 1-3 disorder
       Region 6uve B 4-26 order
       Region 6uve B 83-105 order
       Region 6uve B 106-113 disorder
       Region 6uve B 114-201 order
       Region 6uve B 202-209 disorder
 Evidence X-RAY 6uve C Reference
       Region 6uve C 1-2 disorder
       Region 6uve C 3-26 order
       Region 6uve C 83-206 order
       Region 6uve C 207-209 disorder
Seq 1-44,85-209 Hetero hexamer :
 Evidence X-RAY 7xgg B Reference
       Region 7xgg B 1-2 disorder
       Region 7xgg B 3-28 order
       Region 7xgg B 29-38 disorder
       Region 7xgg B 39-44 order
       Region 7xgg B 85-197 order
       Region 7xgg B 198-209 disorder
 Evidence X-RAY 7xgg C Reference
       Region 7xgg C 1-30 order
       Region 7xgg C 31-39 disorder
       Region 7xgg C 40-44 order
       Region 7xgg C 85-196 order
       Region 7xgg C 197-209 disorder
 Evidence X-RAY 7xgg E Reference
       Region 7xgg E 1-2 disorder
       Region 7xgg E 3-31 order
       Region 7xgg E 32-40 disorder
       Region 7xgg E 41-44 order
       Region 7xgg E 85-197 order
       Region 7xgg E 198-209 disorder
 Evidence X-RAY 7xgg F Reference
       Region 7xgg F 1-28 order
       Region 7xgg F 29-40 disorder
       Region 7xgg F 41-44 order
       Region 7xgg F 85-197 order
       Region 7xgg F 198-209 disorder
Seq 1-23,83-209 Hetero tetramer :
 Evidence X-RAY 4qvx A Reference
       Region 4qvx A 1-1 disorder
       Region 4qvx A 2-22 order
       Region 4qvx A 23-23 disorder
       Region 4qvx A 83-196 order
       Region 4qvx A 197-209 disorder
 Evidence X-RAY 4qvx B Reference
       Region 4qvx B 1-1 disorder
       Region 4qvx B 2-22 order
       Region 4qvx B 23-23 disorder
       Region 4qvx B 83-196 order
       Region 4qvx B 197-209 disorder
Seq 1-44,85-209 Hetero dimer : IID00753Complex
 Evidence NMR 6ijq B Reference
       Region 6ijq B 1-44 order
       Region 6ijq B 29-41 high_rmsd
       Region 6ijq B 85-209 order
       Region 6ijq B 159-169 high_rmsd
Seq 1-26,83-209 Hetero tetramer : IID00746Complex
 Evidence X-RAY 2yq6 A Reference
       Region 2yq6 A 1-26 order
       Region 2yq6 A 83-196 order
       Region 2yq6 A 197-209 disorder
 Evidence X-RAY 2yq7 A Reference
       Region 2yq7 A 1-26 order
       Region 2yq7 A 83-196 order
       Region 2yq7 A 197-209 disorder
 Evidence X-RAY 4a1w A Reference
       Region 4a1w A 1-26 order
       Region 4a1w A 83-197 order
       Region 4a1w A 198-209 disorder
 Evidence X-RAY 4a1w D Reference
       Region 4a1w D 1-26 order
       Region 4a1w D 83-196 order
       Region 4a1w D 197-209 disorder
 Evidence X-RAY 4a1w B Reference
       Region 4a1w B 1-26 order
       Region 4a1w B 83-197 order
       Region 4a1w B 198-209 disorder
 Evidence X-RAY 4a1w C Reference
       Region 4a1w C 1-2 disorder
       Region 4a1w C 3-26 order
       Region 4a1w C 83-196 order
       Region 4a1w C 197-209 disorder
 Evidence X-RAY 5vx3 A Reference
       Region 5vx3 A 1-26 order
       Region 5vx3 A 83-196 order
       Region 5vx3 A 197-209 disorder
 Evidence X-RAY 5vx3 E Reference
       Region 5vx3 E 1-26 order
       Region 5vx3 E 83-197 order
       Region 5vx3 E 198-209 disorder
 Evidence X-RAY 5vx3 C Reference
       Region 5vx3 C 1-26 order
       Region 5vx3 C 83-196 order
       Region 5vx3 C 197-209 disorder
 Evidence X-RAY 5vx3 G Reference
       Region 5vx3 G 1-26 order
       Region 5vx3 G 83-197 order
