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IID00910
 UniprotO14776
ProteinTranscription elongation regulator 1
GeneTCERG1
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
1098
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 99-107 Hetero dimer : IID00200Complex
 Evidence X-RAY 3q1i E Reference
       Region 3q1i E 99-100 disorder
       Region 3q1i E 101-107 order
Seq 428-464 Homo tetramer :
 Evidence 2nnt A Reference
       Region 2nnt A 428-457 order
       Region 2nnt A 458-464 disorder
 Evidence 2nnt B Reference
       Region 2nnt B 428-457 order
       Region 2nnt B 458-464 disorder
 Evidence 2nnt C Reference
       Region 2nnt C 428-457 order
       Region 2nnt C 458-464 disorder
 Evidence 2nnt D Reference
       Region 2nnt D 428-457 order
       Region 2nnt D 458-464 disorder
Seq 428-464 Monomer :
 Evidence NMR 2mw9 A Reference
       Region 2mw9 A 428-431 disorder
       Region 2mw9 A 432-464 order
 Evidence NMR 2mwa A Reference
       Region 2mwa A 428-430 disorder
       Region 2mwa A 431-464 order
       Region 2mwa A 431-431 high_rmsd
       Region 2mwa A 464-464 high_rmsd
 Evidence NMR 2mwb A Reference
       Region 2mwb A 428-430 disorder
       Region 2mwb A 431-464 order
       Region 2mwb A 431-431 high_rmsd
 Evidence NMR 2mwd A Reference
       Region 2mwd A 433-460 order
 Evidence NMR 2mwe A Reference
       Region 2mwe A 433-460 order
 Evidence NMR 2mwf A Reference
       Region 2mwf A 433-464 order
 Evidence NMR 2n4r A Reference
       Region 2n4r A 428-464 order
       Region 2n4r A 428-431 high_rmsd
 Evidence NMR 2n4s A Reference
       Region 2n4s A 428-464 order
       Region 2n4s A 428-431 high_rmsd
 Evidence NMR 2n4t A Reference
       Region 2n4t A 428-464 order
       Region 2n4t A 428-431 high_rmsd
 Evidence NMR 2n4u A Reference
       Region 2n4u A 428-464 order
       Region 2n4u A 428-430 high_rmsd
 Evidence NMR 2n4v A Reference
       Region 2n4v A 428-464 order
       Region 2n4v A 428-431 high_rmsd
 Evidence NMR 2n4w A Reference
       Region 2n4w A 428-464 order
       Region 2n4w A 428-431 high_rmsd
Seq 520-579 Monomer :
 Evidence NMR 2dk7 A Reference
       Region 2dk7 A 520-579 order
Seq 651-724 Monomer :
 Evidence NMR 2dod A Reference
       Region 2dod A 651-719 order
       Region 2dod A 651-654 high_rmsd
       Region 2dod A 719-719 high_rmsd
 Evidence NMR 2kis A Reference
       Region 2kis A 659-724 order
       Region 2kis A 723-724 high_rmsd
Seq 661-845 Homo dimer :
 Evidence X-RAY 3hfh A Reference
       Region 3hfh A 661-736 order
       Region 3hfh A 737-757 disorder
       Region 3hfh A 758-845 order
 Evidence X-RAY 3hfh B Reference
       Region 3hfh B 661-845 order
Seq 717-786 Monomer :
 Evidence NMR 2e71 A Reference
       Region 2e71 A 717-786 order
       Region 2e71 A 717-720 high_rmsd
       Region 2e71 A 783-786 high_rmsd
 Evidence NMR 2kiq A Reference
       Region 2kiq A 724-724 disorder
       Region 2kiq A 725-781 order
       Region 2kiq A 782-782 disorder
Seq 784-853 Monomer :
 Evidence NMR 2doe A Reference
       Region 2doe A 784-853 order
       Region 2doe A 784-789 high_rmsd
       Region 2doe A 852-853 high_rmsd
Seq 888-959 Monomer :
 Evidence NMR 2dof A Reference
       Region 2dof A 888-959 order
       Region 2dof A 888-890 high_rmsd
       Region 2dof A 959-959 high_rmsd
Seq 895-1081 Monomer :
 Evidence X-RAY 4fqg A Reference
       Region 4fqg A 895-1077 order
       Region 4fqg A 1078-1081 disorder
 Evidence X-RAY 4fqg B Reference
       Region 4fqg B 895-1080 order
       Region 4fqg B 1081-1081 disorder
SeqProS predicted 101-107 This region is predicted to be disordered by AlphaFold (pLDDT <68.5) and NeProc. Hetero dimer : IID00200Complex
       Region 3q1i E 101-107 order
Seqphosphorylation
    638-638 Phosphoserine
    933-933 Phosphoserine
    834-834 Phosphoserine
    11-11 Phosphoserine
 
Prediction
NeProc
Disorder 1-452,464-656,784-791,901-928,1083-1098
Order 453-463,657-783,792-900,929-1082
ProS 1-5,13-18,140-155,262-328,339-347,377-380,434-452,471-475,484-488,533-548,564-571,627-631,784-791,901-928,1089-1093
AlphaFold
Disorder 1-135,152-153,164-165,170-170,173-173,253-433,470-517,519-521,577-641,741-742,851-851,1084-1098
Order 136-151,154-163,166-169,171-172,174-252,434-469,518-518,522-576,642-740,743-850,852-1083
Pfam Hmmer
431->460 133-162 530->559
SEG 40-92 ,97-121 ,178-256 ,258-345 ,356-371 ,418-431 ,458-516 ,624-637 ,639-656 ,711-724 ,1083-1087
Function
Function in SwissProt
Transcription factor that binds RNA polymerase II and inhibits the elongation of transcripts from target promoters. Regulates transcription elongation in a TATA box-dependent manner. Necessary for TAT-dependent activation of the human immunodeficiency virus type 1 (HIV-1) promoter.