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IID00907
 UniprotO00273
ProteinDNA fragmentation factor subunit alpha
GeneDFFA
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
331
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seqdisorder 1-116
 Evidence NMR¸ CD The NTD of DFF45 exhibits a spectrum typical for a disordered protein (Fig. 2C). Because nonspecific aggregation can also lead to such an appearance of the HSQC spectra, we recorded a CD spectrum of DFF45 NTD, which showed a lack of secondary structure (Fig. 2B) and confirmed that NTD of DFF45 is indeed disordered. Reference
       Region 1-116 disorder
Seq 11-100 Hetero dimer :
 Evidence NMR 1ibx B Reference
       Region 1ibx B 11-11 disorder
       Region 1ibx B 12-100 order
       Region 1ibx B 12-15 high_rmsd
       Region 1ibx B 100-100 high_rmsd
Seq 225-331 Monomer :
 Evidence NMR 1iyr A Reference
       Region 1iyr A 225-307 order
       Region 1iyr A 225-236 high_rmsd
       Region 1iyr A 299-307 high_rmsd
       Region 1iyr A 308-331 disorder
 Evidence NMR 1koy A Reference
       Region 1koy A 239-300 order
SeqProS verified 16-99 The residues with high_rmsd are excluded from the ProS. Hetero dimer :
       Region 1ibx B 12-100 order
       Region 1-116 disorder
Seqphosphorylation
    243-243 Phosphothreonine
    315-315 Phosphoserine
Seqacetylation
    1-1 N-acetylmethionine
 
Prediction
NeProc
Disorder 1-16,203-234,309-331
Order 17-202,235-308
ProS 1-6,203-207,219-234,316-320,326-331
AlphaFold
Disorder 1-18,26-30,50-58,90-91,94-122,209-237,248-252,314-331
Order 19-25,31-49,59-89,92-93,123-208,238-247,253-313
SEG 133-146
Function
Function in SwissProt
Inhibitor of the caspase-activated DNase (DFF40).