       Region 5vx3 G 198-209 disorder
Seq 1-44,85-209 Hetero tetramer : A0A369S334
 Evidence X-RAY 6yli A Reference
       Region 6yli A 1-29 order
       Region 6yli A 30-38 disorder
       Region 6yli A 39-44 order
       Region 6yli A 85-200 order
       Region 6yli A 201-209 disorder
 Evidence X-RAY 6yli C Reference
       Region 6yli C 1-28 order
       Region 6yli C 29-38 disorder
       Region 6yli C 39-44 order
       Region 6yli C 85-201 order
       Region 6yli C 202-209 disorder
Seq 1-26,83-209 Homo dodecamer :
 Evidence X-RAY 6uvf A Reference
       Region 6uvf A 1-26 order
       Region 6uvf A 83-196 order
       Region 6uvf A 197-209 disorder
 Evidence X-RAY 6uvf B Reference
       Region 6uvf B 1-26 order
       Region 6uvf B 83-196 order
       Region 6uvf B 197-209 disorder
 Evidence X-RAY 6uvf C Reference
       Region 6uvf C 1-26 order
       Region 6uvf C 83-196 order
       Region 6uvf C 197-209 disorder
 Evidence X-RAY 6uvf D Reference
       Region 6uvf D 1-26 order
       Region 6uvf D 83-196 order
       Region 6uvf D 197-209 disorder
 Evidence X-RAY 6uvf E Reference
       Region 6uvf E 1-26 order
       Region 6uvf E 83-195 order
       Region 6uvf E 196-209 disorder
 Evidence X-RAY 6uvf F Reference
       Region 6uvf F 1-26 order
       Region 6uvf F 83-196 order
       Region 6uvf F 197-209 disorder
 Evidence X-RAY 6uvf G Reference
       Region 6uvf G 1-26 order
       Region 6uvf G 83-195 order
       Region 6uvf G 196-209 disorder
 Evidence X-RAY 6uvf H Reference
       Region 6uvf H 1-26 order
       Region 6uvf H 83-196 order
       Region 6uvf H 197-209 disorder
 Evidence X-RAY 6uvf I Reference
       Region 6uvf I 1-2 disorder
       Region 6uvf I 3-26 order
       Region 6uvf I 83-196 order
       Region 6uvf I 197-209 disorder
 Evidence X-RAY 6uvf J Reference
       Region 6uvf J 1-26 order
       Region 6uvf J 83-195 order
       Region 6uvf J 196-209 disorder
 Evidence X-RAY 6uvf K Reference
       Region 6uvf K 1-26 order
       Region 6uvf K 83-202 order
       Region 6uvf K 203-209 disorder
 Evidence X-RAY 6uvf L Reference
       Region 6uvf L 1-26 order
       Region 6uvf L 83-195 order
       Region 6uvf L 196-209 disorder
Seq 1-26,79-209 Hetero dimer :
 Evidence X-RAY 4cin A Reference
       Region 4cin A 1-1 disorder
       Region 4cin A 2-26 order
       Region 4cin A 83-197 order
       Region 4cin A 198-209 disorder
 Evidence X-RAY 4cin C Reference
       Region 4cin C 79-79 disorder
       Region 4cin C 80-102 order
 Evidence X-RAY 4cin B Reference
       Region 4cin B 1-26 order
       Region 4cin B 83-105 order
       Region 4cin B 106-112 disorder
       Region 4cin B 113-197 order
       Region 4cin B 198-209 disorder
 Evidence X-RAY 4cin D Reference
       Region 4cin D 79-82 disorder
       Region 4cin D 83-101 order
       Region 4cin D 102-102 disorder
Seq 1-26,83-209 Hetero tetramer : I3XMW8
 Evidence X-RAY 5b1z A Reference
       Region 5b1z A 1-26 order
       Region 5b1z A 83-200 order
       Region 5b1z A 201-209 disorder
 Evidence X-RAY 5b1z B Reference
       Region 5b1z B 1-26 order
       Region 5b1z B 83-200 order
       Region 5b1z B 201-209 disorder
Seq 1-25,83-209 Hetero tetramer :
 Evidence X-RAY 7lh7 A Reference
       Region 7lh7 A 1-2 disorder
       Region 7lh7 A 3-25 order
       Region 7lh7 A 83-207 order
       Region 7lh7 A 208-209 disorder
