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IID00776
 UniprotP09874
ProteinPoly [ADP-ribose] polymerase 1
GenePARP1
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
1014
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-108 Monomer :
 Evidence NMR 2l30 A Reference
       Region 2l30 A 1-108 order
       Region 2l30 A 1-3 high_rmsd
       Region 2l30 A 97-99 high_rmsd
       Region 2l30 A 104-108 high_rmsd
 Evidence NMR 2dmj A Reference
       Region 2dmj A 1-93 order
       Region 2dmj A 1-3 high_rmsd
Seq 1-214 Monomer :
 Evidence NMR 2n8a A Reference
       Region 2n8a A 1-214 order
       Region 2n8a A 1-3 high_rmsd
       Region 2n8a A 94-106 high_rmsd
       Region 2n8a A 203-214 high_rmsd
Seq 1-96,216-366,527-662,677-786 Hetero dodecamer :
 Evidence X-RAY 7s81 A Reference
       Region 7s81 A 1-4 disorder
       Region 7s81 A 5-95 order
       Region 7s81 A 96-96 disorder
 Evidence X-RAY 7s81 F Reference
       Region 7s81 F 1-5 disorder
       Region 7s81 F 6-90 order
       Region 7s81 F 91-96 disorder
 Evidence X-RAY 7s81 I Reference
       Region 7s81 I 1-4 disorder
       Region 7s81 I 5-91 order
       Region 7s81 I 92-96 disorder
 Evidence X-RAY 7s81 N Reference
       Region 7s81 N 1-5 disorder
       Region 7s81 N 6-94 order
       Region 7s81 N 95-96 disorder
 Evidence X-RAY 7s81 B Reference
       Region 7s81 B 216-228 disorder
       Region 7s81 B 229-358 order
       Region 7s81 B 359-366 disorder
 Evidence X-RAY 7s81 G Reference
       Region 7s81 G 216-223 disorder
       Region 7s81 G 224-358 order
       Region 7s81 G 359-366 disorder
 Evidence X-RAY 7s81 J Reference
       Region 7s81 J 216-222 disorder
       Region 7s81 J 223-361 order
       Region 7s81 J 362-366 disorder
 Evidence X-RAY 7s81 O Reference
       Region 7s81 O 216-221 disorder
       Region 7s81 O 222-359 order
       Region 7s81 O 360-366 disorder
 Evidence X-RAY 7s81 C Reference
       Region 7s81 C 527-530 disorder
       Region 7s81 C 531-644 order
       Region 7s81 C 645-662 disorder
       Region 7s81 C 677-677 disorder
       Region 7s81 C 678-776 order
       Region 7s81 C 777-786 disorder
 Evidence X-RAY 7s81 H Reference
       Region 7s81 H 527-530 disorder
       Region 7s81 H 531-647 order
       Region 7s81 H 648-662 disorder
       Region 7s81 H 677-693 disorder
       Region 7s81 H 694-776 order
       Region 7s81 H 777-786 disorder
 Evidence X-RAY 7s81 K Reference
       Region 7s81 K 527-530 disorder
       Region 7s81 K 531-646 order
       Region 7s81 K 647-662 disorder
       Region 7s81 K 677-689 disorder
       Region 7s81 K 690-776 order
       Region 7s81 K 777-786 disorder
 Evidence X-RAY 7s81 P Reference
       Region 7s81 P 527-531 disorder
       Region 7s81 P 532-644 order
       Region 7s81 P 645-662 disorder
       Region 7s81 P 677-692 disorder
       Region 7s81 P 693-775 order
       Region 7s81 P 776-786 disorder
Seq 1-95,206-366,527-662,677-786 Hetero dimer :
 Evidence X-RAY 7s68 A Reference
       Region 7s68 A 1-4 disorder
       Region 7s68 A 5-91 order
       Region 7s68 A 92-95 disorder
       Region 7s68 A 206-223 disorder
       Region 7s68 A 224-359 order
       Region 7s68 A 360-366 disorder
 Evidence X-RAY 7s68 B Reference
       Region 7s68 B 527-531 disorder
       Region 7s68 B 532-644 order
       Region 7s68 B 645-662 disorder
       Region 7s68 B 677-678 disorder
       Region 7s68 B 679-776 order
       Region 7s68 B 777-786 disorder
Seq 1-95,206-366,518-686,689-1014 Hetero tetramer :
 Evidence X-RAY 7s6h A Reference
       Region 7s6h A 1-5 disorder
       Region 7s6h A 6-91 order
       Region 7s6h A 92-95 disorder
       Region 7s6h A 206-222 disorder
       Region 7s6h A 223-359 order
       Region 7s6h A 360-366 disorder
 Evidence X-RAY 7s6h C Reference
       Region 7s6h C 1-5 disorder
       Region 7s6h C 6-90 order
       Region 7s6h C 91-95 disorder
       Region 7s6h C 206-223 disorder
       Region 7s6h C 224-359 order
       Region 7s6h C 360-366 disorder
 Evidence X-RAY 7s6m A Reference
       Region 7s6m A 1-5 disorder
       Region 7s6m A 6-91 order
       Region 7s6m A 92-95 disorder
       Region 7s6m A 206-226 disorder
       Region 7s6m A 227-359 order
       Region 7s6m A 360-366 disorder
 Evidence X-RAY 7s6m C Reference
       Region 7s6m C 1-5 disorder
       Region 7s6m C 6-91 order
       Region 7s6m C 92-95 disorder
       Region 7s6m C 206-223 disorder
       Region 7s6m C 224-359 order
       Region 7s6m C 360-366 disorder
 Evidence X-RAY 7s6h B Reference
       Region 7s6h B 518-530 disorder
       Region 7s6h B 531-646 order
       Region 7s6h B 647-659 disorder
       Region 7s6h B 660-686 order
       Region 7s6h B 689-781 order
       Region 7s6h B 782-787 disorder
       Region 7s6h B 788-1014 order
 Evidence X-RAY 7s6h D Reference
       Region 7s6h D 518-530 disorder
       Region 7s6h D 531-647 order
       Region 7s6h D 648-661 disorder
       Region 7s6h D 662-686 order
       Region 7s6h D 689-780 order
       Region 7s6h D 781-783 disorder
       Region 7s6h D 784-1014 order
 Evidence X-RAY 7s6m B Reference
       Region 7s6m B 518-530 disorder
       Region 7s6m B 531-646 order
       Region 7s6m B 647-661 disorder
       Region 7s6m B 662-686 order
       Region 7s6m B 689-780 order
       Region 7s6m B 781-786 disorder
       Region 7s6m B 787-1014 order
 Evidence X-RAY 7s6m D Reference
       Region 7s6m D 518-530 disorder
       Region 7s6m D 531-646 order
       Region 7s6m D 647-659 disorder
       Region 7s6m D 660-686 order
       Region 7s6m D 689-780 order
       Region 7s6m D 781-784 disorder
       Region 7s6m D 785-1014 order
