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IID00772
 UniprotP07900
ProteinHeat shock protein HSP 90-alpha
GeneHSP90AA1
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
732
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-236 Homo dimer :
 Evidence X-RAY 1yer A Reference
       Region 1yer A 9-16 disorder
       Region 1yer A 17-223 order
       Region 1yer A 224-236 disorder
 Evidence X-RAY 2bsm A Reference
       Region 2bsm A 2-15 disorder
       Region 2bsm A 16-223 order
       Region 2bsm A 224-236 disorder
 Evidence X-RAY 2bt0 A Reference
       Region 2bt0 A 2-15 disorder
       Region 2bt0 A 16-223 order
       Region 2bt0 A 224-236 disorder
 Evidence X-RAY 2bt0 B Reference
       Region 2bt0 B 2-15 disorder
       Region 2bt0 B 16-223 order
       Region 2bt0 B 224-236 disorder
 Evidence X-RAY 2jjc A Reference
       Region 2jjc A 9-12 disorder
       Region 2jjc A 14-16 disorder
       Region 2jjc A 17-223 order
 Evidence X-RAY 2qg0 A Reference
       Region 2qg0 A 17-223 order
 Evidence X-RAY 2qg0 B Reference
       Region 2qg0 B 17-223 order
 Evidence X-RAY 2uwd A Reference
       Region 2uwd A 2-15 disorder
       Region 2uwd A 16-223 order
       Region 2uwd A 224-236 disorder
 Evidence X-RAY 2xab A Reference
       Region 2xab A 9-15 disorder
       Region 2xab A 16-223 order
       Region 2xab A 224-236 disorder
 Evidence X-RAY 2xab B Reference
       Region 2xab B 9-15 disorder
       Region 2xab B 16-223 order
       Region 2xab B 224-236 disorder
 Evidence X-RAY 2ye2 A Reference
       Region 2ye2 A 9-15 disorder
       Region 2ye2 A 16-223 order
       Region 2ye2 A 224-236 disorder
 Evidence X-RAY 2ye3 A Reference
       Region 2ye3 A 9-15 disorder
       Region 2ye3 A 16-223 order
       Region 2ye3 A 224-236 disorder
 Evidence X-RAY 2ye4 A Reference
       Region 2ye4 A 9-15 disorder
       Region 2ye4 A 16-223 order
       Region 2ye4 A 224-236 disorder
 Evidence X-RAY 2ye5 A Reference
       Region 2ye5 A 9-15 disorder
       Region 2ye5 A 16-223 order
       Region 2ye5 A 224-236 disorder
 Evidence X-RAY 2ye6 A Reference
       Region 2ye6 A 9-15 disorder
       Region 2ye6 A 16-223 order
       Region 2ye6 A 224-236 disorder
 Evidence X-RAY 2ye8 A Reference
       Region 2ye8 A 9-15 disorder
       Region 2ye8 A 16-223 order
       Region 2ye8 A 224-236 disorder
 Evidence X-RAY 2ye9 A Reference
       Region 2ye9 A 9-15 disorder
       Region 2ye9 A 16-223 order
       Region 2ye9 A 224-236 disorder
 Evidence X-RAY 2yea A Reference
       Region 2yea A 9-15 disorder
       Region 2yea A 16-223 order
       Region 2yea A 224-236 disorder
 Evidence X-RAY 2yeb A Reference
       Region 2yeb A 9-15 disorder
       Region 2yeb A 16-223 order
       Region 2yeb A 224-236 disorder
 Evidence X-RAY 2yec A Reference
       Region 2yec A 9-15 disorder
       Region 2yec A 16-223 order
       Region 2yec A 224-236 disorder
 Evidence X-RAY 2yed A Reference
       Region 2yed A 9-15 disorder
       Region 2yed A 16-223 order
       Region 2yed A 224-236 disorder
 Evidence X-RAY 2yee A Reference
       Region 2yee A 9-15 disorder
       Region 2yee A 16-223 order
       Region 2yee A 224-236 disorder
 Evidence X-RAY 2yi0 A Reference
       Region 2yi0 A 1-15 disorder
       Region 2yi0 A 16-224 order
       Region 2yi0 A 225-229 disorder
 Evidence X-RAY 2yi6 A Reference
       Region 2yi6 A 1-15 disorder
       Region 2yi6 A 16-224 order
       Region 2yi6 A 225-229 disorder
 Evidence X-RAY 2yi7 A Reference
       Region 2yi7 A 1-15 disorder
       Region 2yi7 A 16-224 order
       Region 2yi7 A 225-229 disorder
 Evidence X-RAY 3ft5 A Reference
       Region 3ft5 A 9-15 disorder
       Region 3ft5 A 16-176 order
       Region 3ft5 A 177-177 disorder
       Region 3ft5 A 178-223 order
       Region 3ft5 A 224-236 disorder
 Evidence X-RAY 3ft8 A Reference
       Region 3ft8 A 9-15 disorder
       Region 3ft8 A 16-175 order
       Region 3ft8 A 176-177 disorder
       Region 3ft8 A 178-223 order
       Region 3ft8 A 224-236 disorder
 Evidence X-RAY 3hek A Reference
       Region 3hek A 9-9 disorder
       Region 3hek A 10-225 order
 Evidence X-RAY 3hek B Reference
       Region 3hek B 9-225 order
 Evidence X-RAY 3hyy A Reference
       Region 3hyy A 9-15 disorder
       Region 3hyy A 16-223 order
       Region 3hyy A 224-236 disorder
 Evidence X-RAY 3hyz A Reference
       Region 3hyz A 9-15 disorder
       Region 3hyz A 16-108 order
       Region 3hyz A 109-112 disorder
       Region 3hyz A 113-175 order
       Region 3hyz A 176-176 disorder
       Region 3hyz A 177-224 order
       Region 3hyz A 225-236 disorder
 Evidence X-RAY 3hyz B Reference
       Region 3hyz B 9-15 disorder
       Region 3hyz B 16-224 order
       Region 3hyz B 225-236 disorder
 Evidence X-RAY 3hz1 A Reference
       Region 3hz1 A 9-15 disorder
       Region 3hz1 A 16-223 order
       Region 3hz1 A 224-236 disorder
 Evidence X-RAY 3hz5 A Reference
       Region 3hz5 A 9-15 disorder
       Region 3hz5 A 16-223 order
       Region 3hz5 A 224-236 disorder
 Evidence X-RAY 4awo A Reference
       Region 4awo A 9-16 disorder
       Region 4awo A 17-123 order
       Region 4awo A 124-126 disorder
       Region 4awo A 127-224 order
       Region 4awo A 225-236 disorder
 Evidence X-RAY 4awo B Reference
       Region 4awo B 9-16 disorder
       Region 4awo B 17-123 order
       Region 4awo B 124-126 disorder
       Region 4awo B 127-223 order
       Region 4awo B 224-236 disorder
 Evidence X-RAY 4awp A Reference
       Region 4awp A 9-16 disorder
       Region 4awp A 17-123 order
       Region 4awp A 124-126 disorder
       Region 4awp A 127-223 order
       Region 4awp A 224-236 disorder
 Evidence X-RAY 4awp B Reference
       Region 4awp B 9-16 disorder
       Region 4awp B 17-123 order
       Region 4awp B 124-126 disorder
       Region 4awp B 127-223 order
       Region 4awp B 224-236 disorder
 Evidence X-RAY 4awq A Reference
       Region 4awq A 9-16 disorder
       Region 4awq A 17-123 order
       Region 4awq A 124-126 disorder
       Region 4awq A 127-223 order
       Region 4awq A 224-236 disorder
 Evidence X-RAY 4awq B Reference
       Region 4awq B 9-16 disorder
       Region 4awq B 17-123 order
       Region 4awq B 124-126 disorder
       Region 4awq B 127-223 order
       Region 4awq B 224-236 disorder
 Evidence X-RAY 4cwf A Reference
       Region 4cwf A 9-15 disorder
       Region 4cwf A 16-223 order
       Region 4cwf A 224-236 disorder
 Evidence X-RAY 4cwn A Reference
       Region 4cwn A 9-16 disorder
       Region 4cwn A 17-223 order
       Region 4cwn A 224-236 disorder
 Evidence X-RAY 4fcp A Reference
       Region 4fcp A 1-15 disorder
       Region 4fcp A 16-223 order
       Region 4fcp A 224-236 disorder
 Evidence X-RAY 4fcp B Reference
       Region 4fcp B 1-15 disorder
       Region 4fcp B 16-223 order
       Region 4fcp B 224-236 disorder
 Evidence X-RAY 4l93 A Reference
       Region 4l93 A 9-16 disorder
       Region 4l93 A 17-223 order
       Region 4l93 A 224-236 disorder
 Evidence X-RAY 4l93 B Reference
       Region 4l93 B 9-16 disorder
       Region 4l93 B 17-223 order
       Region 4l93 B 224-236 disorder
 Evidence X-RAY 5fnc A Reference
       Region 5fnc A 1-15 disorder
       Region 5fnc A 16-223 order
       Region 5fnc A 224-236 disorder
 Evidence X-RAY 5fnd A Reference
       Region 5fnd A 1-15 disorder
       Region 5fnd A 16-223 order
       Region 5fnd A 224-236 disorder
 Evidence X-RAY 5ggz A Reference
       Region 5ggz A 16-224 order
