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IID00888
 UniprotQ9UBF8
ProteinPhosphatidylinositol 4-kinase beta
GenePI4KB
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
816
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-68 Hetero dimer : Q9H3P7
 Evidence NMR 2n73 B Reference
       Region 2n73 B 1-39 disorder
       Region 2n73 B 1-39 high_rmsd
       Region 2n73 B 40-65 order
       Region 2n73 B 66-68 disorder
       Region 2n73 B 66-68 high_rmsd
Seqdisorder 41-67
 Evidence HDX-MS Reference
       Region 41-67 disorder
Seq 121-422,523-799 Hetero dimer : P62491
 Evidence X-RAY 5c46 E Reference
       Region 5c46 E 121-127 disorder
       Region 5c46 E 128-221 order
       Region 5c46 E 222-231 disorder
       Region 5c46 E 232-243 order
       Region 5c46 E 244-248 disorder
       Region 5c46 E 288-303 disorder
       Region 5c46 E 319-320 disorder
       Region 5c46 E 321-419 order
       Region 5c46 E 420-422 disorder
       Region 5c46 E 523-526 disorder
       Region 5c46 E 527-698 order
       Region 5c46 E 699-705 disorder
       Region 5c46 E 706-797 order
       Region 5c46 E 798-799 disorder
 Evidence X-RAY 5c4g E Reference
       Region 5c4g E 121-127 disorder
       Region 5c4g E 128-221 order
       Region 5c4g E 222-231 disorder
       Region 5c4g E 232-242 order
       Region 5c4g E 243-248 disorder
       Region 5c4g E 288-303 disorder
       Region 5c4g E 319-320 disorder
       Region 5c4g E 321-419 order
       Region 5c4g E 420-422 disorder
       Region 5c4g E 523-525 disorder
       Region 5c4g E 526-698 order
       Region 5c4g E 699-708 disorder
       Region 5c4g E 709-797 order
       Region 5c4g E 798-799 disorder
 Evidence X-RAY 5fbl A Reference
       Region 5fbl A 128-221 order
       Region 5fbl A 222-231 disorder
       Region 5fbl A 232-242 order
       Region 5fbl A 243-320 disorder
       Region 5fbl A 321-421 order
       Region 5fbl A 422-422 disorder
       Region 5fbl A 523-530 disorder
       Region 5fbl A 531-697 order
       Region 5fbl A 698-707 disorder
       Region 5fbl A 708-799 order
 Evidence X-RAY 5fbq A Reference
       Region 5fbq A 128-221 order
       Region 5fbq A 222-231 disorder
       Region 5fbq A 232-244 order
       Region 5fbq A 245-320 disorder
       Region 5fbq A 321-421 order
       Region 5fbq A 422-422 disorder
       Region 5fbq A 523-530 disorder
       Region 5fbq A 531-697 order
       Region 5fbq A 698-707 disorder
       Region 5fbq A 708-799 order
 Evidence X-RAY 5fbr A Reference
       Region 5fbr A 128-221 order
       Region 5fbr A 222-231 disorder
       Region 5fbr A 232-242 order
       Region 5fbr A 243-320 disorder
       Region 5fbr A 321-421 order
       Region 5fbr A 422-422 disorder
       Region 5fbr A 523-530 disorder
       Region 5fbr A 531-697 order
       Region 5fbr A 698-707 disorder
       Region 5fbr A 708-799 order
 Evidence X-RAY 5fbv A Reference
       Region 5fbv A 128-221 order
       Region 5fbv A 222-231 disorder
       Region 5fbv A 232-242 order
       Region 5fbv A 243-320 disorder
       Region 5fbv A 321-421 order
       Region 5fbv A 422-422 disorder
       Region 5fbv A 523-530 disorder
       Region 5fbv A 531-697 order
       Region 5fbv A 698-707 disorder
       Region 5fbv A 708-799 order
 Evidence X-RAY 5fbw A Reference
       Region 5fbw A 128-221 order
       Region 5fbw A 222-231 disorder
       Region 5fbw A 232-242 order
       Region 5fbw A 243-320 disorder
       Region 5fbw A 321-421 order
       Region 5fbw A 422-422 disorder
       Region 5fbw A 523-530 disorder
       Region 5fbw A 531-695 order
       Region 5fbw A 696-707 disorder
       Region 5fbw A 708-799 order
Seq 121-248,523-799 Hetero tetramer : O02810,P62491
 Evidence X-RAY 5euq E Reference
       Region 5euq E 121-127 disorder
       Region 5euq E 128-221 order
       Region 5euq E 222-231 disorder
       Region 5euq E 232-242 order
