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IID00908
 UniprotO00444
ProteinSerine/threonine-protein kinase PLK4
GenePLK4
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
970
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 2-275 Monomer :
 Evidence X-RAY 3cok A Reference
       Region 3cok A 2-162 order
       Region 3cok A 163-190 disorder
       Region 3cok A 191-217 order
       Region 3cok A 218-222 disorder
       Region 3cok A 223-266 order
       Region 3cok A 267-275 disorder
 Evidence X-RAY 3cok B Reference
       Region 3cok B 2-162 order
       Region 3cok B 163-189 disorder
       Region 3cok B 190-211 order
       Region 3cok B 212-217 disorder
       Region 3cok B 218-266 order
       Region 3cok B 267-275 disorder
 Evidence X-RAY 4jxf A Reference
       Region 4jxf A 4-165 order
       Region 4jxf A 166-190 disorder
       Region 4jxf A 191-211 order
       Region 4jxf A 212-215 disorder
       Region 4jxf A 216-267 order
       Region 4jxf A 268-269 disorder
 Evidence X-RAY 4yur A Reference
       Region 4yur A 2-4 disorder
       Region 4yur A 5-155 order
       Region 4yur A 156-188 disorder
       Region 4yur A 189-211 order
       Region 4yur A 212-214 disorder
       Region 4yur A 215-266 order
       Region 4yur A 267-275 disorder
Seq 580-808 Hetero trimer : O94986
 Evidence X-RAY 4n7v A Reference
       Region 4n7v A 580-585 disorder
       Region 4n7v A 586-807 order
       Region 4n7v A 808-808 disorder
 Evidence X-RAY 4n7v B Reference
       Region 4n7v B 580-585 disorder
       Region 4n7v B 586-807 order
       Region 4n7v B 808-808 disorder
Seq 580-808 Hetero tetramer :
 Evidence X-RAY 4n7z A Reference
       Region 4n7z A 580-585 disorder
       Region 4n7z A 586-667 order
       Region 4n7z A 668-669 disorder
       Region 4n7z A 670-806 order
       Region 4n7z A 807-808 disorder
Seq 581-808 Homo octamer :
 Evidence X-RAY 6n46 A Reference
       Region 6n46 A 581-587 disorder
       Region 6n46 A 588-652 order
       Region 6n46 A 653-660 disorder
       Region 6n46 A 661-807 order
       Region 6n46 A 808-808 disorder
 Evidence X-RAY 6n46 B Reference
       Region 6n46 B 581-587 disorder
       Region 6n46 B 588-652 order
       Region 6n46 B 653-660 disorder
       Region 6n46 B 661-807 order
       Region 6n46 B 808-808 disorder
 Evidence X-RAY 6n46 C Reference
       Region 6n46 C 581-587 disorder
       Region 6n46 C 588-652 order
       Region 6n46 C 653-660 disorder
       Region 6n46 C 661-807 order
       Region 6n46 C 808-808 disorder
 Evidence X-RAY 6n46 D Reference
       Region 6n46 D 581-587 disorder
       Region 6n46 D 588-652 order
       Region 6n46 D 653-660 disorder
       Region 6n46 D 661-807 order
       Region 6n46 D 808-808 disorder
 Evidence X-RAY 6n46 E Reference
       Region 6n46 E 581-587 disorder
       Region 6n46 E 588-652 order
       Region 6n46 E 653-660 disorder
       Region 6n46 E 661-807 order
       Region 6n46 E 808-808 disorder
 Evidence X-RAY 6n46 F Reference
       Region 6n46 F 581-587 disorder
       Region 6n46 F 588-652 order
       Region 6n46 F 653-660 disorder
       Region 6n46 F 661-807 order
       Region 6n46 F 808-808 disorder
 Evidence X-RAY 6n46 G Reference
       Region 6n46 G 581-587 disorder
       Region 6n46 G 588-652 order
       Region 6n46 G 653-660 disorder
       Region 6n46 G 661-807 order
       Region 6n46 G 808-808 disorder
 Evidence X-RAY 6n46 H Reference
       Region 6n46 H 581-587 disorder
       Region 6n46 H 588-652 order
       Region 6n46 H 653-660 disorder
       Region 6n46 H 661-807 order
       Region 6n46 H 808-808 disorder
Seq 581-808 Homo dimer :
 Evidence X-RAY 4n9j A Reference
       Region 4n9j A 581-585 disorder
       Region 4n9j A 586-807 order
       Region 4n9j A 808-808 disorder
 Evidence X-RAY 4n9j B Reference
       Region 4n9j B 581-585 disorder
       Region 4n9j B 586-807 order
       Region 4n9j B 808-808 disorder
 Evidence X-RAY 6n45 A Reference
       Region 6n45 A 581-585 disorder
       Region 6n45 A 586-624 order
       Region 6n45 A 625-630 disorder
       Region 6n45 A 631-654 order