       Region 5ggz A 225-225 disorder
 Evidence X-RAY 5ggz B Reference
       Region 5ggz B 16-224 order
       Region 5ggz B 225-225 disorder
 Evidence X-RAY 5ggz C Reference
       Region 5ggz C 16-224 order
       Region 5ggz C 225-225 disorder
 Evidence X-RAY 5ggz D Reference
       Region 5ggz D 16-225 order
 Evidence X-RAY 5j64 A Reference
       Region 5j64 A 9-15 disorder
       Region 5j64 A 16-223 order
       Region 5j64 A 224-236 disorder
 Evidence X-RAY 5j6m A Reference
       Region 5j6m A 9-15 disorder
       Region 5j6m A 16-226 order
       Region 5j6m A 227-234 disorder
 Evidence X-RAY 5j6n A Reference
       Region 5j6n A 9-15 disorder
       Region 5j6n A 16-224 order
       Region 5j6n A 225-234 disorder
 Evidence X-RAY 5j80 A Reference
       Region 5j80 A 9-16 disorder
       Region 5j80 A 17-224 order
       Region 5j80 A 225-233 disorder
 Evidence X-RAY 5j82 A Reference
       Region 5j82 A 9-15 disorder
       Region 5j82 A 16-223 order
       Region 5j82 A 224-233 disorder
 Evidence X-RAY 5j86 A Reference
       Region 5j86 A 9-15 disorder
       Region 5j86 A 16-223 order
       Region 5j86 A 224-233 disorder
 Evidence X-RAY 5j8m A Reference
       Region 5j8m A 9-15 disorder
       Region 5j8m A 16-224 order
       Region 5j8m A 225-233 disorder
 Evidence X-RAY 5j8m B Reference
       Region 5j8m B 9-15 disorder
       Region 5j8m B 16-224 order
       Region 5j8m B 225-233 disorder
 Evidence X-RAY 5j8u A Reference
       Region 5j8u A 9-16 disorder
       Region 5j8u A 17-224 order
       Region 5j8u A 225-233 disorder
 Evidence X-RAY 5j8u B Reference
       Region 5j8u B 9-16 disorder
       Region 5j8u B 17-223 order
       Region 5j8u B 224-233 disorder
 Evidence X-RAY 5j9x A Reference
       Region 5j9x A 9-15 disorder
       Region 5j9x A 16-223 order
       Region 5j9x A 224-233 disorder
 Evidence X-RAY 6b9a A Reference
       Region 6b9a A 1-15 disorder
       Region 6b9a A 16-225 order
       Region 6b9a A 226-236 disorder
 Evidence X-RAY 6b9a B Reference
       Region 6b9a B 1-15 disorder
       Region 6b9a B 16-224 order
       Region 6b9a B 225-236 disorder
 Evidence X-RAY 6cyg A Reference
       Region 6cyg A 1-15 disorder
       Region 6cyg A 16-225 order
       Region 6cyg A 226-236 disorder
 Evidence X-RAY 6cyg B Reference
       Region 6cyg B 1-15 disorder
       Region 6cyg B 16-225 order
       Region 6cyg B 226-236 disorder
 Evidence X-RAY 6cyh A Reference
       Region 6cyh A 1-15 disorder
       Region 6cyh A 16-225 order
       Region 6cyh A 226-236 disorder
 Evidence X-RAY 6cyh B Reference
       Region 6cyh B 1-15 disorder
       Region 6cyh B 16-225 order
       Region 6cyh B 226-236 disorder
 Evidence X-RAY 8agi A Reference
       Region 8agi A 1-14 disorder
       Region 8agi A 15-225 order
       Region 8agi A 226-236 disorder
 Evidence X-RAY 8agi B Reference
       Region 8agi B 1-15 disorder
       Region 8agi B 16-222 order
       Region 8agi B 223-236 disorder
 Evidence X-RAY 8agj A Reference
       Region 8agj A 1-14 disorder
       Region 8agj A 15-226 order
       Region 8agj A 227-236 disorder
 Evidence X-RAY 8agj B Reference
       Region 8agj B 1-15 disorder
       Region 8agj B 16-222 order
       Region 8agj B 223-236 disorder
 Evidence X-RAY 8agl A Reference
       Region 8agl A 1-14 disorder
       Region 8agl A 15-225 order
       Region 8agl A 226-236 disorder
 Evidence X-RAY 8agl B Reference
       Region 8agl B 1-15 disorder
       Region 8agl B 16-222 order
       Region 8agl B 223-236 disorder
Seq 1-236 Homo tetramer :
 Evidence X-RAY 5zr3 A Reference
       Region 5zr3 A 1-11 disorder
       Region 5zr3 A 12-223 order
       Region 5zr3 A 224-236 disorder
 Evidence X-RAY 5zr3 C Reference
       Region 5zr3 C 1-11 disorder
       Region 5zr3 C 12-227 order
       Region 5zr3 C 228-236 disorder
 Evidence X-RAY 5zr3 E Reference
       Region 5zr3 E 1-15 disorder
       Region 5zr3 E 16-223 order
       Region 5zr3 E 224-236 disorder
 Evidence X-RAY 5zr3 G Reference
       Region 5zr3 G 1-11 disorder
       Region 5zr3 G 12-223 order
       Region 5zr3 G 224-236 disorder
Seq 1-293 Monomer :
 Evidence X-RAY 1byq A Reference
       Region 1byq A 9-10 disorder
       Region 1byq A 11-223 order
       Region 1byq A 224-236 disorder
 Evidence X-RAY 1osf A Reference
       Region 1osf A 9-223 order
 Evidence X-RAY 1uy6 A Reference
       Region 1uy6 A 2-16 disorder
       Region 1uy6 A 17-223 order
       Region 1uy6 A 224-236 disorder
 Evidence X-RAY 1uy7 A Reference
       Region 1uy7 A 2-15 disorder
       Region 1uy7 A 16-223 order
       Region 1uy7 A 224-236 disorder
 Evidence X-RAY 1uy8 A Reference
       Region 1uy8 A 2-16 disorder
       Region 1uy8 A 17-223 order
       Region 1uy8 A 224-236 disorder
 Evidence X-RAY 1uy9 A Reference
       Region 1uy9 A 2-15 disorder
       Region 1uy9 A 16-223 order
       Region 1uy9 A 224-236 disorder
 Evidence X-RAY 1uyc A Reference
       Region 1uyc A 2-15 disorder
       Region 1uyc A 16-223 order
       Region 1uyc A 224-236 disorder
 Evidence X-RAY 1uyd A Reference
       Region 1uyd A 2-15 disorder
       Region 1uyd A 16-224 order
       Region 1uyd A 225-236 disorder
 Evidence X-RAY 1uye A Reference
       Region 1uye A 2-15 disorder
       Region 1uye A 16-224 order
       Region 1uye A 225-236 disorder
 Evidence X-RAY 1uyf A Reference
       Region 1uyf A 2-15 disorder
       Region 1uyf A 16-224 order
       Region 1uyf A 225-236 disorder
 Evidence X-RAY 1uyg A Reference
       Region 1uyg A 2-15 disorder
       Region 1uyg A 16-223 order
       Region 1uyg A 224-236 disorder
 Evidence X-RAY 1uyh A Reference
       Region 1uyh A 2-15 disorder
       Region 1uyh A 16-223 order
       Region 1uyh A 224-236 disorder
 Evidence X-RAY 1uyi A Reference
       Region 1uyi A 2-15 disorder
       Region 1uyi A 16-223 order
       Region 1uyi A 224-236 disorder
 Evidence X-RAY 1uyk A Reference
       Region 1uyk A 2-15 disorder
       Region 1uyk A 16-223 order
       Region 1uyk A 224-236 disorder
 Evidence X-RAY 1uyl A Reference
       Region 1uyl A 2-16 disorder
       Region 1uyl A 17-223 order
       Region 1uyl A 224-236 disorder
 Evidence X-RAY 1yc1 A Reference
       Region 1yc1 A 9-14 disorder
       Region 1yc1 A 15-224 order
       Region 1yc1 A 225-236 disorder
 Evidence X-RAY 1yc3 A Reference
       Region 1yc3 A 9-9 disorder
       Region 1yc3 A 10-223 order
       Region 1yc3 A 224-236 disorder
 Evidence X-RAY 1yc4 A Reference
       Region 1yc4 A 9-14 disorder
       Region 1yc4 A 15-224 order
       Region 1yc4 A 225-236 disorder
 Evidence X-RAY 1yes A Reference
       Region 1yes A 9-10 disorder
       Region 1yes A 11-223 order
       Region 1yes A 224-236 disorder
 Evidence X-RAY 1yet A Reference
       Region 1yet A 9-10 disorder
       Region 1yet A 11-223 order
       Region 1yet A 224-236 disorder
 Evidence X-RAY 2byh A Reference
       Region 2byh A 11-225 order
       Region 2byh A 226-236 disorder
 Evidence X-RAY 2byi A Reference
       Region 2byi A 11-225 order
       Region 2byi A 226-236 disorder
 Evidence X-RAY 2bz5 A Reference
       Region 2bz5 A 2-15 disorder
       Region 2bz5 A 16-225 order
       Region 2bz5 A 226-236 disorder
 Evidence X-RAY 2bz5 B Reference
       Region 2bz5 B 2-15 disorder
       Region 2bz5 B 16-225 order
       Region 2bz5 B 226-236 disorder
 Evidence X-RAY 2ccs A Reference
       Region 2ccs A 1-15 disorder
       Region 2ccs A 16-223 order
       Region 2ccs A 224-236 disorder
 Evidence X-RAY 2cct A Reference