       Region 5euq E 243-248 disorder
       Region 5euq E 523-527 disorder
       Region 5euq E 528-698 order
       Region 5euq E 699-708 disorder
       Region 5euq E 709-797 order
       Region 5euq E 798-799 disorder
Seq 121-303,319-422,523-799 Hetero dodecamer : O75154,P62491
 Evidence X-RAY 4d0m G Reference
       Region 4d0m G 121-127 disorder
       Region 4d0m G 128-221 order
       Region 4d0m G 222-231 disorder
       Region 4d0m G 232-242 order
       Region 4d0m G 243-303 disorder
       Region 4d0m G 319-320 disorder
       Region 4d0m G 321-421 order
       Region 4d0m G 422-422 disorder
       Region 4d0m G 523-527 disorder
       Region 4d0m G 528-697 order
       Region 4d0m G 698-705 disorder
       Region 4d0m G 706-799 order
 Evidence X-RAY 4d0m I Reference
       Region 4d0m I 121-127 disorder
       Region 4d0m I 128-221 order
       Region 4d0m I 222-231 disorder
       Region 4d0m I 232-242 order
       Region 4d0m I 243-303 disorder
       Region 4d0m I 319-320 disorder
       Region 4d0m I 321-421 order
       Region 4d0m I 422-422 disorder
       Region 4d0m I 523-527 disorder
       Region 4d0m I 528-697 order
       Region 4d0m I 698-705 disorder
       Region 4d0m I 706-799 order
 Evidence X-RAY 4d0m M Reference
       Region 4d0m M 121-127 disorder
       Region 4d0m M 128-221 order
       Region 4d0m M 222-231 disorder
       Region 4d0m M 232-242 order
       Region 4d0m M 243-303 disorder
       Region 4d0m M 319-320 disorder
       Region 4d0m M 321-421 order
       Region 4d0m M 422-422 disorder
       Region 4d0m M 523-527 disorder
       Region 4d0m M 528-697 order
       Region 4d0m M 698-705 disorder
       Region 4d0m M 706-799 order
 Evidence X-RAY 4d0m Q Reference
       Region 4d0m Q 121-127 disorder
       Region 4d0m Q 128-221 order
       Region 4d0m Q 222-231 disorder
       Region 4d0m Q 232-242 order
       Region 4d0m Q 243-303 disorder
       Region 4d0m Q 319-320 disorder
       Region 4d0m Q 321-421 order
       Region 4d0m Q 422-422 disorder
       Region 4d0m Q 523-527 disorder
       Region 4d0m Q 528-697 order
       Region 4d0m Q 698-705 disorder
       Region 4d0m Q 706-799 order
Seq 121-303,319-422,523-799 Hetero hexamer : P62491
 Evidence X-RAY 4d0l A Reference
       Region 4d0l A 121-127 disorder
       Region 4d0l A 128-221 order
       Region 4d0l A 222-231 disorder
       Region 4d0l A 232-242 order
       Region 4d0l A 243-303 disorder
       Region 4d0l A 319-320 disorder
       Region 4d0l A 321-421 order
       Region 4d0l A 422-422 disorder
       Region 4d0l A 523-527 disorder
       Region 4d0l A 528-697 order
       Region 4d0l A 698-705 disorder
       Region 4d0l A 706-799 order
 Evidence X-RAY 4d0l C Reference
       Region 4d0l C 121-127 disorder
       Region 4d0l C 128-221 order
       Region 4d0l C 222-230 disorder
       Region 4d0l C 231-243 order
       Region 4d0l C 244-303 disorder
       Region 4d0l C 319-320 disorder
       Region 4d0l C 321-421 order
       Region 4d0l C 422-422 disorder
       Region 4d0l C 523-524 disorder
       Region 4d0l C 525-698 order
       Region 4d0l C 699-705 disorder
       Region 4d0l C 706-799 order
 Evidence X-RAY 4d0l E Reference
       Region 4d0l E 121-127 disorder
       Region 4d0l E 128-221 order
       Region 4d0l E 222-231 disorder
       Region 4d0l E 232-243 order
       Region 4d0l E 244-303 disorder
       Region 4d0l E 319-320 disorder
       Region 4d0l E 321-419 order
       Region 4d0l E 420-422 disorder
       Region 4d0l E 523-525 disorder
       Region 4d0l E 526-799 order
Seq 121-303,319-422,523-799 Hetero dodecamer : O75154,P62491
 Evidence X-RAY 4d0m c Reference
       Region 4d0m c 121-127 disorder
       Region 4d0m c 128-221 order
       Region 4d0m c 222-231 disorder
       Region 4d0m c 232-242 order
       Region 4d0m c 243-303 disorder
       Region 4d0m c 319-320 disorder
       Region 4d0m c 321-421 order