Seq 1-97,207-366,518-1014 Hetero trimer :
 Evidence X-RAY 4oqa A Reference
       Region 4oqa A 1-5 disorder
       Region 4oqa A 6-91 order
       Region 4oqa A 92-97 disorder
       Region 4oqa A 207-223 disorder
       Region 4oqa A 224-359 order
       Region 4oqa A 360-366 disorder
 Evidence X-RAY 4oqa C Reference
       Region 4oqa C 518-530 disorder
       Region 4oqa C 531-575 order
       Region 4oqa C 576-583 disorder
       Region 4oqa C 584-644 order
       Region 4oqa C 645-661 disorder
       Region 4oqa C 662-1011 order
       Region 4oqa C 1012-1014 disorder
Seq 1-97,207-366,518-1014 Hetero trimer :
 Evidence X-RAY 4oqa D Reference
       Region 4oqa D 1-5 disorder
       Region 4oqa D 6-91 order
       Region 4oqa D 92-97 disorder
       Region 4oqa D 207-223 disorder
       Region 4oqa D 224-359 order
       Region 4oqa D 360-366 disorder
 Evidence X-RAY 4oqa F Reference
       Region 4oqa F 518-530 disorder
       Region 4oqa F 531-575 order
       Region 4oqa F 576-583 disorder
       Region 4oqa F 584-644 order
       Region 4oqa F 645-661 disorder
       Region 4oqa F 662-1011 order
       Region 4oqa F 1012-1014 disorder
Seq 1-97,207-366,518-1014 Hetero trimer :
 Evidence X-RAY 4opx A Reference
       Region 4opx A 1-5 disorder
       Region 4opx A 6-91 order
       Region 4opx A 92-97 disorder
       Region 4opx A 207-223 disorder
       Region 4opx A 224-359 order
       Region 4opx A 360-366 disorder
 Evidence X-RAY 4opx C Reference
       Region 4opx C 518-530 disorder
       Region 4opx C 531-575 order
       Region 4opx C 576-583 disorder
       Region 4opx C 584-644 order
       Region 4opx C 645-661 disorder
       Region 4opx C 662-1011 order
       Region 4opx C 1012-1014 disorder
Seq 1-97,207-366,518-1014 Hetero trimer :
 Evidence X-RAY 4oqb A Reference
       Region 4oqb A 1-5 disorder
       Region 4oqb A 6-91 order
       Region 4oqb A 92-97 disorder
       Region 4oqb A 207-223 disorder
       Region 4oqb A 224-359 order
       Region 4oqb A 360-366 disorder
 Evidence X-RAY 4oqb C Reference
       Region 4oqb C 518-530 disorder
       Region 4oqb C 531-575 order
       Region 4oqb C 576-583 disorder
       Region 4oqb C 584-644 order
       Region 4oqb C 645-661 disorder
       Region 4oqb C 662-1011 order
       Region 4oqb C 1012-1014 disorder
Seq 1-97,207-366,518-1014 Hetero trimer :
 Evidence X-RAY 4opx D Reference
       Region 4opx D 1-5 disorder
       Region 4opx D 6-91 order
       Region 4opx D 92-97 disorder
       Region 4opx D 207-223 disorder
       Region 4opx D 224-359 order
       Region 4opx D 360-366 disorder
 Evidence X-RAY 4opx F Reference
       Region 4opx F 518-530 disorder
       Region 4opx F 531-575 order
       Region 4opx F 576-583 disorder
       Region 4opx F 584-644 order
       Region 4opx F 645-661 disorder
       Region 4opx F 662-1011 order
       Region 4opx F 1012-1014 disorder
Seq 1-96,216-366,518-1014 Hetero trimer :
 Evidence X-RAY 4dqy A Reference
       Region 4dqy A 1-5 disorder
       Region 4dqy A 6-91 order
       Region 4dqy A 92-96 disorder
 Evidence X-RAY 4dqy D Reference
       Region 4dqy D 1-5 disorder
       Region 4dqy D 6-91 order
       Region 4dqy D 92-96 disorder
 Evidence X-RAY 4dqy B Reference
       Region 4dqy B 216-223 disorder
       Region 4dqy B 224-359 order
       Region 4dqy B 360-366 disorder
 Evidence X-RAY 4dqy E Reference
       Region 4dqy E 216-223 disorder
       Region 4dqy E 224-359 order
       Region 4dqy E 360-366 disorder
 Evidence X-RAY 4dqy C Reference
       Region 4dqy C 518-530 disorder
       Region 4dqy C 531-575 order
       Region 4dqy C 576-583 disorder
       Region 4dqy C 584-644 order
       Region 4dqy C 645-661 disorder
       Region 4dqy C 662-1011 order
       Region 4dqy C 1012-1014 disorder
 Evidence X-RAY 4dqy F Reference
       Region 4dqy F 518-530 disorder
       Region 4dqy F 531-575 order
       Region 4dqy F 576-583 disorder
       Region 4dqy F 584-644 order
       Region 4dqy F 645-661 disorder
       Region 4dqy F 662-1011 order
       Region 4dqy F 1012-1014 disorder
Seq 1-97,207-366,518-1014 Hetero trimer :
 Evidence X-RAY 4oqb D Reference
       Region 4oqb D 1-5 disorder
       Region 4oqb D 6-91 order
       Region 4oqb D 92-97 disorder
       Region 4oqb D 207-223 disorder
       Region 4oqb D 224-359 order
       Region 4oqb D 360-366 disorder
 Evidence X-RAY 4oqb F Reference
       Region 4oqb F 518-530 disorder
       Region 4oqb F 531-575 order
       Region 4oqb F 576-583 disorder
       Region 4oqb F 584-644 order
       Region 4oqb F 645-661 disorder
       Region 4oqb F 662-1011 order
       Region 4oqb F 1012-1014 disorder
Seq 2-96 Homo dimer :
 Evidence X-RAY 3od8 A Reference
       Region 3od8 A 2-4 disorder
       Region 3od8 A 5-91 order
       Region 3od8 A 92-96 disorder
 Evidence X-RAY 3od8 B Reference
       Region 3od8 B 2-4 disorder
       Region 3od8 B 5-91 order
       Region 3od8 B 92-96 disorder
 Evidence X-RAY 3od8 C Reference
       Region 3od8 C 2-4 disorder
       Region 3od8 C 5-91 order
       Region 3od8 C 92-96 disorder
 Evidence X-RAY 3od8 D Reference
       Region 3od8 D 2-4 disorder
       Region 3od8 D 5-93 order
       Region 3od8 D 94-96 disorder
 Evidence X-RAY 3od8 E Reference
       Region 3od8 E 2-4 disorder
       Region 3od8 E 5-91 order
       Region 3od8 E 92-96 disorder
 Evidence X-RAY 3od8 F Reference
       Region 3od8 F 2-4 disorder
       Region 3od8 F 5-94 order
       Region 3od8 F 95-96 disorder
 Evidence X-RAY 3od8 G Reference
       Region 3od8 G 2-4 disorder
       Region 3od8 G 5-91 order
