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IID00767
 UniprotP05106
ProteinIntegrin beta-3
GeneITGB3
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
788
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 27-487 Hetero tetramer : P08514
 Evidence X-RAY 2vdk B Reference
       Region 2vdk B 27-98 order
       Region 2vdk B 99-104 disorder
       Region 2vdk B 105-487 order
Seq 27-487 Hetero hexamer : P08514
 Evidence X-RAY 1tye B Reference
       Region 1tye B 27-466 order
 Evidence X-RAY 1tye D Reference
       Region 1tye D 27-466 order
 Evidence X-RAY 1tye F Reference
       Region 1tye F 27-466 order
 Evidence X-RAY 3fcu B Reference
       Region 3fcu B 27-98 order
       Region 3fcu B 99-104 disorder
       Region 3fcu B 105-487 order
 Evidence X-RAY 3fcu D Reference
       Region 3fcu D 27-98 order
       Region 3fcu D 99-104 disorder
       Region 3fcu D 105-487 order
 Evidence X-RAY 3fcu F Reference
       Region 3fcu F 27-98 order
       Region 3fcu F 99-104 disorder
       Region 3fcu F 105-487 order
Seq 27-487 Hetero tetramer : P08514
 Evidence X-RAY 2vdm B Reference
       Region 2vdm B 27-98 order
       Region 2vdm B 99-103 disorder
       Region 2vdm B 104-487 order
Seq 27-487 Hetero pentamer : P02679,P08514
 Evidence X-RAY 2vdo B Reference
       Region 2vdo B 27-98 order
       Region 2vdo B 99-104 disorder
       Region 2vdo B 105-487 order
Seq 27-487 Hetero pentamer : P02679,P08514
 Evidence X-RAY 2vdp B Reference
       Region 2vdp B 27-98 order
       Region 2vdp B 99-104 disorder
       Region 2vdp B 105-487 order
Seq 27-487 Hetero pentamer : P02679,P08514
 Evidence X-RAY 2vdr B Reference
       Region 2vdr B 27-98 order
       Region 2vdr B 99-104 disorder
       Region 2vdr B 105-487 order
Seq 27-487 Hetero tetramer : P08514
 Evidence X-RAY 2vc2 B Reference
       Region 2vc2 B 27-98 order
       Region 2vc2 B 99-102 disorder
       Region 2vc2 B 103-487 order
Seq 27-487 Hetero pentamer : P02679,P08514
 Evidence X-RAY 2vdq B Reference
       Region 2vdq B 27-98 order
       Region 2vdq B 99-104 disorder
       Region 2vdq B 105-487 order
Seq 27-487 Hetero tetramer : P08514
 Evidence X-RAY 2vdn B Reference
       Region 2vdn B 27-98 order
       Region 2vdn B 99-104 disorder
       Region 2vdn B 105-487 order
Seq 27-487 Hetero tetramer : P08514
 Evidence X-RAY 2vdl B Reference
       Region 2vdl B 27-98 order
       Region 2vdl B 99-103 disorder
       Region 2vdl B 104-487 order
Seq 27-497 Hetero octamer : P08514
 Evidence X-RAY 3nif B Reference
       Region 3nif B 27-492 order
       Region 3nif B 493-497 disorder
 Evidence X-RAY 3nif D Reference
       Region 3nif D 27-493 order
       Region 3nif D 494-497 disorder
Seq 27-497 Hetero octamer : P08514
 Evidence X-RAY 7td8 B Reference
       Region 7td8 B 27-492 order
       Region 7td8 B 493-497 disorder
 Evidence X-RAY 7td8 D Reference
       Region 7td8 D 27-497 order
Seq 27-497 Hetero decamer : P08514
 Evidence X-RAY 4z7q B Reference
       Region 4z7q B 27-492 order
       Region 4z7q B 493-497 disorder
 Evidence X-RAY 4z7q D Reference
       Region 4z7q D 27-497 order