       Region 2cct A 1-15 disorder
       Region 2cct A 16-223 order
       Region 2cct A 224-236 disorder
 Evidence X-RAY 2ccu A Reference
       Region 2ccu A 1-15 disorder
       Region 2ccu A 16-223 order
       Region 2ccu A 224-236 disorder
 Evidence X-RAY 2fwy A Reference
       Region 2fwy A 1-16 disorder
       Region 2fwy A 17-223 order
       Region 2fwy A 224-236 disorder
 Evidence X-RAY 2fwz A Reference
       Region 2fwz A 1-15 disorder
       Region 2fwz A 16-223 order
       Region 2fwz A 224-236 disorder
 Evidence X-RAY 2h55 A Reference
       Region 2h55 A 1-15 disorder
       Region 2h55 A 16-224 order
       Region 2h55 A 225-236 disorder
 Evidence X-RAY 2qf6 A Reference
       Region 2qf6 A 17-223 order
 Evidence X-RAY 2qf6 B Reference
       Region 2qf6 B 17-223 order
 Evidence X-RAY 2qf6 C Reference
       Region 2qf6 C 17-223 order
 Evidence X-RAY 2qf6 D Reference
       Region 2qf6 D 17-223 order
 Evidence X-RAY 2qfo A Reference
       Region 2qfo A 17-223 order
 Evidence X-RAY 2qfo B Reference
       Region 2qfo B 17-223 order
 Evidence X-RAY 2qg2 A Reference
       Region 2qg2 A 17-223 order
 Evidence X-RAY 2vci A Reference
       Region 2vci A 1-15 disorder
       Region 2vci A 16-223 order
       Region 2vci A 224-236 disorder
 Evidence X-RAY 2vcj A Reference
       Region 2vcj A 1-15 disorder
       Region 2vcj A 16-223 order
       Region 2vcj A 224-236 disorder
 Evidence X-RAY 2wi1 A Reference
       Region 2wi1 A 1-15 disorder
       Region 2wi1 A 16-223 order
       Region 2wi1 A 224-236 disorder
 Evidence X-RAY 2wi2 A Reference
       Region 2wi2 A 1-15 disorder
       Region 2wi2 A 16-223 order
       Region 2wi2 A 224-236 disorder
 Evidence X-RAY 2wi2 B Reference
       Region 2wi2 B 1-15 disorder
       Region 2wi2 B 16-223 order
       Region 2wi2 B 224-236 disorder
 Evidence X-RAY 2wi3 A Reference
       Region 2wi3 A 1-15 disorder
       Region 2wi3 A 16-223 order
       Region 2wi3 A 224-236 disorder
 Evidence X-RAY 2wi4 A Reference
       Region 2wi4 A 1-15 disorder
       Region 2wi4 A 16-223 order
       Region 2wi4 A 224-236 disorder
 Evidence X-RAY 2wi5 A Reference
       Region 2wi5 A 1-15 disorder
       Region 2wi5 A 16-223 order
       Region 2wi5 A 224-236 disorder
 Evidence X-RAY 2wi6 A Reference
       Region 2wi6 A 1-15 disorder
       Region 2wi6 A 16-223 order
       Region 2wi6 A 224-236 disorder
 Evidence X-RAY 2wi7 A Reference
       Region 2wi7 A 1-15 disorder
       Region 2wi7 A 16-223 order
       Region 2wi7 A 224-236 disorder
 Evidence X-RAY 2xdk A Reference
       Region 2xdk A 9-10 disorder
       Region 2xdk A 11-225 order
       Region 2xdk A 226-236 disorder
 Evidence X-RAY 2xdl A Reference
       Region 2xdl A 9-16 disorder
       Region 2xdl A 17-223 order
       Region 2xdl A 224-236 disorder
 Evidence X-RAY 2xds A Reference
       Region 2xds A 9-16 disorder
       Region 2xds A 17-223 order
       Region 2xds A 224-236 disorder
 Evidence X-RAY 2xdu A Reference
       Region 2xdu A 14-16 disorder
       Region 2xdu A 17-224 order
 Evidence X-RAY 2xdx A Reference
       Region 2xdx A 9-10 disorder
       Region 2xdx A 11-223 order
       Region 2xdx A 224-236 disorder
 Evidence X-RAY 2xhr A Reference
       Region 2xhr A 9-16 disorder
       Region 2xhr A 17-224 order
       Region 2xhr A 225-236 disorder
 Evidence X-RAY 2xht A Reference
       Region 2xht A 9-11 disorder
       Region 2xht A 12-223 order
       Region 2xht A 224-236 disorder
 Evidence X-RAY 2xhx A Reference
       Region 2xhx A 9-10 disorder
       Region 2xhx A 11-223 order
       Region 2xhx A 224-236 disorder
 Evidence X-RAY 2xjg A Reference
       Region 2xjg A 9-10 disorder
       Region 2xjg A 11-223 order
       Region 2xjg A 224-236 disorder
 Evidence X-RAY 2xjj A Reference
       Region 2xjj A 9-16 disorder
       Region 2xjj A 17-223 order
       Region 2xjj A 224-236 disorder
 Evidence X-RAY 2xjj B Reference
       Region 2xjj B 9-16 disorder
       Region 2xjj B 17-223 order
       Region 2xjj B 224-236 disorder
 Evidence X-RAY 2xjx A Reference
       Region 2xjx A 9-10 disorder
       Region 2xjx A 11-231 order
       Region 2xjx A 232-236 disorder
 Evidence X-RAY 2xk2 A Reference
       Region 2xk2 A 9-11 disorder
       Region 2xk2 A 12-224 order
       Region 2xk2 A 225-236 disorder
 Evidence X-RAY 2ye7 A Reference
       Region 2ye7 A 9-15 disorder
       Region 2ye7 A 16-223 order
       Region 2ye7 A 224-236 disorder
 Evidence X-RAY 2yef A Reference
       Region 2yef A 9-10 disorder
       Region 2yef A 11-226 order
       Region 2yef A 227-236 disorder
 Evidence X-RAY 2yeg A Reference
       Region 2yeg A 9-15 disorder
       Region 2yeg A 16-223 order
       Region 2yeg A 224-236 disorder
 Evidence X-RAY 2yeg B Reference
       Region 2yeg B 9-15 disorder
       Region 2yeg B 16-223 order
       Region 2yeg B 224-236 disorder
 Evidence X-RAY 2yeh A Reference
       Region 2yeh A 9-15 disorder
       Region 2yeh A 16-223 order
       Region 2yeh A 224-236 disorder
 Evidence X-RAY 2yei A Reference
       Region 2yei A 9-15 disorder
       Region 2yei A 16-223 order
       Region 2yei A 224-236 disorder
 Evidence X-RAY 2yej A Reference
       Region 2yej A 9-15 disorder
       Region 2yej A 16-223 order
       Region 2yej A 224-236 disorder
 Evidence X-RAY 2yi5 A Reference
       Region 2yi5 A 1-15 disorder
       Region 2yi5 A 16-110 order
       Region 2yi5 A 111-113 disorder
       Region 2yi5 A 114-225 order
       Region 2yi5 A 226-229 disorder
 Evidence X-RAY 2yjw A Reference
       Region 2yjw A 18-223 order
 Evidence X-RAY 2yjx A Reference
       Region 2yjx A 18-223 order
 Evidence X-RAY 2yk2 A Reference
       Region 2yk2 A 18-223 order
 Evidence X-RAY 2yk9 A Reference
       Region 2yk9 A 18-223 order
 Evidence X-RAY 2ykb A Reference
       Region 2ykb A 18-223 order
 Evidence X-RAY 2ykc A Reference
       Region 2ykc A 18-223 order
 Evidence X-RAY 2yke A Reference
       Region 2yke A 18-223 order
 Evidence X-RAY 2yki A Reference
       Region 2yki A 18-223 order
 Evidence X-RAY 2ykj A Reference
       Region 2ykj A 18-223 order
 Evidence X-RAY 3b24 A Reference
       Region 3b24 A 9-15 disorder
       Region 3b24 A 16-224 order
       Region 3b24 A 225-236 disorder
 Evidence X-RAY 3b24 B Reference
       Region 3b24 B 9-15 disorder
       Region 3b24 B 16-225 order
       Region 3b24 B 226-236 disorder
 Evidence X-RAY 3b25 A Reference
       Region 3b25 A 9-15 disorder
       Region 3b25 A 16-225 order
       Region 3b25 A 226-236 disorder
 Evidence X-RAY 3b26 A Reference
       Region 3b26 A 9-15 disorder
       Region 3b26 A 16-224 order
       Region 3b26 A 225-236 disorder
 Evidence X-RAY 3b26 B Reference
       Region 3b26 B 9-15 disorder
       Region 3b26 B 16-225 order
       Region 3b26 B 226-236 disorder
 Evidence X-RAY 3b27 A Reference
       Region 3b27 A 9-9 disorder
       Region 3b27 A 10-224 order
       Region 3b27 A 225-236 disorder
 Evidence X-RAY 3b28 A Reference
       Region 3b28 A 9-15 disorder
       Region 3b28 A 16-225 order
       Region 3b28 A 226-236 disorder
 Evidence X-RAY 3b28 B Reference
       Region 3b28 B 9-15 disorder
       Region 3b28 B 16-225 order
       Region 3b28 B 226-236 disorder
 Evidence X-RAY 3bm9 A Reference
       Region 3bm9 A 14-16 disorder
       Region 3bm9 A 17-223 order
       Region 3bm9 A 224-236 disorder
 Evidence X-RAY 3bmy A Reference
       Region 3bmy A 14-223 order
       Region 3bmy A 224-236 disorder
 Evidence X-RAY 3d0b A Reference
       Region 3d0b A 1-15 disorder