       Region 3od8 G 92-96 disorder
 Evidence X-RAY 3od8 H Reference
       Region 3od8 H 2-4 disorder
       Region 3od8 H 5-92 order
       Region 3od8 H 93-96 disorder
 Evidence X-RAY 3oda A Reference
       Region 3oda A 2-4 disorder
       Region 3oda A 5-91 order
       Region 3oda A 92-96 disorder
 Evidence X-RAY 3oda B Reference
       Region 3oda B 2-5 disorder
       Region 3oda B 6-91 order
       Region 3oda B 92-96 disorder
 Evidence X-RAY 3oda C Reference
       Region 3oda C 2-4 disorder
       Region 3oda C 5-91 order
       Region 3oda C 92-96 disorder
 Evidence X-RAY 3oda D Reference
       Region 3oda D 2-4 disorder
       Region 3oda D 5-93 order
       Region 3oda D 94-96 disorder
 Evidence X-RAY 3oda E Reference
       Region 3oda E 2-5 disorder
       Region 3oda E 6-91 order
       Region 3oda E 92-96 disorder
 Evidence X-RAY 3oda F Reference
       Region 3oda F 2-4 disorder
       Region 3oda F 5-94 order
       Region 3oda F 95-96 disorder
 Evidence X-RAY 3oda G Reference
       Region 3oda G 2-4 disorder
       Region 3oda G 5-91 order
       Region 3oda G 92-96 disorder
 Evidence X-RAY 3oda H Reference
       Region 3oda H 2-4 disorder
       Region 3oda H 5-92 order
       Region 3oda H 93-96 disorder
Seq 5-202 Homo dimer :
 Evidence X-RAY 4av1 A Reference
       Region 4av1 A 5-5 disorder
       Region 4av1 A 6-91 order
       Region 4av1 A 92-202 disorder
 Evidence X-RAY 4av1 C Reference
       Region 4av1 C 5-5 disorder
       Region 4av1 C 6-90 order
       Region 4av1 C 91-202 disorder
 Evidence X-RAY 4av1 B Reference
       Region 4av1 B 5-106 disorder
       Region 4av1 B 107-202 order
 Evidence X-RAY 4av1 D Reference
       Region 4av1 D 5-107 disorder
       Region 4av1 D 108-202 order
Seq 103-223 Monomer :
 Evidence NMR 2l31 A Reference
       Region 2l31 A 103-214 order
       Region 2l31 A 103-107 high_rmsd
       Region 2l31 A 203-214 high_rmsd
 Evidence X-RAY 3odc A Reference
       Region 3odc A 105-108 disorder
       Region 3odc A 109-201 order
       Region 3odc A 202-206 disorder
 Evidence X-RAY 3odc B Reference
       Region 3odc B 105-203 order
       Region 3odc B 204-206 disorder
 Evidence X-RAY 3ode A Reference
       Region 3ode A 105-109 disorder
       Region 3ode A 110-200 order
       Region 3ode A 201-206 disorder
 Evidence X-RAY 3ode B Reference
       Region 3ode B 105-107 disorder
       Region 3ode B 108-200 order
       Region 3ode B 201-206 disorder
 Evidence NMR 2cs2 A Reference
       Region 2cs2 A 103-223 order
       Region 2cs2 A 103-104 high_rmsd
       Region 2cs2 A 204-223 high_rmsd
Seq 216-366 Homo dimer :
 Evidence X-RAY 2riq A Reference
       Region 2riq A 216-224 disorder
       Region 2riq A 225-359 order
       Region 2riq A 360-366 disorder
Seq 233-358 Monomer :
 Evidence NMR 2jvn A Reference
       Region 2jvn A 233-358 order
Seq 387-486 Monomer :
 Evidence NMR 2cok A Reference
       Region 2cok A 387-486 order
       Region 2cok A 485-486 high_rmsd
Seq 518-643 Monomer :
 Evidence NMR 2cr9 A Reference
       Region 2cr9 A 518-643 order
       Region 2cr9 A 518-529 high_rmsd
Seq 655-1014 Monomer :
 Evidence X-RAY 5a00 A Reference
       Region 5a00 A 655-661 disorder
       Region 5a00 A 662-743 order
       Region 5a00 A 744-748 disorder
       Region 5a00 A 749-782 order
       Region 5a00 A 783-786 disorder
       Region 5a00 A 787-1010 order
       Region 5a00 A 1011-1014 disorder
 Evidence X-RAY 6bhv A Reference
       Region 6bhv A 788-788 disorder
       Region 6bhv A 789-1010 order
       Region 6bhv A 1011-1012 disorder
 Evidence X-RAY 6bhv B Reference
       Region 6bhv B 788-788 disorder
       Region 6bhv B 789-1010 order
       Region 6bhv B 1011-1012 disorder
 Evidence X-RAY 6bhv C Reference
       Region 6bhv C 788-788 disorder
       Region 6bhv C 789-879 order
       Region 6bhv C 880-888 disorder
       Region 6bhv C 889-1010 order
       Region 6bhv C 1011-1012 disorder
 Evidence X-RAY 6bhv D Reference
       Region 6bhv D 788-788 disorder
       Region 6bhv D 789-1011 order
       Region 6bhv D 1012-1012 disorder
 Evidence X-RAY 5ds3 A Reference
       Region 5ds3 A 788-822 order
       Region 5ds3 A 823-825 disorder
       Region 5ds3 A 826-1010 order
       Region 5ds3 A 1011-1012 disorder
 Evidence X-RAY 3gjw A Reference
       Region 3gjw A 662-1011 order
 Evidence X-RAY 3gn7 A Reference
       Region 3gn7 A 662-1011 order
 Evidence X-RAY 4gv7 A Reference
       Region 4gv7 A 662-662 disorder
       Region 4gv7 A 663-1010 order
       Region 4gv7 A 1011-1011 disorder
 Evidence X-RAY 4gv7 B Reference
       Region 4gv7 B 662-662 disorder
       Region 4gv7 B 663-1010 order
       Region 4gv7 B 1011-1011 disorder
 Evidence X-RAY 4gv7 C Reference
       Region 4gv7 C 662-662 disorder
       Region 4gv7 C 663-1010 order
       Region 4gv7 C 1011-1011 disorder
 Evidence X-RAY 4gv7 D Reference
       Region 4gv7 D 662-662 disorder
       Region 4gv7 D 663-1010 order
       Region 4gv7 D 1011-1011 disorder
 Evidence X-RAY 4hhy C Reference
       Region 4hhy C 660-661 disorder
       Region 4hhy C 662-720 order
       Region 4hhy C 721-725 disorder
       Region 4hhy C 726-1011 order
 Evidence X-RAY 4hhy D Reference
       Region 4hhy D 660-664 disorder
       Region 4hhy D 665-679 order
       Region 4hhy D 680-683 disorder
       Region 4hhy D 684-688 order
       Region 4hhy D 689-691 disorder
       Region 4hhy D 692-694 order
       Region 4hhy D 695-698 disorder
       Region 4hhy D 699-743 order
       Region 4hhy D 744-752 disorder
       Region 4hhy D 753-777 order
       Region 4hhy D 778-788 disorder
       Region 4hhy D 789-1004 order