Seq 27-497 Hetero octamer : P08514
 Evidence X-RAY 7tpd B Reference
       Region 7tpd B 27-492 order
       Region 7tpd B 493-497 disorder
 Evidence X-RAY 7tpd D Reference
       Region 7tpd D 27-497 order
Seq 27-497 Hetero octamer : P08514
 Evidence X-RAY 3nig B Reference
       Region 3nig B 27-492 order
       Region 3nig B 493-497 disorder
 Evidence X-RAY 3nig D Reference
       Region 3nig D 27-497 order
Seq 27-497 Hetero octamer : P08514
 Evidence X-RAY 3nid B Reference
       Region 3nid B 27-492 order
       Region 3nid B 493-497 disorder
 Evidence X-RAY 3nid D Reference
       Region 3nid D 27-497 order
Seq 27-497 Hetero octamer : P08514
 Evidence X-RAY 7uje B Reference
       Region 7uje B 27-492 order
       Region 7uje B 493-497 disorder
 Evidence X-RAY 7uje D Reference
       Region 7uje D 27-497 order
Seq 27-497 Hetero decamer : P08514
 Evidence X-RAY 7u60 B Reference
       Region 7u60 B 27-28 disorder
       Region 7u60 B 29-492 order
       Region 7u60 B 493-497 disorder
 Evidence X-RAY 7u60 D Reference
       Region 7u60 D 27-28 disorder
       Region 7u60 D 29-497 order
Seq 27-497 Hetero octamer : P08514
 Evidence X-RAY 7tmz B Reference
       Region 7tmz B 27-492 order
       Region 7tmz B 493-497 disorder
 Evidence X-RAY 7tmz D Reference
       Region 7tmz D 27-497 order
Seq 27-497 Hetero octamer : P08514
 Evidence X-RAY 5hdb B Reference
       Region 5hdb B 27-492 order
       Region 5hdb B 493-497 disorder
 Evidence X-RAY 5hdb D Reference
       Region 5hdb D 27-497 order
Seq 27-497 Hetero octamer : P08514
 Evidence X-RAY 7u9v B Reference
       Region 7u9v B 27-492 order
       Region 7u9v B 493-497 disorder
 Evidence X-RAY 7u9v D Reference
       Region 7u9v D 27-497 order
Seq 27-497 Hetero octamer : P08514
 Evidence X-RAY 7u9f B Reference
       Region 7u9f B 27-492 order
       Region 7u9f B 493-497 disorder
 Evidence X-RAY 7u9f D Reference
       Region 7u9f D 27-497 order
Seq 27-497 Hetero octamer : P08514
 Evidence X-RAY 7tho B Reference
       Region 7tho B 27-492 order
       Region 7tho B 493-497 disorder
 Evidence X-RAY 7tho D Reference
       Region 7tho D 27-497 order
Seq 27-498 Hetero octamer : P08514
 Evidence X-RAY 3t3p B Reference
       Region 3t3p B 27-492 order
       Region 3t3p B 493-498 disorder
 Evidence X-RAY 3t3p D Reference
       Region 3t3p D 27-497 order
       Region 3t3p D 498-498 disorder
Seq 27-498 Hetero octamer : P08514
 Evidence X-RAY 7ucy B Reference
       Region 7ucy B 27-492 order
       Region 7ucy B 493-498 disorder
 Evidence X-RAY 7ucy D Reference
       Region 7ucy D 27-497 order
       Region 7ucy D 498-498 disorder
Seq 27-498 Hetero decamer : P08514
 Evidence X-RAY 3zdz B Reference
       Region 3zdz B 27-28 disorder
       Region 3zdz B 29-492 order
       Region 3zdz B 493-498 disorder
 Evidence X-RAY 3zdz D Reference
       Region 3zdz D 27-28 disorder
       Region 3zdz D 29-497 order
       Region 3zdz D 498-498 disorder
Seq 27-498 Hetero decamer : P08514
 Evidence X-RAY 3zdy B Reference
       Region 3zdy B 27-28 disorder
       Region 3zdy B 29-492 order
       Region 3zdy B 493-498 disorder