 Evidence X-RAY 7lh7 B Reference
       Region 7lh7 B 1-3 disorder
       Region 7lh7 B 4-22 order
       Region 7lh7 B 23-25 disorder
       Region 7lh7 B 83-198 order
       Region 7lh7 B 199-209 disorder
Seq 1-26,83-209 Hetero tetramer : O08734
 Evidence X-RAY 5fmj A Reference
       Region 5fmj A 1-26 order
       Region 5fmj A 83-208 order
       Region 5fmj A 209-209 disorder
Seq 1-26,83-209 Hetero tetramer : Q16611
 Evidence X-RAY 5fmk A Reference
       Region 5fmk A 1-1 disorder
       Region 5fmk A 2-26 order
       Region 5fmk A 83-207 order
       Region 5fmk A 208-209 disorder
Seq 1-44,83-209 Hetero dimer : IID00746Complex
 Evidence X-RAY 3fdl A Reference
       Region 3fdl A 1-26 order
       Region 3fdl A 83-194 order
       Region 3fdl A 195-209 disorder
 Evidence X-RAY 3io8 A Reference
       Region 3io8 A 1-26 order
       Region 3io8 A 83-108 order
       Region 3io8 A 109-111 disorder
       Region 3io8 A 112-197 order
       Region 3io8 A 198-209 disorder
 Evidence X-RAY 3io8 C Reference
       Region 3io8 C 1-26 order
       Region 3io8 C 83-197 order
       Region 3io8 C 198-209 disorder
 Evidence X-RAY 4a1u A Reference
       Region 4a1u A 1-26 order
       Region 4a1u A 83-206 order
       Region 4a1u A 207-209 disorder
 Evidence X-RAY 4qvf A Reference
       Region 4qvf A 1-1 disorder
       Region 4qvf A 2-30 order
       Region 4qvf A 31-44 disorder
       Region 4qvf A 85-196 order
       Region 4qvf A 197-209 disorder
Seq 1-26,83-209 Homo tetramer :
 Evidence X-RAY 6uvh A Reference
       Region 6uvh A 1-26 order
       Region 6uvh A 83-196 order
       Region 6uvh A 197-209 disorder
 Evidence X-RAY 6uvh B Reference
       Region 6uvh B 1-26 order
       Region 6uvh B 83-196 order
       Region 6uvh B 197-209 disorder
 Evidence X-RAY 6uvh C Reference
       Region 6uvh C 1-26 order
       Region 6uvh C 83-196 order
       Region 6uvh C 197-209 disorder
 Evidence X-RAY 6uvh D Reference
       Region 6uvh D 1-26 order
       Region 6uvh D 83-196 order
       Region 6uvh D 197-209 disorder
Seq 1-26,83-209 Homo tetramer :
 Evidence X-RAY 4c5d A Reference
       Region 4c5d A 1-26 order
       Region 4c5d A 83-196 order
       Region 4c5d A 197-209 disorder
 Evidence X-RAY 4c5d B Reference
       Region 4c5d B 1-26 order
       Region 4c5d B 83-198 order
       Region 4c5d B 199-209 disorder
Seq 1-25,83-209 Hetero tetramer :
 Evidence X-RAY 6vwc A Reference
       Region 6vwc A 1-1 disorder
       Region 6vwc A 2-25 order
       Region 6vwc A 83-196 order
       Region 6vwc A 197-209 disorder
 Evidence X-RAY 6vwc B Reference
       Region 6vwc B 1-1 disorder
       Region 6vwc B 2-24 order
       Region 6vwc B 25-25 disorder
       Region 6vwc B 83-196 order
       Region 6vwc B 197-209 disorder
Seq 1-209 Hetero dimer : Q16611
 Evidence NMR 1bxl A Reference
       Region 1bxl A 1-44 order
       Region 1bxl A 45-84 disorder
       Region 1bxl A 85-209 order
 Evidence NMR 2lp8 A Reference
       Region 2lp8 A 1-44 order
       Region 2lp8 A 1-1 high_rmsd
       Region 2lp8 A 85-209 order
       Region 2lp8 A 163-169 high_rmsd
Seq 1-209 Hetero dimer : IID00015Complex
 Evidence NMR 2mej A Reference
       Region 2mej A 1-28 order
       Region 2mej A 29-82 disorder
       Region 2mej A 83-198 order
       Region 2mej A 199-209 disorder
Seq 1-26,83-209 Hetero tetramer :