       Region 3d0b A 16-223 order
       Region 3d0b A 224-232 disorder
 Evidence X-RAY 3eko A Reference
       Region 3eko A 9-9 disorder
       Region 3eko A 10-225 order
 Evidence X-RAY 3eko B Reference
       Region 3eko B 9-112 order
       Region 3eko B 113-113 disorder
       Region 3eko B 114-225 order
 Evidence X-RAY 3ekr A Reference
       Region 3ekr A 9-9 disorder
       Region 3ekr A 10-225 order
 Evidence X-RAY 3ekr B Reference
       Region 3ekr B 9-225 order
 Evidence X-RAY 3hhu A Reference
       Region 3hhu A 1-15 disorder
       Region 3hhu A 16-223 order
       Region 3hhu A 224-224 disorder
 Evidence X-RAY 3hhu B Reference
       Region 3hhu B 1-15 disorder
       Region 3hhu B 16-224 order
 Evidence X-RAY 3inw A Reference
       Region 3inw A 10-16 disorder
       Region 3inw A 17-223 order
       Region 3inw A 224-236 disorder
 Evidence X-RAY 3inx A Reference
       Region 3inx A 10-16 disorder
       Region 3inx A 17-223 order
       Region 3inx A 224-236 disorder
 Evidence X-RAY 3k97 A Reference
       Region 3k97 A 9-15 disorder
       Region 3k97 A 16-225 order
       Region 3k97 A 226-236 disorder
 Evidence X-RAY 3k98 A Reference
       Region 3k98 A 9-121 order
       Region 3k98 A 122-125 disorder
       Region 3k98 A 126-225 order
 Evidence X-RAY 3k98 B Reference
       Region 3k98 B 9-225 order
 Evidence X-RAY 3k99 A Reference
       Region 3k99 A 9-225 order
 Evidence X-RAY 3k99 B Reference
       Region 3k99 B 9-10 disorder
       Region 3k99 B 11-225 order
 Evidence X-RAY 3k99 C Reference
       Region 3k99 C 9-10 disorder
       Region 3k99 C 11-225 order
 Evidence X-RAY 3k99 D Reference
       Region 3k99 D 9-9 disorder
       Region 3k99 D 10-225 order
 Evidence X-RAY 3mnr P Reference
       Region 3mnr P 1-15 disorder
       Region 3mnr P 16-224 order
       Region 3mnr P 225-232 disorder
 Evidence X-RAY 3o0i A Reference
       Region 3o0i A 1-15 disorder
       Region 3o0i A 16-223 order
       Region 3o0i A 224-236 disorder
 Evidence X-RAY 3ow6 A Reference
       Region 3ow6 A 17-223 order
 Evidence X-RAY 3owb A Reference
       Region 3owb A 17-223 order
 Evidence X-RAY 3owd A Reference
       Region 3owd A 17-223 order
 Evidence X-RAY 3qdd A Reference
       Region 3qdd A 1-16 disorder
       Region 3qdd A 17-225 order
       Region 3qdd A 226-236 disorder
 Evidence X-RAY 3qtf A Reference
       Region 3qtf A 14-16 disorder
       Region 3qtf A 17-223 order
       Region 3qtf A 224-236 disorder
 Evidence X-RAY 3r4m A Reference
       Region 3r4m A 9-10 disorder
       Region 3r4m A 11-225 order
       Region 3r4m A 226-236 disorder
 Evidence X-RAY 3r4n A Reference
       Region 3r4n A 9-9 disorder
       Region 3r4n A 10-225 order
 Evidence X-RAY 3r4n B Reference
       Region 3r4n B 9-225 order
 Evidence X-RAY 3r4o A Reference
       Region 3r4o A 9-16 disorder
       Region 3r4o A 17-225 order
 Evidence X-RAY 3r4o B Reference
       Region 3r4o B 9-16 disorder
       Region 3r4o B 17-225 order
 Evidence X-RAY 3r4p A Reference
       Region 3r4p A 9-225 order
 Evidence X-RAY 3r4p B Reference
       Region 3r4p B 9-225 order
 Evidence X-RAY 3r91 A Reference
       Region 3r91 A 14-16 disorder
       Region 3r91 A 17-223 order
       Region 3r91 A 224-236 disorder
 Evidence X-RAY 3r92 A Reference
       Region 3r92 A 14-16 disorder
       Region 3r92 A 17-224 order
       Region 3r92 A 225-236 disorder
 Evidence X-RAY 3rkz A Reference
       Region 3rkz A 14-16 disorder
       Region 3rkz A 17-224 order
       Region 3rkz A 225-236 disorder
 Evidence X-RAY 3rlp A Reference
       Region 3rlp A 9-9 disorder
       Region 3rlp A 10-225 order
 Evidence X-RAY 3rlp B Reference
       Region 3rlp B 9-110 order
       Region 3rlp B 111-114 disorder
       Region 3rlp B 115-225 order
 Evidence X-RAY 3rlq A Reference
       Region 3rlq A 9-225 order
 Evidence X-RAY 3rlq B Reference
       Region 3rlq B 9-225 order
 Evidence X-RAY 3rlr A Reference
       Region 3rlr A 9-225 order
 Evidence X-RAY 3rlr B Reference
       Region 3rlr B 9-225 order
 Evidence X-RAY 3t0h A Reference
       Region 3t0h A 9-15 disorder
       Region 3t0h A 16-223 order
       Region 3t0h A 224-236 disorder
 Evidence X-RAY 3t0z A Reference
       Region 3t0z A 9-10 disorder
       Region 3t0z A 11-223 order
       Region 3t0z A 224-236 disorder
 Evidence X-RAY 3t10 A Reference
       Region 3t10 A 9-10 disorder
       Region 3t10 A 11-224 order
       Region 3t10 A 225-236 disorder
 Evidence X-RAY 3t1k A Reference
       Region 3t1k A 9-16 disorder
       Region 3t1k A 17-229 order
       Region 3t1k A 230-236 disorder
 Evidence X-RAY 3t1k B Reference
       Region 3t1k B 9-15 disorder
       Region 3t1k B 16-229 order
       Region 3t1k B 230-236 disorder
 Evidence X-RAY 3t2s A Reference
       Region 3t2s A 9-16 disorder
       Region 3t2s A 17-227 order
       Region 3t2s A 228-236 disorder
 Evidence X-RAY 3t2s B Reference
       Region 3t2s B 9-16 disorder
       Region 3t2s B 17-227 order
       Region 3t2s B 228-236 disorder
 Evidence X-RAY 3tuh A Reference
       Region 3tuh A 16-224 order
 Evidence X-RAY 3tuh B Reference
       Region 3tuh B 16-16 disorder
       Region 3tuh B 17-224 order
 Evidence X-RAY 3vha A Reference
       Region 3vha A 9-10 disorder
       Region 3vha A 11-225 order
       Region 3vha A 226-236 disorder
 Evidence X-RAY 3vhc A Reference
       Region 3vhc A 9-9 disorder
       Region 3vhc A 10-225 order
       Region 3vhc A 226-236 disorder
 Evidence X-RAY 3vhd A Reference
       Region 3vhd A 9-11 disorder
       Region 3vhd A 12-224 order
       Region 3vhd A 225-236 disorder
 Evidence X-RAY 3vhd B Reference
       Region 3vhd B 9-9 disorder
       Region 3vhd B 10-224 order
       Region 3vhd B 225-236 disorder
 Evidence X-RAY 3wha A Reference
       Region 3wha A 9-15 disorder
       Region 3wha A 16-224 order
       Region 3wha A 225-236 disorder
 Evidence X-RAY 3wha B Reference
       Region 3wha B 9-15 disorder
       Region 3wha B 16-224 order
       Region 3wha B 225-236 disorder
 Evidence X-RAY 3wq9 A Reference
       Region 3wq9 A 1-15 disorder
       Region 3wq9 A 16-226 order
       Region 3wq9 A 227-236 disorder
 Evidence X-RAY 4b7p A Reference
       Region 4b7p A 9-11 disorder
       Region 4b7p A 12-225 order
       Region 4b7p A 226-236 disorder
 Evidence X-RAY 4bqg A Reference
       Region 4bqg A 9-15 disorder
       Region 4bqg A 16-224 order
       Region 4bqg A 225-236 disorder
 Evidence X-RAY 4bqj A Reference
       Region 4bqj A 9-11 disorder
       Region 4bqj A 12-224 order
       Region 4bqj A 225-236 disorder
 Evidence X-RAY 4cwo A Reference
       Region 4cwo A 9-15 disorder
       Region 4cwo A 16-225 order
       Region 4cwo A 226-236 disorder
 Evidence X-RAY 4cwp A Reference
       Region 4cwp A 9-16 disorder
       Region 4cwp A 17-223 order
       Region 4cwp A 224-236 disorder
 Evidence X-RAY 4cwq A Reference
       Region 4cwq A 9-16 disorder
       Region 4cwq A 17-223 order
       Region 4cwq A 224-236 disorder
 Evidence X-RAY 4cwr A Reference
       Region 4cwr A 9-16 disorder
       Region 4cwr A 17-223 order
       Region 4cwr A 224-236 disorder
 Evidence X-RAY 4cws A Reference
       Region 4cws A 9-16 disorder
       Region 4cws A 17-223 order
       Region 4cws A 224-236 disorder
 Evidence X-RAY 4cwt A Reference
       Region 4cwt A 9-15 disorder
       Region 4cwt A 16-224 order
       Region 4cwt A 225-236 disorder
 Evidence X-RAY 4eeh A Reference
       Region 4eeh A 9-16 disorder