 Evidence X-RAY 3zdy D Reference
       Region 3zdy D 27-28 disorder
       Region 3zdy D 29-497 order
       Region 3zdy D 498-498 disorder
Seq 27-498 Hetero octamer : P08514
 Evidence X-RAY 7ukp B Reference
       Region 7ukp B 27-492 order
       Region 7ukp B 493-498 disorder
 Evidence X-RAY 7ukp D Reference
       Region 7ukp D 27-497 order
       Region 7ukp D 498-498 disorder
Seq 27-498 Hetero octamer : P08514
 Evidence X-RAY 7l8p B Reference
       Region 7l8p B 27-492 order
       Region 7l8p B 493-498 disorder
 Evidence X-RAY 7l8p D Reference
       Region 7l8p D 27-497 order
       Region 7l8p D 498-498 disorder
Seq 27-498 Hetero octamer : P08514
 Evidence X-RAY 7ubr B Reference
       Region 7ubr B 27-492 order
       Region 7ubr B 493-498 disorder
 Evidence X-RAY 7ubr D Reference
       Region 7ubr D 27-497 order
       Region 7ubr D 498-498 disorder
Seq 27-498 Hetero octamer : P08514
 Evidence X-RAY 7uk9 B Reference
       Region 7uk9 B 27-492 order
       Region 7uk9 B 493-498 disorder
 Evidence X-RAY 7uk9 D Reference
       Region 7uk9 D 27-497 order
       Region 7uk9 D 498-498 disorder
Seq 27-498 Hetero octamer : P08514
 Evidence X-RAY 3zdx B Reference
       Region 3zdx B 27-28 disorder
       Region 3zdx B 29-492 order
       Region 3zdx B 493-498 disorder
 Evidence X-RAY 3zdx D Reference
       Region 3zdx D 27-28 disorder
       Region 3zdx D 29-497 order
       Region 3zdx D 498-498 disorder
Seq 27-498 Hetero octamer : P08514
 Evidence X-RAY 7udg B Reference
       Region 7udg B 27-492 order
       Region 7udg B 493-498 disorder
 Evidence X-RAY 7udg D Reference
       Region 7udg D 27-497 order
       Region 7udg D 498-498 disorder
Seq 27-498 Hetero octamer : P08514
 Evidence X-RAY 7ukt B Reference
       Region 7ukt B 27-492 order
       Region 7ukt B 493-498 disorder
 Evidence X-RAY 7ukt D Reference
       Region 7ukt D 27-497 order
       Region 7ukt D 498-498 disorder
Seq 27-498 Hetero octamer : P08514
 Evidence X-RAY 7udh B Reference
       Region 7udh B 27-492 order
       Region 7udh B 493-498 disorder
 Evidence X-RAY 7udh D Reference
       Region 7udh D 27-497 order
       Region 7udh D 498-498 disorder
Seq 27-498 Hetero octamer : P08514
 Evidence X-RAY 7tct B Reference
       Region 7tct B 27-492 order
       Region 7tct B 493-498 disorder
 Evidence X-RAY 7tct D Reference
       Region 7tct D 27-497 order
       Region 7tct D 498-498 disorder
Seq 27-498 Hetero octamer : P08514
 Evidence X-RAY 7ue0 B Reference
       Region 7ue0 B 27-492 order
       Region 7ue0 B 493-498 disorder
 Evidence X-RAY 7ue0 D Reference
       Region 7ue0 D 27-497 order
       Region 7ue0 D 498-498 disorder
Seq 27-498 Hetero octamer : P08514
 Evidence X-RAY 7uko B Reference
       Region 7uko B 27-492 order
       Region 7uko B 493-498 disorder
 Evidence X-RAY 7uko D Reference
       Region 7uko D 27-497 order
       Region 7uko D 498-498 disorder
Seq 27-498 Hetero octamer : P08514
 Evidence X-RAY 7uh8 B Reference
       Region 7uh8 B 27-492 order
       Region 7uh8 B 493-498 disorder
 Evidence X-RAY 7uh8 D Reference
       Region 7uh8 D 27-497 order