 Evidence X-RAY 6st2 A Reference
       Region 6st2 A 1-26 order
       Region 6st2 A 83-199 order
       Region 6st2 A 200-209 disorder
 Evidence X-RAY 6st2 B Reference
       Region 6st2 B 1-1 disorder
       Region 6st2 B 2-26 order
       Region 6st2 B 83-199 order
       Region 6st2 B 200-209 disorder
Seq 1-211 Monomer :
 Evidence NMR 1lxl A Reference
       Region 1lxl A 1-209 order
 Evidence X-RAY 1maz A Reference
       Region 1maz A 1-27 order
       Region 1maz A 28-80 disorder
       Region 1maz A 81-196 order
       Region 1maz A 197-209 disorder
 Evidence X-RAY 1r2d A Reference
       Region 1r2d A 1-27 order
       Region 1r2d A 28-81 disorder
       Region 1r2d A 82-196 order
       Region 1r2d A 197-211 disorder
 Evidence X-RAY 1r2e A Reference
       Region 1r2e A 1-1 disorder
       Region 1r2e A 2-27 order
       Region 1r2e A 28-79 disorder
       Region 1r2e A 80-196 order
       Region 1r2e A 197-211 disorder
 Evidence X-RAY 1r2g A Reference
       Region 1r2g A 1-27 order
       Region 1r2g A 28-80 disorder
       Region 1r2g A 81-196 order
       Region 1r2g A 197-211 disorder
 Evidence X-RAY 1r2h A Reference
       Region 1r2h A 1-27 order
       Region 1r2h A 28-81 disorder
       Region 1r2h A 82-196 order
       Region 1r2h A 197-211 disorder
 Evidence X-RAY 1r2i A Reference
       Region 1r2i A 1-27 order
       Region 1r2i A 28-81 disorder
       Region 1r2i A 82-197 order
       Region 1r2i A 198-211 disorder
 Evidence NMR 1ysg A Reference
       Region 1ysg A 1-44 order
       Region 1ysg A 85-209 order
 Evidence NMR 1ysi A Reference
       Region 1ysi A 1-44 order
       Region 1ysi A 85-209 order
 Evidence NMR 1ysn A Reference
       Region 1ysn A 1-44 order
       Region 1ysn A 85-209 order
 Evidence NMR 2lpc A Reference
       Region 2lpc A 1-44 order
       Region 2lpc A 85-209 order
       Region 2lpc A 158-169 high_rmsd
 Evidence NMR 2m03 A Reference
       Region 2m03 A 1-44 order
       Region 2m03 A 24-41 high_rmsd
       Region 2m03 A 85-209 order
       Region 2m03 A 156-169 high_rmsd
 Evidence NMR 2me8 A Reference
       Region 2me8 A 1-209 order
       Region 2me8 A 1-1 high_rmsd
       Region 2me8 A 25-84 high_rmsd
       Region 2me8 A 197-209 high_rmsd
 Evidence NMR 2me9 A Reference
       Region 2me9 A 1-209 order
       Region 2me9 A 21-84 high_rmsd
       Region 2me9 A 103-104 high_rmsd
       Region 2me9 A 117-117 high_rmsd
       Region 2me9 A 193-209 high_rmsd
 Evidence NMR 2o1y A Reference
       Region 2o1y A 1-44 order
       Region 2o1y A 85-209 order
 Evidence X-RAY 2yxj A Reference
       Region 2yxj A 1-3 disorder
       Region 2yxj A 4-25 order
       Region 2yxj A 26-42 disorder
       Region 2yxj A 43-44 order
       Region 2yxj A 85-197 order
       Region 2yxj A 198-209 disorder
 Evidence X-RAY 2yxj B Reference
       Region 2yxj B 1-1 disorder
       Region 2yxj B 2-29 order
       Region 2yxj B 30-42 disorder
       Region 2yxj B 43-44 order
       Region 2yxj B 85-196 order
       Region 2yxj B 197-209 disorder
 Evidence X-RAY 3cva X Reference
       Region 3cva X 1-1 disorder
       Region 3cva X 2-27 order
       Region 3cva X 28-81 disorder
       Region 3cva X 82-196 order
       Region 3cva X 197-211 disorder
 Evidence X-RAY 3qkd A Reference
       Region 3qkd A 1-3 disorder
       Region 3qkd A 4-28 order
       Region 3qkd A 29-42 disorder