       Region 4d0m c 422-422 disorder
       Region 4d0m c 523-527 disorder
       Region 4d0m c 528-697 order
       Region 4d0m c 698-705 disorder
       Region 4d0m c 706-799 order
 Evidence X-RAY 4d0m g Reference
       Region 4d0m g 121-127 disorder
       Region 4d0m g 128-221 order
       Region 4d0m g 222-231 disorder
       Region 4d0m g 232-242 order
       Region 4d0m g 243-303 disorder
       Region 4d0m g 319-320 disorder
       Region 4d0m g 321-421 order
       Region 4d0m g 422-422 disorder
       Region 4d0m g 523-527 disorder
       Region 4d0m g 528-697 order
       Region 4d0m g 698-705 disorder
       Region 4d0m g 706-799 order
 Evidence X-RAY 4d0m W Reference
       Region 4d0m W 121-127 disorder
       Region 4d0m W 128-221 order
       Region 4d0m W 222-231 disorder
       Region 4d0m W 232-242 order
       Region 4d0m W 243-303 disorder
       Region 4d0m W 319-320 disorder
       Region 4d0m W 321-421 order
       Region 4d0m W 422-422 disorder
       Region 4d0m W 523-527 disorder
       Region 4d0m W 528-697 order
       Region 4d0m W 698-705 disorder
       Region 4d0m W 706-799 order
 Evidence X-RAY 4d0m Y Reference
       Region 4d0m Y 121-127 disorder
       Region 4d0m Y 128-221 order
       Region 4d0m Y 222-231 disorder
       Region 4d0m Y 232-242 order
       Region 4d0m Y 243-303 disorder
       Region 4d0m Y 319-320 disorder
       Region 4d0m Y 321-421 order
       Region 4d0m Y 422-422 disorder
       Region 4d0m Y 523-527 disorder
       Region 4d0m Y 528-697 order
       Region 4d0m Y 698-705 disorder
       Region 4d0m Y 706-799 order
Seq 121-303,319-422,523-799 Hetero dodecamer : O75154,P62491
 Evidence X-RAY 4d0m A Reference
       Region 4d0m A 121-127 disorder
       Region 4d0m A 128-221 order
       Region 4d0m A 222-231 disorder
       Region 4d0m A 232-242 order
       Region 4d0m A 243-303 disorder
       Region 4d0m A 319-320 disorder
       Region 4d0m A 321-421 order
       Region 4d0m A 422-422 disorder
       Region 4d0m A 523-527 disorder
       Region 4d0m A 528-697 order
       Region 4d0m A 698-705 disorder
       Region 4d0m A 706-799 order
 Evidence X-RAY 4d0m C Reference
       Region 4d0m C 121-127 disorder
       Region 4d0m C 128-221 order
       Region 4d0m C 222-231 disorder
       Region 4d0m C 232-242 order
       Region 4d0m C 243-303 disorder
       Region 4d0m C 319-320 disorder
       Region 4d0m C 321-421 order
       Region 4d0m C 422-422 disorder
       Region 4d0m C 523-527 disorder
       Region 4d0m C 528-697 order
       Region 4d0m C 698-705 disorder
       Region 4d0m C 706-799 order
 Evidence X-RAY 4d0m O Reference
       Region 4d0m O 121-127 disorder
       Region 4d0m O 128-221 order
       Region 4d0m O 222-231 disorder
       Region 4d0m O 232-242 order
       Region 4d0m O 243-303 disorder
       Region 4d0m O 319-320 disorder
       Region 4d0m O 321-421 order
       Region 4d0m O 422-422 disorder
       Region 4d0m O 523-527 disorder
       Region 4d0m O 528-697 order
       Region 4d0m O 698-705 disorder
       Region 4d0m O 706-799 order
 Evidence X-RAY 4d0m S Reference
       Region 4d0m S 121-127 disorder
       Region 4d0m S 128-221 order
       Region 4d0m S 222-231 disorder
       Region 4d0m S 232-242 order
       Region 4d0m S 243-303 disorder
       Region 4d0m S 319-320 disorder
       Region 4d0m S 321-421 order
       Region 4d0m S 422-422 disorder
       Region 4d0m S 523-527 disorder
       Region 4d0m S 528-697 order
       Region 4d0m S 698-705 disorder
       Region 4d0m S 706-799 order
Seq 128-422,523-799 Monomer :
 Evidence X-RAY 4wae A Reference
       Region 4wae A 128-129 disorder
       Region 4wae A 130-223 order
       Region 4wae A 224-313 disorder
       Region 4wae A 314-420 order
       Region 4wae A 421-422 disorder
       Region 4wae A 523-536 disorder
       Region 4wae A 537-798 order
       Region 4wae A 799-799 disorder