       Region 7uh8 D 498-498 disorder
Seq 27-498 Hetero decamer : P08514
 Evidence X-RAY 3ze1 B Reference
       Region 3ze1 B 27-28 disorder
       Region 3ze1 B 29-492 order
       Region 3ze1 B 493-498 disorder
 Evidence X-RAY 3ze1 D Reference
       Region 3ze1 D 27-28 disorder
       Region 3ze1 D 29-497 order
       Region 3ze1 D 498-498 disorder
Seq 27-498 Hetero octamer : P08514
 Evidence X-RAY 7ujk B Reference
       Region 7ujk B 27-492 order
       Region 7ujk B 493-498 disorder
 Evidence X-RAY 7ujk D Reference
       Region 7ujk D 27-497 order
       Region 7ujk D 498-498 disorder
Seq 27-498 Hetero octamer : P08514
 Evidence X-RAY 3t3m B Reference
       Region 3t3m B 27-492 order
       Region 3t3m B 493-498 disorder
 Evidence X-RAY 3t3m D Reference
       Region 3t3m D 27-497 order
       Region 3t3m D 498-498 disorder
Seq 27-498 Hetero decamer : P08514
 Evidence X-RAY 3ze0 B Reference
       Region 3ze0 B 27-27 disorder
       Region 3ze0 B 28-492 order
       Region 3ze0 B 493-498 disorder
 Evidence X-RAY 3ze0 D Reference
       Region 3ze0 D 27-28 disorder
       Region 3ze0 D 29-497 order
       Region 3ze0 D 498-498 disorder
Seq 27-498 Hetero decamer : P08514
 Evidence X-RAY 3ze2 B Reference
       Region 3ze2 B 27-28 disorder
       Region 3ze2 B 29-497 order
       Region 3ze2 B 498-498 disorder
 Evidence X-RAY 3ze2 D Reference
       Region 3ze2 D 27-84 disorder
       Region 3ze2 D 85-97 order
       Region 3ze2 D 98-105 disorder
       Region 3ze2 D 106-459 order
       Region 3ze2 D 460-498 disorder
Seq 27-498 Hetero octamer : P08514
 Evidence X-RAY 7ufh B Reference
       Region 7ufh B 27-492 order
       Region 7ufh B 493-498 disorder
 Evidence X-RAY 7ufh D Reference
       Region 7ufh D 27-497 order
       Region 7ufh D 498-498 disorder
Seq 27-135,378-548 Hetero hexamer : P20701
 Evidence X-RAY 6bxf A Reference
       Region 6bxf A 27-135 order
       Region 6bxf A 378-548 order
 Evidence X-RAY 6bxf B Reference
       Region 6bxf B 27-135 order
       Region 6bxf B 378-548 order
Seq 27-135,378-548 Hetero hexamer : P20701
 Evidence X-RAY 6bxb A Reference
       Region 6bxb A 27-135 order
       Region 6bxb A 378-548 order
 Evidence X-RAY 6bxb B Reference
       Region 6bxb B 27-135 order
       Region 6bxb B 378-548 order
Seq 27-135,378-548 Hetero hexamer : P20701
 Evidence X-RAY 6ckb A Reference
       Region 6ckb A 27-135 order
       Region 6ckb A 378-548 order
 Evidence X-RAY 6ckb B Reference
       Region 6ckb B 27-135 order
       Region 6ckb B 378-548 order
Seq 27-135,378-714 Hetero trimer : P20701
 Evidence X-RAY 6bxj A Reference
       Region 6bxj A 27-135 order
       Region 6bxj A 378-502 order
       Region 6bxj A 503-508 disorder
       Region 6bxj A 509-714 order
Seq 27-716 Hetero tetramer : P08514
 Evidence X-RAY 3fcs B Reference
       Region 3fcs B 27-100 order
       Region 3fcs B 101-104 disorder
       Region 3fcs B 105-502 order
       Region 3fcs B 503-508 disorder
       Region 3fcs B 509-716 order
 Evidence X-RAY 3fcs D Reference
       Region 3fcs D 27-101 order
       Region 3fcs D 102-104 disorder