       Region 4hhy D 1005-1011 disorder
 Evidence X-RAY 4hhy A Reference
       Region 4hhy A 660-661 disorder
       Region 4hhy A 662-1010 order
       Region 4hhy A 1011-1011 disorder
 Evidence X-RAY 4hhy B Reference
       Region 4hhy B 660-662 disorder
       Region 4hhy B 663-779 order
       Region 4hhy B 780-787 disorder
       Region 4hhy B 788-1010 order
       Region 4hhy B 1011-1011 disorder
 Evidence X-RAY 4hhz C Reference
       Region 4hhz C 660-661 disorder
       Region 4hhz C 662-1011 order
 Evidence X-RAY 4hhz D Reference
       Region 4hhz D 660-662 disorder
       Region 4hhz D 663-691 order
       Region 4hhz D 692-699 disorder
       Region 4hhz D 700-709 order
       Region 4hhz D 710-732 disorder
       Region 4hhz D 733-743 order
       Region 4hhz D 744-755 disorder
       Region 4hhz D 756-780 order
       Region 4hhz D 781-789 disorder
       Region 4hhz D 790-1010 order
       Region 4hhz D 1011-1011 disorder
 Evidence X-RAY 4hhz A Reference
       Region 4hhz A 660-661 disorder
       Region 4hhz A 662-1010 order
       Region 4hhz A 1011-1011 disorder
 Evidence X-RAY 4hhz B Reference
       Region 4hhz B 660-661 disorder
       Region 4hhz B 662-1011 order
 Evidence X-RAY 5kpn A Reference
       Region 5kpn A 662-723 order
       Region 5kpn A 724-724 disorder
       Region 5kpn A 725-1011 order
 Evidence X-RAY 5kpn B Reference
       Region 5kpn B 662-723 order
       Region 5kpn B 724-724 disorder
       Region 5kpn B 725-747 order
       Region 5kpn B 748-748 disorder
       Region 5kpn B 749-1011 order
 Evidence X-RAY 5kpo A Reference
       Region 5kpo A 662-723 order
       Region 5kpo A 724-724 disorder
       Region 5kpo A 725-1011 order
 Evidence X-RAY 5kpo B Reference
       Region 5kpo B 662-723 order
       Region 5kpo B 724-724 disorder
       Region 5kpo B 725-747 order
       Region 5kpo B 748-748 disorder
       Region 5kpo B 749-1011 order
 Evidence X-RAY 5kpp A Reference
       Region 5kpp A 662-723 order
       Region 5kpp A 724-724 disorder
       Region 5kpp A 725-1011 order
 Evidence X-RAY 5kpp B Reference
       Region 5kpp B 662-723 order
       Region 5kpp B 724-724 disorder
       Region 5kpp B 725-1011 order
 Evidence X-RAY 5kpq A Reference
       Region 5kpq A 662-723 order
       Region 5kpq A 724-724 disorder
       Region 5kpq A 725-1011 order
 Evidence X-RAY 5kpq B Reference
       Region 5kpq B 662-723 order
       Region 5kpq B 724-724 disorder
       Region 5kpq B 725-1011 order
 Evidence X-RAY 3l3l A Reference
       Region 3l3l A 662-1011 order
 Evidence X-RAY 3l3m A Reference
       Region 3l3m A 662-662 disorder
       Region 3l3m A 663-1010 order
       Region 3l3m A 1011-1011 disorder
 Evidence X-RAY 4l6s A Reference
       Region 4l6s A 662-723 order
       Region 4l6s A 724-724 disorder
       Region 4l6s A 725-1011 order
 Evidence X-RAY 4l6s B Reference
       Region 4l6s B 662-1011 order
 Evidence X-RAY 4pjt A Reference
       Region 4pjt A 662-722 order
       Region 4pjt A 723-725 disorder
       Region 4pjt A 726-744 order
       Region 4pjt A 745-747 disorder
       Region 4pjt A 748-780 order
       Region 4pjt A 781-785 disorder
       Region 4pjt A 786-1010 order
       Region 4pjt A 1011-1011 disorder
 Evidence X-RAY 4pjt B Reference
       Region 4pjt B 662-721 order
       Region 4pjt B 722-725 disorder
       Region 4pjt B 726-743 order
       Region 4pjt B 744-749 disorder
       Region 4pjt B 750-780 order
       Region 4pjt B 781-785 disorder
       Region 4pjt B 786-936 order
       Region 4pjt B 937-938 disorder
       Region 4pjt B 939-1010 order
       Region 4pjt B 1011-1011 disorder
 Evidence X-RAY 4pjt C Reference
       Region 4pjt C 662-781 order
       Region 4pjt C 782-784 disorder
       Region 4pjt C 785-1010 order
       Region 4pjt C 1011-1011 disorder
 Evidence X-RAY 4pjt D Reference
       Region 4pjt D 662-662 disorder
       Region 4pjt D 663-721 order
       Region 4pjt D 722-729 disorder
       Region 4pjt D 730-743 order
       Region 4pjt D 744-748 disorder
       Region 4pjt D 749-779 order
       Region 4pjt D 780-787 disorder
       Region 4pjt D 788-1009 order
       Region 4pjt D 1010-1011 disorder
 Evidence X-RAY 4r5w A Reference
       Region 4r5w A 662-782 order
       Region 4r5w A 783-784 disorder
       Region 4r5w A 785-1011 order
 Evidence X-RAY 4r5w B Reference
       Region 4r5w B 662-782 order
       Region 4r5w B 783-784 disorder
       Region 4r5w B 785-1011 order
 Evidence X-RAY 4r6e A Reference
       Region 4r6e A 662-1010 order
       Region 4r6e A 1011-1011 disorder
 Evidence X-RAY 4r6e B Reference
       Region 4r6e B 662-1011 order
 Evidence X-RAY 4r6e C Reference
       Region 4r6e C 662-1010 order
       Region 4r6e C 1011-1011 disorder
 Evidence X-RAY 4r6e D Reference
       Region 4r6e D 662-662 disorder
       Region 4r6e D 663-1010 order
       Region 4r6e D 1011-1011 disorder
 Evidence X-RAY 2rcw A Reference
       Region 2rcw A 662-1011 order
 Evidence X-RAY 4rv6 A Reference
       Region 4rv6 A 662-783 order
       Region 4rv6 A 784-785 disorder
       Region 4rv6 A 786-1010 order
       Region 4rv6 A 1011-1011 disorder
 Evidence X-RAY 4rv6 B Reference
       Region 4rv6 B 662-1010 order
       Region 4rv6 B 1011-1011 disorder
 Evidence X-RAY 4rv6 C Reference
       Region 4rv6 C 662-782 order
       Region 4rv6 C 783-784 disorder
       Region 4rv6 C 785-1010 order
       Region 4rv6 C 1011-1011 disorder
 Evidence X-RAY 4rv6 D Reference
       Region 4rv6 D 662-1010 order
       Region 4rv6 D 1011-1011 disorder
 Evidence X-RAY 1uk0 A Reference
       Region 1uk0 A 662-1011 order