       Region 4eeh A 17-223 order
       Region 4eeh A 224-236 disorder
 Evidence X-RAY 4eft A Reference
       Region 4eft A 9-16 disorder
       Region 4eft A 17-223 order
       Region 4eft A 224-236 disorder
 Evidence X-RAY 4efu A Reference
       Region 4efu A 9-16 disorder
       Region 4efu A 17-223 order
       Region 4efu A 224-236 disorder
 Evidence X-RAY 4egh A Reference
       Region 4egh A 9-15 disorder
       Region 4egh A 16-224 order
       Region 4egh A 225-236 disorder
 Evidence X-RAY 4egi A Reference
       Region 4egi A 9-9 disorder
       Region 4egi A 10-226 order
       Region 4egi A 227-236 disorder
 Evidence X-RAY 4egk A Reference
       Region 4egk A 9-10 disorder
       Region 4egk A 11-224 order
       Region 4egk A 225-236 disorder
 Evidence X-RAY 4fcq A Reference
       Region 4fcq A 1-15 disorder
       Region 4fcq A 16-223 order
       Region 4fcq A 224-236 disorder
 Evidence X-RAY 4fcr A Reference
       Region 4fcr A 1-15 disorder
       Region 4fcr A 16-111 order
       Region 4fcr A 112-112 disorder
       Region 4fcr A 113-223 order
       Region 4fcr A 224-236 disorder
 Evidence X-RAY 4hy6 A Reference
       Region 4hy6 A 9-16 disorder
       Region 4hy6 A 17-224 order
       Region 4hy6 A 225-236 disorder
 Evidence X-RAY 4jql A Reference
       Region 4jql A 9-9 disorder
       Region 4jql A 10-224 order
       Region 4jql A 225-236 disorder
 Evidence X-RAY 4l8z A Reference
       Region 4l8z A 9-16 disorder
       Region 4l8z A 17-224 order
       Region 4l8z A 225-236 disorder
 Evidence X-RAY 4l90 A Reference
       Region 4l90 A 9-16 disorder
       Region 4l90 A 17-224 order
       Region 4l90 A 225-236 disorder
 Evidence X-RAY 4l91 A Reference
       Region 4l91 A 9-16 disorder
       Region 4l91 A 17-223 order
       Region 4l91 A 224-236 disorder
 Evidence X-RAY 4l94 A Reference
       Region 4l94 A 9-16 disorder
       Region 4l94 A 17-223 order
       Region 4l94 A 224-236 disorder
 Evidence X-RAY 4lwe A Reference
       Region 4lwe A 17-224 order
 Evidence X-RAY 4lwf A Reference
       Region 4lwf A 17-223 order
       Region 4lwf A 224-224 disorder
 Evidence X-RAY 4lwg A Reference
       Region 4lwg A 17-223 order
       Region 4lwg A 224-224 disorder
 Evidence X-RAY 4lwh A Reference
       Region 4lwh A 16-223 order
       Region 4lwh A 224-224 disorder
 Evidence X-RAY 4lwi A Reference
       Region 4lwi A 17-223 order
       Region 4lwi A 224-224 disorder
 Evidence X-RAY 4nh7 A Reference
       Region 4nh7 A 9-16 disorder
       Region 4nh7 A 17-211 order
       Region 4nh7 A 212-212 disorder
       Region 4nh7 A 213-224 order
       Region 4nh7 A 225-236 disorder
 Evidence X-RAY 4nh7 B Reference
       Region 4nh7 B 9-16 disorder
       Region 4nh7 B 17-122 order
       Region 4nh7 B 123-125 disorder
       Region 4nh7 B 126-224 order
       Region 4nh7 B 225-236 disorder
 Evidence X-RAY 4nh8 A Reference
       Region 4nh8 A 9-15 disorder
       Region 4nh8 A 16-224 order
       Region 4nh8 A 225-236 disorder
 Evidence X-RAY 4o04 A Reference
       Region 4o04 A 9-15 disorder
       Region 4o04 A 16-223 order
       Region 4o04 A 224-236 disorder
 Evidence X-RAY 4o05 A Reference
       Region 4o05 A 9-15 disorder
       Region 4o05 A 16-224 order
       Region 4o05 A 225-236 disorder
 Evidence X-RAY 4o07 A Reference
       Region 4o07 A 9-15 disorder
       Region 4o07 A 16-224 order
       Region 4o07 A 225-236 disorder
 Evidence X-RAY 4o09 A Reference
       Region 4o09 A 9-15 disorder
       Region 4o09 A 16-224 order
       Region 4o09 A 225-236 disorder
 Evidence X-RAY 4o0b A Reference
       Region 4o0b A 9-15 disorder
       Region 4o0b A 16-224 order
       Region 4o0b A 225-236 disorder
 Evidence X-RAY 4r3m A Reference
       Region 4r3m A 16-224 order
 Evidence X-RAY 4u93 A Reference
       Region 4u93 A 1-16 disorder
       Region 4u93 A 17-223 order
       Region 4u93 A 224-236 disorder
 Evidence X-RAY 4w7t A Reference
       Region 4w7t A 1-16 disorder
       Region 4w7t A 17-223 order
       Region 4w7t A 224-236 disorder
 Evidence X-RAY 4xip A Reference
       Region 4xip A 9-15 disorder
       Region 4xip A 16-223 order
       Region 4xip A 224-236 disorder
 Evidence X-RAY 4xiq A Reference
       Region 4xiq A 9-15 disorder
       Region 4xiq A 16-224 order
       Region 4xiq A 225-236 disorder
 Evidence X-RAY 4xir A Reference
       Region 4xir A 9-15 disorder
       Region 4xir A 16-223 order
       Region 4xir A 224-236 disorder
 Evidence X-RAY 4xit A Reference
       Region 4xit A 9-15 disorder
       Region 4xit A 16-223 order
       Region 4xit A 224-236 disorder
 Evidence X-RAY 4ykq A Reference
       Region 4ykq A 2-15 disorder
       Region 4ykq A 16-223 order
       Region 4ykq A 224-236 disorder
 Evidence X-RAY 4ykr A Reference
       Region 4ykr A 2-15 disorder
       Region 4ykr A 16-223 order
       Region 4ykr A 224-236 disorder
 Evidence X-RAY 4ykt A Reference
       Region 4ykt A 2-15 disorder
       Region 4ykt A 16-223 order
       Region 4ykt A 224-236 disorder
 Evidence X-RAY 4yku A Reference
       Region 4yku A 2-15 disorder
       Region 4yku A 16-223 order
       Region 4yku A 224-236 disorder
 Evidence X-RAY 4ykw A Reference
       Region 4ykw A 2-10 disorder
       Region 4ykw A 11-223 order
       Region 4ykw A 224-236 disorder
 Evidence X-RAY 4ykw B Reference
       Region 4ykw B 2-10 disorder
       Region 4ykw B 11-223 order
       Region 4ykw B 224-236 disorder
 Evidence X-RAY 4ykx A Reference
       Region 4ykx A 2-15 disorder
       Region 4ykx A 16-223 order
       Region 4ykx A 224-236 disorder
 Evidence X-RAY 4yky A Reference
       Region 4yky A 2-15 disorder
       Region 4yky A 16-223 order
       Region 4yky A 224-236 disorder
 Evidence X-RAY 4ykz A Reference
       Region 4ykz A 2-15 disorder
       Region 4ykz A 16-223 order
       Region 4ykz A 224-236 disorder
 Evidence X-RAY 5cf0 A Reference
       Region 5cf0 A 9-16 disorder
       Region 5cf0 A 17-224 order
       Region 5cf0 A 225-236 disorder
 Evidence X-RAY 5fnf A Reference
       Region 5fnf A 1-15 disorder
       Region 5fnf A 16-223 order
       Region 5fnf A 224-236 disorder
 Evidence X-RAY 5j20 A Reference
       Region 5j20 A 17-223 order
 Evidence X-RAY 5j27 A Reference
       Region 5j27 A 16-224 order
 Evidence X-RAY 5j2v A Reference
       Region 5j2v A 17-223 order
 Evidence X-RAY 5j2x A Reference
       Region 5j2x A 17-224 order
 Evidence X-RAY 5j6l A Reference
       Region 5j6l A 9-15 disorder
       Region 5j6l A 16-223 order
       Region 5j6l A 224-236 disorder
 Evidence X-RAY 5lny A Reference
       Region 5lny A 9-16 disorder
       Region 5lny A 17-223 order
       Region 5lny A 224-236 disorder
 Evidence X-RAY 5lnz A Reference
       Region 5lnz A 9-16 disorder
       Region 5lnz A 17-223 order
       Region 5lnz A 224-236 disorder
 Evidence X-RAY 5lo0 A Reference
       Region 5lo0 A 9-16 disorder
       Region 5lo0 A 17-223 order
       Region 5lo0 A 224-236 disorder
 Evidence X-RAY 5lo1 A Reference
       Region 5lo1 A 9-16 disorder
       Region 5lo1 A 17-65 order
       Region 5lo1 A 66-73 disorder
       Region 5lo1 A 74-121 order
       Region 5lo1 A 122-128 disorder
       Region 5lo1 A 129-223 order
       Region 5lo1 A 224-236 disorder
 Evidence X-RAY 5lo5 A Reference
       Region 5lo5 A 9-16 disorder
       Region 5lo5 A 17-223 order
       Region 5lo5 A 224-236 disorder
 Evidence X-RAY 5lo6 A Reference
       Region 5lo6 A 9-16 disorder
       Region 5lo6 A 17-223 order