       Region 6n45 A 655-656 disorder
       Region 6n45 A 657-754 order
       Region 6n45 A 755-758 disorder
       Region 6n45 A 759-804 order
       Region 6n45 A 805-808 disorder
 Evidence X-RAY 6n45 B Reference
       Region 6n45 B 581-587 disorder
       Region 6n45 B 588-606 order
       Region 6n45 B 607-608 disorder
       Region 6n45 B 609-624 order
       Region 6n45 B 625-632 disorder
       Region 6n45 B 633-652 order
       Region 6n45 B 653-654 disorder
       Region 6n45 B 655-754 order
       Region 6n45 B 755-759 disorder
       Region 6n45 B 760-804 order
       Region 6n45 B 805-808 disorder
Seq 585-807 Hetero dimer : Q5VWP2
 Evidence X-RAY 6w38 B Reference
       Region 6w38 B 585-585 disorder
       Region 6w38 B 586-652 order
       Region 6w38 B 653-656 disorder
       Region 6w38 B 657-807 order
 Evidence X-RAY 6w3i B Reference
       Region 6w3i B 585-652 order
       Region 6w3i B 653-654 disorder
       Region 6w3i B 655-807 order
Seq 585-807 Hetero trimer : Q5VWP2,Q8TEP8
 Evidence X-RAY 6w3j B Reference
       Region 6w3j B 585-585 disorder
       Region 6w3j B 586-652 order
       Region 6w3j B 653-656 disorder
       Region 6w3j B 657-807 order
Seq 884-970 Hetero dimer : IID00981Complex
 Evidence X-RAY 5lhz A Reference
       Region 5lhz A 884-885 disorder
       Region 5lhz A 886-963 order
       Region 5lhz A 964-970 disorder
 Evidence X-RAY 5lhz B Reference
       Region 5lhz B 884-886 disorder
       Region 5lhz B 887-962 order
       Region 5lhz B 963-970 disorder
 Evidence X-RAY 5lhz C Reference
       Region 5lhz C 884-886 disorder
       Region 5lhz C 887-963 order
       Region 5lhz C 964-970 disorder
Seq 884-970 Hetero dimer : IID00981Complex
 Evidence X-RAY 4yyp A Reference
       Region 4yyp A 884-970 order
Seq 884-970 Monomer :
 Evidence NMR 2n19 A Reference
       Region 2n19 A 884-970 order
       Region 2n19 A 884-887 high_rmsd
       Region 2n19 A 966-970 high_rmsd
Seq 884-970 Hetero dimer :
 Evidence X-RAY 5lhy U Reference
       Region 5lhy U 884-889 disorder
       Region 5lhy U 890-966 order
       Region 5lhy U 967-970 disorder
Seq 884-970 Homo dimer :
 Evidence X-RAY 5lhy A Reference
       Region 5lhy A 884-889 disorder
       Region 5lhy A 890-966 order
       Region 5lhy A 967-970 disorder
 Evidence X-RAY 5lhy B Reference
       Region 5lhy B 884-889 disorder
       Region 5lhy B 890-966 order
       Region 5lhy B 967-970 disorder
 Evidence X-RAY 5lhy S Reference
       Region 5lhy S 884-889 disorder
       Region 5lhy S 890-966 order
       Region 5lhy S 967-970 disorder
 Evidence X-RAY 5lhy T Reference
       Region 5lhy T 884-889 disorder
       Region 5lhy T 890-966 order
       Region 5lhy T 967-970 disorder
 Evidence X-RAY 5lhy 1 Reference
       Region 5lhy 1 884-889 disorder
       Region 5lhy 1 890-966 order
       Region 5lhy 1 967-970 disorder
 Evidence X-RAY 5lhy 2 Reference
       Region 5lhy 2 884-889 disorder
       Region 5lhy 2 890-966 order
       Region 5lhy 2 967-970 disorder
 Evidence X-RAY 5lhy 3 Reference
       Region 5lhy 3 884-889 disorder
       Region 5lhy 3 890-966 order
       Region 5lhy 3 967-970 disorder
 Evidence X-RAY 5lhy 4 Reference
       Region 5lhy 4 884-889 disorder
       Region 5lhy 4 890-966 order
       Region 5lhy 4 967-970 disorder
 Evidence X-RAY 5lhy 5 Reference
       Region 5lhy 5 884-889 disorder
       Region 5lhy 5 890-966 order
       Region 5lhy 5 967-970 disorder
 Evidence X-RAY 5lhy 6 Reference
       Region 5lhy 6 884-889 disorder
       Region 5lhy 6 890-966 order
       Region 5lhy 6 967-970 disorder
 Evidence X-RAY 5lhy 7 Reference
       Region 5lhy 7 884-889 disorder
       Region 5lhy 7 890-966 order
       Region 5lhy 7 967-970 disorder
 Evidence X-RAY 5lhy 8 Reference
       Region 5lhy 8 884-889 disorder
       Region 5lhy 8 890-966 order
       Region 5lhy 8 967-970 disorder
 Evidence X-RAY 5lhy C Reference
       Region 5lhy C 884-889 disorder
       Region 5lhy C 890-966 order
       Region 5lhy C 967-970 disorder
 Evidence X-RAY 5lhy D Reference
       Region 5lhy D 884-889 disorder
       Region 5lhy D 890-966 order