       Region 3fcs D 105-502 order
       Region 3fcs D 503-508 disorder
       Region 3fcs D 509-638 order
       Region 3fcs D 639-716 disorder
Seq 27-718 Hetero trimer : P02751,P06756
 Evidence X-RAY 4mmx B Reference
       Region 4mmx B 27-716 order
       Region 4mmx B 717-718 disorder
 Evidence X-RAY 4mmz B Reference
       Region 4mmz B 27-716 order
       Region 4mmz B 717-718 disorder
 Evidence X-RAY 6naj B Reference
       Region 6naj B 27-716 order
Seq 27-718 Hetero trimer : P02751,P06756
 Evidence X-RAY 4mmy B Reference
       Region 4mmy B 27-716 order
       Region 4mmy B 717-718 disorder
Seq 27-718 Hetero tetramer : P06756
 Evidence X-RAY 4o02 B Reference
       Region 4o02 B 27-713 order
       Region 4o02 B 714-718 disorder
Seq 27-718 Hetero trimer : P06756
 Evidence X-RAY 1l5g B Reference
       Region 1l5g B 27-80 disorder
       Region 1l5g B 81-460 order
       Region 1l5g B 461-557 disorder
       Region 1l5g B 558-716 order
       Region 1l5g B 717-718 disorder
Seq 27-721 Hetero trimer : P06756,P12071
 Evidence X-RAY 6msl B Reference
       Region 6msl B 27-716 order
       Region 6msl B 717-721 disorder
 Evidence X-RAY 6msu B Reference
       Region 6msu B 27-716 order
       Region 6msu B 717-721 disorder
Seq 27-721 Hetero dimer : P06756
 Evidence X-RAY 1jv2 B Reference
       Region 1jv2 B 27-80 disorder
       Region 1jv2 B 81-460 order
       Region 1jv2 B 461-557 disorder
       Region 1jv2 B 558-716 order
       Region 1jv2 B 717-718 disorder
 Evidence X-RAY 1m1x B Reference
       Region 1m1x B 27-80 disorder
       Region 1m1x B 81-460 order
       Region 1m1x B 461-557 disorder
       Region 1m1x B 558-716 order
       Region 1m1x B 717-718 disorder
 Evidence X-RAY 1u8c B Reference
       Region 1u8c B 27-76 order
       Region 1u8c B 77-79 disorder
       Region 1u8c B 80-460 order
       Region 1u8c B 461-548 disorder
       Region 1u8c B 549-716 order
       Region 1u8c B 717-718 disorder
 Evidence X-RAY 3ije B Reference
       Region 3ije B 27-721 order
 Evidence X-RAY 4g1e B Reference
       Region 4g1e B 27-59 order
       Region 4g1e B 60-61 disorder
       Region 4g1e B 62-504 order
       Region 4g1e B 505-508 disorder
       Region 4g1e B 509-717 order
 Evidence X-RAY 4g1m B Reference
       Region 4g1m B 27-718 order
 Evidence X-RAY 6mk0 B Reference
       Region 6mk0 B 30-716 order
Seq 29-497 Hetero decamer : P08514
 Evidence X-RAY 4z7o B Reference
       Region 4z7o B 29-492 order
       Region 4z7o B 493-497 disorder
 Evidence X-RAY 4z7o D Reference
       Region 4z7o D 29-497 order
Seq 29-497 Hetero decamer : P08514
 Evidence X-RAY 4z7n B Reference
       Region 4z7n B 29-492 order
       Region 4z7n B 493-497 disorder
 Evidence X-RAY 4z7n D Reference
       Region 4z7n D 29-497 order
Seq 50-61 Hetero trimer : P01903,P79483
 Evidence X-RAY 2q6w C Reference
       Region 2q6w C 50-60 order
       Region 2q6w C 61-61 disorder
 Evidence X-RAY 2q6w F Reference
       Region 2q6w F 50-61 order
Seq 711-753 Monomer :
 Evidence NMR 2l91 A Reference
       Region 2l91 A 711-753 order
       Region 2l91 A 711-716 high_rmsd