 Evidence X-RAY 4wag A Reference
       Region 4wag A 128-129 disorder
       Region 4wag A 130-223 order
       Region 4wag A 224-314 disorder
       Region 4wag A 315-420 order
       Region 4wag A 421-422 disorder
       Region 4wag A 523-536 disorder
       Region 4wag A 537-798 order
       Region 4wag A 799-799 disorder
Seq 289-297 Hetero tetramer : IID00061Complex
 Evidence X-RAY 5nas C Reference
       Region 5nas C 289-289 disorder
       Region 5nas C 290-297 order
 Evidence X-RAY 5nas D Reference
       Region 5nas D 289-289 disorder
       Region 5nas D 290-297 order
Seq 292-297 Hetero dimer : C5DN49
 Evidence X-RAY 5lx2 B Reference
       Region 5lx2 B 292-297 order
Seq 317-428,532-798 Hetero dimer :
 Evidence X-RAY 6gl3 A Reference
       Region 6gl3 A 317-322 disorder
       Region 6gl3 A 323-421 order
       Region 6gl3 A 422-428 disorder
       Region 6gl3 A 532-534 disorder
       Region 6gl3 A 535-696 order
       Region 6gl3 A 697-704 disorder
       Region 6gl3 A 705-797 order
       Region 6gl3 A 798-798 disorder
 Evidence X-RAY 6gl3 B Reference
       Region 6gl3 B 317-327 disorder
       Region 6gl3 B 328-335 order
       Region 6gl3 B 336-341 disorder
       Region 6gl3 B 342-344 order
       Region 6gl3 B 345-360 disorder
       Region 6gl3 B 361-386 order
       Region 6gl3 B 387-393 disorder
       Region 6gl3 B 394-409 order
       Region 6gl3 B 410-412 disorder
       Region 6gl3 B 413-415 order
       Region 6gl3 B 416-428 disorder
       Region 6gl3 B 532-535 disorder
       Region 6gl3 B 536-611 order
       Region 6gl3 B 612-615 disorder
       Region 6gl3 B 616-638 order
       Region 6gl3 B 639-640 disorder
       Region 6gl3 B 641-694 order
       Region 6gl3 B 695-706 disorder
       Region 6gl3 B 707-798 order
SeqProS verified 41-65 Hetero dimer : Q9H3P7
       Region 2n73 B 40-65 order
       Region 41-67 disorder
SeqProS verified 290-297 Hetero tetramer : IID00061Complex
       Region 5nas C 290-297 order
       Region 5nas D 290-297 order
       Region 4wae A 224-313 disorder
SeqProS verified 290-297 Hetero dimer : C5DN49
       Region 5lx2 B 292-297 order
       Region 4wae A 224-313 disorder
Seqphosphorylation
    258-258 Phosphoserine
    263-263 Phosphothreonine
    266-266 Phosphoserine
    275-275 Phosphoserine
    277-277 Phosphoserine
    284-284 Phosphoserine
    294-294 Phosphoserine
    428-428 Phosphoserine
    438-438 Phosphothreonine
    511-511 Phosphoserine
    517-517 Phosphothreonine
    519-519 Phosphothreonine
    294-294 Phosphoserine
Seqacetylation
    2-2 N-acetylglycine
 
Prediction
NeProc
Disorder 1-126,235-315,383-388,396-401,412-518
Order 127-234,316-370,376-382,389-395,402-411,519-816
ProS 29-64,74-90,235-292,297-315,383-388,396-401,412-484,489-518
AlphaFold
Disorder 1-49,51-52,55-56,59-59,62-127,226-226,247-319,421-527,699-707,800-804,807-807,811-811,814-816
Order 50-50,53-54,57-58,60-61,128-225,227-246,320-420,528-698,708-799,805-806,808-810,812-813
Pfam Hmmer
PF00454 558-765 1e-43
SEG 19-31
Function
Function in SwissProt
Phosphorylates phosphatidylinositol (PI) in the first committed step in the production of the second messenger inositol-1,4,5,-trisphosphate (PIP). May regulate Golgi disintegration/reorganization during mitosis, possibly via its phosphorylation. Involved in Golgi-to-plasma membrane trafficking (By similarity) (PubMed:10559940, PubMed:11277933, PubMed:12749687, PubMed:9405935). May play an important role in the inner ear development.
(Microbial infection) Plays an essential role in Aichi virus RNA replication (PubMed:22124328, PubMed:27989622, PubMed:22258260). Recruited by ACBD3 at the viral replication sites (PubMed:22124328, PubMed:27989622).
(Microbial infection) Required for cellular spike-mediated entry of human coronavirus SARS-CoV.
Biological Process
Diagram with PDB data
PI4KB/YWHAZCrystal structure of human 14-3-3 zeta in complex with PI4KIIIB peptide