       Region 5lhy D 967-970 disorder
 Evidence X-RAY 5lhy E Reference
       Region 5lhy E 884-889 disorder
       Region 5lhy E 890-966 order
       Region 5lhy E 967-970 disorder
 Evidence X-RAY 5lhy F Reference
       Region 5lhy F 884-889 disorder
       Region 5lhy F 890-966 order
       Region 5lhy F 967-970 disorder
 Evidence X-RAY 5lhy G Reference
       Region 5lhy G 884-889 disorder
       Region 5lhy G 890-966 order
       Region 5lhy G 967-970 disorder
 Evidence X-RAY 5lhy H Reference
       Region 5lhy H 884-889 disorder
       Region 5lhy H 890-966 order
       Region 5lhy H 967-970 disorder
 Evidence X-RAY 5lhy I Reference
       Region 5lhy I 884-889 disorder
       Region 5lhy I 890-966 order
       Region 5lhy I 967-970 disorder
 Evidence X-RAY 5lhy J Reference
       Region 5lhy J 884-889 disorder
       Region 5lhy J 890-966 order
       Region 5lhy J 967-970 disorder
 Evidence X-RAY 5lhy K Reference
       Region 5lhy K 884-889 disorder
       Region 5lhy K 890-966 order
       Region 5lhy K 967-970 disorder
 Evidence X-RAY 5lhy L Reference
       Region 5lhy L 884-889 disorder
       Region 5lhy L 890-966 order
       Region 5lhy L 967-970 disorder
 Evidence X-RAY 5lhy M Reference
       Region 5lhy M 884-889 disorder
       Region 5lhy M 890-966 order
       Region 5lhy M 967-970 disorder
 Evidence X-RAY 5lhy N Reference
       Region 5lhy N 884-889 disorder
       Region 5lhy N 890-966 order
       Region 5lhy N 967-970 disorder
 Evidence X-RAY 5lhy O Reference
       Region 5lhy O 884-889 disorder
       Region 5lhy O 890-966 order
       Region 5lhy O 967-970 disorder
 Evidence X-RAY 5lhy P Reference
       Region 5lhy P 884-889 disorder
       Region 5lhy P 890-966 order
       Region 5lhy P 967-970 disorder
 Evidence X-RAY 5lhy Q Reference
       Region 5lhy Q 884-889 disorder
       Region 5lhy Q 890-966 order
       Region 5lhy Q 967-970 disorder
 Evidence X-RAY 5lhy R Reference
       Region 5lhy R 884-889 disorder
       Region 5lhy R 890-966 order
       Region 5lhy R 967-970 disorder
Seq 884-970 Hetero dimer :
 Evidence X-RAY 5lhy 9 Reference
       Region 5lhy 9 884-889 disorder
       Region 5lhy 9 890-966 order
       Region 5lhy 9 967-970 disorder
Seqphosphorylation
    401-401 Phosphoserine
    665-665 Phosphoserine
    817-817 Phosphoserine
Seqacetylation
    45-45 N6-acetyllysine
    46-46 N6-acetyllysine
 
Prediction
NeProc
Disorder 275-590,812-884,965-970
Order 1-274,591-807,885-964
ProS 275-291,307-313,340-344,356-378,393-401,411-417,427-435,444-467,475-486,492-510,518-526,543-547,562-568,822-828,851-862
AlphaFold
Disorder 1-3,163-173,268-584,754-756,759-759,795-795,809-810,814-886,964-970
Order 4-162,174-267,585-753,757-758,760-794,796-808,811-813,887-963
SEG 288-303
Function
Function in SwissProt
Serine/threonine-protein kinase that plays a central role in centriole duplication. Able to trigger procentriole formation on the surface of the parental centriole cylinder, leading to the recruitment of centriole biogenesis proteins such as SASS6, CENPJ/CPAP, CCP110, CEP135 and gamma-tubulin. When overexpressed, it is able to induce centrosome amplification through the simultaneous generation of multiple procentrioles adjoining each parental centriole during S phase. Phosphorylates 'Ser-151' of FBXW5 during the G1/S transition, leading to inhibit FBXW5 ability to ubiquitinate SASS6. Its central role in centriole replication suggests a possible role in tumorigenesis, centrosome aberrations being frequently observed in tumors. Also involved in deuterosome-mediated centriole amplification in multiciliated that can generate more than 100 centrioles. Also involved in trophoblast differentiation by phosphorylating HAND1, leading to disrupt the interaction between HAND1 and MDFIC and activate HAND1. Phosphorylates CDC25C and CHEK2. Required for the recruitment of STIL to the centriole and for STIL-mediated centriole amplification (PubMed:22020124). Phosphorylates CEP131 at 'Ser-78' and PCM1 at 'Ser-372' which is essential for proper organization and integrity of centriolar satellites (PubMed:30804208).