       Region 3qkd A 43-44 order
       Region 3qkd A 85-197 order
       Region 3qkd A 198-209 disorder
 Evidence X-RAY 3qkd B Reference
       Region 3qkd B 1-1 disorder
       Region 3qkd B 2-29 order
       Region 3qkd B 30-42 disorder
       Region 3qkd B 43-44 order
       Region 3qkd B 85-196 order
       Region 3qkd B 197-209 disorder
 Evidence X-RAY 3sp7 A Reference
       Region 3sp7 A 1-29 order
       Region 3sp7 A 30-41 disorder
       Region 3sp7 A 42-44 order
       Region 3sp7 A 85-199 order
       Region 3sp7 A 200-209 disorder
 Evidence X-RAY 3spf A Reference
       Region 3spf A 1-25 order
       Region 3spf A 26-41 disorder
       Region 3spf A 42-44 order
       Region 3spf A 85-197 order
       Region 3spf A 198-209 disorder
 Evidence X-RAY 3zk6 A Reference
       Region 3zk6 A 1-1 disorder
       Region 3zk6 A 2-28 order
       Region 3zk6 A 29-40 disorder
       Region 3zk6 A 81-197 order
       Region 3zk6 A 198-209 disorder
 Evidence X-RAY 3zk6 B Reference
       Region 3zk6 B 1-1 disorder
       Region 3zk6 B 2-28 order
       Region 3zk6 B 29-40 disorder
       Region 3zk6 B 81-197 order
       Region 3zk6 B 198-209 disorder
 Evidence X-RAY 3zln A Reference
       Region 3zln A 1-27 order
       Region 3zln A 28-40 disorder
       Region 3zln A 41-44 order
       Region 3zln A 85-196 order
       Region 3zln A 197-209 disorder
 Evidence X-RAY 3zlo A Reference
       Region 3zlo A 1-1 disorder
       Region 3zlo A 2-26 order
       Region 3zlo A 27-40 disorder
       Region 3zlo A 41-44 order
       Region 3zlo A 85-196 order
       Region 3zlo A 197-209 disorder
 Evidence X-RAY 4ehr A Reference
       Region 4ehr A 1-1 disorder
       Region 4ehr A 2-26 order
       Region 4ehr A 27-42 disorder
       Region 4ehr A 43-44 order
       Region 4ehr A 85-196 order
       Region 4ehr A 197-209 disorder
 Evidence NMR 6bf2 A Reference
       Region 6bf2 A 1-209 order
       Region 6bf2 A 32-40 high_rmsd
       Region 6bf2 A 48-48 high_rmsd
       Region 6bf2 A 77-80 high_rmsd
       Region 6bf2 A 202-209 high_rmsd
 Evidence X-RAY 7ca4 A Reference
       Region 7ca4 A 1-27 order
       Region 7ca4 A 28-81 disorder
       Region 7ca4 A 82-197 order
       Region 7ca4 A 198-211 disorder
 Evidence X-RAY 7jgw A Reference
       Region 7jgw A 1-26 order
       Region 7jgw A 83-196 order
       Region 7jgw A 197-209 disorder
Seq 1-211 Homo dimer :
 Evidence X-RAY 2b48 A Reference
       Region 2b48 A 1-24 order
       Region 2b48 A 25-81 disorder
       Region 2b48 A 82-200 order
       Region 2b48 A 201-211 disorder
 Evidence X-RAY 2yj1 A Reference
       Region 2yj1 A 1-26 order
       Region 2yj1 A 83-202 order
       Region 2yj1 A 203-209 disorder
 Evidence X-RAY 2yj1 C Reference
       Region 2yj1 C 1-26 order
       Region 2yj1 C 83-196 order
       Region 2yj1 C 197-209 disorder
 Evidence X-RAY 3fdm A Reference
       Region 3fdm A 1-26 order
       Region 3fdm A 83-198 order
       Region 3fdm A 199-209 disorder
 Evidence X-RAY 3fdm B Reference
       Region 3fdm B 1-26 order
       Region 3fdm B 83-197 order
       Region 3fdm B 198-209 disorder
 Evidence X-RAY 3fdm C Reference
       Region 3fdm C 1-1 disorder
       Region 3fdm C 2-26 order
       Region 3fdm C 83-198 order
       Region 3fdm C 199-209 disorder
 Evidence X-RAY 3inq A Reference
       Region 3inq A 1-2 disorder
