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IID00911
 UniprotO14807
ProteinRas-related protein M-Ras
GeneMRAS
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
208
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-178 Hetero hexamer : IID00311Complex,IID00905Complex
 Evidence X-RAY 7txh A Reference
       Region 7txh A 1-5 disorder
       Region 7txh A 6-178 order
 Evidence X-RAY 7txh D Reference
       Region 7txh D 1-9 disorder
       Region 7txh D 10-178 order
Seq 1-178 Hetero hexamer : IID00311Complex,IID00905Complex
 Evidence X-RAY 7tvf B Reference
       Region 7tvf B 1-3 disorder
       Region 7tvf B 4-178 order
 Evidence X-RAY 7tvf E Reference
       Region 7tvf E 1-5 disorder
       Region 7tvf E 6-178 order
SeqProS possible 40-48 Same region of the homolog (P01112) is disordered in the free state (PMID: 11320243). Hetero hexamer : IID00311Complex,IID00905Complex
       Region 7tvf B 4-178 order
       Region 7tvf E 6-178 order
       Region 7txh A 6-178 order
       Region 7txh D 10-178 order
SeqProS possible 69-73 Same region of the mouse homolog (O08989) is disordered in the free state. Hetero hexamer : IID00311Complex,IID00905Complex
       Region 7tvf B 4-178 order
       Region 7tvf E 6-178 order
       Region 7txh A 6-178 order
       Region 7txh D 10-178 order
 
Prediction
NeProc
Disorder 1-10,179-208
Order 11-178
ProS 201-208
AlphaFold
Disorder 1-9,180-208
Order 10-179
SEG 17-25 ,182-191
Function
Function in SwissProt
Serves as an important signal transducer for a novel upstream stimuli in controlling cell proliferation. Activates the MAP kinase pathway.
Biological Process
See also
Diagram with PDB data
RAF1/YWHAZHuman 14-3-3 isoform zeta in complex with a diphoyphorylated C-RAF peptide and Cotylenin A