       Region 5lo6 A 224-236 disorder
 Evidence X-RAY 5lq9 A Reference
       Region 5lq9 A 17-223 order
 Evidence X-RAY 5lr1 A Reference
       Region 5lr1 A 18-223 order
 Evidence X-RAY 5lr7 A Reference
       Region 5lr7 A 18-223 order
 Evidence X-RAY 5lrl A Reference
       Region 5lrl A 18-223 order
 Evidence X-RAY 5lrz A Reference
       Region 5lrz A 18-223 order
 Evidence X-RAY 5ls1 A Reference
       Region 5ls1 A 17-223 order
 Evidence X-RAY 5m4e A Reference
       Region 5m4e A 9-15 disorder
       Region 5m4e A 16-223 order
       Region 5m4e A 224-236 disorder
 Evidence X-RAY 5m4h A Reference
       Region 5m4h A 9-15 disorder
       Region 5m4h A 16-223 order
       Region 5m4h A 224-236 disorder
 Evidence X-RAY 5nyh A Reference
       Region 5nyh A 9-15 disorder
       Region 5nyh A 16-224 order
       Region 5nyh A 225-236 disorder
 Evidence X-RAY 5nyi A Reference
       Region 5nyi A 9-15 disorder
       Region 5nyi A 16-224 order
       Region 5nyi A 225-235 disorder
 Evidence X-RAY 5oci A Reference
       Region 5oci A 9-16 disorder
       Region 5oci A 17-103 order
       Region 5oci A 104-105 disorder
       Region 5oci A 106-107 order
       Region 5oci A 108-109 disorder
       Region 5oci A 110-223 order
       Region 5oci A 224-236 disorder
 Evidence X-RAY 5od7 A Reference
       Region 5od7 A 9-15 disorder
       Region 5od7 A 16-224 order
       Region 5od7 A 225-236 disorder
 Evidence X-RAY 5odx A Reference
       Region 5odx A 9-15 disorder
       Region 5odx A 16-224 order
       Region 5odx A 225-236 disorder
 Evidence X-RAY 5t21 A Reference
       Region 5t21 A 18-223 order
 Evidence X-RAY 5vyy A Reference
       Region 5vyy A 1-15 disorder
       Region 5vyy A 16-223 order
       Region 5vyy A 224-236 disorder
 Evidence X-RAY 5xqd A Reference
       Region 5xqd A 9-16 disorder
       Region 5xqd A 17-223 order
       Region 5xqd A 224-236 disorder
 Evidence X-RAY 5xqe A Reference
       Region 5xqe A 9-16 disorder
       Region 5xqe A 17-224 order
       Region 5xqe A 225-236 disorder
 Evidence X-RAY 5xr5 A Reference
       Region 5xr5 A 9-16 disorder
       Region 5xr5 A 17-224 order
       Region 5xr5 A 225-236 disorder
 Evidence X-RAY 5xr9 A Reference
       Region 5xr9 A 9-16 disorder
       Region 5xr9 A 17-224 order
       Region 5xr9 A 225-236 disorder
 Evidence X-RAY 5xrb A Reference
       Region 5xrb A 9-16 disorder
       Region 5xrb A 17-223 order
       Region 5xrb A 224-236 disorder
 Evidence X-RAY 5xrd A Reference
       Region 5xrd A 9-15 disorder
       Region 5xrd A 16-223 order
       Region 5xrd A 224-236 disorder
 Evidence X-RAY 5xre A Reference
       Region 5xre A 9-16 disorder
       Region 5xre A 17-223 order
       Region 5xre A 224-236 disorder
 Evidence X-RAY 6b99 A Reference
       Region 6b99 A 1-15 disorder
       Region 6b99 A 16-225 order
       Region 6b99 A 226-236 disorder
 Evidence X-RAY 6ceo A Reference
       Region 6ceo A 1-15 disorder
       Region 6ceo A 16-225 order
       Region 6ceo A 226-236 disorder
 Evidence X-RAY 6ei5 A Reference
       Region 6ei5 A 15-223 order
 Evidence X-RAY 6el5 A Reference
       Region 6el5 A 1-15 disorder
       Region 6el5 A 16-223 order
       Region 6el5 A 224-236 disorder
 Evidence X-RAY 6eln A Reference
       Region 6eln A 17-223 order
 Evidence X-RAY 6elo A Reference
       Region 6elo A 1-16 disorder
       Region 6elo A 17-223 order
       Region 6elo A 224-236 disorder
 Evidence X-RAY 6elp A Reference
       Region 6elp A 1-16 disorder
       Region 6elp A 17-223 order
       Region 6elp A 224-236 disorder
 Evidence X-RAY 6ey8 A Reference
       Region 6ey8 A 1-16 disorder
       Region 6ey8 A 17-223 order
       Region 6ey8 A 224-236 disorder
 Evidence X-RAY 6ey9 A Reference
       Region 6ey9 A 1-15 disorder
       Region 6ey9 A 16-175 order
       Region 6ey9 A 176-176 disorder
       Region 6ey9 A 177-223 order
       Region 6ey9 A 224-236 disorder
 Evidence X-RAY 6eya A Reference
       Region 6eya A 1-16 disorder
       Region 6eya A 17-106 order
       Region 6eya A 107-110 disorder
       Region 6eya A 111-223 order
       Region 6eya A 224-236 disorder
 Evidence X-RAY 6eyb A Reference
       Region 6eyb A 1-16 disorder
       Region 6eyb A 17-223 order
       Region 6eyb A 224-236 disorder
 Evidence X-RAY 6f1n A Reference
       Region 6f1n A 1-14 disorder
       Region 6f1n A 15-223 order
       Region 6f1n A 224-236 disorder
 Evidence X-RAY 6fcj A Reference
       Region 6fcj A 9-15 disorder
       Region 6fcj A 16-223 order
       Region 6fcj A 224-236 disorder
 Evidence X-RAY 6gp4 A Reference
       Region 6gp4 A 1-15 disorder
       Region 6gp4 A 16-225 order
       Region 6gp4 A 226-236 disorder
 Evidence X-RAY 6gp8 A Reference
       Region 6gp8 A 1-226 order
       Region 6gp8 A 227-236 disorder
 Evidence X-RAY 6gpf A Reference
       Region 6gpf A 1-226 order
       Region 6gpf A 227-236 disorder
 Evidence X-RAY 6gph A Reference
       Region 6gph A 1-226 order
       Region 6gph A 227-236 disorder
 Evidence X-RAY 6gpo A Reference
       Region 6gpo A 1-226 order
       Region 6gpo A 227-236 disorder
 Evidence X-RAY 6gpp A Reference
       Region 6gpp A 1-226 order
       Region 6gpp A 227-236 disorder
 Evidence X-RAY 6gpr A Reference
       Region 6gpr A 1-10 disorder
       Region 6gpr A 11-224 order
       Region 6gpr A 225-236 disorder
 Evidence X-RAY 6gpt A Reference
       Region 6gpt A 1-10 disorder
       Region 6gpt A 11-225 order
       Region 6gpt A 226-236 disorder
 Evidence X-RAY 6gpw A Reference
       Region 6gpw A 1-15 disorder
       Region 6gpw A 16-224 order
       Region 6gpw A 225-236 disorder
 Evidence X-RAY 6gpy A Reference
       Region 6gpy A 1-9 disorder
       Region 6gpy A 10-224 order
       Region 6gpy A 225-236 disorder
 Evidence X-RAY 6gq6 A Reference
       Region 6gq6 A 1-10 disorder
       Region 6gq6 A 11-224 order
       Region 6gq6 A 225-236 disorder
 Evidence X-RAY 6gqr A Reference
       Region 6gqr A 1-5 order
       Region 6gqr A 6-10 disorder
       Region 6gqr A 11-224 order
       Region 6gqr A 225-236 disorder
 Evidence X-RAY 6gqs A Reference
       Region 6gqs A 1-227 order
       Region 6gqs A 228-236 disorder
 Evidence X-RAY 6gqu A Reference
       Region 6gqu A 1-226 order
       Region 6gqu A 227-236 disorder
 Evidence X-RAY 6gr1 A Reference
       Region 6gr1 A 1-226 order
       Region 6gr1 A 227-236 disorder
 Evidence X-RAY 6gr3 A Reference
       Region 6gr3 A 1-10 disorder
       Region 6gr3 A 11-224 order
       Region 6gr3 A 225-236 disorder
 Evidence X-RAY 6gr4 A Reference
       Region 6gr4 A 1-15 disorder
       Region 6gr4 A 16-224 order
       Region 6gr4 A 225-236 disorder
 Evidence X-RAY 6gr5 A Reference
       Region 6gr5 A 1-10 disorder
       Region 6gr5 A 11-225 order
       Region 6gr5 A 226-236 disorder
 Evidence X-RAY 6hhr A Reference
       Region 6hhr A 17-224 order
 Evidence X-RAY 6lr9 A Reference
       Region 6lr9 A 9-15 disorder
       Region 6lr9 A 16-226 order
       Region 6lr9 A 227-236 disorder
 Evidence X-RAY 6lsz A Reference
       Region 6lsz A 9-15 disorder
       Region 6lsz A 16-224 order
       Region 6lsz A 225-236 disorder
 Evidence X-RAY 6lt8 A Reference
       Region 6lt8 A 9-15 disorder
       Region 6lt8 A 16-226 order
       Region 6lt8 A 227-236 disorder
 Evidence X-RAY 6lti A Reference
       Region 6lti A 9-15 disorder
       Region 6lti A 16-224 order
       Region 6lti A 225-236 disorder
 Evidence X-RAY 6ltk A Reference
       Region 6ltk A 9-16 disorder