       Region 3inq A 3-26 order
       Region 3inq A 83-196 order
       Region 3inq A 197-209 disorder
 Evidence X-RAY 3inq B Reference
       Region 3inq B 1-26 order
       Region 3inq B 83-196 order
       Region 3inq B 197-209 disorder
 Evidence X-RAY 3wiz A Reference
       Region 3wiz A 1-2 disorder
       Region 3wiz A 3-27 order
       Region 3wiz A 28-40 disorder
       Region 3wiz A 41-44 order
       Region 3wiz A 85-196 order
       Region 3wiz A 197-209 disorder
 Evidence X-RAY 3wiz B Reference
       Region 3wiz B 1-2 disorder
       Region 3wiz B 3-27 order
       Region 3wiz B 28-40 disorder
       Region 3wiz B 41-44 order
       Region 3wiz B 85-196 order
       Region 3wiz B 197-209 disorder
 Evidence X-RAY 3zlr A Reference
       Region 3zlr A 1-26 order
       Region 3zlr A 83-197 order
       Region 3zlr A 198-209 disorder
 Evidence X-RAY 3zlr B Reference
       Region 3zlr B 1-3 disorder
       Region 3zlr B 4-26 order
       Region 3zlr B 83-203 order
       Region 3zlr B 204-209 disorder
 Evidence X-RAY 4c52 A Reference
       Region 4c52 A 1-26 order
       Region 4c52 A 83-196 order
       Region 4c52 A 197-209 disorder
 Evidence X-RAY 4c52 B Reference
       Region 4c52 B 1-26 order
       Region 4c52 B 83-198 order
       Region 4c52 B 199-209 disorder
 Evidence X-RAY 4tuh A Reference
       Region 4tuh A 1-26 order
       Region 4tuh A 83-196 order
       Region 4tuh A 197-209 disorder
 Evidence X-RAY 4tuh B Reference
       Region 4tuh B 1-26 order
       Region 4tuh B 83-196 order
       Region 4tuh B 197-209 disorder
 Evidence X-RAY 4tuh C Reference
       Region 4tuh C 1-26 order
       Region 4tuh C 83-197 order
       Region 4tuh C 198-209 disorder
 Evidence X-RAY 4tuh D Reference
       Region 4tuh D 1-26 order
       Region 4tuh D 83-197 order
       Region 4tuh D 198-209 disorder
 Evidence X-RAY 4tuh E Reference
       Region 4tuh E 1-26 order
       Region 4tuh E 83-196 order
       Region 4tuh E 197-209 disorder
 Evidence X-RAY 4tuh F Reference
       Region 4tuh F 1-26 order
       Region 4tuh F 83-198 order
       Region 4tuh F 199-209 disorder
 Evidence X-RAY 4tuh G Reference
       Region 4tuh G 1-26 order
       Region 4tuh G 83-196 order
       Region 4tuh G 197-209 disorder
 Evidence X-RAY 4tuh H Reference
       Region 4tuh H 1-26 order
       Region 4tuh H 83-197 order
       Region 4tuh H 198-209 disorder
 Evidence X-RAY 6rnu A Reference
       Region 6rnu A 1-1 disorder
       Region 6rnu A 2-28 order
       Region 6rnu A 29-41 disorder
       Region 6rnu A 42-44 order
       Region 6rnu A 85-196 order
       Region 6rnu A 197-209 disorder
 Evidence X-RAY 6rnu B Reference
       Region 6rnu B 1-1 disorder
       Region 6rnu B 2-28 order
       Region 6rnu B 29-41 disorder
       Region 6rnu B 42-44 order
       Region 6rnu B 85-196 order
       Region 6rnu B 197-209 disorder
 Evidence X-RAY 6uvc A Reference
       Region 6uvc A 1-1 disorder
       Region 6uvc A 2-26 order
       Region 6uvc A 83-197 order
       Region 6uvc A 198-209 disorder
 Evidence X-RAY 6uvc B Reference
       Region 6uvc B 1-26 order
       Region 6uvc B 83-197 order
       Region 6uvc B 198-209 disorder
 Evidence X-RAY 6uvd A Reference
       Region 6uvd A 1-26 order
       Region 6uvd A 83-197 order
       Region 6uvd A 198-209 disorder
 Evidence X-RAY 6uvd B Reference
       Region 6uvd B 1-2 disorder