 Evidence X-RAY 1uk0 B Reference
       Region 1uk0 B 662-1011 order
 Evidence X-RAY 1uk1 A Reference
       Region 1uk1 A 662-1011 order
 Evidence X-RAY 1uk1 B Reference
       Region 1uk1 B 662-1011 order
 Evidence X-RAY 4und A Reference
       Region 4und A 662-1010 order
       Region 4und A 1011-1011 disorder
 Evidence X-RAY 4und B Reference
       Region 4und B 662-1010 order
       Region 4und B 1011-1011 disorder
 Evidence X-RAY 4uxb A Reference
       Region 4uxb A 662-722 order
       Region 4uxb A 723-725 disorder
       Region 4uxb A 726-743 order
       Region 4uxb A 744-749 disorder
       Region 4uxb A 750-779 order
       Region 4uxb A 780-787 disorder
       Region 4uxb A 788-823 order
       Region 4uxb A 824-826 disorder
       Region 4uxb A 827-934 order
       Region 4uxb A 935-938 disorder
       Region 4uxb A 939-977 order
       Region 4uxb A 978-980 disorder
       Region 4uxb A 981-1010 order
       Region 4uxb A 1011-1011 disorder
 Evidence X-RAY 4uxb B Reference
       Region 4uxb B 662-743 order
       Region 4uxb B 744-749 disorder
       Region 4uxb B 750-780 order
       Region 4uxb B 781-786 disorder
       Region 4uxb B 787-1009 order
       Region 4uxb B 1010-1011 disorder
 Evidence X-RAY 5wrq A Reference
       Region 5wrq A 662-723 order
       Region 5wrq A 724-724 disorder
       Region 5wrq A 725-1011 order
 Evidence X-RAY 5wrq B Reference
       Region 5wrq B 662-723 order
       Region 5wrq B 724-724 disorder
       Region 5wrq B 725-1011 order
 Evidence X-RAY 5wry A Reference
       Region 5wry A 662-723 order
       Region 5wry A 724-724 disorder
       Region 5wry A 725-1011 order
 Evidence X-RAY 5wry B Reference
       Region 5wry B 662-1011 order
 Evidence X-RAY 5wrz A Reference
       Region 5wrz A 662-723 order
       Region 5wrz A 724-724 disorder
       Region 5wrz A 725-1011 order
 Evidence X-RAY 5wrz B Reference
       Region 5wrz B 662-723 order
       Region 5wrz B 724-724 disorder
       Region 5wrz B 725-1011 order
 Evidence X-RAY 5ws0 A Reference
       Region 5ws0 A 662-723 order
       Region 5ws0 A 724-724 disorder
       Region 5ws0 A 725-1011 order
 Evidence X-RAY 5ws0 B Reference
       Region 5ws0 B 662-723 order
       Region 5ws0 B 724-724 disorder
       Region 5ws0 B 725-1011 order
 Evidence X-RAY 5ws1 A Reference
       Region 5ws1 A 662-723 order
       Region 5ws1 A 724-724 disorder
       Region 5ws1 A 725-1011 order
 Evidence X-RAY 5ws1 B Reference
       Region 5ws1 B 662-723 order
       Region 5ws1 B 724-724 disorder
       Region 5ws1 B 725-1011 order
 Evidence X-RAY 5wtc A Reference
       Region 5wtc A 662-723 order
       Region 5wtc A 724-724 disorder
       Region 5wtc A 725-1011 order
 Evidence X-RAY 5wtc B Reference
       Region 5wtc B 662-723 order
       Region 5wtc B 724-724 disorder
       Region 5wtc B 725-1011 order
 Evidence X-RAY 5xsr A Reference
       Region 5xsr A 662-782 order
       Region 5xsr A 783-784 disorder
       Region 5xsr A 785-823 order
       Region 5xsr A 824-827 disorder
       Region 5xsr A 828-1010 order
       Region 5xsr A 1011-1011 disorder
 Evidence X-RAY 5xst A Reference
       Region 5xst A 662-1010 order
 Evidence X-RAY 5xsu A Reference
       Region 5xsu A 662-781 order
       Region 5xsu A 782-784 disorder
       Region 5xsu A 785-1010 order
       Region 5xsu A 1011-1011 disorder
 Evidence X-RAY 5xsu B Reference
       Region 5xsu B 662-719 order
       Region 5xsu B 720-721 disorder
       Region 5xsu B 722-744 order
       Region 5xsu B 745-746 disorder
       Region 5xsu B 747-781 order
       Region 5xsu B 782-786 disorder
       Region 5xsu B 787-1010 order
       Region 5xsu B 1011-1011 disorder
 Evidence X-RAY 5xsu C Reference
       Region 5xsu C 662-720 order
       Region 5xsu C 721-731 disorder
       Region 5xsu C 732-743 order
       Region 5xsu C 744-748 disorder
       Region 5xsu C 749-780 order
       Region 5xsu C 781-784 disorder
       Region 5xsu C 785-937 order
       Region 5xsu C 938-939 disorder
       Region 5xsu C 940-1011 order
 Evidence X-RAY 5xsu D Reference
       Region 5xsu D 662-664 disorder
       Region 5xsu D 665-691 order
       Region 5xsu D 692-694 disorder
       Region 5xsu D 695-696 order
       Region 5xsu D 697-697 disorder
       Region 5xsu D 698-713 order
       Region 5xsu D 714-714 disorder
       Region 5xsu D 715-720 order
       Region 5xsu D 721-725 disorder
       Region 5xsu D 726-735 order
       Region 5xsu D 736-736 disorder
       Region 5xsu D 737-743 order
       Region 5xsu D 744-748 disorder
       Region 5xsu D 749-754 order
       Region 5xsu D 755-755 disorder
       Region 5xsu D 756-780 order
       Region 5xsu D 781-784 disorder
       Region 5xsu D 785-1009 order
       Region 5xsu D 1010-1011 disorder
 Evidence X-RAY 6nrf A Reference
       Region 6nrf A 788-1010 order
       Region 6nrf A 1011-1012 disorder
 Evidence X-RAY 6nrg A Reference
       Region 6nrg A 788-1010 order
       Region 6nrg A 1011-1012 disorder
 Evidence X-RAY 6nrh A Reference
       Region 6nrh A 788-1010 order
       Region 6nrh A 1011-1012 disorder
 Evidence X-RAY 6nri A Reference
       Region 6nri A 788-1010 order
       Region 6nri A 1011-1012 disorder
 Evidence X-RAY 6nrj A Reference
       Region 6nrj A 788-1010 order
       Region 6nrj A 1011-1012 disorder
 Evidence X-RAY 6ntu A Reference
       Region 6ntu A 788-1010 order
       Region 6ntu A 1011-1012 disorder
Seq 655-1014 Homo dimer :
 Evidence X-RAY 5ha9 A Reference
       Region 5ha9 A 662-1011 order
 Evidence X-RAY 5ha9 B Reference
       Region 5ha9 B 662-1011 order
 Evidence X-RAY 4zzz A Reference