       Region 2l91 A 751-753 high_rmsd
 Evidence NMR 2rmz A Reference
       Region 2rmz A 711-753 order
       Region 2rmz A 711-716 high_rmsd
       Region 2rmz A 751-753 high_rmsd
 Evidence NMR 2rn0 A Reference
       Region 2rn0 A 711-753 order
       Region 2rn0 A 711-717 high_rmsd
       Region 2rn0 A 749-753 high_rmsd
Seq 711-753 Hetero dimer : P08514
 Evidence NMR 2k9j B Reference
       Region 2k9j B 711-753 order
       Region 2k9j B 711-717 high_rmsd
       Region 2k9j B 751-753 high_rmsd
 Evidence NMR 2n9y B Reference
       Region 2n9y B 712-753 order
       Region 2n9y B 712-714 high_rmsd
       Region 2n9y B 752-753 high_rmsd
 Evidence NMR 7kn0 B Reference
       Region 7kn0 B 712-753 order
       Region 7kn0 B 712-714 high_rmsd
       Region 7kn0 B 753-753 high_rmsd
Seq 715-788 Hetero dimer : P08514
 Evidence NMR 2knc B Reference
       Region 2knc B 715-788 order
       Region 2knc B 774-788 high_rmsd
Seq 739-788 Monomer :
 Evidence NMR 1s4x A Reference
       Region 1s4x A 742-788 order
       Region 1s4x A 781-788 high_rmsd
 Evidence NMR 2kv9 B Reference
       Region 2kv9 B 739-788 order
 Evidence NMR 2ljd A Reference
       Region 2ljd A 742-788 order
 Evidence NMR 2lje A Reference
       Region 2lje A 742-788 order
       Region 2lje A 742-745 high_rmsd
       Region 2lje A 772-772 high_rmsd
       Region 2lje A 778-788 high_rmsd
 Evidence NMR 2ljf A Reference
       Region 2ljf A 742-788 order
       Region 2ljf A 781-788 high_rmsd
Seq 742-766 Hetero dimer : P08514
 Evidence NMR 1kup B Reference
       Region 1kup B 742-766 order
 Evidence NMR 1kuz B Reference
       Region 1kuz B 742-766 order
       Region 1kuz B 761-766 high_rmsd
Seq 742-788 Hetero dimer : P08514
 Evidence NMR 1m8o B Reference
       Region 1m8o B 742-788 order
       Region 1m8o B 758-788 high_rmsd
Seq 742-788 Hetero trimer : P08514,P21333
 Evidence NMR 2mtp C Reference
       Region 2mtp C 742-788 order
       Region 2mtp C 761-767 high_rmsd
       Region 2mtp C 784-788 high_rmsd
Seq 762-788 Hetero dimer : IID00511Complex
 Evidence NMR 2l1c B Reference
       Region 2l1c B 762-788 order
       Region 2l1c B 762-763 high_rmsd
Seqdisorder 763-788
 Evidence NMR Reference
       Region 763-788 disorder
Seq 765-776 Hetero dimer : IID50213Complex
 Evidence X-RAY 1miz A Reference
       Region 1miz A 765-769 order
 Evidence X-RAY 1mk7 A Reference
       Region 1mk7 A 765-775 order
 Evidence X-RAY 1mk7 C Reference
       Region 1mk7 C 765-775 order
 Evidence X-RAY 1mk9 A Reference
       Region 1mk9 A 765-776 order
 Evidence X-RAY 1mk9 C Reference
       Region 1mk9 C 765-776 order
 Evidence X-RAY 1mk9 E Reference
       Region 1mk9 E 765-776 order
 Evidence X-RAY 1mk9 G Reference
       Region 1mk9 G 765-776 order
SeqProS verified 765-776 Hetero dimer : IID50213Complex
       Region 1mk9 A 765-776 order
       Region 1mk9 C 765-776 order
       Region 1mk9 E 765-776 order
       Region 1mk9 G 765-776 order
       Region 1mk7 A 765-775 order
       Region 1mk7 C 765-775 order
       Region 1miz A 765-769 order
       Region 763-788 disorder
Seqphosphorylation
    785-785 Phosphotyrosine