       Region 6ltk A 17-224 order
       Region 6ltk A 225-236 disorder
 Evidence X-RAY 6n8x A Reference
       Region 6n8x A 1-15 disorder
       Region 6n8x A 16-225 order
       Region 6n8x A 226-236 disorder
 Evidence X-RAY 6olx A Reference
       Region 6olx A 1-15 disorder
       Region 6olx A 16-224 order
       Region 6olx A 225-236 disorder
 Evidence X-RAY 6u98 A Reference
       Region 6u98 A 2-15 disorder
       Region 6u98 A 16-223 order
       Region 6u98 A 224-236 disorder
 Evidence X-RAY 6u99 A Reference
       Region 6u99 A 2-15 disorder
       Region 6u99 A 16-223 order
       Region 6u99 A 224-236 disorder
 Evidence X-RAY 6u9a A Reference
       Region 6u9a A 2-15 disorder
       Region 6u9a A 16-223 order
       Region 6u9a A 224-236 disorder
 Evidence X-RAY 6u9b A Reference
       Region 6u9b A 2-15 disorder
       Region 6u9b A 16-223 order
       Region 6u9b A 224-236 disorder
 Evidence X-RAY 7dmc A Reference
       Region 7dmc A 16-224 order
 Evidence X-RAY 7lsz A Reference
       Region 7lsz A 1-15 disorder
       Region 7lsz A 16-223 order
       Region 7lsz A 224-293 disorder
 Evidence X-RAY 7lt0 A Reference
       Region 7lt0 A 1-15 disorder
       Region 7lt0 A 16-223 order
       Region 7lt0 A 224-293 disorder
 Evidence X-RAY 7s8y A Reference
       Region 7s8y A 1-15 disorder
       Region 7s8y A 16-224 order
       Region 7s8y A 225-236 disorder
 Evidence X-RAY 7s8z A Reference
       Region 7s8z A 1-15 disorder
       Region 7s8z A 16-224 order
       Region 7s8z A 225-236 disorder
 Evidence X-RAY 7s90 A Reference
       Region 7s90 A 1-14 disorder
       Region 7s90 A 15-224 order
       Region 7s90 A 225-236 disorder
 Evidence X-RAY 7s95 A Reference
       Region 7s95 A 1-15 disorder
       Region 7s95 A 16-225 order
       Region 7s95 A 226-236 disorder
 Evidence X-RAY 7s98 A Reference
       Region 7s98 A 1-15 disorder
       Region 7s98 A 16-225 order
       Region 7s98 A 226-236 disorder
 Evidence X-RAY 7s99 A Reference
       Region 7s99 A 1-15 disorder
       Region 7s99 A 16-224 order
       Region 7s99 A 225-236 disorder
 Evidence X-RAY 7s9f A Reference
       Region 7s9f A 1-10 disorder
       Region 7s9f A 11-224 order
       Region 7s9f A 225-236 disorder
 Evidence X-RAY 7s9g A Reference
       Region 7s9g A 1-15 disorder
       Region 7s9g A 16-225 order
       Region 7s9g A 226-236 disorder
 Evidence X-RAY 7s9h A Reference
       Region 7s9h A 1-15 disorder
       Region 7s9h A 16-224 order
       Region 7s9h A 225-236 disorder
 Evidence X-RAY 7s9i A Reference
       Region 7s9i A 1-15 disorder
       Region 7s9i A 16-225 order
       Region 7s9i A 226-236 disorder
 Evidence X-RAY 7ur3 A Reference
       Region 7ur3 A 1-15 disorder
       Region 7ur3 A 16-223 order
       Region 7ur3 A 224-293 disorder
 Evidence NMR 8b7i A Reference
       Region 8b7i A 9-10 disorder
       Region 8b7i A 11-223 order
       Region 8b7i A 224-236 disorder
 Evidence NMR 8b7j A Reference
       Region 8b7j A 9-10 disorder
       Region 8b7j A 11-223 order
       Region 8b7j A 114-114 high_rmsd
       Region 8b7j A 224-236 disorder
 Evidence X-RAY 8x2r A Reference
       Region 8x2r A 1-15 disorder
       Region 8x2r A 16-225 order
       Region 8x2r A 226-236 disorder
Seq 14-223 Hetero dimer : Q16543
 Evidence NMR 2k5b A Reference
       Region 2k5b A 14-223 order
Seq 293-554 Monomer :
 Evidence X-RAY 6ksq A Reference
       Region 6ksq A 293-293 disorder
       Region 6ksq A 294-546 order
       Region 6ksq A 547-554 disorder
Seq 293-714 Homo hexamer :
 Evidence X-RAY 7rxz A Reference
       Region 7rxz A 293-350 order
       Region 7rxz A 351-357 disorder
       Region 7rxz A 358-618 order
       Region 7rxz A 619-624 disorder
       Region 7rxz A 625-698 order
       Region 7rxz A 699-714 disorder
 Evidence X-RAY 7rxz B Reference
       Region 7rxz B 293-350 order
       Region 7rxz B 351-357 disorder
       Region 7rxz B 358-698 order
       Region 7rxz B 699-714 disorder
 Evidence X-RAY 7rxz C Reference
       Region 7rxz C 293-349 order
       Region 7rxz C 350-357 disorder
       Region 7rxz C 358-698 order
       Region 7rxz C 699-714 disorder
 Evidence X-RAY 7rxz D Reference
       Region 7rxz D 293-350 order
       Region 7rxz D 351-358 disorder
       Region 7rxz D 359-616 order
       Region 7rxz D 617-628 disorder
       Region 7rxz D 629-698 order
       Region 7rxz D 699-714 disorder
 Evidence X-RAY 7rxz E Reference
       Region 7rxz E 293-349 order
       Region 7rxz E 350-358 disorder
       Region 7rxz E 359-698 order
       Region 7rxz E 699-714 disorder
 Evidence X-RAY 7rxz F Reference
       Region 7rxz F 293-349 order
       Region 7rxz F 350-356 disorder
       Region 7rxz F 357-618 order
       Region 7rxz F 619-628 disorder
       Region 7rxz F 629-698 order
       Region 7rxz F 699-714 disorder
Seq 293-714 Homo dimer :
 Evidence X-RAY 7ry0 A Reference
       Region 7ry0 A 293-293 disorder
       Region 7ry0 A 294-349 order
       Region 7ry0 A 350-357 disorder
       Region 7ry0 A 358-616 order
       Region 7ry0 A 617-629 disorder
       Region 7ry0 A 630-699 order
       Region 7ry0 A 700-714 disorder
 Evidence X-RAY 7ry0 B Reference
       Region 7ry0 B 293-348 order
       Region 7ry0 B 349-358 disorder
       Region 7ry0 B 359-614 order
       Region 7ry0 B 615-629 disorder
       Region 7ry0 B 630-700 order
       Region 7ry0 B 701-714 disorder
Seq 293-714 Homo trimer :
 Evidence X-RAY 7ry1 A Reference
       Region 7ry1 A 293-627 order
       Region 7ry1 A 628-629 disorder
       Region 7ry1 A 630-699 order
       Region 7ry1 A 700-714 disorder
 Evidence X-RAY 7ry1 B Reference
       Region 7ry1 B 293-350 order
       Region 7ry1 B 351-355 disorder
       Region 7ry1 B 356-625 order
       Region 7ry1 B 626-630 disorder
       Region 7ry1 B 631-698 order
       Region 7ry1 B 699-714 disorder
 Evidence X-RAY 7ry1 C Reference
       Region 7ry1 C 293-698 order
       Region 7ry1 C 699-714 disorder
Seq 293-732 Homo hexamer :
 Evidence X-RAY 3q6m A Reference
       Region 3q6m A 293-293 disorder
       Region 3q6m A 294-349 order
       Region 3q6m A 350-358 disorder
       Region 3q6m A 359-395 order
       Region 3q6m A 396-404 disorder
       Region 3q6m A 405-615 order
       Region 3q6m A 616-629 disorder
       Region 3q6m A 630-697 order
       Region 3q6m A 698-732 disorder
 Evidence X-RAY 3q6m B Reference
       Region 3q6m B 293-293 disorder
       Region 3q6m B 294-349 order
       Region 3q6m B 350-358 disorder
       Region 3q6m B 359-395 order
       Region 3q6m B 396-404 disorder
       Region 3q6m B 405-615 order
       Region 3q6m B 616-629 disorder
       Region 3q6m B 630-699 order
       Region 3q6m B 700-732 disorder
 Evidence X-RAY 3q6m C Reference
       Region 3q6m C 293-293 disorder
       Region 3q6m C 294-349 order
       Region 3q6m C 350-359 disorder
       Region 3q6m C 360-395 order
       Region 3q6m C 396-405 disorder
       Region 3q6m C 406-614 order
       Region 3q6m C 615-629 disorder
       Region 3q6m C 630-697 order
       Region 3q6m C 698-732 disorder
 Evidence X-RAY 3q6n A Reference
       Region 3q6n A 293-296 disorder
       Region 3q6n A 297-349 order
       Region 3q6n A 350-359 disorder
       Region 3q6n A 360-393 order
       Region 3q6n A 394-406 disorder
       Region 3q6n A 407-611 order
       Region 3q6n A 612-630 disorder
       Region 3q6n A 631-698 order
       Region 3q6n A 699-732 disorder
 Evidence X-RAY 3q6n B Reference
       Region 3q6n B 293-296 disorder
       Region 3q6n B 297-349 order