       Region 6uvd B 3-26 order
       Region 6uvd B 83-196 order
       Region 6uvd B 197-209 disorder
 Evidence X-RAY 7jgv A Reference
       Region 7jgv A 1-26 order
       Region 7jgv A 83-196 order
       Region 7jgv A 197-209 disorder
 Evidence X-RAY 7jgv B Reference
       Region 7jgv B 1-26 order
       Region 7jgv B 83-197 order
       Region 7jgv B 198-209 disorder
Seq 2-20,83-196 Hetero dimer :
 Evidence NMR 2o2m A Reference
       Region 2o2m A 2-20 order
       Region 2o2m A 83-196 order
Seq 2-20,83-196 Hetero dimer :
 Evidence NMR 2o2n A Reference
       Region 2o2n A 2-20 order
       Region 2o2n A 83-196 order
Seq 2-44,85-201 Hetero tetramer : IID00015Complex
 Evidence X-RAY 6lhd A Reference
       Region 6lhd A 2-2 disorder
       Region 6lhd A 3-25 order
       Region 6lhd A 26-44 disorder
       Region 6lhd A 85-103 order
       Region 6lhd A 104-111 disorder
       Region 6lhd A 112-130 order
       Region 6lhd A 131-132 disorder
       Region 6lhd A 133-189 order
       Region 6lhd A 190-201 disorder
 Evidence X-RAY 6lhd B Reference
       Region 6lhd B 2-2 disorder
       Region 6lhd B 3-29 order
       Region 6lhd B 30-43 disorder
       Region 6lhd B 44-44 order
       Region 6lhd B 85-195 order
       Region 6lhd B 196-201 disorder
Seq 29-44 Hetero tetramer : IID00707Complex,IID00746Complex
 Evidence X-RAY 5agx A Reference
       Region 5agx A 29-42 disorder
       Region 5agx A 43-44 order
Seq 29-44 Hetero tetramer : IID00707Complex,IID00746Complex
 Evidence X-RAY 5agx B Reference
       Region 5agx B 29-41 disorder
       Region 5agx B 42-44 order
Seqdisorder 29-44
 Evidence X-RAY 4aq3 B Reference
       Region 4aq3 B 29-44 disorder
Seq 29-44 Hetero hexamer : IID00707Complex
 Evidence X-RAY 6o0l A Reference
       Region 6o0l A 29-42 disorder
       Region 6o0l A 43-44 order
 Evidence X-RAY 6o0l C Reference
       Region 6o0l C 29-42 disorder
       Region 6o0l C 43-44 order
Seq 29-44 Hetero tetramer : IID00669Complex,IID00707Complex
 Evidence X-RAY 5vay B Reference
       Region 5vay B 29-41 disorder
       Region 5vay B 42-44 order
Seqdisorder 29-44
 Evidence X-RAY 4aq3 C Reference
       Region 4aq3 C 29-44 disorder
Seqdisorder 29-44
 Evidence X-RAY 4aq3 A Reference
       Region 4aq3 A 29-44 disorder
Seq 29-44 Hetero trimer : IID00707Complex
 Evidence X-RAY 6o0k A Reference
       Region 6o0k A 29-29 order
       Region 6o0k A 30-42 disorder
       Region 6o0k A 43-44 order
Seq 29-44 Hetero tetramer : IID00669Complex,IID00707Complex
 Evidence X-RAY 5vay C Reference
       Region 5vay C 29-42 disorder
       Region 5vay C 43-44 order
Seq 29-44 Hetero tetramer : IID00707Complex,IID00746Complex
 Evidence X-RAY 5agw B Reference
       Region 5agw B 29-42 disorder
       Region 5agw B 43-44 order
Seq 29-44 Hetero tetradecamer : IID00707Complex
 Evidence X-RAY 4aq3 D Reference
       Region 4aq3 D 29-42 disorder
       Region 4aq3 D 43-44 order
 Evidence X-RAY 4aq3 F Reference
       Region 4aq3 F 29-43 disorder
       Region 4aq3 F 44-44 order
Seq 29-44 Hetero trimer : IID00707Complex
 Evidence X-RAY 6o0m A Reference
       Region 6o0m A 29-42 disorder
       Region 6o0m A 43-44 order
Seq 29-44 Hetero tetramer : IID00669Complex,IID00707Complex
 Evidence X-RAY 5vay A Reference
       Region 5vay A 29-42 disorder
       Region 5vay A 43-44 order
Seq 29-44 Hetero hexamer : IID00707Complex