       Region 4zzz A 655-661 disorder
       Region 4zzz A 662-783 order
       Region 4zzz A 784-786 disorder
       Region 4zzz A 787-1014 order
 Evidence X-RAY 4zzz B Reference
       Region 4zzz B 655-663 disorder
       Region 4zzz B 664-781 order
       Region 4zzz B 782-787 disorder
       Region 4zzz B 788-1011 order
       Region 4zzz B 1012-1014 disorder
 Evidence X-RAY 7aaa A Reference
       Region 7aaa A 662-1011 order
 Evidence X-RAY 7aaa B Reference
       Region 7aaa B 662-1011 order
 Evidence X-RAY 7aab A Reference
       Region 7aab A 662-1011 order
 Evidence X-RAY 7aab B Reference
       Region 7aab B 662-1011 order
 Evidence X-RAY 7aac A Reference
       Region 7aac A 662-1011 order
 Evidence X-RAY 7aac B Reference
       Region 7aac B 662-1011 order
 Evidence X-RAY 7aad A Reference
       Region 7aad A 662-1011 order
 Evidence X-RAY 7aad B Reference
       Region 7aad B 662-1011 order
 Evidence X-RAY 7cmw A Reference
       Region 7cmw A 662-1011 order
 Evidence X-RAY 7cmw B Reference
       Region 7cmw B 662-1011 order
 Evidence X-RAY 6ghk A Reference
       Region 6ghk A 662-782 order
       Region 6ghk A 783-784 disorder
       Region 6ghk A 785-823 order
       Region 6ghk A 824-826 disorder
       Region 6ghk A 827-1011 order
 Evidence X-RAY 6ghk B Reference
       Region 6ghk B 662-782 order
       Region 6ghk B 783-784 disorder
       Region 6ghk B 785-1011 order
 Evidence X-RAY 8he7 A Reference
       Region 8he7 A 662-1011 order
 Evidence X-RAY 8he7 B Reference
       Region 8he7 B 662-1011 order
 Evidence X-RAY 7kk2 A Reference
       Region 7kk2 A 662-1011 order
 Evidence X-RAY 7kk2 B Reference
       Region 7kk2 B 662-1010 order
       Region 7kk2 B 1011-1011 disorder
 Evidence X-RAY 7kk4 A Reference
       Region 7kk4 A 662-744 order
       Region 7kk4 A 745-748 disorder
       Region 7kk4 A 749-780 order
       Region 7kk4 A 781-785 disorder
       Region 7kk4 A 786-1010 order
       Region 7kk4 A 1011-1011 disorder
 Evidence X-RAY 7kk4 B Reference
       Region 7kk4 B 662-744 order
       Region 7kk4 B 745-747 disorder
       Region 7kk4 B 748-780 order
       Region 7kk4 B 781-785 disorder
       Region 7kk4 B 786-1010 order
       Region 7kk4 B 1011-1011 disorder
 Evidence X-RAY 7kk6 A Reference
       Region 7kk6 A 662-1011 order
 Evidence X-RAY 7kk6 B Reference
       Region 7kk6 B 662-1010 order
       Region 7kk6 B 1011-1011 disorder
 Evidence X-RAY 7onr A Reference
       Region 7onr A 662-1011 order
 Evidence X-RAY 7onr B Reference
       Region 7onr B 662-1011 order
 Evidence X-RAY 7ons A Reference
       Region 7ons A 662-1011 order
 Evidence X-RAY 7ons B Reference
       Region 7ons B 662-780 order
       Region 7ons B 781-782 disorder
       Region 7ons B 783-1011 order
 Evidence X-RAY 7ont A Reference
       Region 7ont A 662-1011 order
 Evidence X-RAY 7ont B Reference
       Region 7ont B 662-1011 order
 Evidence X-RAY 6xvw A Reference
       Region 6xvw A 663-745 order
       Region 6xvw A 746-748 disorder
       Region 6xvw A 749-780 order
       Region 6xvw A 781-783 disorder
       Region 6xvw A 784-1011 order
       Region 6xvw A 1012-1014 disorder
 Evidence X-RAY 6xvw B Reference
       Region 6xvw B 663-744 order
       Region 6xvw B 745-749 disorder
       Region 6xvw B 750-1011 order
       Region 6xvw B 1012-1014 disorder
Seq 661-1011 Homo tetramer :
 Evidence X-RAY 6vkk A Reference
       Region 6vkk A 661-661 disorder
       Region 6vkk A 662-780 order
       Region 6vkk A 781-785 disorder
       Region 6vkk A 786-1011 order
 Evidence X-RAY 6vkk B Reference
       Region 6vkk B 661-661 disorder
       Region 6vkk B 662-780 order
       Region 6vkk B 781-785 disorder
       Region 6vkk B 786-1011 order
 Evidence X-RAY 6vkk C Reference
       Region 6vkk C 661-661 disorder
       Region 6vkk C 662-743 order
       Region 6vkk C 744-748 disorder
       Region 6vkk C 749-780 order
       Region 6vkk C 781-785 disorder
       Region 6vkk C 786-1011 order
 Evidence X-RAY 6vkk D Reference
       Region 6vkk D 661-661 disorder
       Region 6vkk D 662-742 order
       Region 6vkk D 743-748 disorder
       Region 6vkk D 749-780 order
       Region 6vkk D 781-785 disorder
       Region 6vkk D 786-1011 order
Seq 661-1011 Homo tetramer :
 Evidence X-RAY 6vko A Reference
       Region 6vko A 661-663 disorder
       Region 6vko A 664-781 order
       Region 6vko A 782-789 disorder
       Region 6vko A 790-1011 order
 Evidence X-RAY 6vko B Reference
       Region 6vko B 661-663 disorder
       Region 6vko B 664-781 order
       Region 6vko B 782-789 disorder
       Region 6vko B 790-1011 order
 Evidence X-RAY 6vko C Reference
       Region 6vko C 661-663 disorder
       Region 6vko C 664-781 order
       Region 6vko C 782-789 disorder
       Region 6vko C 790-1011 order
 Evidence X-RAY 6vko D Reference
       Region 6vko D 661-663 disorder
       Region 6vko D 664-781 order
       Region 6vko D 782-789 disorder
       Region 6vko D 790-1011 order
 Evidence X-RAY 6vkq A Reference
       Region 6vkq A 661-663 disorder
       Region 6vkq A 664-781 order
       Region 6vkq A 782-789 disorder
       Region 6vkq A 790-1011 order
 Evidence X-RAY 6vkq B Reference
       Region 6vkq B 661-663 disorder
       Region 6vkq B 664-781 order
       Region 6vkq B 782-789 disorder
       Region 6vkq B 790-1011 order
 Evidence X-RAY 6vkq C Reference
       Region 6vkq C 661-663 disorder
       Region 6vkq C 664-781 order
       Region 6vkq C 782-789 disorder
       Region 6vkq C 790-1011 order
 Evidence X-RAY 6vkq D Reference
       Region 6vkq D 661-663 disorder
       Region 6vkq D 664-781 order