    779-779 Phosphothreonine; by PDPK1 and PKB/AKT1; in vitro
    773-773 Phosphotyrosine
    767-767 Phosphothreonine
 
Prediction
NeProc
Disorder 1-25,502-515
Order 26-501,516-788
ProS 1-25,511-515
AlphaFold
Disorder 1-27,35-35,101-104,502-510,674-676,698-702,717-717,762-788
Order 28-34,36-100,105-501,511-673,677-697,703-716,718-761
Pfam Hmmer
PF07974 512-547 3.1e-06
PF07974 554-584 0.0008
PF07974 593-624 6.7e-06
PF07965 634-718 2.4e-35
SEG 14-27 ,729-747 ,750-764
Function
Function in SwissProt
Integrin alpha-V/beta-3 (ITGAV:ITGB3) is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrin alpha-IIb/beta-3 (ITGA2B:ITGB3) is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. Integrins alpha-IIb/beta-3 and alpha-V/beta-3 recognize the sequence R-G-D in a wide array of ligands. Integrin alpha-IIb/beta-3 recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial surface. Fibrinogen binding enhances SELP expression in activated platelets (By similarity). ITGAV:ITGB3 binds to fractalkine (CX3CL1) and acts as its coreceptor in CX3CR1-dependent fractalkine signaling (PubMed:23125415, PubMed:24789099). ITGAV:ITGB3 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling (PubMed:20682778). ITGAV:ITGB3 binds to FGF1 and this binding is essential for FGF1 signaling (PubMed:18441324). ITGAV:ITGB3 binds to FGF2 and this binding is essential for FGF2 signaling (PubMed:28302677). ITGAV:ITGB3 binds to IGF1 and this binding is essential for IGF1 signaling (PubMed:19578119). ITGAV:ITGB3 binds to IGF2 and this binding is essential for IGF2 signaling (PubMed:28873464). ITGAV:ITGB3 binds to IL1B and this binding is essential for IL1B signaling (PubMed:29030430). ITGAV:ITGB3 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1 (PubMed:18635536, PubMed:25398877). ITGAV:ITGB3 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1 (PubMed:12807887). In brain, plays a role in synaptic transmission and plasticity. Involved in the regulation of the serotonin neurotransmission, is required to localize to specific compartments within the synapse the serotonin receptor SLC6A4 and for an appropriate reuptake of serotonin. Controls excitatory synaptic strength by regulating GRIA2-containing AMPAR endocytosis, which affects AMPAR abundance and composition (By similarity). ITGAV:ITGB3 act as a receptor for CD40LG (PubMed:31331973). ITGAV:ITGB3 acts as a receptor for IBSP and promotes cell adhesion and migration to IBSP (PubMed:10640428).
(Microbial infection) Integrin ITGAV:ITGB3 acts as a receptor for Herpes virus 8/HHV-8.
(Microbial infection) Integrin ITGAV:ITGB3 acts as a receptor for Coxsackievirus A9.
(Microbial infection) Acts as a receptor for Hantaan virus.
(Microbial infection) Integrin ITGAV:ITGB3 acts as a receptor for Cytomegalovirus/HHV-5.
(Microbial infection) Integrin ITGA5:ITGB3 acts as a receptor for Human metapneumovirus.
(Microbial infection) Integrin ITGAV:ITGB3 acts aP05556s a receptor for Human parechovirus 1.
(Microbial infection) Integrin ITGAV:ITGB3 acts as a receptor for West nile virus.
(Microbial infection) In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.