       Region 3q6n B 350-357 disorder
       Region 3q6n B 358-394 order
       Region 3q6n B 395-407 disorder
       Region 3q6n B 408-611 order
       Region 3q6n B 612-630 disorder
       Region 3q6n B 631-698 order
       Region 3q6n B 699-732 disorder
 Evidence X-RAY 3q6n C Reference
       Region 3q6n C 293-296 disorder
       Region 3q6n C 297-349 order
       Region 3q6n C 350-359 disorder
       Region 3q6n C 360-393 order
       Region 3q6n C 394-406 disorder
       Region 3q6n C 407-552 order
       Region 3q6n C 553-556 disorder
       Region 3q6n C 557-611 order
       Region 3q6n C 612-630 disorder
       Region 3q6n C 631-696 order
       Region 3q6n C 697-732 disorder
 Evidence X-RAY 3q6n D Reference
       Region 3q6n D 293-296 disorder
       Region 3q6n D 297-349 order
       Region 3q6n D 350-359 disorder
       Region 3q6n D 360-394 order
       Region 3q6n D 395-406 disorder
       Region 3q6n D 407-552 order
       Region 3q6n D 553-555 disorder
       Region 3q6n D 556-613 order
       Region 3q6n D 614-630 disorder
       Region 3q6n D 631-698 order
       Region 3q6n D 699-732 disorder
 Evidence X-RAY 3q6n E Reference
       Region 3q6n E 293-296 disorder
       Region 3q6n E 297-348 order
       Region 3q6n E 349-357 disorder
       Region 3q6n E 358-394 order
       Region 3q6n E 395-407 disorder
       Region 3q6n E 408-611 order
       Region 3q6n E 612-630 disorder
       Region 3q6n E 631-697 order
       Region 3q6n E 698-732 disorder
 Evidence X-RAY 3q6n F Reference
       Region 3q6n F 293-296 disorder
       Region 3q6n F 297-349 order
       Region 3q6n F 350-357 disorder
       Region 3q6n F 358-395 order
       Region 3q6n F 396-407 disorder
       Region 3q6n F 408-552 order
       Region 3q6n F 553-556 disorder
       Region 3q6n F 557-614 order
       Region 3q6n F 615-629 disorder
       Region 3q6n F 630-698 order
       Region 3q6n F 699-732 disorder
Seq 724-732 Hetero dimer : Q9H6T3
 Evidence NMR 6fdp B Reference
       Region 6fdp B 724-732 order
Seq 724-732 Hetero dimer : Q9WUD1
 Evidence X-RAY 2c2l E Reference
       Region 2c2l E 724-732 order
 Evidence X-RAY 2c2l F Reference
       Region 2c2l F 724-732 order
 Evidence X-RAY 2c2l G Reference
       Region 2c2l G 724-732 order
 Evidence X-RAY 2c2l H Reference
       Region 2c2l H 724-732 order
Seq 726-732 Hetero dimer : IID50204Complex
 Evidence X-RAY 4cgq Q Reference
       Region 4cgq Q 726-732 order
Seq 726-732 Hetero tetramer : Q9H6T3
 Evidence X-RAY 4cgw C Reference
       Region 4cgw C 726-732 order
 Evidence X-RAY 4cgw D Reference
       Region 4cgw D 726-727 disorder
       Region 4cgw D 728-732 order
Seq 726-732 Hetero dimer : O00170
 Evidence X-RAY 4aif D Reference
       Region 4aif D 726-732 order
 Evidence X-RAY 4aif E Reference
       Region 4aif E 726-732 order
Seq 726-732 Hetero trimer : IID50204Complex
 Evidence X-RAY 4cgu C Reference
       Region 4cgu C 726-732 order
Seq 726-732 Hetero hexamer : Q9H6T3
 Evidence X-RAY 4cgv E Reference
       Region 4cgv E 726-732 order
 Evidence X-RAY 4cgv F Reference
       Region 4cgv F 726-728 disorder
       Region 4cgv F 729-732 order
Seq 728-732 Hetero dimer : P53041
 Evidence NMR 2bug B Reference
       Region 2bug B 728-732 order
SeqProS verified 724-732 TPR binding Hetero dimer : P53041
       Region 2bug B 728-732 order
       Region 3q6m B 700-732 disorder
SeqProS verified 724-732 TPR binding Hetero dimer : Q9WUD1
       Region 2c2l E 724-732 order
       Region 2c2l F 724-732 order
       Region 2c2l G 724-732 order
       Region 2c2l H 724-732 order
       Region 3q6m B 700-732 disorder
SeqProS verified 724-732 TPR binding Hetero tetramer : Q9H6T3
       Region 4cgw C 726-732 order
       Region 4cgw D 728-732 order
       Region 3q6m B 700-732 disorder
SeqProS verified 724-732 TPR binding Hetero trimer : IID50204Complex
       Region 4cgu C 726-732 order
       Region 3q6m B 700-732 disorder
SeqProS verified 724-732 TPR binding Hetero dimer : Q9H6T3
       Region 6fdp B 724-732 order
       Region 3q6m B 700-732 disorder
SeqProS verified 724-732 TPR binding Hetero dimer : IID50204Complex
       Region 4cgq Q 726-732 order
       Region 3q6m B 700-732 disorder
SeqProS verified 724-732 TPR binding Hetero dimer : O00170
       Region 4aif D 726-732 order
       Region 4aif E 726-732 order
       Region 3q6m B 700-732 disorder
SeqProS verified 724-732 TPR binding Hetero hexamer : Q9H6T3
       Region 4cgv E 726-732 order
       Region 4cgv F 729-732 order
       Region 3q6m B 700-732 disorder
Seqphosphorylation
    641-641 Phosphoserine
    492-492 Phosphotyrosine
    476-476 Phosphoserine
    453-453 Phosphoserine
    313-313 Phosphotyrosine
    263-263 Phosphoserine
    252-252 Phosphoserine
    231-231 Phosphoserine
    7-7 Phosphothreonine; by PRKDC
    5-5 Phosphothreonine; by PRKDC
Seqacetylation
    585-585 N6-acetyllysine
    489-489 N6-acetyllysine
    458-458 N6-acetyllysine
    443-443 N6-acetyllysine
    84-84 N6-acetyllysine
    58-58 N6-acetyllysine
 
Prediction
NeProc
Disorder 1-18,256-262,555-557,624-627,700-732
Order 19-255,263-554,558-623,628-699
ProS 624-627,728-732
AlphaFold
Disorder 1-15,123-129,230-240,242-279,374-374,699-732
Order 16-122,130-229,241-241,280-373,375-698
Pfam Hmmer
PF02518 40-193 6.8e-18
SEG 227-289 ,546-569
Function
Function in SwissProt
Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (PubMed:11274138, PubMed:15577939, PubMed:15937123, PubMed:27353360, PubMed:29127155, PubMed:12526792). Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself (PubMed:29127155). Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. After the completion of the chaperoning process, properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformation and finally, ADP is released from HSP90 which acquires an open conformation for the next cycle (PubMed:27295069, PubMed:26991466). Plays a critical role in mitochondrial import, delivers preproteins to the mitochondrial import receptor TOMM70 (PubMed:12526792). Apart from its chaperone activity, it also plays a role in the regulation of the transcription machinery. HSP90 and its co-chaperones modulate transcription at least at three different levels (PubMed:25973397). In the first place, they alter the steady-state levels of certain transcription factors in response to various physiological cues(PubMed:25973397). Second, they modulate the activity of certain epigenetic modifiers, such as histone deacetylases or DNA methyl transferases, and thereby respond to the change in the environment (PubMed:25973397). Third, they participate in the eviction of histones from the promoter region of certain genes and thereby turn on gene expression (PubMed:25973397). Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes (PubMed:11276205). Antagonizes STUB1-mediated inhibition of TGF-beta signaling via inhibition of STUB1-mediated SMAD3 ubiquitination and degradation (PubMed:24613385). Mediates the association of TOMM70 with IRF3 or TBK1 in mitochondrial outer membrane which promotes host antiviral response (PubMed:20628368, PubMed:25609812).
(Microbial infection) Seems to interfere with N.meningitidis NadA-mediated invasion of human cells. Decreasing HSP90 levels increases adhesion and entry of E.coli expressing NadA into human Chang cells; increasing its levels leads to decreased adhesion and invasion.
Biological Process
See also
Diagram with PDB data
ERBB2/ERBINThe Structure of ERBIN PDZ domain bound to the Carboxy-terminal tail of the ErbB2 Receptor