       Region 6vkq D 782-789 disorder
       Region 6vkq D 790-1011 order
Seq 661-1014 Hetero dimer : Q9UNS1
 Evidence X-RAY 4xhu C Reference
       Region 4xhu C 661-664 disorder
       Region 4xhu C 665-722 order
       Region 4xhu C 723-723 disorder
       Region 4xhu C 724-779 order
       Region 4xhu C 780-784 disorder
       Region 4xhu C 785-822 order
       Region 4xhu C 823-827 disorder
       Region 4xhu C 828-979 order
       Region 4xhu C 980-980 disorder
       Region 4xhu C 981-1009 order
       Region 4xhu C 1010-1014 disorder
 Evidence X-RAY 4xhu A Reference
       Region 4xhu A 661-721 order
       Region 4xhu A 722-727 disorder
       Region 4xhu A 728-779 order
       Region 4xhu A 780-784 disorder
       Region 4xhu A 785-1012 order
       Region 4xhu A 1013-1014 disorder
Seq 662-1011 Homo tetramer :
 Evidence X-RAY 7kk3 A Reference
       Region 7kk3 A 662-722 order
       Region 7kk3 A 723-725 disorder
       Region 7kk3 A 726-744 order
       Region 7kk3 A 745-747 disorder
       Region 7kk3 A 748-750 order
       Region 7kk3 A 751-752 disorder
       Region 7kk3 A 753-780 order
       Region 7kk3 A 781-785 disorder
       Region 7kk3 A 786-1010 order
       Region 7kk3 A 1011-1011 disorder
 Evidence X-RAY 7kk3 B Reference
       Region 7kk3 B 662-744 order
       Region 7kk3 B 745-746 disorder
       Region 7kk3 B 747-780 order
       Region 7kk3 B 781-784 disorder
       Region 7kk3 B 785-821 order
       Region 7kk3 B 822-827 disorder
       Region 7kk3 B 828-1010 order
       Region 7kk3 B 1011-1011 disorder
 Evidence X-RAY 7kk3 C Reference
       Region 7kk3 C 662-743 order
       Region 7kk3 C 744-749 disorder
       Region 7kk3 C 750-822 order
       Region 7kk3 C 823-826 disorder
       Region 7kk3 C 827-1010 order
       Region 7kk3 C 1011-1011 disorder
 Evidence X-RAY 7kk3 D Reference
       Region 7kk3 D 662-720 order
       Region 7kk3 D 721-726 disorder
       Region 7kk3 D 727-743 order
       Region 7kk3 D 744-748 disorder
       Region 7kk3 D 749-781 order
       Region 7kk3 D 782-787 disorder
       Region 7kk3 D 788-822 order
       Region 7kk3 D 823-826 disorder
       Region 7kk3 D 827-1010 order
       Region 7kk3 D 1011-1011 disorder
 Evidence X-RAY 7kk5 A Reference
       Region 7kk5 A 662-722 order
       Region 7kk5 A 723-725 disorder
       Region 7kk5 A 726-745 order
       Region 7kk5 A 746-747 disorder
       Region 7kk5 A 748-780 order
       Region 7kk5 A 781-785 disorder
       Region 7kk5 A 786-1010 order
       Region 7kk5 A 1011-1011 disorder
 Evidence X-RAY 7kk5 B Reference
       Region 7kk5 B 662-744 order
       Region 7kk5 B 745-746 disorder
       Region 7kk5 B 747-780 order
       Region 7kk5 B 781-784 disorder
       Region 7kk5 B 785-1010 order
       Region 7kk5 B 1011-1011 disorder
 Evidence X-RAY 7kk5 C Reference
       Region 7kk5 C 662-743 order
       Region 7kk5 C 744-749 disorder
       Region 7kk5 C 750-1010 order
       Region 7kk5 C 1011-1011 disorder
 Evidence X-RAY 7kk5 D Reference
       Region 7kk5 D 662-720 order
       Region 7kk5 D 721-726 disorder
       Region 7kk5 D 727-743 order
       Region 7kk5 D 744-748 disorder
       Region 7kk5 D 749-781 order
       Region 7kk5 D 782-787 disorder
       Region 7kk5 D 788-1010 order
       Region 7kk5 D 1011-1011 disorder
Seq 662-1011 Homo hexamer :
 Evidence X-RAY 2rd6 A Reference
       Region 2rd6 A 662-1011 order
Seq 662-1011 Homo tetramer :
 Evidence X-RAY 1wok A Reference
       Region 1wok A 662-1011 order
 Evidence X-RAY 1wok B Reference
       Region 1wok B 662-1011 order
 Evidence X-RAY 1wok C Reference
       Region 1wok C 662-1011 order
 Evidence X-RAY 1wok D Reference
       Region 1wok D 662-1011 order
Seq 788-1014 Hetero dimer : Q9NWY4
 Evidence X-RAY 6m3i B Reference
       Region 6m3i B 788-880 order
       Region 6m3i B 881-888 disorder
       Region 6m3i B 889-1014 order
Seqphosphorylation
    786-786 Phosphoserine
    782-782 Phosphoserine
    594-594 Phosphothreonine; by PRKDC
    277-277 Phosphoserine
    364-364 Phosphoserine
    368-368 Phosphothreonine
    274-274 Phosphoserine
    185-185 Phosphoserine
    177-177 Phosphoserine
    179-179 Phosphoserine
    41-41 Phosphoserine
Seqacetylation
    621-621 N6-acetyllysine
    600-600 N6-acetyllysine
    131-131 N6-acetyllysine
    97-97 N6-acetyllysine
    105-105 N6-acetyllysine
    2-2 N-acetylalanine
 
Prediction
NeProc
Disorder 1-4,96-109,202-215,358-388,483-521,648-661,781-786
Order 5-91,110-201,216-357,389-482,522-647,662-780,787-1014
ProS 202-202,483-493
AlphaFold
Disorder 1-6,61-61,92-108,202-228,359-387,482-531,643-660,694-695,697-700,781-783,1011-1014
Order 7-60,62-91,109-201,229-358,388-481,532-642,661-693,696-696,701-780,784-1010
Pfam Hmmer
PF00645 12-90 1.8e-39
PF00645 116-200 9.8e-44
PF08063 279-332 3.1e-34
PF00533 385-463 7.2e-12
PF05406 548-633 8.9e-40
PF02877 662-795 1.4e-82
PF00644 797-1007 3.2e-123
SEG 220-239 ,358-386 ,433-448 ,483-495 ,497-509 ,998-1010
Function
Function in SwissProt