 Evidence X-RAY 6o0o A Reference
       Region 6o0o A 29-43 disorder
       Region 6o0o A 44-44 order
 Evidence X-RAY 6o0o C Reference
       Region 6o0o C 29-43 disorder
       Region 6o0o C 44-44 order
Seq 29-44 Hetero tetramer : IID00669Complex,IID00707Complex
 Evidence X-RAY 5vay D Reference
       Region 5vay D 29-42 disorder
       Region 5vay D 43-44 order
Seqdisorder 29-44
 Evidence X-RAY 4aq3 E Reference
       Region 4aq3 E 29-44 disorder
Seq 29-44 Hetero tetramer : IID00707Complex,IID00746Complex
 Evidence X-RAY 5agw A Reference
       Region 5agw A 29-42 disorder
       Region 5agw A 43-44 order
Seq 29-44 Hetero trimer : IID00707Complex
 Evidence X-RAY 4ieh A Reference
       Region 4ieh A 29-42 disorder
       Region 4ieh A 43-44 order
Seq 29-44 Hetero trimer : IID00707Complex
 Evidence X-RAY 6o0p A Reference
       Region 6o0p A 29-29 order
       Region 6o0p A 30-42 disorder
       Region 6o0p A 43-44 order
Seq 29-44 Hetero trimer : IID00707Complex
 Evidence NMR 8u27 A Reference
       Region 8u27 A 29-44 order
       Region 8u27 A 29-38 high_rmsd
Seq 83-197 Hetero octamer :
 Evidence X-RAY 6hjl A Reference
       Region 6hjl A 83-197 order
 Evidence X-RAY 6hjl B Reference
       Region 6hjl B 83-195 order
 Evidence X-RAY 6hjl E Reference
       Region 6hjl E 83-195 order
 Evidence X-RAY 6hjl F Reference
       Region 6hjl F 83-195 order
Seq 83-209 Hetero hexamer : IID00746Complex,IID50336Complex
 Evidence X-RAY 5c3g A Reference
       Region 5c3g A 83-196 order
       Region 5c3g A 197-209 disorder
Seq 202-233 Monomer :
 Evidence NMR 6f46 A Reference
       Region 6f46 A 202-233 order
       Region 6f46 A 202-211 high_rmsd
       Region 6f46 A 232-233 high_rmsd
SeqProS verified 51-66 Allosteric regulation of Bcl-xL enabled by posttranslational modifications in the IDR. The ProS region is defined based on Fig.3 in PMID: 29507390. :
       Region 6bf2 A 1-209 order
       Region 1r2g A 28-80 disorder
Seqphosphorylation
    62-62 Phosphoserine; by CDK1
    49-49 Phosphoserine; by PLK3
    49-49 Phosphoserine; by PLK3
    62-62 Phosphoserine; by CDK1
 
Prediction
NeProc
Disorder 28-82,201-212,231-233
Order 1-27,83-200,213-230
ProS 31-36,53-65,207-212,231-233
AlphaFold
Disorder 1-1,29-81,105-105,108-108,197-233
Order 2-28,82-104,106-107,109-196
Pfam Hmmer
PF02180 1-27 2.5e-14
PF00452 90-188 4.3e-59
Function
Function in SwissProt
Potent inhibitor of cell death. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis.
Isoform Bcl-X(L) also regulates presynaptic plasticity, including neurotransmitter release and recovery, number of axonal mitochondria as well as size and number of synaptic vesicle clusters. During synaptic stimulation, increases ATP availability from mitochondria through regulation of mitochondrial membrane ATP synthase F(1)F(0) activity and regulates endocytic vesicle retrieval in hippocampal neurons through association with DMN1L and stimulation of its GTPase activity in synaptic vesicles. May attenuate inflammation impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release (PubMed
17418785).
Isoform Bcl-X(S) promotes apoptosis.
Biological Process
See also
Diagram with PDB data
TP73/BCL2L1Solution structure of BCL-XL bound to P73-TAD peptide
BECN1/BCL2L1Solution structure of the Bcl-xL/Beclin-1 complex
BBC3/BCL2L1Solution structure of BCL-xL in complex with PUMA BH3 peptide