Poly-ADP-ribosyltransferase that mediates poly-ADP-ribosylation of proteins and plays a key role in DNA repair (PubMed:17177976, PubMed:18172500, PubMed:20388712, PubMed:19344625, PubMed:19661379, PubMed:21680843, PubMed:23230272, PubMed:25043379, PubMed:26344098, PubMed:32028527, PubMed:30104678, PubMed:33186521, PubMed:31796734, PubMed:32358582, PubMed:34737271, PubMed:34465625, PubMed:18055453, PubMed:22582261, PubMed:26626479, PubMed:26626480, PubMed:32241924). Mediates glutamate, aspartate, serine, histidine or tyrosine ADP-ribosylation of proteins: the ADP-D-ribosyl group of NAD(+) is transferred to the acceptor carboxyl group of target residues and further ADP-ribosyl groups are transferred to the 2'-position of the terminal adenosine moiety, building up a polymer with an average chain length of 20-30 units (PubMed:7852410, PubMed:9315851, PubMed:19764761, PubMed:25043379, PubMed:28190768, PubMed:29954836, PubMed:35393539). Serine ADP-ribosylation of proteins constitutes the primary form of ADP-ribosylation of proteins in response to DNA damage (PubMed:33186521, PubMed:34874266). Specificity for the different amino acids is conferred by interacting factors, such as HPF1 and NMNAT1 (PubMed:28190768, PubMed:29954836, PubMed:32028527, PubMed:33186521, PubMed:34874266, PubMed:34625544, PubMed:33589610). Following interaction with HPF1, catalyzes serine ADP-ribosylation of target proteins; HPF1 confers serine specificity by completing the PARP1 active site (PubMed:28190768, PubMed:29954836, PubMed:32028527, PubMed:33186521, PubMed:34874266, PubMed:34625544, PubMed:33589610). Also catalyzes tyrosine ADP-ribosylation of target proteins following interaction with HPF1 (PubMed:30257210, PubMed:29954836). Following interaction with NMNAT1, catalyzes glutamate and aspartate ADP-ribosylation of target proteins; NMNAT1 confers glutamate and aspartate specificity (By similarity). PARP1 initiates the repair of DNA breaks: recognizes and binds DNA breaks within chromatin and recruits HPF1, licensing serine ADP-ribosylation of target proteins, such as histones (H2BS6ADPr and H3S10ADPr), thereby promoting decompaction of chromatin and the recruitment of repair factors leading to the reparation of DNA strand breaks (PubMed:17177976, PubMed:18172500, PubMed:19344625, PubMed:19661379, PubMed:23230272, PubMed:27067600, PubMed:34874266, PubMed:34465625). HPF1 initiates serine ADP-ribosylation but restricts the polymerase activity of PARP1 in order to limit the length of poly-ADP-ribose chains (PubMed:34732825, PubMed:33683197, PubMed:34795260). In addition to base excision repair (BER) pathway, also involved in double-strand breaks (DSBs) repair: together with TIMELESS, accumulates at DNA damage sites and promotes homologous recombination repair by mediating poly-ADP-ribosylation (PubMed:26344098, PubMed:30356214). Mediates the poly-ADP-ribosylation of a number of proteins, including itself, APLF, CHFR, RPA1 and NFAT5 (PubMed:17396150, PubMed:19764761, PubMed:24906880, PubMed:34049076). In addition to proteins, also able to ADP-ribosylate DNA: catalyzes ADP-ribosylation of DNA strand break termini containing terminal phosphates and a 2'-OH group in single- and double-stranded DNA, respectively (PubMed:27471034). Required for PARP9 and DTX3L recruitment to DNA damage sites (PubMed:23230272). PARP1-dependent PARP9-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites (PubMed:23230272). PARP1-mediated DNA repair in neurons plays a role in sleep: senses DNA damage in neurons and promotes sleep, facilitating efficient DNA repair (By similarity). In addition to DNA repair, also involved in other processes, such as transcription regulation, programmed cell death, membrane repair, adipogenesis and innate immunity (PubMed:17177976, PubMed:19344625, PubMed:15607977, PubMed:27256882, PubMed:32844745, PubMed:32315358, PubMed:35124853, PubMed:35460603, PubMed:35393539). Acts as a repressor of transcription: binds to nucleosomes and modulates chromatin structure in a manner similar to histone H1, thereby altering RNA polymerase II (PubMed:15607977, PubMed:22464733). Acts both as a positive and negative regulator of transcription elongation, depending on the context (PubMed:27256882, PubMed:35393539). Acts as a positive regulator of transcription elongation by mediating poly-ADP-ribosylation of NELFE, preventing RNA-binding activity of NELFE and relieving transcription pausing (PubMed:27256882). Acts as a negative regulator of transcription elongation in response to DNA damage by catalyzing poly-ADP-ribosylation of CCNT1, disrupting the phase separation activity of CCNT1 and subsequent activation of CDK9 (PubMed:35393539). Involved in replication fork progression following interaction with CARM1: mediates poly-ADP-ribosylation at replication forks, slowing fork progression (PubMed:33412112). Poly-ADP-ribose chains generated by PARP1 also play a role in poly-ADP-ribose-dependent cell death, a process named parthanatos (By similarity). Also acts as a negative regulator of the cGAS-STING pathway (PubMed:32844745, PubMed:32315358, PubMed:35460603). Acts by mediating poly-ADP-ribosylation of CGAS: PARP1 translocates into the cytosol following phosphorylation by PRKDC and catalyzes poly-ADP-ribosylation and inactivation of CGAS (PubMed:35460603). Acts as a negative regulator of adipogenesis: catalyzes poly-ADP-ribosylation of histone H2B on 'Glu-35' (H2BE35ADPr) following interaction with NMNAT1, inhibiting phosphorylation of H2B at 'Ser-36' (H2BS36ph), thereby blocking expression of pro-adipogenetic genes (By similarity). Involved in the synthesis of ATP in the nucleus, together with NMNAT1, PARG and NUDT5 (PubMed:27257257). Nuclear ATP generation is required for extensive chromatin remodeling events that are energy-consuming (PubMed:27257257).
Promotes AIFM1-mediated apoptosis (PubMed:33168626). This form, which translocates into the cytoplasm following cleavage by caspase-3 (CASP3) and caspase-7 (CASP7) in response to apoptosis, is auto-poly-ADP-ribosylated and serves as a poly-ADP-ribose carrier to induce AIFM1-mediated apoptosis (PubMed:33168626).
This cleavage form irreversibly binds to DNA breaks and interferes with DNA repair, promoting DNA damage-induced apoptosis.